Details of the Probe

General Information of Probe

Probe ID
LDPC0535
Probe Name
C307
Synonyms
Z3426216171
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 331.33
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C15H20F3N3O2
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-1-[3-(trifluoromethoxymethyl)piperidin-1-yl]propan-1-one
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)N2CCCC(C2)COC(F)(F)F
InChI
InChI=1S/C15H20F3N3O2/c1-2-3-7-14(19-20-14)8-6-13(22)21-9-4-5-12(10-21)11-23-15(16,17)18/h1,12H,3-11H2
InChIKey
STBZBOJNWKBGIO-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

57 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 5.62  LDD1975 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 5.17  LDD1975 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 14.12  LDD1975 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 18.25  LDD1975 
Acid ceramidase (ASAH1) LDTP05905 8.51  LDD1975 
ADP-dependent glucokinase (ADPGK) LDTP11127 8.40  LDD1975 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 5.21  LDD1975 
Beta-galactosidase (GLB1) LDTP02837 6.82  LDD1975 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 6.54  LDD1975 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 5.17  LDD1975 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 5.86  LDD1975 
Cytochrome b5 type B (CYB5B) LDTP00697 9.71  LDD1975 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 14.52  LDD1975 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 8.51  LDD1975 
Delta(24)-sterol reductase (DHCR24) LDTP06375 9.92  LDD1975 
Dihydrofolate reductase (DHFR) LDTP01769 6.11  LDD1975 
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) LDTP11259 5.62  LDD1975 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 5.62  LDD1975 
Glutathione S-transferase A4 (GSTA4) LDTP00575 5.62  LDD1975 
Heme A synthase COX15 (COX15) LDTP07931 8.46  LDD1975 
Heme oxygenase 1 (HMOX1) LDTP02359 12.38  LDD1975 
Heme oxygenase 2 (HMOX2) LDTP03540 11.31  LDD1975 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 6.36  LDD1975 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 7.01  LDD1975 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 49.18  LDD1975 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 7.26  LDD1975 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.17  LDD1975 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 5.74  LDD1975 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 4.96  LDD1975 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 6.02  LDD1975 
NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) LDTP01219 5.13  LDD1975 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 8.11  LDD1975 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 8.17  LDD1975 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 6.45  LDD1975 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 10.56  LDD1975 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 5.43  LDD1975 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 5.70  LDD1975 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 16.68  LDD1975 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 9.99  LDD1975 
Phospholipase A2 group XV (PLA2G15) LDTP09088 5.98  LDD1975 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 7.73  LDD1975 
Probable methyltransferase TARBP1 (TARBP1) LDTP05850 6.15  LDD1975 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 6.77  LDD1975 
Prostaglandin reductase 3 (PTGR3) LDTP15422 8.51  LDD1975 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 7.52  LDD1975 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 6.36  LDD1975 
Protein O-GlcNAcase (OGA) LDTP00988 5.58  LDD1975 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 5.39  LDD1975 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 16.91  LDD1975 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 7.84  LDD1975 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 6.28  LDD1975 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 5.21  LDD1975 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 6.96  LDD1975 
Sulfotransferase 2A1 (SULT2A1) LDTP05493 19.43  LDD1975 
Thiol S-methyltransferase TMT1A (TMT1A) LDTP12056 15.24  LDD1975 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 5.31  LDD1975 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 5.50  LDD1975 
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⏷ Show the Full List of 57 Enzyme
48 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 8.63  LDD1975 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 8.82  LDD1975 
BRI3-binding protein (BRI3BP) LDTP15648 6.59  LDD1975 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 30.48  LDD1975 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 5.06  LDD1975 
