Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C231  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 170 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 99.0
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 93.1
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 84.4
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 78.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 76.6
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 73.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 70.5
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 65.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 61.8
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 58.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 57.7
 LDTP04581  Holocytochrome c-type synthase (HCCS) 56.5
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 54.9
 LDTP09285  Atypical kinase COQ8A, mitochondrial (COQ8A) 53.1
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 52.3
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 46.9
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 46.2
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 44.9
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 41.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 41.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 40.2
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 38.9
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 36.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 35.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 34.5
 LDTP09251  Atlastin-2 (ATL2) 33.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 33.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 32.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 32.4
 LDTP07931  Heme A synthase COX15 (COX15) 32.2
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 31.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 31.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 30.1
 LDTP03145  Catechol O-methyltransferase (COMT) 29.9
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 28.8
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 28.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 28.6
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 27.1
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 27.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 27.1
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 26.5
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 26.2
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 26.2
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 25.8
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 25.8
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 25.3
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 24.9
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 24.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 24.4
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 23.9
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 23.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 23.8
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 23.4
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 23.3
 LDTP02837  Beta-galactosidase (GLB1) 23.1
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 23.1
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 22.3
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 21.9
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 21.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 21.3
 LDTP10020  Ras-related protein Rab-24 (RAB24) 21.3
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 21.1
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 20.8
 LDTP05905  Acid ceramidase (ASAH1) 20.4
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 20.4
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 20.4
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 20.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 20.1
 LDTP10329  Ceramide synthase 2 (CERS2) 19.7
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 19.6
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 19.4
 LDTP09814  Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) 19.3
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 19.0
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 19.0
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 18.8
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 18.6
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 18.3
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 17.9
 LDTP06142  Squalene monooxygenase (SQLE) 17.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 17.8
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 17.6
 LDTP02539  Lysosomal acid phosphatase (ACP2) 17.4
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 17.0
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 17.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) 16.9
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 16.6
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 16.6
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 16.4
 LDTP11284  Phosphatidylserine synthase 2 (PTDSS2) 16.4
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 16.3
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 16.3
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 16.3
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 16.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 16.2
 LDTP06617  Ceramide glucosyltransferase (UGCG) 16.1
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 16.0
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 15.8
 LDTP12180  Retinol dehydrogenase 14 (RDH14) 15.7
 LDTP00877  Protein SCO2 homolog, mitochondrial (SCO2) 15.6
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 15.3
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 15.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 15.3
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 15.2
 LDTP15155  Thiol S-methyltransferase TMT1B (TMT1B) 15.1
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 15.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 15.0
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 15.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 15.0
