Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C165  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 73 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 76.1
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 37.5
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 37.3
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 33.8
 LDTP00697  Cytochrome b5 type B (CYB5B) 32.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 31.1
 LDTP04581  Holocytochrome c-type synthase (HCCS) 30.5
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 29.0
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 28.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 26.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 26.5
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 26.5
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 25.5
 LDTP16026  Probable cysteine--tRNA ligase, mitochondrial (CARS2) 25.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 24.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 24.4
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) 23.9
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 23.9
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 23.6
 LDTP10329  Ceramide synthase 2 (CERS2) 22.9
 LDTP14534  Arginyl-tRNA--protein transferase 1 (ATE1) 22.5
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 22.3
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 20.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 20.1
 LDTP05905  Acid ceramidase (ASAH1) 20.0
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 19.8
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 19.2
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 19.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 18.9
 LDTP02260  Beta-glucuronidase (GUSB) 18.1
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 17.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 17.3
 LDTP05446  Ubiquitin-protein ligase E3A (UBE3A) 17.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 16.7
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 16.7
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 16.0
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 15.9
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 15.6
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 15.6
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 15.5
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) 15.2
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 15.0
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 14.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 14.9
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 14.8
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.7
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 14.5
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 14.5
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 14.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 14.3
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 14.3
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 14.3
 LDTP00325  Pirin (PIR) 14.1
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 13.8
 LDTP07961  Protein arginine methyltransferase NDUFAF7, mitochondrial (NDUFAF7) 13.8
 LDTP03787  Choline kinase alpha (CHKA) 13.5
 LDTP13408  Cell division cycle protein 23 homolog (CDC23) 13.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 13.5
 LDTP09110  NAD(P)H-hydrate epimerase (NAXE) 13.5
 LDTP06322  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) 13.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 13.4
 LDTP01300  Cartilage-associated protein (CRTAP) 13.3
 LDTP07525  Protein arginine N-methyltransferase 9 (PRMT9) 13.2
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 13.1
 LDTP10441  E3 ubiquitin-protein ligase Itchy homolog (ITCH) 12.8
 LDTP13702  E3 ubiquitin-protein ligase TRIM33 (TRIM33) 12.8
 LDTP02505  Lysosomal protective protein (CTSA) 12.8
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 12.8
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 12.6
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 12.6
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 12.4
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 12.3
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 12.2
Transporter and channel
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 68.6
 LDTP13201  Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B) 55.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 50.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 50.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 40.8
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 33.4
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 32.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 32.7
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 31.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 31.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 30.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 28.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 26.9
 LDTP20002  Transmembrane protein 160 (TMEM160) 24.6
 LDTP11615  Protein tweety homolog 3 (TTYH3) 23.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 21.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.5
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 20.0
 LDTP16813  Tetraspanin-3 (TSPAN3) 19.0
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 18.8
 LDTP05900  Metaxin-1 (MTX1) 18.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 17.5
 LDTP05273  Spectrin beta chain, non-erythrocytic 1 (SPTBN1) 17.1
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 16.9
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 16.9
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 16.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 16.3
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 16.2
 LDTP11609  Endoplasmic reticulum junction formation protein lunapark (LNPK) 15.8
