Details of the Target

General Information of Target

Target ID LDTP10499
Target Name Lipid scramblase CLPTM1L (CLPTM1L)
Gene Name CLPTM1L
Gene ID 81037
Synonyms
CRR9; Lipid scramblase CLPTM1L; Cisplatin resistance-related protein 9; CRR9p; Cleft lip and palate transmembrane protein 1-like protein; CLPTM1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRKQAKPRSLKDPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQVFESLS
DITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPC
QFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECD
AAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDW
KMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHM
EQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPD
SNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAV
LQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCN
FCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLS
GSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKK
SRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTV
LPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFV
FFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQG
KVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTP
NCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETL
LQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYM
CPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGF
RCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDL
VKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRC
SSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKC
QMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPV
CFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHSS
Target Bioclass
Transporter and channel
Family
CLPTM1 family
Subcellular location
Endoplasmic reticulum membrane
Function
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.
Uniprot ID
Q96KA5
Ensemble ID
ENST00000320895.10
HGNC ID
HGNC:24308

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.F279LfsTer2 .
DU145 Insertion: p.W374LfsTer17 .
HCC1395 SNV: p.K313N .
HUCCT1 Deletion: p.N521KfsTer31 .
LS180 Deletion: p.W374GfsTer4 .
MCC13 Deletion: p.I359LfsTer6 .
MFE319 SNV: p.D39E .
MOLT4 SNV: p.F302L .
SKOV3 SNV: p.L246V .
SW756 SNV: p.D273H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.87  LDD0197  [1]
TH211
 Probe Info  		Y209(14.28)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K199(2.65)  LDD0277  [4]
m-APA
 Probe Info  		10.23  LDD0403  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
DBIA
 Probe Info  		C496(0.92)  LDD1507  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 103 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.90  LDD1725  [9]
C022
 Probe Info  		14.52  LDD1728  [9]
C040
 Probe Info  		9.51  LDD1740  [9]
C049
 Probe Info  		5.43  LDD1747  [9]
C053
 Probe Info  		5.17  LDD1751  [9]
C055
 Probe Info  		16.00  LDD1752  [9]
C056
 Probe Info  		27.86  LDD1753  [9]
C063
 Probe Info  		14.93  LDD1760  [9]
C070
 Probe Info  		13.36  LDD1766  [9]
C072
 Probe Info  		8.11  LDD1768  [9]
C082
 Probe Info  		5.31  LDD1774  [9]
C087
 Probe Info  		6.92  LDD1779  [9]
C091
 Probe Info  		11.24  LDD1782  [9]
C092
 Probe Info  		19.16  LDD1783  [9]
C094
 Probe Info  		27.28  LDD1785  [9]
C095
 Probe Info  		5.17  LDD1786  [9]
C100
 Probe Info  		7.26  LDD1789  [9]
C106
 Probe Info  		30.27  LDD1793  [9]
C107
 Probe Info  		7.94  LDD1794  [9]
C108
 Probe Info  		11.39  LDD1795  [9]
C112
 Probe Info  		35.02  LDD1799  [9]
C130
 Probe Info  		6.45  LDD1812  [9]
C134
 Probe Info  		34.78  LDD1816  [9]
C135
 Probe Info  		13.74  LDD1817  [9]
C139
 Probe Info  		10.34  LDD1821  [9]
C143
 Probe Info  		13.93  LDD1825  [9]
C153
 Probe Info  		17.51  LDD1834  [9]
C158
 Probe Info  		9.19  LDD1838  [9]
C159
 Probe Info  		11.16  LDD1839  [9]
C160
 Probe Info  		10.13  LDD1840  [9]
C161
 Probe Info  		18.13  LDD1841  [9]
C163
 Probe Info  		5.82  LDD1843  [9]
C169
 Probe Info  		35.02  LDD1849  [9]
C186
 Probe Info  		8.22  LDD1864  [9]
C187
 Probe Info  		23.26  LDD1865  [9]
C193
 Probe Info  		5.17  LDD1869  [9]
C194
 Probe Info  		10.48  LDD1870  [9]
C201
 Probe Info  		31.78  LDD1877  [9]
C210
 Probe Info  		72.00  LDD1884  [9]
C218
 Probe Info  		20.11  LDD1892  [9]
C219
 Probe Info  		6.28  LDD1893  [9]
C220
 Probe Info  		19.43  LDD1894  [9]
C225
 Probe Info  		5.62  LDD1898  [9]
C226
 Probe Info  		5.58  LDD1899  [9]
C228
 Probe Info  		24.76  LDD1901  [9]
C231
 Probe Info  		23.59  LDD1904  [9]
C232
 Probe Info  		37.01  LDD1905  [9]
C233
 Probe Info  		8.75  LDD1906  [9]
C234
 Probe Info  		5.78  LDD1907  [9]
C235
 Probe Info  		25.81  LDD1908  [9]
C238
 Probe Info  		12.55  LDD1911  [9]
C243
 Probe Info  		13.64  LDD1916  [9]
C246
 Probe Info  		18.25  LDD1919  [9]
C251
 Probe Info  		69.07  LDD1924  [9]
C252
 Probe Info  		31.78  LDD1925  [9]
C255
 Probe Info  		5.39  LDD1928  [9]
C264
 Probe Info  		20.97  LDD1935  [9]
C277
 Probe Info  		7.62  LDD1947  [9]
C278
 Probe Info  		64.00  LDD1948  [9]
C282
 Probe Info  		21.11  LDD1952  [9]
C285
 Probe Info  		28.25  LDD1955  [9]
C287
 Probe Info  		15.24  LDD1957  [9]
C288
 Probe Info  		8.51  LDD1958  [9]
C289
 Probe Info  		60.13  LDD1959  [9]
C293
 Probe Info  		30.70  LDD1963  [9]
C296
 Probe Info  		19.84  LDD1966  [9]
C299
 Probe Info  		13.55  LDD1968  [9]
C310
