General Information of Target

Target ID LDTP12476
Target Name Translation initiation factor eIF2B subunit gamma (EIF2B3)
Gene Name EIF2B3
Gene ID 8891
Synonyms
Translation initiation factor eIF2B subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDPRNTAMLGLGSDSEGFSRKSPSAISTGTLVSKREVELEKNTKEEEDLRKRNRERNIEA
GKDDGLTDAQQQFSVKETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTTIKHPR
KALKSGKMTDEKNEHCPSKRDPSKLYKKADDVAAIECQSEEVIRLHSQGENNPLSKKLSP
VHSEMADYINATPSTLLGSRDPDLKDRALLNGGTSVTEKLAQLIATCPPSKSSKTKPKKL
GTGTTAGLVSKDLIRKAGVGSVAGIIHKDLIKKPTISTAVGLVTKDPGKKPVFNAAVGLV
NKDSVKKLGTGTTAVFINKNLGKKPGTITTVGLLSKDSGKKLGIGIVPGLVHKESGKKLG
LGTVVGLVNKDLGKKLGSTVGLVAKDCAKKIVASSAMGLVNKDIGKKLMSCPLAGLISKD
AINLKAEALLPTQEPLKASCSTNINNQESQELSESLKDSATSKTFEKNVVRQNKESILEK
FSVRKEIINLEKEMFNEGTCIQQDSFSSSEKGSYETSKHEKQPPVYCTSPDFKMGGASDV
STAKSPFSAVGESNLPSPSPTVSVNPLTRSPPETSSQLAPNPLLLSSTTELIEEISESVG
KNQFTSESTHLNVGHRSVGHSISIECKGIDKEVNDSKTTHIDIPRISSSLGKKPSLTSES
SIHTITPSVVNFTSLFSNKPFLKLGAVSASDKHCQVAESLSTSLQSKPLKKRKGRKPRWT
KVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMKNIGPPSFVDHDFLKRRLP
KLSKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKRGRPKSKEMPQLE
GPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQMRSP
VKMKPPVLSVAPFVATESPSKLESESDNHRSSSDFFESEDQLQDPDDLDDSHRPSVCSMS
DLEMEPDKKITKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHN
TVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGILSGSPTSLAVLEQTAQQA
AGSALGQILPPLLPSSASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHLHS
RQGSMIQTLAMKKASKGRRRLSPPTLLPNSPSHLSELTSLKEATPSPISESHSDETIPSD
SGIGTDNNSTSDRAEKFCGQKKRRHSFEHVSLIPPETSTVLSSLKEKHKHKCKRRNHDYL
SYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIF
RINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYP
SYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAGHLLLNPAKYH
KKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSSEQPQV
SMDTGSSRSVLESLKRYRFGKDAVGERYKHKEKHRCHMSCPHLSPSKSLINREEQWVHRE
PSESSPLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHTNLFTSAIGSCRVSNPN
SSGRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTLAGSQPTSDKPSQRPSESTNC
SPTRKRSSSESTSSTVNGVPSRSPRLVASGDDSVDSLLQRMVQNEDQEPMEKSIDAVIAT
ASAPPSSSPGRSHSKDRTLGKPDSLLVPAVTSDSCNNSISLLSEKLTSSCSPHHIKRSVV
EAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQA
VVSMQAFQAAQFVNPELNRDEEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLKRKGWL
LEEQTRKKQKPLPEEEEQENNKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKK
PPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSG
KYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKK
PDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIR
TKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARF
INHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKC
RGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTP
TRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGI
CRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYK
DSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKVFR
NAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHE
KDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMI
PRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLD
IFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCC
VLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTP
KKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPS
LEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNA
IDVTYLLEEGSGRKLRRRTLFIPENSFRK
Target Bioclass
Other
Family
EIF-2B gamma/epsilon subunits family
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Uniprot ID
Q9NR50
Ensemble ID
ENST00000360403.7
HGNC ID
HGNC:3259
ChEMBL ID
CHEMBL4295961

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.Q448P DBIA    Probe Info 
BT549 SNV: p.I109T .
