Details of the Target

General Information of Target

Target ID LDTP05041
Target Name Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)
Gene Name GNAI1
Gene ID 2770
Synonyms
Guanine nucleotide-binding protein G(i) subunit alpha-1; Adenylate cyclase-inhibiting G alpha protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Target Bioclass
Other
Family
G-alpha family, G(i/o/t/z) subfamily
Subcellular location
Nucleus
Function
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase.
Uniprot ID
P63096
Ensemble ID
ENST00000351004.8
HGNC ID
HGNC:4384
ChEMBL ID
CHEMBL4741

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.F108V DBIA    Probe Info 
HCT15 SNV: p.I93T; p.D341G DBIA    Probe Info 
SW403 SNV: p.H195Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K17(2.51)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
BTD
 Probe Info  		C66(0.77)  LDD2091  [3]
AHL-Pu-1
 Probe Info  		C351(2.17); C254(2.43)  LDD0169  [4]
DBIA
 Probe Info  		C139(0.88)  LDD0531  [5]
ATP probe
 Probe Info  		K29(0.00); K35(0.00)  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
WYneN
 Probe Info  		C254(0.00); C66(0.00)  LDD0021  [8]
WYneO
 Probe Info  		C254(0.00); C66(0.00)  LDD0022  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
TFBX
 Probe Info  		C351(0.00); C139(0.00)  LDD0148  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		8.90  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C229
 Probe Info  		9.85  LDD1902  [13]
C231
 Probe Info  		15.35  LDD1904  [13]
C232
 Probe Info  		40.79  LDD1905  [13]
C234
 Probe Info  		6.41  LDD1907  [13]
C235
 Probe Info  		20.11  LDD1908  [13]
C285
 Probe Info  		22.01  LDD1955  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C66(0.96)  LDD2117  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C351(2.17); C254(2.43)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C139(0.88)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C139(1.07); C66(1.08); C305(0.83)  LDD1508  [14]
 LDCM0216  AC100 HCT 116 C139(0.75); C286(0.43); C305(0.43)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C139(0.81); C286(0.49); C305(0.49)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C139(0.79); C286(0.38); C305(0.38)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C139(0.61); C286(0.33); C305(0.33)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C139(1.00); C286(0.31); C305(0.31)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C139(0.79); C286(0.40); C305(0.40)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C139(0.64); C286(0.37); C305(0.37)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C139(0.79); C286(0.26); C305(0.26)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C139(0.69); C286(0.31); C305(0.31)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C139(0.81); C286(0.34); C305(0.34)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C139(1.04); C66(1.03); C305(0.95)  LDD1509  [14]
 LDCM0227  AC110 HCT 116 C139(0.65); C286(0.40); C305(0.40)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C139(0.57); C286(0.34); C305(0.34)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C139(0.60); C286(0.33); C305(0.33)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C286(0.88); C305(0.88)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C286(0.57); C305(0.57)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C286(0.44); C305(0.44)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C286(0.51); C305(0.51)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C286(0.72); C305(0.72)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C286(0.64); C305(0.64)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C286(0.62); C305(0.62)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C139(1.02); C66(1.02); C305(0.95)  LDD1510  [14]
 LDCM0238  AC120 HCT 116 C286(0.61); C305(0.61)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C286(0.61); C305(0.61)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C286(0.66); C305(0.66)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C286(1.18); C305(1.18)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C286(1.44); C305(1.44)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C286(0.90); C305(0.90)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C286(0.45); C305(0.45)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C286(0.64); C305(0.64)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C286(1.11); C305(1.08)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C286(0.87); C305(1.02)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C286(1.00); C305(1.04)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C286(1.09); C305(1.02)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C286(0.87); C305(0.95)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C286(0.94); C305(0.94)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C286(1.03); C305(1.11)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C286(1.09); C305(1.05)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C286(0.94); C305(0.92)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C286(0.86); C305(0.90)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C286(1.07); C305(1.17)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C286(1.02); C305(1.03)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C139(0.99); C66(1.13); C305(0.93)  LDD1512  [14]
 LDCM0260  AC140 HEK-293T C286(0.73); C305(0.89)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C286(0.96); C305(0.98)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C286(0.92); C305(0.96)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C305(0.95)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C305(1.03)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C305(1.07)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C305(1.10)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C305(1.03)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C305(1.02)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C305(1.08)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C139(1.11); C66(1.07); C305(0.91)  LDD1513  [14]
