Details of the Target

General Information of Target

Target ID LDTP11127
Target Name ADP-dependent glucokinase (ADPGK)
Gene Name ADPGK
Gene ID 83440
Synonyms
ADP-dependent glucokinase; ADP-GK; ADPGK; EC 2.7.1.147; RbBP-35
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTSTSPAAMLLRRLRRLSWGSTAVQLFILTVVTFGLLAPLACHRLLHSYFYLRHWHLNQ
MSQEFLQQSLKEGEAALHYFEELPSANGSVPIVWQATPRPWLVITIITVDRQPGFHYVLQ
VVSQFHRLLQQCGPQCEGHQLFLCNVERSVSHFDAKLLSKYVPVANRYEGTEDDYGDDPS
TNSFEKEKQDYVYCLESSLQTYNPDYVLMVEDDAVPEEQIFPVLEHLLRARFSEPHLRDA
LYLKLYHPERLQHYINPEPMRILEWVGVGMLLGPLLTWIYMRFASRPGFSWPVMLFFSLY
SMGLVELVGRHYFLELRRLSPSLYSVVPASQCCTPAMLFPAPAARRTLTYLSQVYCHKGF
GKDMALYSLLRAKGERAYVVEPNLVKHIGLFSSLRYNFHPSLL
Target Bioclass
Enzyme
Family
ADP-dependent glucokinase family
Subcellular location
Secreted
Function Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
Uniprot ID
Q9BRR6
Ensemble ID
ENST00000311669.12
HGNC ID
HGNC:25250

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.A168V DBIA    Probe Info 
HCT15 SNV: p.M1? DBIA    Probe Info 
HUPT4 SNV: p.A60S DBIA    Probe Info 
LN18 SNV: p.F231C DBIA    Probe Info 
MCC13 SNV: p.S284F DBIA    Probe Info 
MCF7 SNV: p.E216K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.68  LDD0197  [1]
CHEMBL5175495
 Probe Info  		5.53  LDD0196  [2]
W1
 Probe Info  		16.96  LDD0235  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C178(1.16)  LDD2099  [5]
AHL-Pu-1
 Probe Info  		C40(3.79)  LDD0171  [6]
Alkyne-RA190
 Probe Info  		5.02  LDD0299  [7]
EA-probe
 Probe Info  		C40(0.74)  LDD2210  [8]
DBIA
 Probe Info  		C40(1.08); C415(1.26)  LDD0531  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
m-APA
 Probe Info  		N.A.  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C415(0.00); C40(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
PF-06672131
 Probe Info  		N.A.  LDD0017  [15]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C415(0.00); C178(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C415(0.00); C178(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C470(0.00); C415(0.00); C178(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 131 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		27.47  LDD1725  [20]
C022
 Probe Info  		11.55  LDD1728  [20]
C027
 Probe Info  		11.79  LDD1733  [20]
C040
 Probe Info  		19.56  LDD1740  [20]
C041
 Probe Info  		6.54  LDD1741  [20]
C049
 Probe Info  		7.16  LDD1747  [20]
C053
 Probe Info  		5.86  LDD1751  [20]
C055
 Probe Info  		54.57  LDD1752  [20]
C056
 Probe Info  		67.65  LDD1753  [20]
C063
 Probe Info  		19.29  LDD1760  [20]
C067
 Probe Info  		5.17  LDD1763  [20]
C070
 Probe Info  		19.16  LDD1766  [20]
C072
 Probe Info  		13.09  LDD1768  [20]
C082
 Probe Info  		5.62  LDD1774  [20]
C091
 Probe Info  		48.50  LDD1782  [20]
C092
 Probe Info  		83.29  LDD1783  [20]
C094
 Probe Info  		99.73  LDD1785  [20]
C095
 Probe Info  		7.01  LDD1786  [20]
C100
 Probe Info  		5.46  LDD1789  [20]
C106
 Probe Info  		34.30  LDD1793  [20]
C107
 Probe Info  		8.00  LDD1794  [20]
C108
 Probe Info  		10.27  LDD1795  [20]
C112
 Probe Info  		46.53  LDD1799  [20]
C130
 Probe Info  		8.11  LDD1812  [20]
C134
 Probe Info  		50.21  LDD1816  [20]
C135
 Probe Info  		17.39  LDD1817  [20]
C139
 Probe Info  		14.32  LDD1821  [20]
C140
 Probe Info  		8.28  LDD1822  [20]
C141
 Probe Info  		13.36  LDD1823  [20]
C143
 Probe Info  		25.99  LDD1825  [20]
C153
 Probe Info  		21.11  LDD1834  [20]
C158
 Probe Info  		12.91  LDD1838  [20]
C159
 Probe Info  		17.15  LDD1839  [20]
C160
 Probe Info  		18.51  LDD1840  [20]
C161
 Probe Info  		23.26  LDD1841  [20]
C163
 Probe Info  		8.88  LDD1843  [20]
C165
 Probe Info  		16.68  LDD1845  [20]
C166
 Probe Info  		9.85  LDD1846  [20]
C169
 Probe Info  		51.27  LDD1849  [20]
C177
 Probe Info  		12.47  LDD1856  [20]
C178
 Probe Info  		36.76  LDD1857  [20]
C186
 Probe Info  		8.82  LDD1864  [20]
C187
 Probe Info  		24.93  LDD1865  [20]
C194
 Probe Info  		12.91  LDD1870  [20]
C196
 Probe Info  		19.56  LDD1872  [20]
C198
 Probe Info  		14.72  LDD1874  [20]
C201
 Probe Info  		44.32  LDD1877  [20]
C206
 Probe Info  		19.03  LDD1881  [20]
C210
 Probe Info  		77.71  LDD1884  [20]
C213
 Probe Info  		14.62  LDD1887  [20]
C214
 Probe Info  		5.50  LDD1888  [20]
C218
 Probe Info  		31.78  LDD1892  [20]
C219
 Probe Info  		9.13  LDD1893  [20]
C220
 Probe Info  		32.22  LDD1894  [20]
C225
 Probe Info  		5.58  LDD1898  [20]
C226
 Probe Info  		5.86  LDD1899  [20]
C228
 Probe Info  		29.24  LDD1901  [20]
C231
 Probe Info  		15.03  LDD1904  [20]
C238
 Probe Info  		24.59  LDD1911  [20]
C243
 Probe Info  		11.16  LDD1916  [20]
C246
 Probe Info  		16.22  LDD1919  [20]
C251
 Probe Info  		53.08  LDD1924  [20]
C252
 Probe Info  		29.45  LDD1925  [20]
C264
 Probe Info  		28.05  LDD1935  [20]
C265
 Probe Info  		16.56  LDD1936  [20]
C270
 Probe Info  		6.92  LDD1940  [20]
C273
 Probe Info  		6.92  LDD1943  [20]
C277
 Probe Info  		10.63  LDD1947  [20]
C278
 Probe Info  		88.65  LDD1948  [20]
C282
 Probe Info  		26.54  LDD1952  [20]
C284
 Probe Info  		21.86  LDD1954  [20]
C285
 Probe Info  		60.13  LDD1955  [20]
C287
 Probe Info  		19.56  LDD1957  [20]
C288
 Probe Info  		8.75  LDD1958  [20]
C289
 Probe Info  		79.34  LDD1959  [20]
C290
 Probe Info  		5.98  LDD1960  [20]
C293
 Probe Info  		52.71  LDD1963  [20]
C296
 Probe Info  		25.99  LDD1966  [20]
C299
 Probe Info  		17.15  LDD1968  [20]
C301
 Probe Info  		5.74  LDD1970  [20]
C304
 Probe Info  		5.50  LDD1973  [20]
C305
 Probe Info  		18.25  LDD1974  [20]
C307
 Probe Info  		8.40  LDD1975  [20]
C310
 Probe Info  		31.56  LDD1977  [20]
C313
 Probe Info  		13.64  LDD1980  [20]
C314
 Probe Info  		25.46  LDD1981  [20]
C317
 Probe Info  		6.73  LDD1983  [20]
C320
 Probe Info  		5.35  LDD1986  [20]
C322
 Probe Info  		16.34  LDD1988  [20]
C326
 Probe Info  		15.78  LDD1990  [20]
C338
 Probe Info  		13.64  LDD2001  [20]
C339
 Probe Info  		8.00  LDD2002  [20]
C343
