Details of the Target

General Information of Target

Target ID LDTP14511
Target Name ATP synthase subunit g, mitochondrial (ATP5MG)
Gene Name ATP5MG
Gene ID 10632
Synonyms
ATP5L; ATP synthase subunit g, mitochondrial; ATPase subunit g; ATP synthase membrane subunit g
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKK
RGLYDQYGEEGLKTGGGTSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRP
FSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLE
EIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPA
DIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGT
VKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS
Target Bioclass
Transporter and channel
Family
ATPase g subunit family
Subcellular location
Mitochondrion
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Uniprot ID
O75964
Ensemble ID
ENST00000300688.8
HGNC ID
HGNC:14247

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y22(16.42)  LDD0260  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
1d-yne
 Probe Info  		N.A.  LDD0356  [3]
NHS
 Probe Info  		K11(0.00); K55(0.00); K24(0.00); K66(0.00)  LDD0010  [4]
SF
 Probe Info  		Y22(0.00); Y32(0.00)  LDD0028  [5]
STPyne
 Probe Info  		K66(0.00); K24(0.00)  LDD0009  [4]
1c-yne
 Probe Info  		K66(0.00); K11(0.00)  LDD0228  [3]
PAL-AfBPP Probe
Click To Hide/Show 167 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.28  LDD1711  [6]
C002
 Probe Info  		5.86  LDD1712  [6]
C003
 Probe Info  		28.44  LDD1713  [6]
C004
 Probe Info  		12.55  LDD1714  [6]
C007
 Probe Info  		8.51  LDD1716  [6]
C010
 Probe Info  		10.78  LDD1719  [6]
C011
 Probe Info  		7.89  LDD1720  [6]
C017
 Probe Info  		7.41  LDD1725  [6]
C018
 Probe Info  		5.24  LDD1726  [6]
C022
 Probe Info  		24.25  LDD1728  [6]
C026
 Probe Info  		12.55  LDD1732  [6]
C027
 Probe Info  		5.31  LDD1733  [6]
C039
 Probe Info  		10.93  LDD1739  [6]
C040
 Probe Info  		38.59  LDD1740  [6]
C041
 Probe Info  		24.93  LDD1741  [6]
C044
 Probe Info  		5.66  LDD1743  [6]
C049
 Probe Info  		13.93  LDD1747  [6]
C052
 Probe Info  		5.90  LDD1750  [6]
C055
 Probe Info  		78.25  LDD1752  [6]
C056
 Probe Info  		74.03  LDD1753  [6]
C059
 Probe Info  		5.31  LDD1756  [6]
C063
 Probe Info  		34.78  LDD1760  [6]
C064
 Probe Info  		9.65  LDD1761  [6]
C067
 Probe Info  		8.11  LDD1763  [6]
C070
 Probe Info  		30.06  LDD1766  [6]
C071
 Probe Info  		10.93  LDD1767  [6]
C072
 Probe Info  		21.41  LDD1768  [6]
C082
 Probe Info  		14.62  LDD1774  [6]
C085
 Probe Info  		11.47  LDD1777  [6]
C087
 Probe Info  		14.12  LDD1779  [6]
C091
 Probe Info  		45.57  LDD1782  [6]
C092
 Probe Info  		44.32  LDD1783  [6]
C094
 Probe Info  		88.03  LDD1785  [6]
C095
 Probe Info  		11.08  LDD1786  [6]
C106
 Probe Info  		56.49  LDD1793  [6]
C107