 LDTP08530  Mitofusin-1 (MFN1) 14.8
 LDTP02283  Cytochrome c1, heme protein, mitochondrial (CYC1) 14.7
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 14.7
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 14.7
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) 14.6
 LDTP03249  Plasma membrane calcium-transporting ATPase 4 (ATP2B4) 14.5
 LDTP12608  Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) 14.3
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 14.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 14.1
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 13.9
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 13.9
 LDTP00416  CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) 13.8
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 13.8
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) 13.8
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 13.7
 LDTP14427  Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) 13.6
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 13.6
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 13.6
 LDTP02505  Lysosomal protective protein (CTSA) 13.5
 LDTP11494  Neurolysin, mitochondrial (NLN) 13.5
 LDTP00344  Stearoyl-CoA desaturase (SCD) 13.4
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 13.3
 LDTP00836  ATPase GET3 (GET3) 13.3
 LDTP04531  Hexokinase-2 (HK2) 13.3
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 13.3
 LDTP12752  NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) 13.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 13.3
 LDTP05006  Ras-related protein Rab-1A (RAB1A) 13.2
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 13.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 12.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.8
 LDTP09835  GPI-anchor transamidase (PIGK) 12.8
 LDTP00267  DNA-directed RNA polymerase, mitochondrial (POLRMT) 12.7
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 12.7
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 12.6
 LDTP01300  Cartilage-associated protein (CRTAP) 12.6
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 12.6
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 12.6
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 12.5
 LDTP04895  Ras-related protein Rab-10 (RAB10) 12.5
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 12.4
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 12.3
 LDTP10973  Thioredoxin, mitochondrial (TXN2) 12.3
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 12.2
 LDTP01560  NADH dehydrogenase 1 subunit C2 (NDUFC2) 12.2
 LDTP02757  Cytochrome b-c1 complex subunit 7 (UQCRB) 12.1
 LDTP00399  Torsin-1A (TOR1A) 12.1
 LDTP00400  Torsin-1B (TOR1B) 12.0
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 12.0
 LDTP09000  Lysophospholipase D GDPD1 (GDPD1) 12.0
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 12.0
 LDTP12708  Distal membrane-arm assembly complex protein 2 (DMAC2) 11.9
 LDTP05408  Antigen peptide transporter 1 (TAP1) 11.8
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 11.7
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 11.7
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 11.7
 LDTP09059  Protein O-glucosyltransferase 1 (POGLUT1) 11.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 11.6
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 11.5
 LDTP06322  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) 11.5
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 11.4
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.3
Transporter and channel
Click to Show/Hide to Show 148 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 99.7
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 99.7
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 99.7
 LDTP16813  Tetraspanin-3 (TSPAN3) 99.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 99.7
 LDTP15648  BRI3-binding protein (BRI3BP) 83.3
 LDTP11927  Essential MCU regulator, mitochondrial (SMDT1) 81.0
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 65.8
 LDTP15481  Transmembrane protein 87A (TMEM87A) 64.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 60.1
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 52.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 51.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 50.9
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 49.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 48.8
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 47.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 46.5
 LDTP07156  Protein wntless homolog (WLS) 46.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 45.9
 LDTP11245  Derlin-1 (DERL1) 45.3
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 44.9
 LDTP00592  Surfeit locus protein 4 (SURF4) 44.6
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 43.4
 LDTP20002  Transmembrane protein 160 (TMEM160) 43.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 42.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 42.2
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 41.4
 LDTP10065  Transmembrane protein 230 (TMEM230) 39.1
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 38.9
 LDTP01804  ATP synthase subunit a (MT-ATP6) 38.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 37.5
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 37.5
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 37.3
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 37.0
 LDTP04787  Transmembrane protein 33 (TMEM33) 36.5
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 35.8
 LDTP12383  Protein GPR108 (GPR108) 33.6
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 33.4
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 33.4
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 33.1
 LDTP08881  Transmembrane protein 199 (TMEM199) 32.7
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 32.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 31.1
 LDTP11250  MICOS complex subunit MIC26 (APOO) 31.1
 LDTP02215  Prosaposin (PSAP) 31.1
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 30.9
 LDTP13833  Integral membrane protein 2B (ITM2B) 30.3
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 30.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 30.1
