Details of the Probe

General Information of Probe

Probe ID
LDPC0416
Probe Name
C177
Synonyms
Z4225967588
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 344.36
Lipid-water partition coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C14H15F3N4OS
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-4-methyl-2-(2,2,2-trifluoroethyl)-1,3-thiazole-5-carboxamide
Canonical SMILES
CC1=C(SC(=N1)CC(F)(F)F)C(=O)NCCC2(N=N2)CCC#C
InChI
InChI=1S/C14H15F3N4OS/c1-3-4-5-13(20-21-13)6-7-18-12(22)11-9(2)19-10(23-11)8-14(15,16)17/h1H,4-8H2,2H3,(H,18,22)
InChIKey
RFBOVLUSGVVPQY-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

82 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 12.13  LDD1856 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 8.28  LDD1856 
Acid ceramidase (ASAH1) LDTP05905 7.41  LDD1856 
ADP-dependent glucokinase (ADPGK) LDTP11127 12.47  LDD1856 
Alpha-galactosidase A (GLA) LDTP02141 9.00  LDD1856 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 8.88  LDD1856 
Anaphase-promoting complex subunit 7 (ANAPC7) LDTP13409 8.69  LDD1856 
Antigen peptide transporter 1 (TAP1) LDTP05408 8.57  LDD1856 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 8.00  LDD1856 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 18.13  LDD1856 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 10.85  LDD1856 
ATPase GET3 (GET3) LDTP00836 8.46  LDD1856 
Beta-galactosidase (GLB1) LDTP02837 11.31  LDD1856 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 7.52  LDD1856 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 11.08  LDD1856 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 10.20  LDD1856 
Calcium-transporting ATPase type 2C member 1 (ATP2C1) LDTP05228 11.24  LDD1856 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 7.94  LDD1856 
Ceramide synthase 2 (CERS2) LDTP10329 7.73  LDD1856 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 7.62  LDD1856 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 7.46  LDD1856 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 10.48  LDD1856 
Cytochrome b5 type B (CYB5B) LDTP00697 18.90  LDD1856 
Cytosolic purine 5'-nucleotidase (NT5C2) LDTP04327 8.69  LDD1856 
Delta(24)-sterol reductase (DHCR24) LDTP06375 7.46  LDD1856 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 9.78  LDD1856 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 7.21  LDD1856 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 11.08  LDD1856 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 10.27  LDD1856 
Epoxide hydrolase 1 (EPHX1) LDTP02175 15.78  LDD1856 
Exonuclease 1 (EXO1) LDTP13751 9.58  LDD1856 
Ferrochelatase, mitochondrial (FECH) LDTP03198 9.13  LDD1856 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 17.27  LDD1856 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 25.28  LDD1856 
Heme oxygenase 1 (HMOX1) LDTP02359 11.08  LDD1856 
Heme oxygenase 2 (HMOX2) LDTP03540 38.59  LDD1856 
Histone-lysine N-methyltransferase SETDB1 (SETDB1) LDTP06295 8.17  LDD1856 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 12.04  LDD1856 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 7.67  LDD1856 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 31.56  LDD1856 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 26.17  LDD1856 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.82  LDD1856 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 29.24  LDD1856 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 26.17  LDD1856 
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) LDTP00975 10.93  LDD1856 
Multiple inositol polyphosphate phosphatase 1 (MINPP1) LDTP13678 9.38  LDD1856 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 11.55  LDD1856 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 8.75  LDD1856 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 17.15  LDD1856 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 21.56  LDD1856 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 8.34  LDD1856 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 15.24  LDD1856 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 8.28  LDD1856 
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) LDTP08617 8.63  LDD1856 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 8.17  LDD1856 