HT115 SNV: p.N41D DBIA    Probe Info 
ICC8 SNV: p.K148E DBIA    Probe Info 
JURKAT SNV: p.P95L .
LS180 SNV: p.K148E DBIA    Probe Info 
MKN1 SNV: p.V160M DBIA    Probe Info 
PANC0403 SNV: p.D107N DBIA    Probe Info 
SKMEL30 SNV: p.Q363H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
15.00  LDD0402  [1]
TH211
 Probe Info 
Y124(20.00); Y278(16.16); Y319(6.16); Y231(5.62)  LDD0257  [2]
TH216
 Probe Info 
Y264(20.00); Y278(20.00)  LDD0259  [2]
STPyne
 Probe Info 
K134(3.69); K165(0.98); K189(10.00)  LDD0277  [3]
BTD
 Probe Info 
C64(0.76)  LDD1699  [4]
ONAyne
 Probe Info 
K165(7.69)  LDD0275  [3]
AHL-Pu-1
 Probe Info 
C285(2.17); C281(2.63)  LDD0168  [5]
HHS-482
 Probe Info 
Y264(0.36)  LDD0287  [6]
HHS-465
 Probe Info 
Y231(2.56)  LDD2237  [7]
DBIA
 Probe Info 
C281(1.22); C285(1.22); C64(1.08)  LDD0078  [8]
ATP probe
 Probe Info 
K367(0.00); K371(0.00); K235(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info 
C334(0.00); C77(0.00); C64(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info 
C281(0.00); C77(0.00); C334(0.00); C379(0.00)  LDD0032  [11]
Lodoacetamide azide
 Probe Info 
C424(0.00); C206(0.00); C334(0.00); C106(0.00)  LDD0037  [10]
NAIA_4
 Probe Info 
C285(0.00); C281(0.00); C334(0.00)  LDD2226  [12]
TFBX
 Probe Info 
N.A.  LDD0027  [13]
WYneN
 Probe Info 
N.A.  LDD0021  [14]
1d-yne
 Probe Info 
N.A.  LDD0356  [15]
IPM
 Probe Info 
N.A.  LDD0005  [14]
VSF
 Probe Info 
N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info 
C285(0.00); C64(0.00)  LDD0018  [16]
1c-yne
 Probe Info 
N.A.  LDD0228  [15]
Acrolein
 Probe Info 
C334(0.00); C379(0.00)  LDD0217  [17]
Methacrolein
 Probe Info 
N.A.  LDD0218  [17]
W1
 Probe Info 
C334(0.00); C281(0.00); C285(0.00)  LDD0236  [18]
AOyne
 Probe Info 
15.00  LDD0443  [19]
NAIA_5
 Probe Info 
C300(0.00); C206(0.00); C424(0.00); C106(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C071
 Probe Info 
9.00  LDD1767  [20]
C147
 Probe Info 
15.03  LDD1829  [20]
C161
 Probe Info 
9.78  LDD1841  [20]
C177
 Probe Info 
10.63  LDD1856  [20]
C187
 Probe Info 
33.36  LDD1865  [20]
C191
 Probe Info 
16.56  LDD1868  [20]
C193
 Probe Info 
6.96  LDD1869  [20]
C196
 Probe Info 
14.12  LDD1872  [20]
C289
 Probe Info 
33.13  LDD1959  [20]
C293
 Probe Info 
17.03  LDD1963  [20]
C322
 Probe Info 
6.41  LDD1988  [20]
C413
 Probe Info 
14.03  LDD2069  [20]
C419
 Probe Info 
9.38  LDD2074  [20]
FFF probe11
 Probe Info 
20.00  LDD0471  [21]
FFF probe13
 Probe Info 
7.17  LDD0476  [21]
FFF probe14
 Probe Info 
13.81  LDD0477  [21]
FFF probe3
 Probe Info 
7.89  LDD0465  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C64(1.00)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C424(0.77); C379(0.80)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C64(1.11)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C285(2.17); C281(2.63)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C64(2.77); C285(2.19); C281(3.26)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C64(1.07); C281(1.23); C285(1.05); C424(0.87)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C64(1.28); C281(1.05); C285(1.02)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C64(1.09); C281(1.09); C285(1.16)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C64(1.18); C281(1.03); C285(1.12)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C64(1.11); C281(1.05); C285(0.96)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C64(1.28); C281(1.23); C285(1.37)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C64(1.03); C281(1.04); C285(1.07)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C64(1.11); C281(1.13); C285(1.12)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C64(1.16); C281(1.26); C285(1.16)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C64(1.04); C281(0.74); C285(0.90)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C64(1.16); C281(0.91); C285(0.98)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C64(1.22); C281(0.84); C285(0.88)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C64(1.21); C281(1.04); C285(1.01)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C64(1.14); C281(0.87); C285(0.96)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C64(1.18); C281(0.97); C285(1.05)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C64(1.24); C281(0.90); C285(1.10)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C64(0.96); C281(0.92); C285(1.00)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C64(1.08); C281(1.08); C285(0.99)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C64(1.15); C281(1.44); C285(1.30)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C64(1.20); C281(1.33); C285(1.14)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C64(1.03); C281(2.27); C285(1.07)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C64(1.01); C281(1.52); C285(1.12)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C64(1.14); C281(1.31); C285(1.02)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C64(1.19); C281(1.06); C285(1.04)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C64(1.10); C281(1.54); C285(1.55)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C64(0.96); C281(1.84); C285(0.98)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C64(1.06); C281(1.05); C285(1.04)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C64(0.94); C281(1.01); C285(0.99)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C64(0.94); C281(1.81); C285(1.04)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C64(1.04); C281(1.01); C285(1.13)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C64(1.18); C281(1.04); C285(1.08)