Details of the Target

General Information of Target

Target ID LDTP09547
Target Name Scavenger receptor class B member 1 (SCARB1)
Gene Name SCARB1
Gene ID 949
Synonyms
CD36L1; CLA1; Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; CD antigen CD36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIP
IPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQ
FQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIM
WGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGL
SKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYR
FVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTG
LHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESG
AMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSH
SLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLE
GLGPSLGGGTGS
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
CD36 family
Subcellular location
Cell membrane
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.; (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate.; (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus.; (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding.
TTD ID
T62998
Uniprot ID
Q8WTV0
DrugMap ID
TTRE324
Ensemble ID
ENST00000261693.11
HGNC ID
HGNC:1664
ChEMBL ID
CHEMBL1914272

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		14.23  LDD0324  [1]
DA-P2
 Probe Info  		4.96  LDD0348  [2]
CHEMBL5175495
 Probe Info  		10.59  LDD0196  [3]
TG42
 Probe Info  		12.96  LDD0326  [4]
FBP2
 Probe Info  		3.08  LDD0323  [1]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K288(3.35)  LDD0277  [6]
ONAyne
 Probe Info  		K42(1.54)  LDD0275  [6]
OPA-S-S-alkyne
 Probe Info  		K42(0.27); K288(0.70)  LDD3494  [7]
Propranolol-CA-4PAP
 Probe Info  		4.20  LDD0271  [8]
Jackson_14
 Probe Info  		2.22  LDD0123  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [10]
PAL-AfBPP Probe
Click To Hide/Show 200 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.39  LDD1711  [11]
C004
 Probe Info  		7.06  LDD1714  [11]
C007
 Probe Info  		5.82  LDD1716  [11]
C010
 Probe Info  		13.93  LDD1719  [11]
C011
 Probe Info  		8.17  LDD1720  [11]
C012
 Probe Info  		5.21  LDD1721  [11]
C018
 Probe Info  		9.71  LDD1726  [11]
C022
 Probe Info  		12.91  LDD1728  [11]
C024
 Probe Info  		5.66  LDD1730  [11]
C026
 Probe Info  		10.20  LDD1732  [11]
C027
 Probe Info  		5.39  LDD1733  [11]
C036
 Probe Info  		5.21  LDD1736  [11]
C039
 Probe Info  		6.77  LDD1739  [11]
C040
 Probe Info  		10.85  LDD1740  [11]
C041
 Probe Info  		15.89  LDD1741  [11]
C042
 Probe Info  		4.92  LDD1742  [11]
C044
 Probe Info  		7.57  LDD1743  [11]
C055
 Probe Info  		16.68  LDD1752  [11]
C060
 Probe Info  		7.52  LDD1757  [11]
C063
 Probe Info  		22.01  LDD1760  [11]
C064
 Probe Info  		11.88  LDD1761  [11]
C067
 Probe Info  		8.94  LDD1763  [11]
C070
 Probe Info  		16.11  LDD1766  [11]
C071
 Probe Info  		14.22  LDD1767  [11]
C072
 Probe Info  		18.64  LDD1768  [11]