 Probe Info  		32.90  LDD2005  [20]
C355
 Probe Info  		28.64  LDD2016  [20]
C356
 Probe Info  		10.85  LDD2017  [20]
C357
 Probe Info  		5.82  LDD2018  [20]
C362
 Probe Info  		99.73  LDD2023  [20]
C363
 Probe Info  		22.63  LDD2024  [20]
C364
 Probe Info  		26.35  LDD2025  [20]
C366
 Probe Info  		18.13  LDD2027  [20]
C367
 Probe Info  		7.62  LDD2028  [20]
C373
 Probe Info  		12.82  LDD2033  [20]
C376
 Probe Info  		11.00  LDD2036  [20]
C378
 Probe Info  		6.50  LDD2037  [20]
C380
 Probe Info  		5.70  LDD2039  [20]
C382
 Probe Info  		22.94  LDD2041  [20]
C383
 Probe Info  		15.56  LDD2042  [20]
C386
 Probe Info  		7.06  LDD2045  [20]
C388
 Probe Info  		99.73  LDD2047  [20]
C390
 Probe Info  		55.33  LDD2049  [20]
C399
 Probe Info  		11.96  LDD2058  [20]
C403
 Probe Info  		36.25  LDD2061  [20]
C407
 Probe Info  		24.25  LDD2064  [20]
C413
 Probe Info  		14.72  LDD2069  [20]
C424
 Probe Info  		14.32  LDD2079  [20]
C426
 Probe Info  		28.64  LDD2081  [20]
C429
 Probe Info  		25.28  LDD2084  [20]
C431
 Probe Info  		27.47  LDD2086  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
FFF probe3
 Probe Info  		20.00  LDD0464  [21]
JN0003
 Probe Info  		20.00  LDD0469  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
A-DA
 Probe Info  		2.09  LDD0145  [23]
BD-F
 Probe Info  		C40(0.00); W36(0.00)  LDD0024  [24]
LD-F
 Probe Info  		S38(0.00); W36(0.00)  LDD0015  [24]
DA-2
 Probe Info  		N.A.  LDD0070  [25]
OEA-DA
 Probe Info  		12.81  LDD0046  [26]
STS-1
 Probe Info  		N.A.  LDD0068  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C178(1.12)  LDD2117  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C40(3.79)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C40(1.08); C415(1.26)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C40(0.95); C415(1.19)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C40(0.81)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C40(1.00)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C40(1.13)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C40(0.92)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C40(1.05)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C40(1.00)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C40(1.03)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C40(1.05)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C40(0.90)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C40(1.20)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C40(0.92); C415(1.37)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C40(0.93)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C40(1.10)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C40(1.17)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C40(1.09)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C40(1.07)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C40(0.83)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C40(0.76)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C40(0.77)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C40(0.96)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C40(0.79)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C40(0.81); C415(1.28)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C40(0.84)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C40(0.81)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C40(0.78)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C40(0.80)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C40(0.90)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C40(0.77)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C40(0.86)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C40(0.79)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C40(1.16)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C40(1.11)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C40(0.92)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C40(1.06)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C40(0.89)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C40(1.08)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C40(1.23)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C40(1.10)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C40(0.87)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C40(1.16)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C40(1.13)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C40(1.14)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C40(0.98); C415(1.09)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C40(1.05)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C40(1.07)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C40(0.81)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C40(0.90)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C40(0.97)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C40(1.11)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C40(1.25)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C40(0.98)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C40(2.15)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C40(1.31)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C40(0.97); C415(1.04)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C40(1.18)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C40(1.18)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C40(1.28)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C40(1.55)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C40(1.19)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C40(1.11)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C40(0.97)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C40(1.03)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C40(0.96)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C40(1.15)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C40(1.09)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