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C64(1.25); C281(1.76); C285(1.03)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C64(1.14); C281(1.28); C285(1.28)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C64(1.05); C281(1.09); C285(1.25)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C64(1.18); C281(1.18); C285(1.34)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C64(1.04); C281(1.01); C285(1.11)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C64(1.23); C281(0.88); C285(1.10)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C64(1.26); C281(0.87); C285(1.20)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C64(1.24); C281(1.14); C285(1.39)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C64(1.22); C281(0.93); C285(1.31)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C64(1.24); C281(1.02); C285(1.25)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C64(1.20); C281(0.86); C285(1.12)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C64(1.39); C281(1.00); C285(1.43)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C64(1.42); C281(1.13); C285(1.33)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C64(1.13); C281(1.10); C285(1.04)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C64(1.44); C281(0.92); C285(1.32)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C64(1.40); C281(0.92); C285(1.44)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C64(1.39); C281(0.98); C285(1.07)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C64(1.07); C281(1.20); C285(1.21)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C64(1.07); C285(1.22); C281(1.25)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C64(0.96); C281(1.08); C285(1.09)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C64(1.15); C281(1.37); C285(1.37)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C64(1.12); C281(1.31); C285(1.34)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C64(1.20); C285(1.62); C281(1.69)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C64(1.17); C285(1.30); C281(1.41)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C64(1.11); C281(1.14); C285(1.17)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C64(1.11); C285(1.25); C281(1.26)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C64(1.02); C281(1.13); C285(1.14)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C64(1.10); C281(1.41); C285(1.43)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C64(1.43); C285(1.83); C281(1.87)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C64(1.13); C281(1.28); C285(1.26)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C64(1.18); C281(1.38); C285(1.38)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C64(1.01); C281(1.14); C285(1.13)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C64(0.95); C281(1.01); C285(0.99)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C424(0.83); C64(1.01); C281(1.02); C285(1.09)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C424(1.19); C285(1.26); C281(1.31); C64(1.40)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C285(0.94); C424(1.00); C281(1.13); C64(1.18)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C424(0.82); C64(1.01); C285(1.16); C281(1.38)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C285(0.98); C64(1.13); C281(1.16); C424(1.32)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C285(0.99); C281(1.03); C64(1.06); C424(1.24)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C424(0.90); C285(0.94); C64(1.00); C281(1.03)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C424(0.96); C285(0.98); C64(1.03); C281(1.15)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C285(0.88); C64(0.96); C281(1.01); C424(1.03)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C64(0.99); C285(0.99); C281(1.01)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C285(1.08); C281(1.09); C64(1.14)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C64(1.05); C285(1.07); C281(1.14)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C64(1.05); C285(1.11); C281(1.22)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C285(1.11); C64(1.13); C281(1.13)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C285(0.92); C424(1.03); C281(1.06); C64(1.10)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C64(1.24); C285(1.26); C281(1.30)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C64(1.07); C285(1.15); C281(1.17)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C64(1.19); C285(1.37); C281(1.50)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C64(1.05); C285(1.21); C281(1.28)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C64(1.24); C285(1.38); C281(1.44)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C281(0.95); C285(0.97); C64(0.98)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C281(0.86); C285(0.88); C64(1.09)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C281(0.83); C285(0.88); C64(0.91)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C281(0.89); C285(0.98); C64(0.99)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C281(0.90); C285(1.00); C64(1.16)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C64(1.05); C285(1.10); C424(1.10); C281(1.32)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C281(1.09); C285(1.15); C64(1.81)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C281(0.95); C285(0.97); C64(1.14)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C281(1.03); C285(1.12); C64(1.12)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C281(0.97); C285(1.05); C64(1.17)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