C082
 Probe Info  		5.66  LDD1774  [11]
C085
 Probe Info  		9.85  LDD1777  [11]
C087
 Probe Info  		9.13  LDD1779  [11]
C089
 Probe Info  		8.94  LDD1781  [11]
C091
 Probe Info  		11.47  LDD1782  [11]
C092
 Probe Info  		22.47  LDD1783  [11]
C094
 Probe Info  		24.93  LDD1785  [11]
C106
 Probe Info  		27.47  LDD1793  [11]
C107
 Probe Info  		13.00  LDD1794  [11]
C108
 Probe Info  		16.80  LDD1795  [11]
C110
 Probe Info  		7.36  LDD1797  [11]
C112
 Probe Info  		33.36  LDD1799  [11]
C115
 Probe Info  		5.54  LDD1802  [11]
C117
 Probe Info  		5.24  LDD1804  [11]
C130
 Probe Info  		17.51  LDD1812  [11]
C134
 Probe Info  		20.82  LDD1816  [11]
C135
 Probe Info  		14.12  LDD1817  [11]
C139
 Probe Info  		17.39  LDD1821  [11]
C140
 Probe Info  		15.45  LDD1822  [11]
C141
 Probe Info  		27.86  LDD1823  [11]
C143
 Probe Info  		21.41  LDD1825  [11]
C145
 Probe Info  		15.89  LDD1827  [11]
C147
 Probe Info  		13.18  LDD1829  [11]
C153
 Probe Info  		20.82  LDD1834  [11]
C156
 Probe Info  		15.89  LDD1836  [11]
C158
 Probe Info  		17.03  LDD1838  [11]
C159
 Probe Info  		19.70  LDD1839  [11]
C160
 Probe Info  		21.11  LDD1840  [11]
C161
 Probe Info  		20.82  LDD1841  [11]
C163
 Probe Info  		14.42  LDD1843  [11]
C166
 Probe Info  		12.91  LDD1846  [11]
C169
 Probe Info  		27.47  LDD1849  [11]
C170
 Probe Info  		12.21  LDD1850  [11]
C173
 Probe Info  		5.54  LDD1853  [11]
C174
 Probe Info  		6.32  LDD1854  [11]
C177
 Probe Info  		14.93  LDD1856  [11]
C178
 Probe Info  		23.59  LDD1857  [11]
C183
 Probe Info  		10.13  LDD1861  [11]
C186
 Probe Info  		11.88  LDD1864  [11]
C187
 Probe Info  		20.82  LDD1865  [11]
C193
 Probe Info  		13.27  LDD1869  [11]
C194
 Probe Info  		14.72  LDD1870  [11]
C197
 Probe Info  		8.69  LDD1873  [11]
C198
 Probe Info  		14.93  LDD1874  [11]
C199
 Probe Info  		9.06  LDD1875  [11]
C201
 Probe Info  		39.95  LDD1877  [11]
C204
 Probe Info  		8.00  LDD1879  [11]
C205
 Probe Info  		8.63  LDD1880  [11]
C206
 Probe Info  		29.86  LDD1881  [11]
C208
 Probe Info  		7.36  LDD1883  [11]
C210
 Probe Info  		39.12  LDD1884  [11]
C211
 Probe Info  		15.56  LDD1885  [11]
C213
 Probe Info  		20.53  LDD1887  [11]
C215
 Probe Info  		6.50  LDD1889  [11]
C216
 Probe Info  		7.26  LDD1890  [11]
C217
 Probe Info  		12.73  LDD1891  [11]
C218
 Probe Info  		11.08  LDD1892  [11]
C219
 Probe Info  		14.52  LDD1893  [11]
C220
 Probe Info  		17.39  LDD1894  [11]
C223
 Probe Info  		8.11  LDD1897  [11]
C225
 Probe Info  		10.93  LDD1898  [11]
C226
 Probe Info  		7.94  LDD1899  [11]
C228
 Probe Info  		24.93  LDD1901  [11]
C229
 Probe Info  		15.03  LDD1902  [11]
C231
 Probe Info  		19.97  LDD1904  [11]
C233
 Probe Info  		30.91  LDD1906  [11]
C234
 Probe Info  		12.38  LDD1907  [11]
C235
 Probe Info  		29.04  LDD1908  [11]
C239
 Probe Info  		8.34  LDD1912  [11]
C240
 Probe Info  		19.16  LDD1913  [11]
C242
 Probe Info  		7.78  LDD1915  [11]