 LDCM0271  AC150 HEK-293T C305(1.08)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C305(0.92)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C305(0.93)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C305(1.00)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C305(0.97)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C305(1.01)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C305(0.93)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C305(1.10)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C66(0.92); C305(0.87)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C139(1.17); C66(0.99); C305(0.83)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C139(1.10); C66(0.99); C305(0.81)  LDD1517  [14]
 LDCM0279  AC2 HCT 116 C139(1.12)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C139(1.00); C66(1.02); C305(0.99)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C139(1.10); C305(0.81); C286(1.33)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C139(1.04); C66(1.01); C305(1.01)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C139(1.05); C66(0.96); C305(1.04)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C139(1.03); C66(1.08); C305(0.90)  LDD1523  [14]
 LDCM0285  AC25 HCT 116 C139(1.01); C286(1.14); C305(1.14)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C286(0.58); C305(0.58); C139(0.84)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C286(0.64); C305(0.64); C139(0.89)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C286(0.68); C305(0.68); C139(0.86)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C139(0.52); C286(0.64); C305(0.64)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C139(1.00)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C139(0.50); C286(0.77); C305(0.77)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C286(0.56); C305(0.56); C139(0.71)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C286(0.39); C305(0.39); C139(0.47)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C286(0.63); C305(0.63); C139(0.91)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C286(0.54); C305(0.54); C139(0.77)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C286(0.81); C305(0.81); C139(1.08)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C286(0.81); C305(0.81); C139(1.06)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C286(0.87); C305(0.87); C139(1.45)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C286(0.94); C305(0.94); C139(1.15)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C286(0.47); C305(0.47); C139(0.85)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C139(0.41)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C286(0.45); C305(0.45); C139(0.73)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C286(0.65); C305(0.65); C139(0.98)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C286(0.57); C305(0.57); C139(0.99)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C286(0.53); C305(0.53); C139(1.02)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C286(0.53); C305(0.53); C139(1.16)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C286(0.39); C305(0.39); C139(1.03)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C286(1.14); C305(1.14); C139(1.37)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C286(0.94); C305(0.94); C139(2.21)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C286(1.12); C305(1.12); C139(2.29)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C286(0.47); C305(0.47); C139(1.26)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C139(0.39)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C286(0.60); C305(0.60); C139(1.35)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C139(1.39); C286(1.47); C305(1.47)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C286(1.03); C305(1.03); C139(1.57)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C286(0.62); C305(0.62); C139(1.37)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C286(0.77); C305(0.77); C139(1.49)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C286(0.49); C305(0.49); C139(1.13)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C286(0.27); C305(0.27); C139(1.06)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C305(1.15)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C305(1.09)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C305(0.99)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C139(1.07); C66(0.99); C305(1.00)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C305(0.94)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C305(1.14)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C305(1.11)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C305(0.92)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C305(1.17)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C305(1.39)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C305(1.09)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C305(1.16)  LDD0929  [5]
 LDCM0334  AC7 HEK-293T C139(0.99); C66(1.09); C305(1.00)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C139(1.00); C66(1.07); C305(0.97)  LDD1569  [14]
 LDCM0349  AC83 HEK-293T C286(0.76); C305(0.76)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C286(0.59); C305(0.59)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C286(0.67); C305(0.67)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C286(0.62); C305(0.62)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C286(0.74); C305(0.74)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C286(0.71); C305(0.71)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C286(0.69); C305(0.69)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C286(0.61); C305(0.61)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C286(0.69); C305(0.69)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C286(0.69); C305(0.69)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C286(0.63); C305(0.63)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C286(0.58); C305(0.58)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C286(0.69); C305(0.69)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C286(0.64); C305(0.64)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C286(0.58); C305(0.58)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C286(0.05); C305(0.05); C139(0.72)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C286(0.72); C305(0.72); C139(0.75)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C139(1.03); C305(0.93); C286(1.10)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C66(0.99); C305(0.88)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C139(1.05); C66(1.07); C305(0.99)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 