Importin subunit alpha-1 (KPNA2) LDTP04501 5.78  LDD1975 
Lysosomal-associated transmembrane protein 4A (LAPTM4A) LDTP06275 9.65  LDD1975 
Lysosome membrane protein 2 (SCARB2) LDTP06034 12.64  LDD1975 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 5.86  LDD1975 
Major facilitator superfamily domain-containing protein 8 (MFSD8) LDTP09261 8.69  LDD1975 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 6.73  LDD1975 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 8.75  LDD1975 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 12.30  LDD1975 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 15.56  LDD1975 
Mpv17-like protein 2 (MPV17L2) LDTP14952 8.11  LDD1975 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 7.94  LDD1975 
Nucleoporin NDC1 (NDC1) LDTP11213 6.96  LDD1975 
Prosaposin (PSAP) LDTP02215 5.35  LDD1975 
Protein Mpv17 (MPV17) LDTP03869 5.54  LDD1975 
Protein tweety homolog 3 (TTYH3) LDTP11615 17.88  LDD1975 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 10.78  LDD1975 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 6.23  LDD1975 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 5.24  LDD1975 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 11.88  LDD1975 
Signal recognition particle subunit SRP68 (SRP68) LDTP13262 6.19  LDD1975 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 5.46  LDD1975 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 6.06  LDD1975 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 4.99  LDD1975 
Sorting nexin-5 (SNX5) LDTP14174 4.96  LDD1975 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 9.85  LDD1975 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 6.63  LDD1975 
Surfeit locus protein 4 (SURF4) LDTP00592 5.43  LDD1975 
Tetraspanin-10 (TSPAN10) LDTP15967 5.24  LDD1975 
Tetraspanin-3 (TSPAN3) LDTP16813 9.32  LDD1975 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 8.63  LDD1975 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 7.06  LDD1975 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 5.03  LDD1975 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 5.74  LDD1975 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 6.63  LDD1975 
Transmembrane protein 126A (TMEM126A) LDTP15948 8.11  LDD1975 
Transmembrane protein 160 (TMEM160) LDTP20002 6.54  LDD1975 
Transmembrane protein 199 (TMEM199) LDTP08881 7.16  LDD1975 
Transmembrane protein 87A (TMEM87A) LDTP15481 5.86  LDD1975 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 5.21  LDD1975 
Vang-like protein 1 (VANGL1) LDTP09288 5.46  LDD1975 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 24.42  LDD1975 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 14.52  LDD1975 
Zinc transporter 7 (SLC30A7) LDTP09180 8.11  LDD1975 
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⏷ Show the Full List of 48 Transporter and channel
26 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
60S ribosomal export protein NMD3 (NMD3) LDTP10200 13.45  LDD1975 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 9.38  LDD1975 
Apolipoprotein L2 (APOL2) LDTP11076 6.92  LDD1975 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 5.74  LDD1975 
CYFIP-related Rac1 interactor B (CYRIB) LDTP12642 16.56  LDD1975 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 7.26  LDD1975 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 73.01  LDD1975 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 17.15  LDD1975 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 5.66  LDD1975 
Large proline-rich protein BAG6 (BAG6) LDTP04094 7.84  LDD1975 
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) LDTP15240 5.82  LDD1975 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 23.26  LDD1975 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 6.87  LDD1975 
Negative elongation factor C/D (NELFCD) LDTP08594 6.45  LDD1975 
Nucleobindin-2 (NUCB2) LDTP05160 15.35  LDD1975 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 5.54  LDD1975 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 6.23  LDD1975 
Protein CEBPZOS (CEBPZOS) LDTP18883 16.91  LDD1975 
Protein FAM114A2 (FAM114A2) LDTP16080 6.06  LDD1975 
Protein FAM162A (FAM162A) LDTP10056 5.31  LDD1975 
Protein unc-119 homolog B (UNC119B) LDTP00105 13.74  LDD1975 
Reticulon-3 (RTN3) LDTP01522 6.28  LDD1975 
Reticulon-4 (RTN4) LDTP12412 5.17  LDD1975 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 6.63  LDD1975 
Syntaxin-18 (STX18) LDTP13086 5.24  LDD1975 
Tetraspanin-6 (TSPAN6) LDTP14458 12.38  LDD1975 
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⏷ Show the Full List of 26 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1975 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587