 Probe Info  		22.16  LDD1794  [6]
C108
 Probe Info  		33.82  LDD1795  [6]
C112
 Probe Info  		67.65  LDD1799  [6]
C129
 Probe Info  		11.00  LDD1811  [6]
C130
 Probe Info  		16.80  LDD1812  [6]
C134
 Probe Info  		53.45  LDD1816  [6]
C135
 Probe Info  		30.06  LDD1817  [6]
C139
 Probe Info  		37.01  LDD1821  [6]
C140
 Probe Info  		20.68  LDD1822  [6]
C141
 Probe Info  		30.27  LDD1823  [6]
C143
 Probe Info  		58.89  LDD1825  [6]
C145
 Probe Info  		8.17  LDD1827  [6]
C147
 Probe Info  		7.21  LDD1829  [6]
C153
 Probe Info  		48.50  LDD1834  [6]
C158
 Probe Info  		11.63  LDD1838  [6]
C159
 Probe Info  		25.99  LDD1839  [6]
C160
 Probe Info  		22.63  LDD1840  [6]
C161
 Probe Info  		39.40  LDD1841  [6]
C163
 Probe Info  		15.67  LDD1843  [6]
C165
 Probe Info  		28.05  LDD1845  [6]
C166
 Probe Info  		9.65  LDD1846  [6]
C169
 Probe Info  		45.25  LDD1849  [6]
C177
 Probe Info  		12.64  LDD1856  [6]
C178
 Probe Info  		82.71  LDD1857  [6]
C186
 Probe Info  		10.06  LDD1864  [6]
C187
 Probe Info  		41.36  LDD1865  [6]
C191
 Probe Info  		17.75  LDD1868  [6]
C193
 Probe Info  		7.52  LDD1869  [6]
C194
 Probe Info  		23.75  LDD1870  [6]
C196
 Probe Info  		31.78  LDD1872  [6]
C197
 Probe Info  		9.06  LDD1873  [6]
C198
 Probe Info  		19.70  LDD1874  [6]
C201
 Probe Info  		62.25  LDD1877  [6]
C206
 Probe Info  		45.25  LDD1881  [6]
C210
 Probe Info  		49.87  LDD1884  [6]
C211
 Probe Info  		36.00  LDD1885  [6]
C213
 Probe Info  		23.92  LDD1887  [6]
C218
 Probe Info  		30.91  LDD1892  [6]
C219
 Probe Info  		18.13  LDD1893  [6]
C220
 Probe Info  		55.72  LDD1894  [6]
C225
 Probe Info  		9.85  LDD1898  [6]
C226
 Probe Info  		8.28  LDD1899  [6]
C228
 Probe Info  		37.01  LDD1901  [6]
C229
 Probe Info  		14.93  LDD1902  [6]
C231
 Probe Info  		43.41  LDD1904  [6]
C232
 Probe Info  		72.50  LDD1905  [6]
C233
 Probe Info  		45.57  LDD1906  [6]
C234
 Probe Info  		9.71  LDD1907  [6]
C235
 Probe Info  		77.17  LDD1908  [6]
C238
 Probe Info  		32.00  LDD1911  [6]
C240
 Probe Info  		23.43  LDD1913  [6]
C243
 Probe Info  		35.26  LDD1916  [6]
C244
 Probe Info  		38.85  LDD1917  [6]
C245
 Probe Info  		12.38  LDD1918  [6]
C246
 Probe Info  		41.93  LDD1919  [6]
C249
 Probe Info  		28.64  LDD1922  [6]
C252
 Probe Info  		19.70  LDD1925  [6]
C264
 Probe Info  		46.21  LDD1935  [6]
C265
 Probe Info  		24.59  LDD1936  [6]
C269
 Probe Info  		6.28  LDD1939  [6]
C270
 Probe Info  		14.12  LDD1940  [6]
C273
 Probe Info  		6.54  LDD1943  [6]
C277
 Probe Info  		25.46  LDD1947  [6]
C278
 Probe Info  		99.73  LDD1948  [6]
C280
 Probe Info  		14.83  LDD1950  [6]
C282
 Probe Info  		46.85  LDD1952  [6]
C284
 Probe Info  		38.32  LDD1954  [6]
C285
 Probe Info  		71.51  LDD1955  [6]
C286
 Probe Info  		8.94  LDD1956  [6]
C287
