Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C064  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 88 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 40.8
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 33.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 32.4
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 27.3
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 20.3
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 19.2
 LDTP03787  Choline kinase alpha (CHKA) 18.5
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 16.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 16.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 13.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 13.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 12.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 12.3
 LDTP02505  Lysosomal protective protein (CTSA) 12.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 11.8
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 11.7
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 11.3
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 11.2
 LDTP02359  Heme oxygenase 1 (HMOX1) 11.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 11.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 10.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 10.4
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 10.3
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 9.6
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 9.5
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 9.4
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 9.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 9.3
 LDTP00645  Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) 9.3
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 9.3
 LDTP10329  Ceramide synthase 2 (CERS2) 9.2
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 9.1
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 9.1
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 9.0
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 9.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 9.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 8.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 8.9
 LDTP04394  Poly(A) polymerase alpha (PAPOLA) 8.6
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 8.4
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.4
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 8.4
 LDTP06617  Ceramide glucosyltransferase (UGCG) 8.3
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 8.3
 LDTP16258  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (PIGL) 8.3
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 8.3
 LDTP04555  Serine/threonine-protein kinase PLK1 (PLK1) 8.1
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 8.1
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 8.1
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.1
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 7.9
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 7.8
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 7.5
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 7.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 7.4
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 7.4
 LDTP06511  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) 7.4
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 7.3
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.3
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.3
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 7.3
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 7.1
 LDTP13814  Phospholipase A-2-activating protein (PLAA) 7.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 7.0
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 7.0
 LDTP00988  Protein O-GlcNAcase (OGA) 7.0
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) 6.9
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 6.9
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 6.8
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 6.8
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 6.7
 LDTP07502  Putative ATP-dependent RNA helicase DHX57 (DHX57) 6.7
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 6.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 6.6
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.5
 LDTP01769  Dihydrofolate reductase (DHFR) 6.4
 LDTP12386  Polyamine-transporting ATPase 13A2 (ATP13A2) 6.4
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 6.4
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 6.4
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 6.3
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 6.3
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 6.3
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 6.2
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 6.1
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 6.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 6.1
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 6.1
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 5.9
Transporter and channel
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 52.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 27.5
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 26.7
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 22.3
 LDTP15481  Transmembrane protein 87A (TMEM87A) 16.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 13.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.8
 LDTP20002  Transmembrane protein 160 (TMEM160) 12.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 12.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 12.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 12.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 11.9
 LDTP12383  Protein GPR108 (GPR108) 11.4
 LDTP15948  Transmembrane protein 126A (TMEM126A) 11.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 11.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 10.9
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 10.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 10.3
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 10.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 9.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 9.8
 LDTP07236  Protein GPR107 (GPR107) 9.7
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 9.6
 LDTP01016  Exocyst complex component 3 (EXOC3) 9.6
 LDTP02740  Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) 9.6
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 9.4
 LDTP15648  BRI3-binding protein (BRI3BP) 9.4
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 9.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 9.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 9.1
 LDTP05900  Metaxin-1 (MTX1) 8.6
 LDTP03546  Translocator protein (TSPO) 8.5
 LDTP02215  Prosaposin (PSAP) 8.1
 LDTP09788  Sorting nexin-19 (SNX19) 8.0
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 7.7
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 7.7
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 7.3
 LDTP10065  Transmembrane protein 230 (TMEM230) 7.1
 LDTP00010  Intraflagellar transport protein 56 (IFT56) 6.5
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 6.5
 LDTP00592  Surfeit locus protein 4 (SURF4) 6.5
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.2
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 6.2
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 6.1
 LDTP03380  Stomatin (STOM) 6.0
 LDTP09769  Zinc transporter SLC39A7 (SLC39A7) 6.0
 LDTP11291  Transmembrane emp24 domain-containing protein 9 (TMED9) 5.9
Other
Click to Show/Hide to Show 52 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 43.1
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 32.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 21.7
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 20.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 18.9
 LDTP11312  DET1- and DDB1-associated protein 1 (DDA1) 18.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 17.6
 LDTP11076  Apolipoprotein L2 (APOL2) 15.6
 LDTP05375  Nucleobindin-1 (NUCB1) 15.6
 LDTP05160  Nucleobindin-2 (NUCB2) 15.2
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 14.7
 LDTP14458  Tetraspanin-6 (TSPAN6) 13.5
 LDTP17580  FHF complex subunit HOOK-interacting protein 2B (FHIP2B) 11.9
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 11.8
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 11.2
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 10.9
 LDTP01522  Reticulon-3 (RTN3) 10.1
 LDTP13086  Syntaxin-18 (STX18) 9.6
 LDTP13402  Dynactin subunit 4 (DCTN4) 9.1
 LDTP01652  Centrosomal protein 43 (CEP43) 9.1
 LDTP09509  Rap guanine nucleotide exchange factor 6 (RAPGEF6) 8.6
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 8.5
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.4
 LDTP18569  PRELI domain containing protein 3B (PRELID3B) 8.3
 LDTP01359  Dynactin subunit 3 (DCTN3) 8.2
 LDTP08766  Vacuolar protein sorting-associated protein 52 homolog (VPS52) 7.9
 LDTP14939  Membralin (TMEM259) 7.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 7.8
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 7.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 7.5
 LDTP18132  Protein FAM136A (FAM136A) 7.4
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 7.3
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 7.2
 LDTP02960  Negative elongation factor E (NELFE) 7.0
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 7.0
 LDTP13656  Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) 6.9
 LDTP05277  Protein SET (SET) 6.9
 LDTP01225  Mediator of RNA polymerase II transcription subunit 24 (MED24) 6.8
 LDTP11670  Mitochondrial fission factor (MFF) 6.8
 LDTP10056  Protein FAM162A (FAM162A) 6.8
 LDTP08000  Dymeclin (DYM) 6.8
 LDTP00859  Synaptogyrin-2 (SYNGR2) 6.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 6.7
 LDTP12412  Reticulon-4 (RTN4) 6.5
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 6.5
 LDTP12629  T-complex protein 11-like protein 1 (TCP11L1) 6.5
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 6.2
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 6.1
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 6.0
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 6.0
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 6.0
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 6.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587