 LDTP07236  Protein GPR107 (GPR107) 15.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 15.6
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 15.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 15.5
 LDTP10065  Transmembrane protein 230 (TMEM230) 15.0
 LDTP02215  Prosaposin (PSAP) 14.9
 LDTP12383  Protein GPR108 (GPR108) 14.9
 LDTP15648  BRI3-binding protein (BRI3BP) 14.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 14.5
 LDTP09288  Vang-like protein 1 (VANGL1) 14.4
 LDTP11116  45 kDa calcium-binding protein (SDF4) 14.2
 LDTP11213  Nucleoporin NDC1 (NDC1) 13.9
 LDTP01217  Metaxin-2 (MTX2) 13.8
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 13.8
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 13.7
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 13.6
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 13.5
 LDTP07058  Transmembrane protein 201 (TMEM201) 13.5
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 13.4
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 13.4
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 13.0
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 12.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 12.7
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 12.6
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 12.5
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 12.4
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 12.3
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 12.3
 LDTP16190  Protein FAM8A1 (FAM8A1) 12.3
 LDTP00810  Exportin-T (XPOT) 12.1
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08006  PHD finger-like domain-containing protein 5A (PHF5A) 17.3
 LDTP05065  Y-box-binding protein 1 (YBX1) 15.6
Other
Click to Show/Hide to Show 78 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08594  Negative elongation factor C/D (NELFCD) 38.9
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 34.5
 LDTP11076  Apolipoprotein L2 (APOL2) 30.9
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 30.3
 LDTP06952  DBIRD complex subunit ZNF326 (ZNF326) 29.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 28.1
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 26.9
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 26.9
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 26.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 26.4
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 26.0
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 25.3
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 24.4
 LDTP06097  Reticulocalbin-2 (RCN2) 22.6
 LDTP03775  RNA-binding protein FUS (FUS) 22.2
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 21.6
 LDTP05160  Nucleobindin-2 (NUCB2) 21.4
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 21.4
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 21.3
 LDTP06391  Protein transport protein Sec23B (SEC23B) 21.3
 LDTP13086  Syntaxin-18 (STX18) 21.1
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 20.3
 LDTP01075  Protein CutA (CUTA) 19.8
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 18.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 18.6
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 18.5
 LDTP00887  Calumenin (CALU) 18.4
 LDTP14259  Testis-expressed protein 264 (TEX264) 17.8
 LDTP01600  BAG family molecular chaperone regulator 4 (BAG4) 17.5
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 17.4
 LDTP12412  Reticulon-4 (RTN4) 17.4
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 17.3
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 17.1
 LDTP11643  Superkiller complex protein 8 (SKIC8) 17.1
 LDTP05318  RNA-binding protein EWS (EWSR1) 16.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 16.9
 LDTP01362  Survival of motor neuron-related-splicing factor 30 (SMNDC1) 16.8
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 16.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 16.7
 LDTP06305  WD repeat-containing protein 43 (WDR43) 16.7
 LDTP12775  GATOR2 complex protein MIOS (MIOS) 16.4
 LDTP11324  RNA-binding protein 4 (RBM4) 16.3
 LDTP01246  KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) 16.2
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) 15.9
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 15.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 15.1
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 15.0
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 14.9
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 14.8
 LDTP13591  A-kinase anchor protein 8-like (AKAP8L) 14.7
 LDTP16156  Protein PALS2 (PALS2) 14.7
 LDTP05226  RNA-binding protein 3 (RBM3) 14.6
 LDTP05768  Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0) 14.5
 LDTP18272  Transmembrane protein 209 (TMEM209) 14.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 14.3
 LDTP08224  Protein LYRIC (MTDH) 14.2
 LDTP05800  Serine/arginine-rich splicing factor 9 (SRSF9) 14.2
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 14.2
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 14.1
 LDTP10093  Mitochondrial calcium uniporter regulator 1 (MCUR1) 13.9
 LDTP05274  Nucleolysin TIAR (TIAL1) 13.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 13.5
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 13.5
 LDTP05375  Nucleobindin-1 (NUCB1) 13.5
 LDTP06352  Reticulocalbin-1 (RCN1) 13.3
 LDTP10684  RNA-binding protein 14 (RBM14) 13.1
 LDTP04356  Emerin (EMD) 13.0
 LDTP09970  RNA-binding protein with multiple splicing (RBPMS) 13.0
 LDTP03598  Cytotoxic granule associated RNA binding protein TIA1 (TIA1) 12.9
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 12.9
 LDTP05277  Protein SET (SET) 12.9
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 12.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 12.7
 LDTP01522  Reticulon-3 (RTN3) 12.7
 LDTP10056  Protein FAM162A (FAM162A) 12.6
 LDTP00859  Synaptogyrin-2 (SYNGR2) 12.6
 LDTP06390  Protein transport protein Sec23A (SEC23A) 12.5
 LDTP02297  Vimentin (VIM) 12.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587