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 30.1
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 30.1
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 28.8
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 28.6
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 28.2
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 27.5
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 27.1
 LDTP07531  Sideroflexin-4 (SFXN4) 26.9
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 25.1
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 24.9
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 24.6
 LDTP02266  Synaptophysin (SYP) 24.1
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 23.6
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 22.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 22.5
 LDTP12191  Vezatin (VEZT) 22.5
 LDTP07667  Transmembrane protein 205 (TMEM205) 22.2
 LDTP01060  PRA1 family protein 2 (PRAF2) 22.0
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 21.7
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 21.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 21.6
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 21.4
 LDTP14717  ATP synthase subunit e, mitochondrial (ATP5ME) 21.3
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 21.3
 LDTP05900  Metaxin-1 (MTX1) 21.1
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 21.0
 LDTP01454  SUN domain-containing protein 1 (SUN1) 21.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.8
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 20.8
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 20.5
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.5
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 20.4
 LDTP16190  Protein FAM8A1 (FAM8A1) 20.4
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 20.3
 LDTP07236  Protein GPR107 (GPR107) 20.0
 LDTP07467  Rhomboid domain-containing protein 2 (RHBDD2) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP11732  Magnesium transporter protein 1 (MAGT1) 19.7
 LDTP00590  Protein RER1 (RER1) 19.7
 LDTP01380  Wolframin (WFS1) 19.7
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 19.6
 LDTP05780  Syntaxin-5 (STX5) 19.4
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 19.3
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 19.2
 LDTP09288  Vang-like protein 1 (VANGL1) 19.2
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 19.0
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 19.0
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 18.6
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 18.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 18.4
 LDTP11812  Protein ARV1 (ARV1) 18.1
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 17.8
 LDTP03405  Calnexin (CANX) 17.5
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 16.9
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 16.6
 LDTP07058  Transmembrane protein 201 (TMEM201) 16.6
 LDTP07152  Acyl-CoA-binding domain-containing protein 5 (ACBD5) 16.4
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 16.3
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 16.3
 LDTP10370  Solute carrier family 41 member 3 (SLC41A3) 16.2
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 16.1
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 16.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 15.9
 LDTP04501  Importin subunit alpha-1 (KPNA2) 15.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 15.7
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 15.5
 LDTP01352  PRA1 family protein 3 (ARL6IP5) 15.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 15.3
 LDTP01531  Sorting nexin-4 (SNX4) 15.3
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) 15.3
 LDTP08030  Autophagy-related protein 9A (ATG9A) 15.0
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 15.0
 LDTP06994  ER membrane protein complex subunit 4 (EMC4) 14.7
 LDTP03546  Translocator protein (TSPO) 14.4
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 14.4
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 14.4
 LDTP04749  Peroxisomal biogenesis factor 3 (PEX3) 14.2
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 13.9
 LDTP01217  Metaxin-2 (MTX2) 13.8
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 13.2
 LDTP03717  Prohibitin 1 (PHB1) 13.0
 LDTP10621  Sideroflexin-2 (SFXN2) 12.9
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 12.7
 LDTP10036  BOS complex subunit NCLN (NCLN) 12.6
 LDTP11041  Calcium uptake protein 1, mitochondrial (MICU1) 12.6
 LDTP12090  Sideroflexin-1 (SFXN1) 12.6
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 12.3
 LDTP00546  Secretory carrier-associated membrane protein 1 (SCAMP1) 12.3
 LDTP10804  Chloride channel CLIC-like protein 1 (CLCC1) 12.2
 LDTP00451  Secretory carrier-associated membrane protein 3 (SCAMP3) 12.2
 LDTP13243  Translocation protein SEC63 homolog (SEC63) 12.1
 LDTP10343  Vacuole membrane protein 1 (VMP1) 12.0
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 11.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 11.6
 LDTP01631  Mitochondrial pyruvate carrier 2 (MPC2) 11.6
 LDTP09987  Secretory carrier-associated membrane protein 4 (SCAMP4) 11.5
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 11.4
 LDTP10985  Equilibrative nucleoside transporter 1 (SLC29A1) 11.4
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 11.4
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 12.6
 LDTP09694  Paraspeckle component 1 (PSPC1) 11.9
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 24.4
 LDTP03772  Basigin (BSG) 20.5
 LDTP11355  Junctional adhesion molecule C (JAM3) 14.1
Other
Click to Show/Hide to Show 124 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 99.7
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 99.7
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 99.7
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 99.7
 LDTP10056  Protein FAM162A (FAM162A) 99.7
 LDTP01522  Reticulon-3 (RTN3) 99.7
 LDTP08224  Protein LYRIC (MTDH) 90.5
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 85.0
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 80.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 74.0
 LDTP01494  Protein YIF1A (YIF1A) 69.6