C40(0.98); C415(1.13)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C40(1.03)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C40(1.18)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C40(1.11)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C40(1.32)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C40(1.27)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C40(0.91)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C40(1.02)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C40(1.04)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C40(1.13)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C40(1.21)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C40(0.95); C415(1.16)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C40(1.29)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C40(1.07)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C40(1.19)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C40(0.96)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C40(1.08)  LDD0612  [9]
 LDCM0296  AC35 PaTu 8988t C40(1.22)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C40(1.09)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C40(1.06)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C40(1.14)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C40(1.27)  LDD1179  [9]
 LDCM0301  AC4 HCT 116 C40(0.96); C415(1.16)  LDD0618  [9]
 LDCM0302  AC40 PaTu 8988t C40(1.05)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C40(1.17)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C40(0.96)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C40(1.06)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C40(1.74)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C40(1.37)  LDD1186  [9]
 LDCM0308  AC46 HCT 116 C415(0.75); C40(0.97)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C415(0.66); C40(0.96)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C415(0.68); C40(1.15)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C415(0.61); C40(1.18)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C40(0.97); C415(1.37)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C415(0.88); C40(1.42)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C415(0.80); C40(0.89)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C40(1.06); C415(1.07)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C415(0.72); C40(1.05)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C415(0.82); C40(1.07)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C415(0.74); C40(0.95)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C415(0.45); C40(1.16)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C40(1.20); C415(1.35)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C40(1.15); C415(1.19)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C415(1.20); C40(1.39)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C415(0.92); C40(1.02)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C415(1.31); C40(1.33)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C40(1.21); C415(1.30)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C40(1.20); C415(1.23)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C40(1.23); C415(1.33)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C415(1.52); C40(1.54)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C415(1.23); C40(1.58)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C415(0.96); C40(1.51)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C415(1.02); C40(1.58)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C40(0.99); C415(1.41)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C40(0.84); C415(0.84)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C40(0.85); C415(1.12)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C415(0.77); C40(0.79)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C40(0.85); C415(1.45)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C40(0.94); C415(1.19)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C415(0.80); C40(1.00)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C415(0.63); C40(0.83)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C415(0.46); C40(0.85)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C40(0.85); C415(0.87)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C40(0.80); C415(1.16)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C40(0.67); C415(0.93)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C40(0.85); C415(1.23)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C415(0.99); C40(0.99)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C40(0.70); C415(1.06)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C40(0.70); C415(1.24)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C415(0.24); C40(0.84)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C40(1.24)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C40(1.51)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C40(1.16)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C40(1.15)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C40(1.05)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C40(1.27)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C40(1.19)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C40(1.10)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C40(1.39)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C40(1.33)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C40(1.41)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C40(1.08)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C40(1.02)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C40(1.20)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C40(1.54)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C40(1.17)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C40(0.92)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C40(1.00); C415(1.26)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C40(0.93); C415(1.09)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C415(0.90); C40(1.14)  LDD0592  [9]
