Details of the Target

General Information of Target

Target ID LDTP06391
Target Name Protein transport protein Sec23B (SEC23B)
Gene Name SEC23B
Gene ID 10483
Synonyms
Protein transport protein Sec23B; hSec23B; SEC23-related protein B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVL
CSRPTCKAVLNPLCQVDYRAKLWACNFCFQRNQFPPAYGGISEVNQPAELMPQFSTIEYV
IQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDM
NLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGP
GMVVGDELKIPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLL
EMKCCANLTGGYMVMGDSFNTSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAG
AIGPCVSLNVKGPCVSENELGVGGTSQWKICGLDPTSTLGIYFEVVNQHNTPIPQGGRGA
IQFVTHYQHSSTQRRIRVTTIARNWADVQSQLRHIEAAFDQEAAAVLMARLGVFRAESEE
GPDVLRWLDRQLIRLCQKFGQYNKEDPTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSPD
ESSYYRHHFARQDLTQSLIMIQPILYSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVI
YLGETIAQWRKAGYQDMPEYENFKHLLQAPLDDAQEILQARFPMPRYINTEHGGSQARFL
LSKVNPSQTHNNLYAWGQETGAPILTDDVSLQVFMDHLKKLAVSSAC
Target Bioclass
Other
Family
SEC23/SEC24 family, SEC23 subfamily
Subcellular location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
Uniprot ID
Q15437
Ensemble ID
ENST00000262544.6
HGNC ID
HGNC:10702

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.53  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y707(20.00)  LDD0257  [4]
TH214
 Probe Info  		Y707(8.47)  LDD0258  [4]
TH216
 Probe Info  		Y707(9.63)  LDD0259  [4]
ONAyne
 Probe Info  		K320(1.38)  LDD0274  [5]
STPyne
 Probe Info  		K320(10.00)  LDD0277  [5]
Probe 1
 Probe Info  		Y562(20.34); Y674(58.61); Y680(21.05); Y707(14.39)  LDD3495  [6]
BTD
 Probe Info  		C180(1.09)  LDD1700  [7]
HHS-482
 Probe Info  		Y707(0.75)  LDD0285  [8]
HHS-475
 Probe Info  		Y707(0.49); Y674(0.79)  LDD0264  [9]
HHS-465
 Probe Info  		Y674(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C767(0.98); C434(0.89)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C74(0.00); C434(0.00); C425(0.00); C451(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C434(0.00); C425(0.00); C451(0.00); C767(0.00)  LDD0037  [14]
NAIA_4
 Probe Info  		C40(0.00); C451(0.00)  LDD2226  [16]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
IPM
 Probe Info  		N.A.  LDD0005  [19]
PF-06672131
 Probe Info  		N.A.  LDD0017  [20]
1c-yne
 Probe Info  		K564(0.00); K237(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
NAIA_5
 Probe Info  		C425(0.00); C451(0.00); C180(0.00); C40(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C039
 Probe Info  		8.28  LDD1739  [22]
C165
 Probe Info  		21.26  LDD1845  [22]
C191
 Probe Info  		13.36  LDD1868  [22]
C206
 Probe Info  		23.75  LDD1881  [22]
C220
 Probe Info  		23.59  LDD1894  [22]
C236
 Probe Info  		6.23  LDD1909  [22]
C238
 Probe Info  		12.55  LDD1911  [22]
C242
 Probe Info  		4.99  LDD1915  [22]
C249
 Probe Info  		14.32  LDD1922  [22]
FFF probe11
 Probe Info  		5.42  LDD0472  [23]
FFF probe13
 Probe Info  		18.23  LDD0475  [23]
FFF probe3
 Probe Info  		20.00  LDD0465  [23]
JN0003
 Probe Info  		12.52  LDD0469  [23]
STS-1
 Probe Info  		N.A.  LDD0136  [24]
STS-2
 Probe Info  		N.A.  LDD0139  [24]
OEA-DA
 Probe Info  		7.43  LDD0046  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C180(0.52)  LDD2132  [7]
 LDCM0214  AC1 HCT 116 C61(1.13); C180(1.11); C425(1.43); C74(1.26)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C61(1.30); C180(1.06); C434(0.95); C767(0.94)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C61(0.48); C180(0.74); C434(0.74); C74(1.12)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C61(0.53); C180(0.80); C434(0.74); C74(0.57)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C61(0.66); C180(0.80); C434(0.85); C74(0.93)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C61(0.50); C180(0.90); C434(0.77); C74(0.72)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C61(0.89); C180(0.86); C434(0.84); C74(1.22)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C61(0.53); C180(0.83); C434(0.64); C74(0.91)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C61(0.54); C180(0.80); C434(0.66); C74(0.82)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C61(0.51); C180(0.99); C434(0.55); C74(0.97)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C61(0.69); C180(0.78); C434(1.46); C74(1.11)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C61(1.40); C180(0.77); C434(1.20); C74(1.05)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C61(1.12); C180(1.13); C434(0.68); C767(0.94)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C61(0.56); C180(0.83); C434(0.95); C74(0.96)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C61(0.61); C180(0.85); C434(1.18); C74(0.85)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C61(0.53); C180(0.96); C434(0.77); C74(1.02)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C61(1.16); C180(1.04); C425(1.11); C434(1.30)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C61(1.06); C180(1.05); C425(0.95); C434(1.04)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C61(1.01); C180(1.18); C425(0.89); C434(1.02)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