 LDTP12412  Reticulon-4 (RTN4) 66.7
 LDTP05160  Nucleobindin-2 (NUCB2) 61.0
 LDTP00859  Synaptogyrin-2 (SYNGR2) 58.5
 LDTP14939  Membralin (TMEM259) 51.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 50.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 49.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 47.2
 LDTP05277  Protein SET (SET) 42.5
 LDTP13086  Syntaxin-18 (STX18) 41.6
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 36.5
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 34.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 33.8
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 33.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 32.9
 LDTP18272  Transmembrane protein 209 (TMEM209) 32.9
 LDTP19963  TraB domain-containing protein (TRABD) 32.4
 LDTP03926  Centrin-2 (CETN2) 32.2
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 30.5
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 29.4
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 28.8
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 27.1
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 25.6
 LDTP01652  Centrosomal protein 43 (CEP43) 25.3
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 25.1
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 24.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 23.8
 LDTP14716  ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) 22.9
 LDTP10442  Thioredoxin domain-containing protein 15 (TXNDC15) 22.8
 LDTP10924  Prohibitin-2 (PHB2) 22.5
 LDTP12677  DnaJ homolog subfamily C member 11 (DNAJC11) 22.3
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 22.2
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 22.2
 LDTP08248  NLR family member X1 (NLRX1) 22.2
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 22.0
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 21.0
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 19.7
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 19.6
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 19.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 19.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 18.9
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 18.6
 LDTP19859  Small integral membrane protein 12 (SMIM12) 18.4
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 18.3
 LDTP15398  Protein FAM177A1 (FAM177A1) 18.3
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 18.0
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 17.9
 LDTP10357  RUS family member 1 (RUSF1) 17.5
 LDTP06097  Reticulocalbin-2 (RCN2) 16.9
 LDTP01167  Reticulon-2 (RTN2) 16.9
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 16.7
 LDTP06413  Microtubule-associated protein RP/EB family member 2 (MAPRE2) 16.1
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 16.1
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 15.9
 LDTP09787  Nicastrin (NCSTN) 15.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 15.7
 LDTP05054  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GNG5) 15.7
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 15.7
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 15.6
 LDTP05041  Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1) 15.3
 LDTP00512  Protein transport protein Sec16A (SEC16A) 14.9
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 14.8
 LDTP08094  Wings apart-like protein homolog (WAPL) 14.8
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 14.7
 LDTP11065  Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) 14.7
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 14.6
 LDTP06210  Golgin subfamily B member 1 (GOLGB1) 14.5
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 14.5
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 14.4
 LDTP10275  Mitochondrial potassium channel (CCDC51) 14.4
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 14.3
 LDTP13800  Proteasome maturation protein (POMP) 14.2
 LDTP02927  Ganglioside GM2 activator (GM2A) 14.1
 LDTP08300  Reticulophagy regulator 3 (RETREG3) 14.0
 LDTP04356  Emerin (EMD) 13.9
 LDTP02443  Calmodulin-3 (CALM3) 13.7
 LDTP11910  Golgi phosphoprotein 3-like (GOLPH3L) 13.7
 LDTP00632  Syntaxin-7 (STX7) 13.7
 LDTP07655  Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) 13.6
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 13.5
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 13.5
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 13.5
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) 13.4
 LDTP00875  Striatin (STRN) 13.3
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 13.2
 LDTP13982  Mitochondrial fission 1 protein (FIS1) 13.2
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 13.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 13.1
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 13.0
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 12.9
 LDTP13967  Transmembrane emp24 domain-containing protein 5 (TMED5) 12.9
 LDTP01711  Protein ecdysoneless homolog (ECD) 12.8
 LDTP16285  Transducin beta-like protein 2 (TBL2) 12.8
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) 12.7
 LDTP13664  Syntaxin-8 (STX8) 12.7
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 12.6
 LDTP09644  m-AAA protease-interacting protein 1, mitochondrial (MAIP1) 12.6
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 12.5
 LDTP10113  Mitochondrial import receptor subunit TOM6 homolog (TOMM6) 12.5
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 12.5
 LDTP13630  Neudesin (NENF) 12.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 12.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 12.0
 LDTP08389  Syntaxin-12 (STX12) 12.0
 LDTP15356  Ribonucleoprotein PTB-binding 1 (RAVER1) 11.9
 LDTP00887  Calumenin (CALU) 11.8
 LDTP08594  Negative elongation factor C/D (NELFCD) 11.8
 LDTP06404  Surfeit locus protein 1 (SURF1) 11.8
 LDTP12692  Armadillo repeat-containing protein 1 (ARMC1) 11.6
 LDTP10207  Mitochondrial import inner membrane translocase subunit TIM14 (DNAJC19) 11.6
 LDTP05922  Dynactin subunit 2 (DCTN2) 11.5
 LDTP09297  Large ribosomal subunit protein mL64 (GADD45GIP1) 11.5
 LDTP07574  Superkiller complex protein 3 (SKIC3) 11.4
 LDTP19625  Integral membrane protein GPR180 (GPR180) 11.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587