 Probe Info  		42.81  LDD1957  [6]
C288
 Probe Info  		16.80  LDD1958  [6]
C289
 Probe Info  		85.04  LDD1959  [6]
C290
 Probe Info  		12.13  LDD1960  [6]
C293
 Probe Info  		37.53  LDD1963  [6]
C296
 Probe Info  		24.25  LDD1966  [6]
C299
 Probe Info  		16.11  LDD1968  [6]
C304
 Probe Info  		6.11  LDD1973  [6]
C305
 Probe Info  		22.94  LDD1974  [6]
C307
 Probe Info  		8.82  LDD1975  [6]
C310
 Probe Info  		10.85  LDD1977  [6]
C313
 Probe Info  		22.16  LDD1980  [6]
C314
 Probe Info  		43.41  LDD1981  [6]
C317
 Probe Info  		9.92  LDD1983  [6]
C322
 Probe Info  		6.92  LDD1988  [6]
C326
 Probe Info  		9.25  LDD1990  [6]
C333
 Probe Info  		5.35  LDD1996  [6]
C338
 Probe Info  		19.70  LDD2001  [6]
C339
 Probe Info  		15.67  LDD2002  [6]
C343
 Probe Info  		29.04  LDD2005  [6]
C346
 Probe Info  		12.82  LDD2007  [6]
C348
 Probe Info  		12.64  LDD2009  [6]
C349
 Probe Info  		25.46  LDD2010  [6]
C350
 Probe Info  		56.89  LDD2011  [6]
C355
 Probe Info  		81.01  LDD2016  [6]
C356
 Probe Info  		27.10  LDD2017  [6]
C357
 Probe Info  		15.89  LDD2018  [6]
C362
 Probe Info  		99.73  LDD2023  [6]
C363
 Probe Info  		39.67  LDD2024  [6]
C364
 Probe Info  		40.50  LDD2025  [6]
C366
 Probe Info  		18.77  LDD2027  [6]
C367
 Probe Info  		9.51  LDD2028  [6]
C373
 Probe Info  		10.63  LDD2033  [6]
C376
 Probe Info  		14.03  LDD2036  [6]
C378
 Probe Info  		6.19  LDD2037  [6]
C380
 Probe Info  		7.46  LDD2039  [6]
C382
 Probe Info  		22.01  LDD2041  [6]
C383
 Probe Info  		18.90  LDD2042  [6]
C386
 Probe Info  		12.91  LDD2045  [6]
C388
 Probe Info  		81.01  LDD2047  [6]
C390
 Probe Info  		99.73  LDD2049  [6]
C391
 Probe Info  		44.94  LDD2050  [6]
C396
 Probe Info  		5.31  LDD2055  [6]
C397
 Probe Info  		17.27  LDD2056  [6]
C399
 Probe Info  		18.90  LDD2058  [6]
C403
 Probe Info  		23.92  LDD2061  [6]
C405
 Probe Info  		5.62  LDD2063  [6]
C407
 Probe Info  		31.56  LDD2064  [6]
C409
 Probe Info  		5.66  LDD2066  [6]
C413
 Probe Info  		31.34  LDD2069  [6]
C424
 Probe Info  		17.03  LDD2079  [6]
C426
 Probe Info  		35.75  LDD2081  [6]
C429
 Probe Info  		22.94  LDD2084  [6]
C431
 Probe Info  		35.02  LDD2086  [6]
FFF probe11
 Probe Info  		19.84  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]
FFF probe2
 Probe Info  		19.06  LDD0463  [7]
FFF probe3
 Probe Info  		20.00  LDD0464  [7]
FFF probe9
 Probe Info  		7.38  LDD0470  [7]
JN0003
 Probe Info  		20.00  LDD0469  [7]
STS-2
 Probe Info  		N.A.  LDD0138  [8]
AEA-DA
 Probe Info  		3.13  LDD0334  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0137  SR-4995 HEK-293T 3.13  LDD0334  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SPRY domain-containing protein 4 (SPRYD4) . Q8WW59

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570