C61(0.99); C180(1.15); C425(0.86); C434(0.95)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C61(0.98); C180(1.08); C425(0.99); C434(0.87)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C61(1.06); C180(1.07); C425(0.95); C434(1.16)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C61(1.05); C180(1.15); C425(0.88); C434(1.05)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C61(1.15); C180(1.19); C434(0.96); C767(1.01)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C61(1.02); C180(1.13); C425(0.96); C434(1.06)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C61(0.97); C180(1.18); C425(1.00); C434(1.10)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C61(1.10); C180(1.06); C425(0.83); C434(1.22)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C61(1.46); C180(1.38); C425(0.91); C434(1.10)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C61(0.99); C180(1.03); C425(1.10); C434(1.17)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C61(1.05); C180(0.98); C425(0.95); C434(1.14)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C61(1.01); C180(1.15); C425(0.84); C434(1.26)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C61(0.97); C180(1.15); C425(0.89); C434(1.34)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C61(1.20); C425(2.12); C434(1.20); C85(3.01)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C61(1.15); C425(2.20); C434(1.08); C85(1.00)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C61(1.04); C425(1.24); C434(1.01); C85(0.96)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C61(1.02); C425(1.41); C434(1.05); C85(1.24)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C61(0.91); C425(1.16); C434(1.09); C85(0.54)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C61(0.94); C425(1.18); C434(1.07); C85(1.02)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C61(0.76); C425(1.05); C434(0.96); C85(0.79)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C61(1.00); C425(1.22); C434(1.02); C85(0.88)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C61(0.78); C425(0.91); C434(1.05); C85(0.68)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C61(0.70); C425(1.07); C434(1.05); C85(0.87)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C61(0.55); C425(0.90); C434(1.03); C85(1.14)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C61(0.65); C425(0.85); C434(0.99); C85(0.45)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C61(1.12); C180(1.11); C434(0.80); C767(0.72)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C61(0.53); C425(0.79); C434(1.08); C85(0.44)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C61(0.53); C425(0.85); C434(1.03); C85(0.66)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C61(0.78); C425(1.01); C434(1.06); C85(0.61)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C61(0.83); C74(0.74); C88(0.83); C767(0.97)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C74(0.74); C88(0.92); C180(1.00); C767(1.01)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C88(0.66); C74(0.87); C180(0.92); C767(0.93)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C88(0.57); C74(0.83); C180(1.09); C767(1.14)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C88(0.68); C74(0.85); C767(0.94); C180(1.05)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C88(0.42); C74(0.66); C767(0.94); C180(1.28)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C88(0.59); C74(0.81); C767(1.19); C180(1.21)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C767(0.86); C434(0.89); C180(1.19); C61(1.27)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C74(0.89); C88(0.90); C180(1.08); C61(1.21)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C74(1.02); C180(1.06); C61(1.23); C767(1.30)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C88(0.70); C74(0.77); C767(0.96); C180(1.11)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C88(0.33); C74(0.81); C767(1.11); C180(1.44)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C61(1.07); C180(1.14); C74(0.77); C767(1.23)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C61(1.23); C180(1.17); C74(0.76); C767(1.10)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C61(1.27); C180(1.17); C74(0.95); C767(1.16)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C61(1.26); C180(1.01); C74(1.10); C767(1.07)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C88(0.82); C180(0.82); C434(0.98); C767(1.01)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C88(0.78); C180(0.98); C434(0.99); C767(1.26)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C88(0.78); C434(0.95); C180(0.98); C767(1.12)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C61(1.01); C425(1.03); C180(1.09); C74(1.14)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C434(0.90); C88(0.92); C180(0.96); C61(1.09)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C434(0.93); C88(0.98); C180(0.99); C767(1.24)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C88(0.71); C434(0.91); C61(0.95); C180(1.05)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C434(0.91); C88