C281(0.90); C285(0.98); C64(1.21)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C281(1.04); C285(1.05); C64(1.22)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C285(0.99); C281(1.04); C424(1.15); C64(1.21)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C424(0.75); C285(0.90); C281(0.92); C64(1.18)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C285(0.93); C281(0.97); C424(1.20); C64(1.34)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C424(0.96); C285(1.16); C281(1.21); C64(1.33)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C424(1.09); C285(1.10); C64(1.12); C281(1.35)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C285(1.13); C424(1.16); C281(1.21); C64(1.56)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C424(0.83); C285(0.97); C64(1.06); C281(1.08)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C424(0.73); C285(0.95); C281(1.00); C64(1.16)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C424(0.89); C285(1.11); C64(1.13); C281(1.16)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C424(0.97); C285(1.11); C281(1.18); C64(1.27)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C424(0.89); C285(1.27); C281(1.33); C64(1.36)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C424(1.33); C285(1.39); C281(1.45); C64(1.56)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C281(1.28); C285(1.28); C64(1.40)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C64(1.30); C285(1.39); C281(1.54)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C64(1.36); C285(1.59); C281(1.89)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C285(1.22); C64(1.26); C281(1.26)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C64(1.23); C285(1.46); C281(1.55)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C285(1.05); C281(1.18); C64(1.43)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C64(1.14); C285(1.37); C281(1.56)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C64(1.22); C285(1.38); C281(1.48)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C285(1.37); C64(1.46); C281(1.56)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C285(1.26); C281(1.37); C64(1.48)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C285(1.27); C281(1.35); C64(1.47)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C285(1.45); C281(1.62); C64(1.68)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C285(1.05); C64(1.12); C281(1.17)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C285(1.06); C281(1.10); C64(1.21)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C281(1.07); C285(1.08); C64(1.90)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C281(1.04); C285(1.09); C64(1.24)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C64(1.08); C285(1.12); C281(1.15)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C285(1.07); C64(1.09); C281(1.10)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C285(1.37); C281(1.45); C64(1.49)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C281(1.18); C285(1.23); C64(1.47)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C285(1.45); C281(1.50); C64(1.62)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C64(1.19); C285(1.23); C281(1.27)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C64(1.20); C285(1.23); C281(1.35)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C285(1.03); C64(1.13); C281(1.14)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C285(1.04); C281(1.13); C64(1.18)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C285(1.21); C281(1.25); C64(1.26)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C285(1.03); C281(1.16); C64(1.16)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C64(1.15); C285(1.34); C281(1.40)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C285(1.56); C281(1.58); C64(1.77)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C64(1.38); C281(1.56); C285(1.63)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C64(1.38); C281(1.65); C285(1.67)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C281(1.15); C285(1.20); C64(1.23)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C281(1.13); C285(1.13); C64(1.16)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C64(1.04); C285(1.14); C281(1.19)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C64(1.06); C285(1.22); C281(1.29)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C64(1.14); C285(1.22); C281(1.31)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C285(0.96); C281(0.98); C64(1.06)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C64(1.26); C285(1.59); C281(1.62)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C64(1.25); C285(1.47); C281(1.48)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C64(1.07); C281(1.14); C285(1.16)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C64(1.08); C281(1.15); C285(1.22)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C64(1.07); C281(1.10); C285(1.12)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C64(1.07); C281(1.28); C285(1.28)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C64(1.25); C281(1.46); C285(1.46)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C281(1.24); C64(1.25); C285(1.26)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C281(1.07); C64(1.18); C285(1.26)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C424(0.93)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C64(1.13); C281(0.97); C285(0.97)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C281(1.08); C285(1.08); C64(1.22)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C281(1.38); C285(1.41); C64(1.47)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.61  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C281(1.22); C285(1.22); C64(1.08)  LDD0078  [8]
