Details of the Probe

General Information of Probe

Probe ID
LDPC0503
Probe Name
C273
Synonyms
Z4225968259
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 341.29
Lipid-water partition coefficient (xlogp) 1.8
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C14H14F3N5O2
IUPAC Name
(1S,2R)-N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2-[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2CC2C3=NC(=NO3)C(F)(F)F
InChI
InChI=1S/C14H14F3N5O2/c1-2-3-4-13(21-22-13)5-6-18-10(23)8-7-9(8)11-19-12(20-24-11)14(15,16)17/h1,8-9H,3-7H2,(H,18,23)/t8-,9+/m0/s1
InChIKey
GQMRBMUMVMUCMV-DTWKUNHWSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

60 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 8.88  LDD1943 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 6.28  LDD1943 
Acid ceramidase (ASAH1) LDTP05905 6.15  LDD1943 
ADP-dependent glucokinase (ADPGK) LDTP11127 6.92  LDD1943 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 15.14  LDD1943 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 7.21  LDD1943 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 5.31  LDD1943 
Beta-galactosidase (GLB1) LDTP02837 6.77  LDD1943 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 5.39  LDD1943 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 10.85  LDD1943 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 7.46  LDD1943 
Cartilage-associated protein (CRTAP) LDTP01300 14.12  LDD1943 
Ceramide glucosyltransferase (UGCG) LDTP06617 6.73  LDD1943 
Ceramide synthase 2 (CERS2) LDTP10329 7.89  LDD1943 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 14.32  LDD1943 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 11.31  LDD1943 
Cytochrome b5 type B (CYB5B) LDTP00697 12.55  LDD1943 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 5.74  LDD1943 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 6.28  LDD1943 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 5.13  LDD1943 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 6.32  LDD1943 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 5.39  LDD1943 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 8.69  LDD1943 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 5.82  LDD1943 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 6.50  LDD1943 
Epoxide hydrolase 1 (EPHX1) LDTP02175 5.74  LDD1943 
Ferrochelatase, mitochondrial (FECH) LDTP03198 5.31  LDD1943 
Fumarylacetoacetase (FAH) LDTP02868 4.92  LDD1943 
Heme oxygenase 1 (HMOX1) LDTP02359 12.73  LDD1943 
Heme oxygenase 2 (HMOX2) LDTP03540 8.63  LDD1943 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 7.26  LDD1943 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 7.67  LDD1943 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 9.00  LDD1943 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 5.06  LDD1943 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 10.27  LDD1943 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 7.52  LDD1943 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 6.06  LDD1943 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 6.54  LDD1943 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 11.08  LDD1943 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 9.25  LDD1943 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 5.50  LDD1943 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 5.74  LDD1943 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 11.16  LDD1943 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 20.68  LDD1943 
NADPH--cytochrome P450 reductase (POR) LDTP02848 4.99  LDD1943 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 12.82  LDD1943 
Phospholipase A2 group XV (PLA2G15) LDTP09088 6.06  LDD1943 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 7.16  LDD1943 
Prostaglandin reductase 1 (PTGR1) LDTP06227 5.98  LDD1943 
Prostaglandin reductase 3 (PTGR3) LDTP15422 4.99  LDD1943 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 10.85  LDD1943 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 7.73  LDD1943 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 5.31  LDD1943 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 5.17  LDD1943 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 10.34  LDD1943 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 11.55  LDD1943 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 5.06  LDD1943 
TLC domain-containing protein 1 (TLCD1) LDTP10182 13.18  LDD1943 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 8.88  LDD1943 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 8.57  LDD1943 
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⏷ Show the Full List of 60 Enzyme
48 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 17.39  LDD1943 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 6.54  LDD1943 