(0.92); C180(1.12); C767(1.16)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C434(0.92); C180(1.01); C61(1.06); C767(1.15)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C425(0.72); C88(0.92); C434(0.94); C180(0.98)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C425(0.61); C88(0.74); C434(0.85); C61(0.95)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C425(0.62); C61(0.80); C434(0.97); C180(1.01)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C425(0.54); C88(0.85); C434(0.92); C180(1.02)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C61(0.60); C88(0.61); C425(0.66); C434(0.87)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C767(1.11); C61(1.11); C88(1.11); C180(1.14)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C61(0.52); C425(0.62); C88(0.68); C434(0.85)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C425(0.49); C61(0.73); C88(0.79); C434(0.87)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C425(0.47); C61(0.64); C88(0.70); C434(0.79)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C425(0.52); C434(0.83); C88(0.90); C61(0.92)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C425(0.48); C88(0.86); C434(0.86); C61(0.92)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C180(0.81); C767(0.90); C61(1.12); C434(1.12)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C180(0.82); C767(0.85); C61(0.85); C434(0.97)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C180(0.79); C61(0.79); C425(0.96); C434(1.01)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C61(0.85); C767(0.90); C180(0.95); C434(1.02)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C180(0.84); C61(0.96); C425(0.99); C434(1.02)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C767(1.02); C88(1.06); C180(1.13); C61(1.28)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C61(0.76); C767(0.85); C180(0.85); C425(0.98)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C61(0.63); C180(0.78); C434(0.92); C767(1.08)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C61(0.78); C180(0.82); C767(0.88); C434(0.98)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C61(0.56); C180(0.79); C434(0.82); C425(0.90)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C61(0.52); C180(0.89); C767(0.98); C425(1.01)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C61(0.63); C425(0.86); C180(0.88); C434(1.03)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C74(0.50); C61(0.81); C434(0.87); C88(0.91)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C74(0.72); C88(0.75); C61(0.82); C425(0.89)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C88(0.39); C364(0.54); C365(0.54); C74(0.56)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C74(0.47); C88(0.55); C364(0.62); C365(0.62)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C767(1.05); C61(1.06); C88(1.15); C180(1.17)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C74(0.46); C364(0.63); C365(0.63); C88(0.65)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C74(0.52); C61(0.80); C88(0.96); C364(0.96)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C74(0.55); C61(0.75); C364(0.78); C365(0.78)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C88(0.69); C425(0.80); C434(0.89); C61(0.90)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C74(0.58); C364(0.66); C365(0.66); C61(0.70)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C88(0.59); C434(0.73); C425(0.74); C364(0.77)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C88(0.52); C425(0.63); C74(0.65); C364(0.67)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C425(0.65); C434(0.71); C88(0.86); C61(0.97)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C425(0.55); C434(0.61); C61(0.90); C767(0.94)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C425(0.72); C85(0.93); C88(0.95); C434(0.99)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C61(0.89); C434(1.00); C180(1.06); C767(1.07)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C425(0.53); C434(0.61); C85(0.83); C88(0.93)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C425(0.49); C434(0.56); C85(0.81); C88(0.82)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C425(0.63); C434(0.68); C85(0.80); C88(0.80)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C425(0.57); C434(0.66); C88(0.90); C85(1.14)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C425(0.61); C434(0.66); C88(0.81); C85(1.01)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C88(0.78); C425(0.79); C434(0.90); C85(1.00)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C425(0.70); C85(0.79); C88(0.87); C434(0.91)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C425(0.48); C88(0.59); C434(0.60); C85(0.74)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C85(0.54); C364(0.58); C365(0.58); C88(0.67)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C364(0.53); C365(0.53); C85(0.56); C425(0.62)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C767(0.91); C434(0.95); C61(1.01); C180(1.07)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C85(0.34); C88(0.51); C364(0.62); C365(0.62)