 LDCM0630  CCW28-3 231MFP C106(1.07); C334(0.15)  LDD2214  [22]
 LDCM0108  Chloroacetamide HeLa C334(0.00); C379(0.00); C64(0.00); C77(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C379(1.57); C424(1.37); C206(1.14); C379(0.91)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C424(0.90); C64(1.02); C285(1.19); C281(1.27)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C424(0.84); C285(1.40); C281(1.44); C64(1.52)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C64(1.10); C424(1.12); C285(1.21); C281(1.45)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C285(1.14); C281(1.21); C64(1.30)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C64(1.03); C281(1.12); C285(1.17)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C285(1.03); C64(1.04); C281(1.11)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C281(1.10); C64(1.12); C285(1.14)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C424(0.98); C285(1.11); C281(1.15); C64(1.20)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C424(1.09); C285(1.41); C281(1.47); C64(1.48)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C424(1.10); C285(1.26); C281(1.28); C64(1.37)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C424(1.11); C281(1.26); C64(1.40); C285(1.47)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C424(1.02); C285(1.13); C64(1.25); C281(1.28)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C424(0.84); C285(1.45); C281(1.50); C64(1.83)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C424(1.06); C285(1.21); C64(1.39); C281(1.55)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C424(1.08); C64(1.25); C285(1.25); C281(1.44)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C64(0.99); C285(1.04); C281(1.07)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C64(1.13); C285(1.35); C281(1.45)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C64(1.37); C285(1.39); C281(1.49)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C64(1.16); C281(1.21); C285(1.21)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C64(1.12); C285(1.15); C281(1.19)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C281(1.29); C285(1.34); C64(1.39)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C281(0.97); C285(1.03); C64(1.13)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C64(1.03); C281(1.04); C285(1.11)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C285(1.11); C281(1.14); C424(1.17); C64(1.41)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C281(0.86); C285(0.89); C64(1.07)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C64(1.22); C424(1.28); C285(1.35); C281(1.37)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C424(0.96); C285(1.03); C281(1.07); C64(1.51)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C424(0.82); C285(1.53); C281(1.56); C64(7.96)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C424(1.22); C285(1.26); C281(1.30); C64(1.40)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C281(1.03); C64(1.05); C285(1.11)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C64(1.05); C285(1.37); C281(1.38)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C64(1.13); C285(1.14); C281(1.31)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C64(1.24); C285(1.31); C281(1.51)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C424(0.88); C64(1.20); C281(1.38); C285(1.43)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C424(0.89); C64(1.21); C281(1.26); C285(1.26)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C424(0.90); C64(1.48); C281(1.98); C285(2.05)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C285(0.93); C64(0.96); C281(1.27)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C285(1.00); C281(1.18); C64(1.40)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C285(0.87); C281(0.96); C64(1.09)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C285(0.91); C64(1.10); C281(1.18)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C64(1.00); C424(1.30); C281(1.53); C285(1.53)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C285(0.96); C64(1.09); C281(1.16)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C285(1.20); C281(1.23); C64(1.40)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C285(1.28); C281(1.53); C64(1.66)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C285(0.97); C64(1.04); C281(1.31)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C285(1.01); C64(1.21); C281(1.52)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C64(1.13); C281(1.52); C285(1.15)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C64(1.06); C281(1.51); C285(0.96)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C64(1.02); C281(1.09); C285(0.78)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C64(1.23); C281(1.44); C285(0.95)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C64(1.15); C281(1.22); C285(1.09)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C64(1.13); C281(1.24); C285(1.22); C424(1.02)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C64(0.97); C281(1.13); C285(0.86)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C64(1.10); C281(1.28); C285(1.29); C424(0.75)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C64(1.44); C281(1.19); C285(1.16); C424(0.98)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C64(1.52); C281(1.78); C285(1.66); C424(0.65)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C64(1.98); C281(1.47); C285(1.43); C424(0.98)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