 LDCM0199  BPK-21 T cell C40(9.67)  LDD0517  [28]
 LDCM0200  BPK-25 T cell C40(4.02)  LDD0516  [28]
 LDCM0108  Chloroacetamide HeLa C415(0.00); C178(0.00); H121(0.00); H494(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C40(0.61)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C40(1.12)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C40(1.32)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C40(0.88); C415(1.26)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C40(1.01); C415(1.10)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C40(0.98); C415(1.22)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C40(0.84); C415(1.23)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C40(0.83); C415(1.18)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C40(1.09)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C40(1.07)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C40(1.03)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C40(1.02)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C40(1.15)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C40(1.06)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C40(1.03)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C40(1.17)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C40(1.04)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C40(1.19)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C40(1.27)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C40(1.27)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C40(1.07)  LDD0703  [9]
 LDCM0387  CL117 PaTu 8988t C40(1.00)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C40(1.17)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C40(0.89)  LDD1268  [9]
 LDCM0390  CL12 HCT 116 C40(1.12)  LDD0707  [9]
 LDCM0391  CL120 PaTu 8988t C40(1.13)  LDD1270  [9]
 LDCM0392  CL121 HCT 116 C415(0.65); C40(1.17)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C415(0.73); C40(1.11)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C415(0.85); C40(1.69)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C415(0.79); C40(1.15)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C40(1.15); C415(1.30)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C415(0.93); C40(1.30)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C40(1.10); C415(1.20)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C415(1.34); C40(1.45)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C40(1.01)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C40(0.94)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C40(1.23)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C40(0.95)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C40(1.21)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C40(1.05)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C40(1.20)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C40(0.83)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C40(1.18)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C40(1.47)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C40(1.67)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C40(0.98)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C40(1.27)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C40(1.91)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C40(1.21)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C40(1.10)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C40(1.58)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C40(1.26)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C40(0.92)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C40(0.97)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C40(1.09)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C40(1.18)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C40(3.15)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C40(1.46)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C40(1.27)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C40(1.26)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C40(1.26)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C40(1.29)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C40(1.25)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C40(1.29)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C40(1.08)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C40(1.52)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C40(1.36)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C40(1.45)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C40(1.30)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C40(0.76)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C40(0.89)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C40(0.85)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C40(0.79)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C40(1.04)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C40(0.93)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C40(1.00)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C40(0.81)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C40(0.71)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C40(1.38)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C40(0.72)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C40(1.11)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C40(1.08)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C40(0.96)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C40(0.96)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C40(1.13)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C40(0.76)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C40(0.81)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C40(0.94)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