Details of the Target

General Information of Target

Target ID LDTP13606
Target Name Mammalian ependymin-related protein 1 (EPDR1)
Gene Name EPDR1
Gene ID 54749
Synonyms
MERP1; UCC1; Mammalian ependymin-related protein 1; MERP-1; Upregulated in colorectal cancer gene 1 protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRLRNGTVATALAFITSFLTLSWYTTWQNGKEKLIAYQREFLALKERLRIAEHRISQRSS
ELNTIVQQFKRVGAETNGSKDALNKFSDNTLKLLKELTSKKSLQVPSIYYHLPHLLKNEG
SLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGET
DIDYVHGVVANLEKEFSKEISSGLVEVISPPESYYPDLTNLKETFGDSKERVRWRTKQNL
DYCFLMMYAQEKGIYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMF
QAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQ
HVGLHSSLSGKIQKLTDKDYMKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWA
ITPIAGDYILFKFDKPVNVESYLFHSGNQEHPGDILLNTTVEVLPFKSEGLEISKETKDK
RLEDGYFRIGKFENGVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKKATN
Target Bioclass
Other
Family
Ependymin family
Subcellular location
Lysosome lumen
Function Binds anionic lipids and gangliosides at acidic pH.
Uniprot ID
Q9UM22
Ensemble ID
ENST00000199448.9
HGNC ID
HGNC:17572