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C85(0.65); C364(0.71); C365(0.71); C88(0.75)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C364(0.82); C365(0.82); C61(0.85); C74(0.85)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C85(0.47); C364(0.56); C365(0.56); C88(0.62)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C85(0.34); C364(0.44); C365(0.44); C425(0.52)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C85(0.33); C364(0.50); C365(0.50); C88(0.50)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C85(0.61); C88(0.69); C61(0.73); C364(0.75)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C85(0.58); C364(0.62); C365(0.62); C88(0.67)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C364(0.54); C365(0.54); C85(0.57); C425(0.64)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C61(0.74); C85(0.83); C88(0.84); C74(0.84)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C434(0.88); C767(0.92); C61(1.06); C180(1.18)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C85(0.61); C364(0.64); C365(0.64); C88(0.70)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C364(0.59); C365(0.59); C85(0.60); C88(0.71)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C85(0.18); C364(0.43); C365(0.43); C88(0.43)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C434(0.94); C88(0.96); C61(1.00); C180(1.24)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C434(0.92); C88(1.07); C61(1.11); C180(1.14)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C88(0.86); C434(0.88); C180(1.00); C61(1.32)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C88(0.67); C434(0.95); C180(1.05); C61(1.14)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C88(0.85); C434(0.85); C180(1.00); C767(1.15)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C88(0.64); C434(0.87); C180(1.03); C767(1.12)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C88(0.66); C434(0.96); C180(1.04); C767(1.22)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C88(0.70); C61(0.96); C180(0.97); C767(1.06)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C88(0.89); C434(1.12); C61(1.13); C180(1.16)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C88(0.95); C61(1.08); C434(1.11); C180(1.11)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C88(0.87); C434(0.89); C180(1.07); C61(1.19)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C88(0.97); C180(0.98); C434(1.14); C61(1.22)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C88(0.67); C434(0.86); C180(0.88); C767(1.12)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C88(0.87); C180(0.98); C434(1.05); C767(1.16)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C88(0.60); C434(0.81); C180(1.05); C61(1.17)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C88(0.36); C85(0.39); C434(0.50); C61(0.53)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C88(0.47); C85(0.51); C61(0.57); C180(0.73)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C180(0.71)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C61(0.94); C180(1.09); C434(1.11); C767(0.98)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C434(0.87); C767(1.04); C180(1.07); C61(1.18)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C434(0.88); C61(1.04); C767(1.07); C180(1.36)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 12.07  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C767(0.98); C434(0.89)  LDD0078  [11]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C180(0.90); C40(0.43)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C425(0.78); C434(0.92); C180(1.00); C61(1.04)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C425(0.58); C434(0.74); C180(0.82); C61(1.10)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C88(0.99); C180(1.11); C61(1.12); C74(1.29)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C767(0.86); C61(1.05); C434(1.05); C180(1.17)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C767(0.81); C434(0.87); C61(1.08); C180(1.09)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C434(0.87); C767(0.90); C180(0.99); C61(1.11)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C434(0.81); C767(0.91); C180(1.03); C61(1.18)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C88(0.43); C180(0.85); C434(0.98); C767(1.27)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C88(0.51); C434(0.79); C180(0.82); C767(1.37)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C88(0.45); C434(1.00); C180(1.04); C767(1.26)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C88(0.69); C434(0.91); C180(0.92); C767(1.08)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C88(0.37); C434(0.90); C180(0.99); C61(1.30)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C425(0.63); C434(0.77); C180(0.90); C61(1.37)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C88(0.62); C434(0.77); C61(0.98); C180(1.14)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C88(0.53); C434(0.92); C180(1.16); C61(1.35)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C88(0.79); C425(0.91); C767(0.91); C61(0.94)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