Phenylalanine--tRNA ligase beta subunit (FARSB) LDTP12586 11.47  LDD1856 
Phospholipase A2 group XV (PLA2G15) LDTP09088 12.47  LDD1856 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 8.00  LDD1856 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 8.88  LDD1856 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 78.79  LDD1856 
Prostaglandin reductase 3 (PTGR3) LDTP15422 10.70  LDD1856 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 11.00  LDD1856 
Proteasome subunit beta type-5 (PSMB5) LDTP03419 9.45  LDD1856 
Protein O-GlcNAcase (OGA) LDTP00988 10.78  LDD1856 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 7.31  LDD1856 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 11.00  LDD1856 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 8.82  LDD1856 
RAC-beta serine/threonine-protein kinase (AKT2) LDTP03608 8.06  LDD1856 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 18.77  LDD1856 
Ribonuclease T2 (RNASET2) LDTP00316 8.06  LDD1856 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 8.88  LDD1856 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 8.94  LDD1856 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 8.75  LDD1856 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 9.99  LDD1856 
Squalene synthase (FDFT1) LDTP03842 7.46  LDD1856 
Synaptic vesicle membrane protein VAT-1 homolog (VAT1) LDTP10887 7.36  LDD1856 
TLC domain-containing protein 1 (TLCD1) LDTP10182 10.20  LDD1856 
Ubiquitin carboxyl-terminal hydrolase 47 (USP47) LDTP10495 7.94  LDD1856 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 19.70  LDD1856 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 7.67  LDD1856 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 11.96  LDD1856 
X-ray repair cross-complementing protein 6 (XRCC6) LDTP02640 11.88  LDD1856 
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⏷ Show the Full List of 82 Enzyme
50 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit a (MT-ATP6) LDTP01804 55.72  LDD1856 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 12.64  LDD1856 
BRI3-binding protein (BRI3BP) LDTP15648 11.39  LDD1856 
CMP-sialic acid transporter (SLC35A1) LDTP05116 16.22  LDD1856 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 14.42  LDD1856 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 9.25  LDD1856 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 15.78  LDD1856 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 7.62  LDD1856 
Lysosome membrane protein 2 (SCARB2) LDTP06034 35.75  LDD1856 
Major facilitator superfamily domain-containing protein 8 (MFSD8) LDTP09261 14.12  LDD1856 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 8.46  LDD1856 
Metaxin-1 (MTX1) LDTP05900 11.55  LDD1856 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 7.41  LDD1856 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 11.47  LDD1856 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 7.21  LDD1856 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 11.71  LDD1856 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 8.00  LDD1856 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 29.45  LDD1856 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 27.67  LDD1856 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 19.84  LDD1856 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 22.16  LDD1856 
Mpv17-like protein 2 (MPV17L2) LDTP14952 23.75  LDD1856 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 12.30  LDD1856 
Nucleoporin NDC1 (NDC1) LDTP11213 7.57  LDD1856 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 8.94  LDD1856 
Pinin (PNN) LDTP11855 18.90  LDD1856 
Prenylated Rab acceptor protein 1 (RABAC1) LDTP13320 8.75  LDD1856 
Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) LDTP18053 8.75  LDD1856 
Prosaposin (PSAP) LDTP02215 8.11  LDD1856 
Protein GPR107 (GPR107) LDTP07236 26.54  LDD1856 
Protein GPR108 (GPR108) LDTP12383 16.34  LDD1856 
Protein tweety homolog 3 (TTYH3) LDTP11615 18.64  LDD1856 
Reduced folate transporter (SLC19A1) LDTP03952 8.69  LDD1856 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 14.93  LDD1856 
Sideroflexin-2 (SFXN2) LDTP10621 8.17  LDD1856 
