Details of the Target

General Information of Target

Target ID LDTP06948
Target Name Protein YIF1B (YIF1B)
Gene Name YIF1B
Gene ID 90522
Synonyms
Protein YIF1B; YIP1-interacting factor homolog B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHPAGLAAAAAGTPRLRKWPSKRRIPVSQPGMADPHQLFDDTSSAQSRGYGAQRAPGGLS
YPAASPTPHAAFLADPVSNMAMAYGSSLAAQGKELVDKNIDRFIPITKLKYYFAVDTMYV
GRKLGLLFFPYLHQDWEVQYQQDTPVAPRFDVNAPDLYIPAMAFITYVLVAGLALGTQDR
FSPDLLGLQASSALAWLTLEVLAILLSLYLVTVNTDLTTIDLVAFLGYKYVGMIGGVLMG
LLFGKIGYYLVLGWCCVAIFVFMIRTLRLKILADAAAEGVPVRGARNQLRMYLTMAVAAA
QPMLMYWLTFHLVR
Target Bioclass
Other
Family
YIF1 family
Subcellular location
Endoplasmic reticulum membrane
Function
Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi. Plays a key role in targeting to neuronal dendrites receptors such as HTR1A. Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments.
Uniprot ID
Q5BJH7
Ensemble ID
ENST00000329420.12
HGNC ID
HGNC:30511

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K108(9.64)  LDD0277  [1]
Jackson_14
 Probe Info  		2.27  LDD0123  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
AOyne
 Probe Info  		9.50  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		2.76  LDD0398  [5]
C017
 Probe Info  		6.59  LDD1725  [6]
C055
 Probe Info  		26.35  LDD1752  [6]
C056
 Probe Info  		57.28  LDD1753  [6]
C070
 Probe Info  		9.99  LDD1766  [6]
C072
 Probe Info  		7.67  LDD1768  [6]
C112
 Probe Info  		37.79  LDD1799  [6]
C134
 Probe Info  		34.54  LDD1816  [6]
C135
 Probe Info  		11.55  LDD1817  [6]
C177
 Probe Info  		7.73  LDD1856  [6]
C178
 Probe Info  		20.39  LDD1857  [6]
C246
 Probe Info  		15.56  LDD1919  [6]
C285
 Probe Info  		34.78  LDD1955  [6]
C286
 Probe Info  		4.99  LDD1956  [6]
C287
 Probe Info  		16.91  LDD1957  [6]
C288
 Probe Info  		10.78  LDD1958  [6]
C289
 Probe Info  		83.29  LDD1959  [6]
C290
 Probe Info  		6.19  LDD1960  [6]
C362
 Probe Info  		26.91  LDD2023  [6]
C383
 Probe Info  		10.70  LDD2042  [6]
C388
 Probe Info  		99.73  LDD2047  [6]
C390
 Probe Info  		34.54  LDD2049  [6]
C391
 Probe Info  		24.42  LDD2050  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		13.96  LDD0477  [7]
FFF probe2
 Probe Info  		18.84  LDD0463  [7]
A-DA
 Probe Info  		2.09  LDD0145  [8]
OEA-DA
 Probe Info  		16.86  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.27  LDD0123  [2]
 LDCM0084  Ro 48-8071 A-549 2.09  LDD0145  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prosaposin receptor GPR37 (GPR37) G-protein coupled receptor 1 family O15354
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Latexin (LXN) Protease inhibitor I47 (latexin) family Q9BS40

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570