 Probe Info  		8.69  LDD1977  [9]
C314
 Probe Info  		12.30  LDD1981  [9]
C322
 Probe Info  		6.11  LDD1988  [9]
C326
 Probe Info  		7.11  LDD1990  [9]
C343
 Probe Info  		16.34  LDD2005  [9]
C348
 Probe Info  		14.03  LDD2009  [9]
C349
 Probe Info  		20.97  LDD2010  [9]
C350
 Probe Info  		57.28  LDD2011  [9]
C355
 Probe Info  		27.28  LDD2016  [9]
C356
 Probe Info  		8.46  LDD2017  [9]
C357
 Probe Info  		5.21  LDD2018  [9]
C362
 Probe Info  		97.01  LDD2023  [9]
C363
 Probe Info  		22.16  LDD2024  [9]
C364
 Probe Info  		29.65  LDD2025  [9]
C366
 Probe Info  		7.78  LDD2027  [9]
C367
 Probe Info  		5.28  LDD2028  [9]
C373
 Probe Info  		5.03  LDD2033  [9]
C388
 Probe Info  		64.00  LDD2047  [9]
C390
 Probe Info  		99.73  LDD2049  [9]
C391
 Probe Info  		17.75  LDD2050  [9]
C396
 Probe Info  		5.13  LDD2055  [9]
C403
 Probe Info  		16.56  LDD2061  [9]
C407
 Probe Info  		22.78  LDD2064  [9]
C420
 Probe Info  		10.27  LDD2075  [9]
C426
 Probe Info  		12.73  LDD2081  [9]
C429
 Probe Info  		12.91  LDD2084  [9]
C431
 Probe Info  		19.43  LDD2086  [9]
FFF probe11
 Probe Info  		20.00  LDD0471  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [10]
FFF probe14
 Probe Info  		20.00  LDD0477  [10]
FFF probe2
 Probe Info  		20.00  LDD0463  [10]
FFF probe3
 Probe Info  		20.00  LDD0464  [10]
STS-1
 Probe Info  		N.A.  LDD0136  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [11]
A-DA
 Probe Info  		2.24  LDD0145  [12]
OEA-DA
 Probe Info  		16.73  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C496(0.92)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C496(0.93)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C496(0.93)  LDD1509  [7]
 LDCM0270  AC15 HEK-293T C496(0.94)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C496(1.00)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C496(0.97)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C496(0.63)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C496(0.88)  LDD1518  [7]
 LDCM0281  AC21 HEK-293T C496(1.13); C412(0.86)  LDD1520  [7]
 LDCM0283  AC23 HEK-293T C496(1.17)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C496(1.17)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C496(1.15)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C496(0.82)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C496(0.76)  LDD1526  [7]
 LDCM0289  AC29 HEK-293T C496(1.05); C412(0.98)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C496(0.88)  LDD1529  [7]
 LDCM0292  AC31 HEK-293T C496(0.93)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C496(1.22)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C496(0.94)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C496(0.90)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C496(0.86)  LDD1535  [7]
 LDCM0298  AC37 HEK-293T C496(0.91); C412(0.96)  LDD1537  [7]
 LDCM0300  AC39 HEK-293T C496(0.89)  LDD1539  [7]
 LDCM0302  AC40 HEK-293T C496(0.87)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C496(1.00)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C496(0.96)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C496(1.60)  LDD1544  [7]
 LDCM0307  AC45 HEK-293T C496(1.01); C412(0.95)  LDD1546  [7]
 LDCM0309  AC47 HEK-293T C496(0.93)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C496(0.98)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C496(1.04)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C496(0.95); C412(0.84)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C496(0.99)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C496(0.87)  LDD1553  [7]
 LDCM0316  AC53 HEK-293T C496(1.31); C412(1.00)  LDD1555  [7]
 LDCM0318  AC55 HEK-293T C496(1.02)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C496(1.04)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C496(0.88)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C496(0.81)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C496(0.73)  LDD1561  [7]
 LDCM0325  AC61 HEK-293T C496(1.17); C412(0.95)  LDD1564  [7]
 LDCM0327  AC63 HEK-293T C496(0.80)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C496(1.12)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C496(0.69)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C496(0.99)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C496(0.93); C412(0.97)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C496(0.99)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C496(1.05)  LDD1514  [7]
 LDCM0156  Aniline NCI-H1299 10.23  LDD0403  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0369  CL100 HEK-293T C496(0.88)  LDD1573  [7]
 LDCM0371  CL102 HEK-293T C496(1.18)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C496(0.97)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C496(1.12)  LDD1577  [7]
 LDCM0375  CL106 HEK-293T C496(1.35)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C496(0.94)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C496(0.97)  LDD1581  [7]
 LDCM0379  CL11 HEK-293T C496(0.76)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C496(1.46)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C496(0.96)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C496(0.97)  LDD1586  [7]
 LDCM0384  CL114 HEK-293T C496(0.89)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C496(1.14)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C496(1.09)  LDD1590  [7]