Sideroflexin-4 (SFXN4) LDTP07531 9.25  LDD1856 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 21.26  LDD1856 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 53.45  LDD1856 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 16.80  LDD1856 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 8.82  LDD1856 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 11.71  LDD1856 
Stomatin (STOM) LDTP03380 7.89  LDD1856 
Tetraspanin-3 (TSPAN3) LDTP16813 24.42  LDD1856 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 10.20  LDD1856 
Transmembrane protein 126A (TMEM126A) LDTP15948 15.14  LDD1856 
Transmembrane protein 199 (TMEM199) LDTP08881 17.27  LDD1856 
Transmembrane protein 205 (TMEM205) LDTP07667 7.67  LDD1856 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 14.62  LDD1856 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 24.08  LDD1856 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 22.63  LDD1856 
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⏷ Show the Full List of 50 Transporter and channel
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Golgi pH regulator B (GPR89B) LDTP14610 8.06  LDD1856 
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47 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Angiomotin (AMOT) LDTP06868 9.06  LDD1856 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 12.55  LDD1856 
BAG family molecular chaperone regulator 5 (BAG5) LDTP13507 8.17  LDD1856 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 10.27  LDD1856 
Centromere protein P (CENPP) LDTP07419 11.47  LDD1856 
Clustered mitochondria protein homolog (CLUH) LDTP14486 11.24  LDD1856 
Collectin-12 (COLEC12) LDTP07031 10.85  LDD1856 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 7.46  LDD1856 
Divergent protein kinase domain 2A (DIPK2A) LDTP09143 11.24  LDD1856 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 7.94  LDD1856 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 10.27  LDD1856 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 11.88  LDD1856 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 13.00  LDD1856 
Golgi apparatus protein 1 (GLG1) LDTP09920 11.31  LDD1856 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 8.11  LDD1856 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 11.79  LDD1856 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 7.73  LDD1856 
Large proline-rich protein BAG6 (BAG6) LDTP04094 31.56  LDD1856 
LYR motif-containing protein 2 (LYRM2) LDTP18467 9.00  LDD1856 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.41  LDD1856 
Mdm2-binding protein (MTBP) LDTP15714 9.85  LDD1856 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 13.27  LDD1856 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 11.39  LDD1856 
Neudesin (NENF) LDTP13630 10.63  LDD1856 
Neuferricin (CYB5D2) LDTP15623 29.45  LDD1856 
Nucleobindin-2 (NUCB2) LDTP05160 11.24  LDD1856 
Optic atrophy 3 protein (OPA3) LDTP16006 12.30  LDD1856 
Oxysterol-binding protein-related protein 6 (OSBPL6) LDTP11533 22.16  LDD1856 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 10.41  LDD1856 
Programmed cell death protein 5 (PDCD5) LDTP00417 7.36  LDD1856 
Protein FAM114A2 (FAM114A2) LDTP16080 7.94  LDD1856 
Protein FAM162A (FAM162A) LDTP10056 8.17  LDD1856 
Protein unc-119 homolog B (UNC119B) LDTP00105 8.51  LDD1856 
Protein YIF1B (YIF1B) LDTP06948 7.73  LDD1856 
Reticulocalbin-2 (RCN2) LDTP06097 9.13  LDD1856 
Reticulon-3 (RTN3) LDTP01522 13.74  LDD1856 
RUS family member 1 (RUSF1) LDTP10357 7.94  LDD1856 
Synaptogyrin-2 (SYNGR2) LDTP00859 7.78  LDD1856 
Syntaxin-18 (STX18) LDTP13086 9.06  LDD1856 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 7.52  LDD1856 
TraB domain-containing protein (TRABD) LDTP19963 7.41  LDD1856 
Translation initiation factor eIF2B subunit gamma (EIF2B3) LDTP12476 10.63  LDD1856 
Trophoblast glycoprotein (TPBG) LDTP05960 7.84  LDD1856 
U6 snRNA-associated Sm-like protein LSm3 (LSM3) LDTP04979 10.70  LDD1856 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 11.39  LDD1856 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 13.00  LDD1856 
UPF0690 protein C1orf52 (C1orf52) LDTP17730 7.31  LDD1856 
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⏷ Show the Full List of 47 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1856 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587