Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C229  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 43.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 33.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 30.7
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 29.0
 LDTP04689  Adenosine kinase (ADK) 28.8
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 24.4
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 19.3
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 17.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 17.1
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 17.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 17.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 16.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 16.0
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 15.7
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 15.7
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 15.6
 LDTP09285  Atypical kinase COQ8A, mitochondrial (COQ8A) 15.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 15.2
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 14.9
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 14.9
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 14.8
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 14.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 14.4
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 13.6
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 13.6
 LDTP02505  Lysosomal protective protein (CTSA) 13.5
 LDTP02837  Beta-galactosidase (GLB1) 13.3
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 13.2
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 13.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 13.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 13.2
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 13.0
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 12.9
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 12.6
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 12.1
 LDTP04581  Holocytochrome c-type synthase (HCCS) 11.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.5
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 11.4
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 11.4
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 11.3
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 11.1
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 10.9
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 10.6
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 10.3
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 10.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 10.2
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 9.8
 LDTP05905  Acid ceramidase (ASAH1) 9.6
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 9.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.5
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 9.4
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 9.4
 LDTP00813  5-hydroxymethyl-dUMP N-hydrolase (DNPH1) 9.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 9.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 8.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 8.9
 LDTP09251  Atlastin-2 (ATL2) 8.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 8.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 8.9
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.8
 LDTP02539  Lysosomal acid phosphatase (ACP2) 8.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 8.6
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 8.6
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 8.2
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 8.0
 LDTP07931  Heme A synthase COX15 (COX15) 8.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 7.9
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 7.8
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 7.7
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) 7.7
 LDTP00988  Protein O-GlcNAcase (OGA) 7.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 7.6
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 7.5
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 7.5
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 7.4
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 7.4
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 7.2
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 7.2
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 7.2
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) 7.1
 LDTP01372  Carboxypeptidase D (CPD) 7.1
 LDTP10329  Ceramide synthase 2 (CERS2) 7.0
 LDTP04183  Lanosterol synthase (LSS) 7.0
Transporter and channel
Click to Show/Hide to Show 71 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16813  Tetraspanin-3 (TSPAN3) 58.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 31.8
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 28.1
 LDTP07156  Protein wntless homolog (WLS) 24.1
 LDTP01804  ATP synthase subunit a (MT-ATP6) 23.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 23.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 22.6
 LDTP12383  Protein GPR108 (GPR108) 22.2
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 20.1
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 20.0
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 18.9
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 18.6
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 18.5
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 18.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 17.8
 LDTP15481  Transmembrane protein 87A (TMEM87A) 17.8
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 17.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 17.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 17.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 17.1
 LDTP05900  Metaxin-1 (MTX1) 17.0
 LDTP15648  BRI3-binding protein (BRI3BP) 16.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 16.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 16.4
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 16.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 15.9
 LDTP02215  Prosaposin (PSAP) 15.7
 LDTP11927  Essential MCU regulator, mitochondrial (SMDT1) 15.5
 LDTP11615  Protein tweety homolog 3 (TTYH3) 15.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 15.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 14.9
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 14.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 14.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 13.6
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 13.4
 LDTP13833  Integral membrane protein 2B (ITM2B) 13.2
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 13.1
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 13.1
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 13.1
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 12.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 12.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 12.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 12.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 11.2
 LDTP20002  Transmembrane protein 160 (TMEM160) 11.1
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 10.9
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 10.4
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 10.4
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 10.3
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 9.7
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 9.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 9.4
 LDTP07667  Transmembrane protein 205 (TMEM205) 9.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 9.3
 LDTP11213  Nucleoporin NDC1 (NDC1) 9.1
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 8.9
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 8.8
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 7.8
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 7.8
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 7.8
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 7.7
 LDTP09288  Vang-like protein 1 (VANGL1) 7.7
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 7.6
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 7.3
 LDTP10370  Solute carrier family 41 member 3 (SLC41A3) 7.3
 LDTP12191  Vezatin (VEZT) 7.3
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 7.3
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 7.3
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 7.2
 LDTP03952  Reduced folate transporter (SLC19A1) 7.1
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14241  eIF5-mimic protein 1 (BZW2) 7.2
Other
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 62.2
 LDTP10056  Protein FAM162A (FAM162A) 36.5
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 32.2
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 24.1
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 23.9
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 22.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 22.5
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 21.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 19.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 17.1
 LDTP01494  Protein YIF1A (YIF1A) 16.6
 LDTP01522  Reticulon-3 (RTN3) 16.6
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 14.9
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 14.2
 LDTP01652  Centrosomal protein 43 (CEP43) 13.4
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 13.1
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 12.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 12.3
 LDTP14939  Membralin (TMEM259) 12.1
 LDTP05277  Protein SET (SET) 11.6
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 11.6
 LDTP05160  Nucleobindin-2 (NUCB2) 11.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 11.5
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 11.4
 LDTP16080  Protein FAM114A2 (FAM114A2) 11.3
 LDTP01638  YEATS domain-containing protein 4 (YEATS4) 11.3
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 11.1
 LDTP05868  Protein unc-119 homolog A (UNC119) 10.6
 LDTP00875  Striatin (STRN) 10.5
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 10.3
 LDTP08224  Protein LYRIC (MTDH) 10.1
 LDTP05041  Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1) 9.8
 LDTP02047  Calpain small subunit 1 (CAPNS1) 9.6
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 9.6
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 9.5
 LDTP12412  Reticulon-4 (RTN4) 9.1
 LDTP01359  Dynactin subunit 3 (DCTN3) 9.1
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 9.1
 LDTP07655  Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) 8.6
 LDTP13086  Syntaxin-18 (STX18) 8.5
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 8.5
 LDTP08248  NLR family member X1 (NLRX1) 8.4
 LDTP19963  TraB domain-containing protein (TRABD) 7.9
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 7.7
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 7.6
 LDTP01711  Protein ecdysoneless homolog (ECD) 7.6
 LDTP18132  Protein FAM136A (FAM136A) 7.2
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 7.2
 LDTP06097  Reticulocalbin-2 (RCN2) 7.2
 LDTP00105  Protein unc-119 homolog B (UNC119B) 7.1
 LDTP06527  Alpha-internexin (INA) 7.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587