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.E216G .
HEP3B217 SNV: p.G29S; p.T189K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		20.00  LDD0387  [1]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0391  [1]
FBPP2
 Probe Info  		49.53  LDD0318  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
DBIA
 Probe Info  		C88(3.21)  LDD3314  [4]
BTD
 Probe Info  		C88(1.35)  LDD2093  [5]
IPM
 Probe Info  		C88(1.33)  LDD1701  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
AOyne
 Probe Info  		11.70  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 117 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.19  LDD1711  [8]
C003
 Probe Info  		15.24  LDD1713  [8]
C004
 Probe Info  		11.96  LDD1714  [8]
C007
 Probe Info  		8.46  LDD1716  [8]
C008
 Probe Info  		7.84  LDD1717  [8]
C010
 Probe Info  		12.55  LDD1719  [8]
C011
 Probe Info  		15.14  LDD1720  [8]
C017
 Probe Info  		10.20  LDD1725  [8]
C045
 Probe Info  		8.06  LDD1744  [8]
C052
 Probe Info  		5.17  LDD1750  [8]
C053
 Probe Info  		8.57  LDD1751  [8]
C056
 Probe Info  		25.11  LDD1753  [8]
C060
 Probe Info  		5.86  LDD1757  [8]
C063
 Probe Info  		37.53  LDD1760  [8]
C064
 Probe Info  		20.82  LDD1761  [8]
C067
 Probe Info  		9.00  LDD1763  [8]
C070
 Probe Info  		39.67  LDD1766  [8]
C071
 Probe Info  		15.45  LDD1767  [8]
C072
 Probe Info  		12.82  LDD1768  [8]
C073
 Probe Info  		7.57  LDD1769  [8]
C078
 Probe Info  		7.67  LDD1771  [8]
C082
 Probe Info  		7.01  LDD1774  [8]
C085
 Probe Info  		10.63  LDD1777  [8]
C087
 Probe Info  		23.26  LDD1779  [8]
C089
 Probe Info  		13.36  LDD1781  [8]
C091
 Probe Info  		29.86  LDD1782  [8]
C092
 Probe Info  		99.73  LDD1783  [8]
C106
 Probe Info  		19.16  LDD1793  [8]
C107
 Probe Info  		11.79  LDD1794  [8]
C108
 Probe Info  		13.36  LDD1795  [8]
C112
 Probe Info  		34.78  LDD1799  [8]
C115
 Probe Info  		9.38  LDD1802  [8]
C129
 Probe Info  		7.41  LDD1811  [8]
C134
 Probe Info  		37.01  LDD1816  [8]
C135
 Probe Info  		14.42  LDD1817  [8]
C139
 Probe Info  		22.63  LDD1821  [8]
C140
 Probe Info  		17.27  LDD1822  [8]
C141
 Probe Info  		43.11  LDD1823  [8]
C143
 Probe Info  		23.43  LDD1825  [8]
C145
 Probe Info  		17.63  LDD1827  [8]
C147
 Probe Info  		22.63  LDD1829  [8]
C149
 Probe Info  		7.78  LDD1830  [8]
C153
 Probe Info  		26.54  LDD1834  [8]
C156
 Probe Info  		5.86  LDD1836  [8]
C159
 Probe Info  		23.43  LDD1839  [8]
C160
 Probe Info  		29.65  LDD1840  [8]
C161
 Probe Info  		38.59  LDD1841  [8]
C169
 Probe Info  		35.75  LDD1849  [8]
C170
 Probe Info  		49.87  LDD1850  [8]
C171
 Probe Info  		18.51  LDD1851  [8]
C177
 Probe Info  		7.41  LDD1856  [8]
C178
 Probe Info  		19.56  LDD1857  [8]
C183
 Probe Info  		9.51  LDD1861  [8]
C184
 Probe Info  		6.41  LDD1862  [8]
C186
 Probe Info  		13.93  LDD1864  [8]
C194
 Probe Info  		32.45  LDD1870  [8]
C197
 Probe Info  		23.10  LDD1873  [8]
C198
 Probe Info  		59.30  LDD1874  [8]
C201
 Probe Info  		97.01  LDD1877  [8]
C204
 Probe Info  		8.17  LDD1879  [8]
C205
 Probe Info  		13.55  LDD1880  [8]
C206
 Probe Info  		54.57  LDD1881  [8]
C208
 Probe Info  		17.51  LDD1883  [8]
C210
 Probe Info  		53.82  LDD1884  [8]
C211
 Probe Info  		50.21  LDD1885  [8]
C212
 Probe Info  		9.51  LDD1886  [8]
C213
 Probe Info  		33.59  LDD1887  [8]
C220
 Probe Info  		25.28  LDD1894  [8]
C222
 Probe Info  		8.82  LDD1896  [8]
C223
 Probe Info  		21.56  LDD1897  [8]
C225
 Probe Info  		26.72  LDD1898  [8]
C226
 Probe Info  		20.68  LDD1899  [8]
C228
 Probe Info  		32.45  LDD1901  [8]
C229
 Probe Info  		23.92  LDD1902  [8]
C231
 Probe Info  		22.16  LDD1904  [8]
C232
 Probe Info  		56.10  LDD1905  [8]
C233
 Probe Info  		24.25  LDD1906  [8]
C243
 Probe Info  		14.42  LDD1916  [8]
C246
 Probe Info  		23.59  LDD1919  [8]
C249
 Probe Info  		50.56  LDD1922  [8]
C277
 Probe Info  		9.13  LDD1947  [8]
C280
 Probe Info  		9.92  LDD1950  [8]
C282
 Probe Info  		14.32  LDD1952  [8]
C293
 Probe Info  		20.53  LDD1963  [8]
C296
 Probe Info  		15.03  LDD1966  [8]
C299
 Probe Info  		15.89  LDD1968  [8]
C300
 Probe Info  		7.01  LDD1969  [8]
C302
 Probe Info  		7.26  LDD1971  [8]
C303
 Probe Info  		6.28  LDD1972  [8]
C305
 Probe Info  		24.93  LDD1974  [8]
C310
 Probe Info  		13.83  LDD1977  [8]
C343
 Probe Info  		20.68  LDD2005  [8]
C346
 Probe Info  		42.22  LDD2007  [8]
C355
 Probe Info  		99.73  LDD2016  [8]
C356
 Probe Info  		58.08  LDD2017  [8]
C357
 Probe Info  		14.42  LDD2018  [8]
C360
 Probe Info  		11.71  LDD2021  [8]
C361
 Probe Info  		45.25  LDD2022  [8]
C373
 Probe Info  		5.31  LDD2033  [8]
C376
 Probe Info  		9.71  LDD2036  [8]
C378
 Probe Info  		15.35  LDD2037  [8]
C380
 Probe Info  		8.46  LDD2039  [8]
C382
 Probe Info  		30.06  LDD2041  [8]
C383
 Probe Info  		26.17  LDD2042  [8]
C386
 Probe Info  		7.16  LDD2045  [8]
C388
 Probe Info  		42.22  LDD2047  [8]
C389
 Probe Info  		5.24  LDD2048  [8]
C390
 Probe Info  		93.70  LDD2049  [8]
C396
 Probe Info  		6.15  LDD2055  [8]
C399
 Probe Info  		17.39  LDD2058  [8]
C403
 Probe Info  		27.47  LDD2061  [8]
C407
 Probe Info  		14.83  LDD2064  [8]
C408
 Probe Info  		5.21  LDD2065  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe12
 Probe Info  		20.00  LDD0473  [9]
JN0003
 Probe Info  		20.00  LDD0469  [9]
Kambe_31
 Probe Info  		5.44  LDD0128  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C88(1.27)  LDD2152  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C88(1.05)  LDD1702  [5]
 LDCM0073  Kambe_cp3 PC-3 5.44  LDD0128  [10]
 LDCM0022  KB02 22RV1 C88(2.51)  LDD2243  [4]
 LDCM0023  KB03 MDA-MB-231 C88(1.33)  LDD1701  [5]
 LDCM0024  KB05 IGR37 C88(3.21)  LDD3314  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C88(1.35)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C88(0.88)  LDD2099  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C88(0.88)  LDD2109  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C88(1.00)  LDD2125  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C88(1.39)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C88(1.03)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C88(1.35)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C88(1.20)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C88(0.18)  LDD2150  [5]
 LDCM0099  Phenelzine MDA-MB-231 20.00  LDD0388  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.