Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C072  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 36.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 28.8
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 28.4
 LDTP12490  Sphingosine kinase 2 (SPHK2) 25.8
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 24.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 23.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 22.9
 LDTP04263  Cysteine--tRNA ligase, cytoplasmic (CARS1) 22.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 21.9
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 20.0
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 19.8
 LDTP03842  Squalene synthase (FDFT1) 19.6
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 18.8
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 18.4
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 18.3
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 16.8
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 16.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 16.7
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 16.6
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 15.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 15.5
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 14.9
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 14.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 14.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 14.2
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 14.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 13.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 13.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 13.8
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 13.5
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 13.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 13.1
 LDTP02359  Heme oxygenase 1 (HMOX1) 13.1
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 12.6
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 12.2
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 11.8
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 11.6
 LDTP05905  Acid ceramidase (ASAH1) 11.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 11.5
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 11.3
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 11.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 11.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 11.0
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 10.9
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 10.6
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 10.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 10.3
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 10.3
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 9.9
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 9.8
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 9.8
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 9.7
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 9.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 9.3
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 9.1
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 9.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 9.0
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 9.0
 LDTP03822  Activin receptor type-1B (ACVR1B) 8.6
 LDTP06617  Ceramide glucosyltransferase (UGCG) 8.6
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 8.6
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 8.6
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 8.3
 LDTP10329  Ceramide synthase 2 (CERS2) 8.1
 LDTP08532  Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) 7.9
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 7.9
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 7.8
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 7.8
 LDTP06977  GPI ethanolamine phosphate transferase 2 (PIGG) 7.7
 LDTP04183  Lanosterol synthase (LSS) 7.7
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.6
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 7.5
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 7.5
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 7.5
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 7.4
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 7.4
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 7.4
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 7.3
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 7.3
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 7.3
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 7.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 7.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 7.2
Transporter and channel
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 45.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 34.1
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 32.9
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 28.6
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 27.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 26.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 25.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 24.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 21.4
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 21.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 18.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 18.4
 LDTP15648  BRI3-binding protein (BRI3BP) 18.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 17.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 17.4
 LDTP16813  Tetraspanin-3 (TSPAN3) 17.0
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 16.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 15.5
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 15.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 15.1
 LDTP20002  Transmembrane protein 160 (TMEM160) 14.4
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 13.6
 LDTP05900  Metaxin-1 (MTX1) 13.5
 LDTP11615  Protein tweety homolog 3 (TTYH3) 13.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.9
 LDTP07156  Protein wntless homolog (WLS) 12.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 12.6
 LDTP07236  Protein GPR107 (GPR107) 12.2
 LDTP10036  BOS complex subunit NCLN (NCLN) 12.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 12.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 12.0
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 11.4
 LDTP11245  Derlin-1 (DERL1) 11.1
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 11.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 10.8
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 10.8
 LDTP12383  Protein GPR108 (GPR108) 10.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 10.6
 LDTP02215  Prosaposin (PSAP) 10.6
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 10.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 10.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 9.8
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 9.7
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 9.7
 LDTP03380  Stomatin (STOM) 9.4
 LDTP03546  Translocator protein (TSPO) 9.4
 LDTP15481  Transmembrane protein 87A (TMEM87A) 9.0
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 8.6
 LDTP08279  Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) 8.5
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 8.5
 LDTP10065  Transmembrane protein 230 (TMEM230) 8.4
 LDTP09288  Vang-like protein 1 (VANGL1) 8.4
 LDTP07063  Hippocampus abundant transcript-like protein 1 (MFSD14B) 8.2
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 8.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 8.1
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 7.9
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 7.6
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 7.5
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 7.5
 LDTP07439  Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) 7.4
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 7.3
 LDTP07667  Transmembrane protein 205 (TMEM205) 7.2
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 7.8
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 44.9
Other
Click to Show/Hide to Show 39 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 50.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 29.2
 LDTP05868  Protein unc-119 homolog A (UNC119) 27.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 27.1
 LDTP08594  Negative elongation factor C/D (NELFCD) 25.5
 LDTP18883  Protein CEBPZOS (CEBPZOS) 19.4
 LDTP01522  Reticulon-3 (RTN3) 17.6
 LDTP03175  Galanin peptides (GAL) 17.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 16.2
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 16.1
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 15.0
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 14.4
 LDTP05375  Nucleobindin-1 (NUCB1) 14.0
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 13.0
 LDTP10056  Protein FAM162A (FAM162A) 12.9
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 12.8
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 12.8
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 12.6
 LDTP05160  Nucleobindin-2 (NUCB2) 12.2
 LDTP08606  Nurim (NRM) 11.9
 LDTP13086  Syntaxin-18 (STX18) 11.8
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 10.9
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 10.9
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 10.3
 LDTP12412  Reticulon-4 (RTN4) 10.1
 LDTP01494  Protein YIF1A (YIF1A) 9.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 8.9
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 8.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 8.6
 LDTP00986  Syntaxin-10 (STX10) 8.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 8.5
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.5
 LDTP05277  Protein SET (SET) 8.1
 LDTP19963  TraB domain-containing protein (TRABD) 8.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 7.9
 LDTP18272  Transmembrane protein 209 (TMEM209) 7.7
 LDTP06948  Protein YIF1B (YIF1B) 7.7
 LDTP13019  Vacuolar protein sorting-associated protein 18 homolog (VPS18) 7.5
 LDTP00859  Synaptogyrin-2 (SYNGR2) 7.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587