C425(0.52); C61(0.62); C88(0.74); C434(0.84)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C61(0.49); C425(0.62); C88(0.72); C434(0.87)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C61(0.64); C425(0.65); C88(0.85); C434(0.90)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C425(0.60); C61(0.90); C434(0.92); C180(1.18)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C425(0.78); C767(0.88); C434(0.92); C61(0.93)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C434(0.91); C61(0.93); C180(0.97); C767(0.98)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C61(0.89); C425(0.90); C180(0.90); C767(0.93)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C425(0.70); C180(0.76); C434(0.89); C61(1.21)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C61(0.73); C180(0.79); C434(1.04); C425(1.06)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C364(0.44); C365(0.44); C88(0.54); C74(0.73)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C364(0.42); C365(0.42); C88(0.58); C425(0.67)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C74(0.64); C61(0.70); C88(0.72); C425(0.80)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C74(0.56); C88(0.72); C364(0.72); C365(0.72)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C85(0.74); C425(0.87); C88(0.92); C434(0.98)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C425(0.82); C434(0.93); C61(0.98); C88(1.01)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C425(0.78); C85(0.86); C88(0.97); C434(0.99)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C425(0.75); C88(0.85); C434(0.91); C85(0.91)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C425(0.47); C434(0.75); C180(0.81); C767(1.12)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C434(0.85); C425(0.88); C180(0.92); C61(1.08)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C425(0.54); C434(0.74); C180(0.87); C767(1.08)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C425(0.76); C61(0.88); C434(0.92); C180(1.07)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C88(0.56); C425(0.62); C61(0.83); C434(0.91)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C425(0.36); C88(0.70); C434(0.77); C61(0.83)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C425(0.49); C88(0.82); C434(0.89); C61(0.93)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C180(0.81); C61(0.90); C434(1.01); C425(1.14)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C425(0.59); C88(0.79); C61(0.84); C434(0.87)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C425(0.46); C88(0.72); C434(0.79); C61(0.87)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C425(0.52); C61(0.91); C434(0.94); C88(1.01)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C88(0.65); C425(0.65); C61(0.91); C364(0.93)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C61(0.88); C180(1.15); C364(1.36); C425(0.55)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C61(0.91); C180(1.10); C364(1.75); C425(0.61)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C61(0.81); C180(1.04); C364(1.25); C425(0.68)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C61(1.16); C180(1.00); C364(1.07); C425(0.61)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C61(0.93); C180(1.11); C364(1.54); C425(0.49)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C61(1.22); C180(1.01); C364(1.21); C425(0.51)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C61(1.01); C180(0.96); C425(1.09); C434(0.98)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C61(0.97); C180(1.06); C364(1.15); C425(0.66)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C61(1.04); C425(0.79); C434(1.00); C767(1.10)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C61(0.97); C180(1.13); C425(0.46); C434(0.76)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C61(0.89); C180(1.16); C425(0.42); C434(0.75)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C61(0.87); C180(0.99); C425(0.60); C434(0.90)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C61(0.67); C180(0.93); C425(0.73); C434(0.89)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C61(0.90); C180(0.96); C425(0.67); C434(0.92)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C61(0.76); C180(0.96); C425(0.71); C434(0.85)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C61(0.85); C180(1.15); C425(0.56); C434(0.82)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C61(1.20); C180(0.81); C425(0.92); C434(0.92)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C61(0.79); C180(0.90); C425(0.58); C434(0.85)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C61(0.89); C180(0.97); C425(2.04); C434(0.84)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C61(0.87); C180(0.89); C425(0.73); C434(0.86)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C61(0.84); C180(1.09); C425(0.61); C434(0.84)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C61(1.00); C180(0.95); C425(0.49); C434(0.81)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C61(0.79); C180(0.98); C425(0.49); C434(0.80)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C61(1.06); C180(0.99); C425(0.83); C434(1.17)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C61(0.78); C180(0.91); C425(0.78); C434(1.03)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C61(0.97); C180(0.85); C425(0.76); C434(1.17)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C61(1.11); C180(0.85); C425(0.95); C434(1.18)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C61(1.42); C180(0.84); C425(0.89); C434(0.90)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C61(1.19); C180(0.85); C425(0.86); C434(1.08)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C61(0.97); C180(0.85); C425(0.83); C434(1.14)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C61(0.93); C180(0.99); C425(0.82); C434(1.14)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C61(0.71); C180(0.87); C425(0.81); C434(1.05)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C61(0.98); C180(0.81); C425(0.78); C434(1.05)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C61(0.95); C180(0.80); C425(1.02); C434(1.11)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C61(0.92); C180(0.91); C425(0.74); C434(1.08)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C61(0.90); C180(0.94); C425(0.77); C434(0.98)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C61(1.09); C180(0.89); C425(0.79); C434(1.08)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C61(1.05); C180(0.85); C425(0.99); C434(1.01)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C61(1.33); C180(0.84); C425(0.58); C434(0.72)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C61(1.04); C180(0.90); C425(0.87); C434(0.96)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C61(0.98); C364(0.95); C365(0.95); C425(1.30)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C61(0.98); C364(1.16); C365(1.16); C425(1.32)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C61(1.00); C364(0.75); C365(0.75); C425(1.91)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C61(1.09); C364(0.53); C365(0.53); C425(0.90)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C61(1.15); C364(0.83); C365(0.83); C425(1.20)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C61(1.07); C364(0.73); C365(0.73); C425(1.08)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C61(1.13); C364(0.70); C365(0.70); C425(1.57)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C61(0.77); C364(0.50); C365(0.50); C425(0.82)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C61(0.87); C364(0.58); C365(0.58); C425(0.85)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C61(1.37); C180(0.84); C425(0.83); C434(0.88)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C61(0.85); C364(0.50); C365(0.50); C425(0.87)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C61(0.83); C364(0.88); C365(0.88); C425(1.34)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C61(0.73); C364(1.09); C365(1.09); C425(1.32)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C61(0.84); C364(0.96); C365(0.96); C425(0.94)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C61(0.89); C364(0.77); C365(0.77); C425(1.41)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C61(0.94); C434(1.16); C74(0.83); C767(1.06)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C61(0.91); C434(0.94); C74(0.65); C767(1.11)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C61(0.82); C434(0.87); C74(0.79); C767(1.19)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C61(0.80); C434(1.04); C74(0.92); C767(1.00)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C61(0.80); C180(0.97); C425(0.96); C434(0.85)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C61(1.00); C434(1.21); C74(0.98); C767(1.18)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C61(0.89); C434(1.09); C74(0.99); C767(1.01)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C61(0.76); C434(1.63); C74(0.84); C767(0.99)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C61(0.73); C434(1.20); C74(0.76); C767(0.99)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C61(0.69); C434(0.76); C74(0.84); C767(1.15)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C61(0.82); C434(0.90); C74(0.89); C767(1.18)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C61(0.92); C434(1.05); C74(0.80); C767(1.14)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C61(1.06); C434(1.26); C74(0.91); C767(0.90)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C61(0.80); C434(1.17); C74(0.86); C767(0.98)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C61(0.75); C434(1.33); C74(0.73); C767(1.05)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C61(0.99); C180(1.00); C425(1.00); C434(0.93)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C61(0.83); C434(1.03); C74(0.67); C767(1.02)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C61(0.89); C180(1.08); C425(0.69); C74(1.02)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C61(0.91); C180(0.97); C425(0.81); C74(0.82)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C61(1.14); C180(0.98); C425(1.18); C74(1.64)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C61(1.14); C180(1.02); C425(1.43); C74(1.65)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C61(0.95); C180(1.08); C425(0.77); C74(1.08)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C61(0.99); C180(1.13); C425(0.86); C74(1.04)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C61(0.88); C180(1.06); C425(0.71); C74(0.96)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C61(1.02); C180(1.11); C425(1.04); C74(1.46)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C61(1.20); C180(1.15); C425(1.26); C74(1.45)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C180(0.89); C61(0.92); C434(0.78); C74(0.96)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C180(0.99)  LDD1702  [7]
