Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C419  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 77 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 65.8
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 63.1
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 54.6
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 46.9
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 43.7
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 37.3
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 37.0
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 35.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 32.4
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 32.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 32.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 31.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 30.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 30.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 27.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 27.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 26.7
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 26.0
 LDTP02837  Beta-galactosidase (GLB1) 25.6
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 25.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 23.4
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 22.5
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 22.3
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 21.1
 LDTP05905  Acid ceramidase (ASAH1) 20.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 20.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 19.3
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 18.9
 LDTP03787  Choline kinase alpha (CHKA) 18.9
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 18.3
 LDTP08390  Kinesin-like protein KIF18B (KIF18B) 17.8
 LDTP02539  Lysosomal acid phosphatase (ACP2) 17.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 17.6
 LDTP02505  Lysosomal protective protein (CTSA) 16.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 16.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 16.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 16.2
 LDTP00988  Protein O-GlcNAcase (OGA) 16.1
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 15.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 14.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 14.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 14.4
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.3
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 13.8
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 13.8
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 13.6
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 13.5
 LDTP02141  Alpha-galactosidase A (GLA) 13.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 13.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 13.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 12.3
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 12.0
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 12.0
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 12.0
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 12.0
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 11.6
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 11.6
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 11.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 11.6
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 11.2
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.0
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 11.0
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 10.9
 LDTP08564  E3 ubiquitin-protein ligase UBR1 (UBR1) 10.9
 LDTP12610  Obg-like ATPase 1 (OLA1) 10.9
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 10.8
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 10.5
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 10.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 9.8
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 9.4
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 9.3
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 9.2
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 9.2
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 9.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 8.9
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 8.9
Transporter and channel
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 69.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 65.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 57.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 53.8
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 50.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 50.2
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 47.5
 LDTP02215  Prosaposin (PSAP) 45.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 42.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 40.8
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 37.8
 LDTP11615  Protein tweety homolog 3 (TTYH3) 35.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 26.4
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 24.4
 LDTP16813  Tetraspanin-3 (TSPAN3) 24.3
 LDTP05900  Metaxin-1 (MTX1) 23.8
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 23.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 22.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 22.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 18.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 17.3
 LDTP20002  Transmembrane protein 160 (TMEM160) 16.8
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 15.9
 LDTP15481  Transmembrane protein 87A (TMEM87A) 14.7
 LDTP09180  Zinc transporter 7 (SLC30A7) 14.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 13.0
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 12.9
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 12.9
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 12.4
 LDTP00010  Intraflagellar transport protein 56 (IFT56) 12.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 12.0
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 10.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 10.6
 LDTP03546  Translocator protein (TSPO) 10.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 10.3
 LDTP11213  Nucleoporin NDC1 (NDC1) 10.3
 LDTP11291  Transmembrane emp24 domain-containing protein 9 (TMED9) 9.6
 LDTP01455  Erlin-2 (ERLIN2) 9.4
 LDTP01234  Erlin-1 (ERLIN1) 9.0
 LDTP11824  Sodium-coupled neutral amino acid symporter 1 (SLC38A1) 8.9
 LDTP07583  Transmembrane protein 65 (TMEM65) 8.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09694  Paraspeckle component 1 (PSPC1) 10.0
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 8.3
Other
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 99.7
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 59.3
 LDTP11076  Apolipoprotein L2 (APOL2) 46.2
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 33.1
 LDTP01522  Reticulon-3 (RTN3) 31.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 30.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 26.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 24.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 24.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 23.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 22.9
 LDTP05160  Nucleobindin-2 (NUCB2) 20.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.1
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 19.0
 LDTP18132  Protein FAM136A (FAM136A) 18.8
 LDTP05868  Protein unc-119 homolog A (UNC119) 18.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 17.6
 LDTP05089  Immunoglobulin-binding protein 1 (IGBP1) 17.1
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 16.4
 LDTP16080  Protein FAM114A2 (FAM114A2) 15.7
 LDTP02927  Ganglioside GM2 activator (GM2A) 15.3
 LDTP10056  Protein FAM162A (FAM162A) 14.6
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 14.4
 LDTP08094  Wings apart-like protein homolog (WAPL) 14.3
 LDTP15714  Mdm2-binding protein (MTBP) 13.9
 LDTP06543  DNA damage-binding protein 1 (DDB1) 13.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 13.5
 LDTP13086  Syntaxin-18 (STX18) 13.4
 LDTP07031  Collectin-12 (COLEC12) 13.1
 LDTP05375  Nucleobindin-1 (NUCB1) 12.5
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 12.0
 LDTP08796  Protein SYS1 homolog (SYS1) 11.8
 LDTP12412  Reticulon-4 (RTN4) 11.6
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 11.2
 LDTP07400  Elongator complex protein 2 (ELP2) 11.2
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 10.1
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 10.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.9
 LDTP10289  Cytoplasmic FMR1-interacting protein 2 (CYFIP2) 9.4
 LDTP12476  Translation initiation factor eIF2B subunit gamma (EIF2B3) 9.4
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 9.0
 LDTP08153  Transmembrane emp24 domain-containing protein 4 (TMED4) 9.0
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 8.8
 LDTP02297  Vimentin (VIM) 8.7
 LDTP09787  Nicastrin (NCSTN) 8.6
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 8.6
 LDTP08606  Nurim (NRM) 8.5
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 8.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587