C243
 Probe Info  		11.39  LDD1916  [11]
C245
 Probe Info  		10.56  LDD1918  [11]
C246
 Probe Info  		18.38  LDD1919  [11]
C252
 Probe Info  		10.27  LDD1925  [11]
C255
 Probe Info  		8.57  LDD1928  [11]
C258
 Probe Info  		7.62  LDD1931  [11]
C260
 Probe Info  		10.41  LDD1932  [11]
C264
 Probe Info  		22.63  LDD1935  [11]
C265
 Probe Info  		18.90  LDD1936  [11]
C266
 Probe Info  		11.16  LDD1937  [11]
C270
 Probe Info  		12.55  LDD1940  [11]
C272
 Probe Info  		5.74  LDD1942  [11]
C273
 Probe Info  		7.73  LDD1943  [11]
C277
 Probe Info  		13.64  LDD1947  [11]
C280
 Probe Info  		13.64  LDD1950  [11]
C282
 Probe Info  		15.24  LDD1952  [11]
C286
 Probe Info  		14.42  LDD1956  [11]
C287
 Probe Info  		18.00  LDD1957  [11]
C288
 Probe Info  		15.67  LDD1958  [11]
C289
 Probe Info  		28.25  LDD1959  [11]
C290
 Probe Info  		7.46  LDD1960  [11]
C292
 Probe Info  		6.50  LDD1962  [11]
C293
 Probe Info  		21.71  LDD1963  [11]
C296
 Probe Info  		13.64  LDD1966  [11]
C297
 Probe Info  		7.16  LDD1967  [11]
C299
 Probe Info  		7.84  LDD1968  [11]
C301
 Probe Info  		5.90  LDD1970  [11]
C303
 Probe Info  		7.26  LDD1972  [11]
C304
 Probe Info  		10.41  LDD1973  [11]
C305
 Probe Info  		10.20  LDD1974  [11]
C307
 Probe Info  		10.78  LDD1975  [11]
C310
 Probe Info  		8.22  LDD1977  [11]
C314
 Probe Info  		21.26  LDD1981  [11]
C320
 Probe Info  		14.52  LDD1986  [11]
C322
 Probe Info  		7.94  LDD1988  [11]
C326
 Probe Info  		22.01  LDD1990  [11]
C327
 Probe Info  		7.36  LDD1991  [11]
C333
 Probe Info  		7.26  LDD1996  [11]
C337
 Probe Info  		5.06  LDD2000  [11]
C338
 Probe Info  		15.24  LDD2001  [11]
C339
 Probe Info  		13.55  LDD2002  [11]
C340
 Probe Info  		6.06  LDD2003  [11]
C342
 Probe Info  		12.13  LDD2004  [11]
C343
 Probe Info  		17.03  LDD2005  [11]
C346
 Probe Info  		14.12  LDD2007  [11]
C347
 Probe Info  		6.32  LDD2008  [11]
C348
 Probe Info  		16.45  LDD2009  [11]
C349
 Probe Info  		23.92  LDD2010  [11]
C350
 Probe Info  		44.32  LDD2011  [11]
C351
 Probe Info  		5.62  LDD2012  [11]
C353
 Probe Info  		10.63  LDD2014  [11]
C354
 Probe Info  		21.71  LDD2015  [11]
C355
 Probe Info  		56.89  LDD2016  [11]
C356
 Probe Info  		16.56  LDD2017  [11]
C357
 Probe Info  		13.00  LDD2018  [11]
C360
 Probe Info  		15.78  LDD2021  [11]
C361
 Probe Info  		38.05  LDD2022  [11]
C362
 Probe Info  		27.67  LDD2023  [11]
C363
 Probe Info  		20.39  LDD2024  [11]
C367
 Probe Info  		5.28  LDD2028  [11]
C373
 Probe Info  		7.78  LDD2033  [11]
C374
 Probe Info  		5.06  LDD2034  [11]
C376
 Probe Info  		10.06  LDD2036  [11]
C378
 Probe Info  		7.16  LDD2037  [11]
C380
 Probe Info  		7.36  LDD2039  [11]
C383
 Probe Info  		12.21  LDD2042  [11]
C386
 Probe Info  		12.04  LDD2045  [11]
C387
 Probe Info  		4.96  LDD2046  [11]
C390
 Probe Info  		54.57  LDD2049  [11]
C391
 Probe Info  		23.10  LDD2050  [11]
C393
 Probe Info  		6.87  LDD2052  [11]
C396