C40(0.93)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C40(1.02)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C40(1.01)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C40(0.86)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C40(0.78)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C40(1.20)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C40(0.93)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C40(1.04)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C40(1.01)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C40(0.80)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C40(1.05)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C40(1.02)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C40(0.92)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C40(0.98)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C40(1.19)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C40(1.12)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C40(1.32)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C40(2.07)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C40(1.24)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C40(1.07)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C40(1.30)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C40(1.48)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C40(1.32)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C40(1.03)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C40(1.04)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C40(1.45)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C40(1.22)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C40(1.32)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C40(1.11)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C40(1.70)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C40(0.96); C415(0.82)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C40(0.97); C415(0.88)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C40(0.96); C415(1.10)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C40(1.02); C415(0.93)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C40(0.94); C415(1.08)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C40(1.06); C415(0.97)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C40(1.14); C415(0.96)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C40(1.02); C415(1.23)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C40(0.92); C415(1.11)  LDD0811  [9]
 LDCM0185  Compound 17 HEK-293T 9.13  LDD0512  [21]
 LDCM0191  Compound 21 HEK-293T 7.12  LDD0508  [21]
 LDCM0190  Compound 34 HEK-293T 10.93  LDD0510  [21]
 LDCM0192  Compound 35 HEK-293T 8.47  LDD0509  [21]
 LDCM0193  Compound 36 HEK-293T 6.31  LDD0511  [21]
 LDCM0495  E2913 HEK-293T C40(0.90); C178(0.95)  LDD1698  [29]
 LDCM0175  Ethacrynic acid HeLa C40(0.74)  LDD2210  [8]
 LDCM0202  EV-93 T cell C40(4.83)  LDD0514  [28]
 LDCM0625  F8 Ramos C178(0.63); C40(0.65)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C178(0.63); C40(1.57)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C178(20.00); C40(0.12)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C178(0.59); C40(2.53)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C178(1.03); C40(0.90)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C178(0.93); C40(3.38)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C178(0.53); C40(1.79)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C178(0.84); C40(0.93)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C178(1.43); C40(2.00)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C178(0.89); C40(1.16)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C178(0.80); C40(0.93)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C178(1.06); C40(1.44)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C178(1.22); C40(1.42)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C178(0.53); C40(2.21)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C40(0.92)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C178(0.98); C40(3.90)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C178(0.73); C40(0.83)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C40(1.40)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C178(1.98); C40(1.50)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C178(1.48); C40(1.11)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C178(0.57); C40(0.70)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C178(0.60); C40(1.80)  LDD2188  [30]
 LDCM0107  IAA HeLa C178(0.00); H121(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C40(1.03)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C40(1.04)  LDD1497  [29]
 LDCM0024  KB05 COLO792 C40(2.23); C415(1.32); C56(2.58)  LDD3310  [31]
 LDCM0109  NEM HeLa H494(0.00); C178(0.00)  LDD0223  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C178(1.16)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C178(1.44)  LDD2107  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C178(1.01)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C178(1.02)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C178(0.94)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C178(0.71)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C178(1.11)  LDD2127  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C178(0.35)  LDD2134  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C178(1.12)  LDD2137  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C178(0.37)  LDD2148  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C40(0.77)  LDD2207  [32]
 LDCM0131  RA190 MM1.R 5.02  LDD0299  [7]
 LDCM0084  Ro 48-8071 A-549 2.09  LDD0145  [23]

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
24 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
25 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
28 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.