 LDCM0625  F8 Ramos C74(0.61); C767(0.97); C40(1.41); C425(0.56)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C74(0.61); C767(0.67); C40(0.57); C425(0.51)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C74(0.34); C40(20.00); C425(0.40); C180(0.90)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C74(0.64); C767(0.70); C40(0.45); C425(0.58)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C74(0.96); C767(1.02); C40(0.51); C425(1.03)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C74(0.94); C767(0.62); C40(0.85); C180(0.96)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C74(0.58); C767(0.51); C40(0.67); C425(0.53)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C74(0.95); C767(0.83); C40(0.65); C425(1.01)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C74(1.17); C767(0.93); C40(0.72); C425(1.45)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C74(1.03); C767(0.86); C40(0.73); C425(1.10)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C74(0.59); C767(0.63); C40(0.88); C425(0.76)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C74(1.10); C767(1.08); C40(0.46); C425(1.10)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C74(1.26); C767(0.90); C40(1.12); C425(1.21)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C74(0.54); C767(0.70); C40(0.52); C425(0.53)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C61(0.92); C364(0.82); C365(0.82); C425(0.99)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C74(0.80); C767(0.90); C40(0.72); C425(0.86)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C74(0.66); C767(0.80); C425(0.59); C180(0.61)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C61(0.75); C180(0.95); C425(0.78); C434(0.86)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C74(1.14); C767(0.98); C40(0.61); C425(1.11)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C74(1.11); C767(1.10); C40(1.21); C425(1.02)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C74(0.51); C767(0.64); C40(0.70); C425(0.46)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C74(0.59); C767(0.62); C40(0.89); C425(0.53)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y707(0.49); Y674(0.79)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y707(0.69); Y674(0.93)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y707(0.58); Y674(0.82)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y707(0.61); Y674(0.77)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y707(0.68); Y674(2.84)  LDD0268  [9]
 LDCM0123  JWB131 DM93 Y707(0.75)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y707(0.75)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y707(0.71)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y707(4.94)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y707(2.53)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y707(0.70)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y707(0.43)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y707(0.82)  LDD0292  [8]
 LDCM0022  KB02 HCT 116 C767(1.32)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C767(1.12)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C767(1.18)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C180(0.93)  LDD2121  [7]
 LDCM0109  NEM HeLa H224(0.00); H685(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C180(1.01)  LDD2089  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C180(0.98)  LDD2093  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C180(0.61)  LDD2098  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C180(1.16)  LDD2119  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C180(0.54)  LDD2133  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C180(1.09)  LDD1700  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C180(1.22)  LDD2146  [7]
 LDCM0131  RA190 MM1.R C767(1.25)  LDD0304  [28]
 LDCM0021  THZ1 HCT 116 C767(1.13); C434(1.05)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A3 (HOXA3) Antp homeobox family O43365
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nesprin-4 (SYNE4) Nesprin family Q8N205
Protein PRRC1 (PRRC1) PRRC1 family Q96M27
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Cleavage and polyadenylation specificity factor subunit 7 (CPSF7) RRM CPSF6/7 family Q8N684
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Protein transport protein Sec24D (SEC24D) SEC23/SEC24 family O94855
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.