C64(1.21); C281(1.44); C285(1.67); C424(0.78)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C64(1.25); C281(1.21); C285(1.35); C424(0.83)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C64(1.31); C281(1.32); C285(1.53); C424(0.82)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C64(1.51); C281(1.38); C285(1.52); C424(0.72)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C64(1.53); C281(1.36); C285(1.40); C424(1.25)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C64(1.26); C281(1.26); C285(1.41); C424(0.67)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C64(1.18); C281(1.13); C285(1.38); C424(0.79)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C64(1.73); C281(1.88); C285(2.96); C424(1.08)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C64(1.40); C281(1.18); C285(1.67); C424(0.95)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C64(1.27); C281(1.23); C285(1.71); C424(0.87)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C64(1.57); C281(1.32); C285(1.52); C424(0.73)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C64(0.93); C281(0.91); C285(0.83)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C64(0.92); C281(0.83); C285(0.80)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C64(0.85); C281(0.92); C285(0.86)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C64(0.98); C281(1.02); C285(0.96)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C64(0.99); C281(0.95); C285(0.94); C424(1.33)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C64(0.89); C281(0.92); C285(0.98)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C64(0.92); C281(0.84); C285(0.91)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C64(0.94); C281(0.99); C285(0.85)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C64(0.83); C281(0.91); C285(0.95)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C64(2.36); C281(0.91); C285(0.84)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C64(0.92); C281(0.83); C285(0.79)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C64(0.90); C281(0.96); C285(0.99)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C64(0.89); C281(1.07); C285(1.06)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C64(0.86); C281(0.93); C285(0.84)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C64(0.92); C281(0.80); C285(0.84)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C64(1.14); C281(1.02); C285(0.97); C424(1.11)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C64(0.94); C281(0.95); C285(0.99)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C64(1.04); C281(1.20); C285(1.08)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C64(1.08); C281(1.21); C285(1.09)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C64(1.09); C281(1.46); C285(1.31)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C64(1.22); C281(2.31); C285(1.82)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C64(1.02); C281(1.17); C285(1.13)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C64(1.39); C281(1.73); C285(1.43)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C64(1.17); C281(1.81); C285(1.52)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C64(1.37); C281(1.47); C285(1.25)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C64(5.07); C281(1.37); C285(1.25)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C64(1.30); C281(1.14); C285(1.11); C424(0.92)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C64(1.18); C281(1.35); C285(1.18)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C64(1.11); C281(1.43); C285(1.27)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C64(1.00); C281(0.98); C285(1.03)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C64(1.11); C281(1.97); C285(1.57)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C64(1.09); C281(1.67); C285(1.42)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C64(1.10); C281(1.07); C285(1.19); C424(1.26)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C64(1.06); C281(1.23); C285(1.31); C424(0.59)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C64(1.17); C281(1.28); C285(1.26); C424(0.77)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C64(1.08); C281(1.19); C285(1.24); C424(0.69)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C64(6.32); C281(5.91); C285(6.02); C424(0.94)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C64(0.99); C281(1.16); C285(1.12); C424(0.71)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C64(1.05); C281(1.04); C285(1.08); C424(1.12)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C64(1.33); C281(1.31); C285(1.39); C424(0.77)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C64(1.39); C281(1.37); C285(1.35); C424(1.05)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C64(1.67); C281(1.77); C285(1.80); C424(0.57)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C64(1.18); C281(1.21); C285(1.22); C424(0.65)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C64(1.08); C281(1.05); C285(1.09); C424(0.90)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C64(1.23); C281(1.06); C285(1.06); C424(0.59)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C64(1.20); C281(1.30); C285(1.37); C424(0.76)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C64(1.77); C281(1.72); C285(1.69); C424(0.71)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C64(1.19); C281(1.26); C285(1.21); C424(0.65)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C64(2.49); C281(1.50); C285(1.63); C424(0.92)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C64(1.09); C281(1.23); C285(1.09); C424(0.65