 LDCM0388  CL118 HEK-293T C496(0.96)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C496(0.81)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C496(0.89)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C496(0.98)  LDD1595  [7]
 LDCM0393  CL122 HEK-293T C496(1.12)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C496(1.86)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C496(1.51)  LDD1599  [7]
 LDCM0397  CL126 HEK-293T C496(1.00)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C496(0.80)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C496(1.08)  LDD1603  [7]
 LDCM0401  CL14 HEK-293T C496(0.87)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C496(1.46)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C496(1.00)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C496(1.06)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C496(0.74)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C496(0.79)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C496(1.00)  LDD1611  [7]
 LDCM0409  CL21 HEK-293T C496(1.07); C412(0.93)  LDD1613  [7]
 LDCM0411  CL23 HEK-293T C496(0.91)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C496(0.89)  LDD1616  [7]
 LDCM0414  CL26 HEK-293T C496(1.17)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C496(0.95)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C496(1.10)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C496(0.91)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C496(1.13)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C496(0.85)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C496(0.98)  LDD1624  [7]
 LDCM0422  CL33 HEK-293T C496(1.49); C412(0.93)  LDD1626  [7]
 LDCM0424  CL35 HEK-293T C496(0.73)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C496(0.88)  LDD1629  [7]
 LDCM0428  CL39 HEK-293T C496(0.79)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C496(0.89)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C496(0.84)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C496(1.04)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C496(0.66)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C496(0.91)  LDD1637  [7]
 LDCM0435  CL45 HEK-293T C496(1.00); C412(1.20)  LDD1639  [7]
 LDCM0437  CL47 HEK-293T C496(0.66)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C496(0.97)  LDD1642  [7]
 LDCM0440  CL5 HEK-293T C496(0.99)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C496(1.19)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C496(0.92)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C496(0.99)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C496(1.58)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C496(0.80)  LDD1649  [7]
 LDCM0448  CL57 HEK-293T C496(1.25); C412(0.89)  LDD1651  [7]
 LDCM0450  CL59 HEK-293T C496(0.70)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C496(0.79)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C496(0.88)  LDD1655  [7]
 LDCM0454  CL62 HEK-293T C496(1.02)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C496(0.88)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C496(1.27)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C496(1.04)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C496(0.82)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C496(0.80)  LDD1662  [7]
 LDCM0461  CL69 HEK-293T C496(1.36); C412(0.92)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C496(0.63)  LDD1665  [7]
 LDCM0464  CL71 HEK-293T C496(0.70)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C496(0.87)  LDD1668  [7]
 LDCM0467  CL74 HEK-293T C496(1.10)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C496(1.66)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C496(0.97)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C496(0.92)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C496(0.65)  LDD1675  [7]
 LDCM0475  CL81 HEK-293T C496(0.86); C412(1.03)  LDD1678  [7]
 LDCM0477  CL83 HEK-293T C496(0.70)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C496(0.88)  LDD1681  [7]
 LDCM0480  CL86 HEK-293T C496(1.18)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C496(1.29)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C496(1.21)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C496(0.94)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C496(0.97); C412(0.97)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C496(2.98)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C496(0.83)  LDD1689  [7]
 LDCM0488  CL93 HEK-293T C496(1.52); C412(0.83)  LDD1691  [7]
 LDCM0490  CL95 HEK-293T C496(0.80)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C496(0.84)  LDD1694  [7]
 LDCM0493  CL98 HEK-293T C496(1.25)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C496(0.98)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C496(0.74)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C496(0.87)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C496(1.16)  LDD1631  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0084  Ro 48-8071 A-549 2.24  LDD0145  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Potassium voltage-gated channel subfamily F member 1 (KCNF1) Potassium channel family Q9H3M0

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570