13.05  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C66(0.77)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C66(0.00); C139(0.00); H57(0.00)  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C286(0.85); C305(0.85); C139(0.96)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C286(0.44); C305(0.44); C139(0.59)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C139(0.36)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C139(1.01); C305(0.93)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C139(1.10); C66(0.94); C305(0.97)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C139(1.08); C305(0.93)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C139(1.05); C66(0.95); C305(1.09)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C139(1.00); C305(0.98)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C139(1.07); C66(1.03); C305(0.93)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C139(1.00); C305(0.99)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C139(1.14); C66(0.96); C305(1.06)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C139(1.06); C305(0.86)  LDD1582  [14]
 LDCM0379  CL11 HCT 116 C286(0.28); C305(0.28); C139(0.45)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C139(1.03); C66(1.06); C305(0.87)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C139(1.10); C305(1.02)  LDD1585  [14]
 LDCM0382  CL112 HCT 116 C139(0.69); C286(0.89); C305(0.89)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C139(0.46); C286(0.47); C305(0.47)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C139(0.47); C286(0.74); C305(0.74)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C139(0.68); C286(0.83); C305(0.83)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C286(0.46); C305(0.46); C139(0.81)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C286(0.24); C305(0.24); C139(0.73)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C286(0.53); C305(0.53); C139(1.02)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C286(0.55); C305(0.55); C139(1.23)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C286(0.29); C305(0.29); C139(0.50)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C286(0.43); C305(0.43); C139(0.97)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C286(1.36); C305(1.36); C139(1.45)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C286(0.76); C305(0.76); C139(1.29)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C286(0.66); C305(0.66); C139(1.43)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C286(0.56); C305(0.56); C139(1.58)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C305(0.99)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C305(1.10)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C305(1.05)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C305(1.31)  LDD0997  [5]
 LDCM0400  CL13 HCT 116 C286(0.51); C305(0.51); C139(0.93)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C286(0.64); C305(0.64); C139(1.02)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C286(0.58); C305(0.58); C139(0.67)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C286(0.59); C305(0.59)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C286(0.85); C305(0.85)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C286(0.92); C305(0.92)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C286(0.73); C305(0.73)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C286(0.86); C305(0.86); C139(1.01)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C286(0.55); C305(0.55)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C286(0.33); C305(0.33)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C286(0.19); C305(0.19)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C286(0.70); C305(0.70)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C286(0.37); C305(0.37)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C286(0.41); C305(0.41)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C286(0.65); C305(0.65)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C286(0.59); C305(0.59)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C286(0.51); C305(0.51)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C286(0.43); C305(0.43)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C139(0.78); C286(0.85); C305(0.85)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C286(0.95); C305(0.95)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C286(0.78); C305(0.78)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C286(0.71); C305(0.71)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C286(0.53); C305(0.53)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C286(0.88); C305(0.88)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C286(0.59); C305(0.59)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C286(0.71); C305(0.71)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C286(0.68); C305(0.68)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C286(0.44); C305(0.44)  LDD1026  [5]
 LDCM0429  CL4 HCT 116 C139(1.08); C286(0.87); C305(0.87)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C286(0.60); C305(0.60)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C286(0.41); C305(0.41)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C286(0.47); C305(0.47)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C286(0.50); C305(0.50)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C286(0.58); C305(0.58)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C286(0.46); C305(0.46)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C139(1.07); C66(1.30); C305(1.09)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C139(1.25); C66(1.17); C305(1.00)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C139(1.11); C66(1.29); C305(1.02)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C139(1.09); C305(1.00)  LDD1643  [14]