)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C64(2.34); C281(1.10); C285(1.04); C424(0.85)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C64(1.49); C281(1.38); C285(1.19); C424(1.01)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C64(1.00); C281(1.97); C285(1.60); C424(0.64)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C64(1.13); C281(1.55); C285(1.39); C424(0.76)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C64(1.12); C281(1.72); C285(1.41); C424(0.97)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C64(1.08); C281(1.57); C285(1.32); C424(0.79)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C64(1.22); C281(1.53); C285(1.30); C424(0.84)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C64(1.31); C281(1.60); C285(1.32); C424(1.29)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C334(0.51)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C424(1.09); C300(0.90); C64(0.82); C77(0.88)  LDD1698  [23]
 LDCM0625  F8 Ramos C334(1.07); C64(6.25); C424(0.78); 1.24  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C334(0.34); C64(0.60); C424(0.67); C77(0.44)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C334(0.17); C64(0.05); C424(1.74); 3.78  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C334(0.62); C64(1.07); C424(0.52); 2.43  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C334(1.29); C64(0.99); C424(1.16); 1.33  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C334(0.78); C64(8.52); C424(0.64); 0.86  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C334(0.32); C64(0.65); C424(0.43); 1.32  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C334(0.81); C64(1.15); C424(1.03); 1.14  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C334(1.20); C64(1.59); C424(1.30); 1.41  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C334(0.92); C64(0.62); C424(1.00); 1.03  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C334(0.68); C64(0.67); C424(0.83); 0.35  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C334(0.74); C64(0.92); C424(0.92); 0.96  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C334(0.89); C64(0.96); C424(1.13); 1.22  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C334(0.58); C64(2.09); C424(0.53); 2.70  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C64(1.24); C281(1.61); C285(1.40)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C334(0.48); C64(0.61); C424(0.97); 1.01  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C334(1.06); C64(6.88); C300(1.46); C424(0.80)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C64(2.30); C281(3.12); C285(2.53); C424(0.95)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C334(0.63); C64(0.85); C424(1.11); 1.54  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C334(1.02); C64(0.85); C424(1.15); 1.05  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C334(0.39); C64(0.71); C300(0.81); C424(0.61)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C334(0.42); C64(1.70); C424(0.54); 5.31  LDD2188  [24]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0125  JWB146 DM93 Y264(0.36)  LDD0287  [6]
 LDCM0022  KB02 HCT 116 C285(9.41); C281(10.13); C379(1.92)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C285(1.91); C281(3.17); C379(1.93)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C285(3.57); C281(3.35); C379(2.01)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0224  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C64(1.09)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C64(1.05)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C424(0.27); C334(0.43)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C64(0.99); C379(0.87)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C64(1.10)  LDD2100  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C64(0.92)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C64(1.06); C424(1.03); C379(0.72)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C64(0.97)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C64(0.88); C379(0.70)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C64(0.99)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C64(0.87)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C64(2.13); C379(2.16)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C424(0.60)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C424(0.78); C379(0.74)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C64(0.88)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C64(0.52)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C379(0.82)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C379(0.88)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C64(1.00)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C424(0.61)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C64(0.83)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C424(0.63)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C424(1.92)  LDD1700  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C424(0.79)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C379(1.90)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C424(0.07)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C64(1.02); C424(1.67)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C424(1.21)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C64(0.43)  LDD2148  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C334(0.92)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C334(0.80)  LDD2207  [25]
 LDCM0021  THZ1 HCT 116 C64(1.01); C285(0.87)  LDD2173  [8]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.