 Probe Info  		6.87  LDD2055  [11]
C399
 Probe Info  		9.19  LDD2058  [11]
C400
 Probe Info  		5.54  LDD2059  [11]
C403
 Probe Info  		15.14  LDD2061  [11]
C405
 Probe Info  		7.78  LDD2063  [11]
C407
 Probe Info  		11.24  LDD2064  [11]
C408
 Probe Info  		7.41  LDD2065  [11]
C413
 Probe Info  		17.51  LDD2069  [11]
C425
 Probe Info  		7.11  LDD2080  [11]
C426
 Probe Info  		22.16  LDD2081  [11]
C428
 Probe Info  		6.59  LDD2083  [11]
C429
 Probe Info  		56.10  LDD2084  [11]
C430
 Probe Info  		6.54  LDD2085  [11]
C431
 Probe Info  		27.28  LDD2086  [11]
C432
 Probe Info  		5.39  LDD2087  [11]
C433
 Probe Info  		22.16  LDD2088  [11]
FFF probe11
 Probe Info  		17.73  LDD0471  [12]
FFF probe12
 Probe Info  		14.39  LDD0473  [12]
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe15
 Probe Info  		14.16  LDD0478  [12]
FFF probe2
 Probe Info  		14.04  LDD0463  [12]
FFF probe3
 Probe Info  		20.00  LDD0464  [12]
FFF probe4
 Probe Info  		12.52  LDD0466  [12]
FFF probe6
 Probe Info  		6.12  LDD0467  [12]
FFF probe7
 Probe Info  		20.00  LDD0483  [12]
FFF probe9
 Probe Info  		20.00  LDD0470  [12]
JN0003
 Probe Info  		20.00  LDD0469  [12]
STS-1
 Probe Info  		N.A.  LDD0137  [13]
STS-2
 Probe Info  		N.A.  LDD0138  [13]
A-DA
 Probe Info  		4.77  LDD0145  [14]
AEA-DA
 Probe Info  		3.54  LDD0334  [15]
OEA-DA
 Probe Info  		20.00  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0189  Compound 16 HEK-293T 5.51  LDD0492  [12]
 LDCM0185  Compound 17 HEK-293T 7.30  LDD0512  [12]
 LDCM0184  Compound 20 HEK-293T 14.60  LDD0503  [12]
 LDCM0191  Compound 21 HEK-293T 6.62  LDD0508  [12]
 LDCM0187  Compound 32 HEK-293T 19.61  LDD0507  [12]
 LDCM0190  Compound 34 HEK-293T 11.30  LDD0497  [12]
 LDCM0192  Compound 35 HEK-293T 4.40  LDD0491  [12]
 LDCM0193  Compound 36 HEK-293T 11.05  LDD0511  [12]
 LDCM0194  Compound 37 HEK-293T 5.85  LDD0498  [12]
 LDCM0195  Compound 38 HEK-293T 5.26  LDD0499  [12]
 LDCM0196  Compound 39 HEK-293T 8.85  LDD0496  [12]
 LDCM0197  Compound 40 HEK-293T 14.49  LDD0495  [12]
 LDCM0181  Compound 41 HEK-293T 5.31  LDD0502  [12]
 LDCM0183  Compound 42 HEK-293T 6.99  LDD0500  [12]
 LDCM0098  Propranolol K562 4.20  LDD0271  [8]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.22  LDD0123  [9]
 LDCM0084  Ro 48-8071 A-549 4.77  LDD0145  [14]
 LDCM0137  SR-4995 HEK-293T 3.54  LDD0334  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Amyloid-beta precursor protein (APP) APP family P05067
CD81 antigen (CD81) Tetraspanin (TM4SF) family P60033
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Jun (JUN) BZIP family P05412
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vitamin E Small molecular drug DB00163
Tocofersolan . DB11635
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphatidyl Serine Small molecular drug DB00144

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
9 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570