 LDCM0440  CL5 HCT 116 C139(0.83); C286(0.63); C305(0.63)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C139(1.08); C66(0.93); C305(0.95)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C139(1.05); C66(0.96); C305(1.11)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C66(0.95); C305(0.89)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C139(1.06); C66(1.10); C305(0.72)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C139(1.08); C66(1.04); C305(0.92)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C139(1.09); C66(1.11); C305(0.96)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C139(1.21); C305(0.79); C286(1.13)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C139(1.16); C66(1.34); C305(1.09)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C139(1.16); C66(1.33); C305(1.04)  LDD1653  [14]
 LDCM0451  CL6 HCT 116 C139(0.84); C286(0.56); C305(0.56)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C139(1.14); C66(1.35); C305(0.93)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C139(1.02); C305(0.92)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C139(1.02); C66(0.96); C305(1.03)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C139(1.10); C305(1.03)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C139(1.03); C66(0.94); C305(0.99)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C66(1.05); C305(0.74)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C139(1.09); C66(1.07); C305(0.88)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C139(1.13); C66(1.05); C305(1.00)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C139(1.13); C66(1.13); C305(1.00)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C139(1.18); C305(0.89); C286(1.33)  LDD1664  [14]
 LDCM0462  CL7 HCT 116 C139(0.65); C286(0.43); C305(0.43)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C139(1.07); C66(1.25); C305(1.12)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C139(1.27); C66(1.28); C305(1.09)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C139(1.11); C66(1.23); C305(0.99)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C139(1.13); C305(0.92)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C139(1.00); C66(0.95); C305(0.95)  LDD1670  [14]
 LDCM0469  CL76 HCT 116 C286(1.01); C305(1.01)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C286(1.33); C305(1.33)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C286(0.59); C305(0.59)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C286(0.42); C305(0.42)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C139(0.43); C286(0.30); C305(0.30)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C286(0.86); C305(0.86)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C286(0.64); C305(0.64)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C286(0.26); C305(0.26)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C286(0.34); C305(0.34)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C286(0.16); C305(0.16)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C286(0.52); C305(0.52)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C286(0.89); C305(0.89)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C286(0.58); C305(0.58)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C286(0.33); C305(0.33)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C286(0.13); C305(0.13)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C139(0.82); C286(0.59); C305(0.59)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C286(0.80); C305(0.80)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C139(0.69)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C139(0.84)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C139(0.89)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C139(0.47)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C139(0.51)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C139(0.72)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C139(0.46)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C139(0.51)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C139(0.50)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C139(1.10); C305(0.99)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C139(1.13); C305(1.04)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C286(0.58); C305(0.58)  LDD1025  [5]
 LDCM0107  IAA HeLa C66(0.00); C139(0.00); H57(0.00)  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C139(0.94); C66(0.89); C305(1.05)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C139(0.95); C66(0.96); C305(1.01)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C87(1.47)  LDD3310  [15]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C66(1.34)  LDD2107  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C325(1.77); C66(1.24)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C66(1.93)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C66(0.81)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C66(1.05)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C66(1.32)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C325(1.11)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C66(0.91)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C66(1.56)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C66(0.97)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C66(1.05)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C66(1.30)  LDD2144  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein-signaling modulator 2 (GPSM2) GPSM family P81274
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Nuclear mitotic apparatus protein 1 (NUMA1) . Q14980
Purkinje cell protein 2 homolog (PCP2) . Q8IVA1
Regulator of G-protein signaling 17 (RGS17) . Q9UGC6

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Tetrafluoroaluminate Ion . DB04444

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840