BRI3-binding protein (BRI3BP) LDTP15648 7.26  LDD1943 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 17.39  LDD1943 
Derlin-1 (DERL1) LDTP11245 5.74  LDD1943 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 34.78  LDD1943 
Importin subunit alpha-1 (KPNA2) LDTP04501 5.46  LDD1943 
Lysosome membrane protein 2 (SCARB2) LDTP06034 6.87  LDD1943 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 12.47  LDD1943 
Major facilitator superfamily domain-containing protein 8 (MFSD8) LDTP09261 5.21  LDD1943 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 9.51  LDD1943 
Metaxin-1 (MTX1) LDTP05900 9.45  LDD1943 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 5.43  LDD1943 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 7.94  LDD1943 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 4.92  LDD1943 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 18.38  LDD1943 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 15.45  LDD1943 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 6.23  LDD1943 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 5.03  LDD1943 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 8.94  LDD1943 
Nucleoporin NDC1 (NDC1) LDTP11213 8.63  LDD1943 
Nucleoporin Nup37 (NUP37) LDTP09203 5.17  LDD1943 
PRA1 family protein 2 (PRAF2) LDTP01060 5.78  LDD1943 
Protein GPR107 (GPR107) LDTP07236 9.58  LDD1943 
Protein GPR108 (GPR108) LDTP12383 10.85  LDD1943 
Protein tweety homolog 3 (TTYH3) LDTP11615 8.34  LDD1943 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 6.32  LDD1943 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 7.73  LDD1943 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 5.13  LDD1943 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 10.78  LDD1943 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 12.64  LDD1943 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 9.00  LDD1943 
Solute carrier family 25 member 44 (SLC25A44) LDTP15733 5.58  LDD1943 
Solute carrier family 35 member F1 (SLC35F1) LDTP15000 5.74  LDD1943 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.98  LDD1943 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 7.01  LDD1943 
Tetraspanin-3 (TSPAN3) LDTP16813 13.83  LDD1943 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 10.06  LDD1943 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 11.08  LDD1943 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 6.63  LDD1943 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 6.68  LDD1943 
Transmembrane protein 126A (TMEM126A) LDTP15948 15.67  LDD1943 
Transmembrane protein 160 (TMEM160) LDTP20002 18.13  LDD1943 
Transmembrane protein 199 (TMEM199) LDTP08881 12.91  LDD1943 
Transmembrane protein 205 (TMEM205) LDTP07667 5.17  LDD1943 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 9.71  LDD1943 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 14.03  LDD1943 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 15.89  LDD1943 
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⏷ Show the Full List of 48 Transporter and channel
25 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 12.13  LDD1943 
Apolipoprotein L2 (APOL2) LDTP11076 11.31  LDD1943 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 5.54  LDD1943 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 19.29  LDD1943 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 7.57  LDD1943 
Large proline-rich protein BAG6 (BAG6) LDTP04094 6.87  LDD1943 
Membralin (TMEM259) LDTP14939 8.11  LDD1943 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 23.26  LDD1943 
Nucleobindin-2 (NUCB2) LDTP05160 8.11  LDD1943 
Plexin-B2 (PLXNB2) LDTP00513 5.17  LDD1943 
Protein CEBPZOS (CEBPZOS) LDTP18883 13.09  LDD1943 
Protein FAM114A2 (FAM114A2) LDTP16080 6.15  LDD1943 
Protein FAM162A (FAM162A) LDTP10056 6.36  LDD1943 
Protein LYRIC (MTDH) LDTP08224 5.06  LDD1943 
Protein unc-119 homolog A (UNC119) LDTP05868 10.27  LDD1943 
Protein unc-119 homolog B (UNC119B) LDTP00105 18.13  LDD1943 
Reticulon-3 (RTN3) LDTP01522 13.27  LDD1943 
Reticulon-4 (RTN4) LDTP12412 8.06  LDD1943 
SAC3 domain-containing protein 1 (SAC3D1) LDTP14373 12.38  LDD1943 
SEC14-like protein 2 (SEC14L2) LDTP01387 6.36  LDD1943 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 5.31  LDD1943 
Syntaxin-18 (STX18) LDTP13086 5.94  LDD1943 
Tetraspanin-6 (TSPAN6) LDTP14458 14.03  LDD1943 
TraB domain-containing protein (TRABD) LDTP19963 5.17  LDD1943 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 6.63  LDD1943 
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⏷ Show the Full List of 25 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1943 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587