Details of the Probe

General Information of Probe

Probe ID
LDPC0405
Probe Name
C165
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 333.395
Lipid-water partition coefficient (xlogp) 3.0702
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C19H19N5O
Canonical SMILES
[H]C#CC([H])([H])C([H])([H])C1(C([H])([H])C([H])([H])C(=O)N2C([H])([H])c3c([H])nn(-c4c([H])c([H])c([H])c([H])c4[H])c3C2([H])[H])N=N1
InChI
InChI=1S/C19H19N5O/c1-2-3-10-19(21-22-19)11-9-18(25)23-13-15-12-20-24(17(15)14-23)16-7-5-4-6-8-16/h1,4-8,12H,3,9-11,13-14H2
InChIKey
KUIHQVVGQONEEX-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

73 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 19.03  LDD1845 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 14.32  LDD1845 
Acid ceramidase (ASAH1) LDTP05905 19.97  LDD1845 
ADP-dependent glucokinase (ADPGK) LDTP11127 16.68  LDD1845 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 12.64  LDD1845 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 37.27  LDD1845 
Arginyl-tRNA--protein transferase 1 (ATE1) LDTP14534 22.47  LDD1845 
Beta-glucuronidase (GUSB) LDTP02260 18.13  LDD1845 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 16.68  LDD1845 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 13.83  LDD1845 
Cartilage-associated protein (CRTAP) LDTP01300 13.27  LDD1845 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 22.32  LDD1845 
Cell division cycle protein 23 homolog (CDC23) LDTP13408 13.45  LDD1845 
Ceramide synthase 2 (CERS2) LDTP10329 22.94  LDD1845 
Choline kinase alpha (CHKA) LDTP03787 13.55  LDD1845 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 15.56  LDD1845 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 20.11  LDD1845 
Cytochrome b5 type B (CYB5B) LDTP00697 32.90  LDD1845 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 29.04  LDD1845 
DCN1-like protein 4 (DCUN1D4) LDTP09799 25.46  LDD1845 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 19.84  LDD1845 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 37.53  LDD1845 
Delta(24)-sterol reductase (DHCR24) LDTP06375 14.52  LDD1845 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 31.12  LDD1845 
E3 ubiquitin-protein ligase Itchy homolog (ITCH) LDTP10441 12.82  LDD1845 
E3 ubiquitin-protein ligase TRIM33 (TRIM33) LDTP13702 12.82  LDD1845 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 17.75  LDD1845 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 17.27  LDD1845 
Enoyl-CoA delta isomerase 2 (ECI2) LDTP01245 23.92  LDD1845 
Epoxide hydrolase 1 (EPHX1) LDTP02175 33.82  LDD1845 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 14.93  LDD1845 
Heme oxygenase 1 (HMOX1) LDTP02359 13.45  LDD1845 
Heme oxygenase 2 (HMOX2) LDTP03540 26.72  LDD1845 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 12.21  LDD1845 
Holocytochrome c-type synthase (HCCS) LDTP04581 30.48  LDD1845 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 18.90  LDD1845 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 15.45  LDD1845 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 19.16  LDD1845 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 13.09  LDD1845 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 20.68  LDD1845 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 14.32  LDD1845 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 14.83  LDD1845 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 14.52  LDD1845 
Lysosomal protective protein (CTSA) LDTP02505 12.82  LDD1845 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 23.59  LDD1845 
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) LDTP12227 15.24  LDD1845 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 12.55  LDD1845 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 15.89  LDD1845 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 15.56  LDD1845 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 15.03  LDD1845 
NAD(P)H-hydrate epimerase (NAXE) LDTP09110 13.45  LDD1845 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 16.00  LDD1845 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 76.11  LDD1845 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 24.42  LDD1845 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 26.54  LDD1845 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 14.32  LDD1845 
Pirin (PIR) LDTP00325 14.12  LDD1845 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 12.38  LDD1845 
Probable cysteine--tRNA ligase, mitochondrial (CARS2) LDTP16026 25.46  LDD1845 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 14.52  LDD1845 
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 12.30  LDD1845 
Prostaglandin reductase 3 (PTGR3) LDTP15422 28.25  LDD1845 
Protein arginine methyltransferase NDUFAF7, mitochondrial (NDUFAF7) LDTP07961 13.83  LDD1845 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 13.18  LDD1845 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 14.93  LDD1845 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 26.54  LDD1845 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 24.59  LDD1845 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 12.82  LDD1845 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 14.72  LDD1845 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 13.36  LDD1845 
Ubiquitin-protein ligase E3A (UBE3A) LDTP05446 17.15  LDD1845 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 23.92  LDD1845 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) LDTP06322 13.45  LDD1845 
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⏷ Show the Full List of 73 Enzyme
59 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 14.22  LDD1845 
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) LDTP01601 16.45  LDD1845 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 16.34  LDD1845 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 13.64  LDD1845 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 28.05  LDD1845 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 12.73  LDD1845 
BRI3-binding protein (BRI3BP) LDTP15648 14.62  LDD1845 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 13.45  LDD1845 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 33.36  LDD1845 
Endoplasmic reticulum junction formation protein lunapark (LNPK) LDTP11609 15.78  LDD1845 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 17.51  LDD1845 
Exportin-T (XPOT) LDTP00810 12.13  LDD1845 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 12.30  LDD1845 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 12.30  LDD1845 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 13.74  LDD1845 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 12.73  LDD1845 
Metaxin-1 (MTX1) LDTP05900 18.25  LDD1845 
Metaxin-2 (MTX2) LDTP01217 13.83  LDD1845 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 20.53  LDD1845 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 19.97  LDD1845 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 15.45  LDD1845 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 68.59  LDD1845 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 50.56  LDD1845 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 12.55  LDD1845 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 14.52  LDD1845 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 26.91  LDD1845 
Nucleoporin NDC1 (NDC1) LDTP11213 13.93  LDD1845 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 18.77  LDD1845 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 13.36  LDD1845 
Prosaposin (PSAP) LDTP02215 14.93  LDD1845 
Protein FAM8A1 (FAM8A1) LDTP16190 12.30  LDD1845 
Protein GPR107 (GPR107) LDTP07236 15.56  LDD1845 
Protein GPR108 (GPR108) LDTP12383 14.93  LDD1845 
Protein tweety homolog 3 (TTYH3) LDTP11615 23.92  LDD1845 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 16.22  LDD1845 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 16.91  LDD1845 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 12.38  LDD1845 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 40.79  LDD1845 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 32.67  LDD1845 
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) LDTP05273 17.15  LDD1845 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 12.47  LDD1845 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 16.91  LDD1845 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 31.34  LDD1845 
Tetraspanin-3 (TSPAN3) LDTP16813 19.03  LDD1845 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 13.00  LDD1845 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 21.56  LDD1845 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 15.56  LDD1845 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 13.36  LDD1845 
Transmembrane protein 126A (TMEM126A) LDTP15948 50.21  LDD1845 
Transmembrane protein 160 (TMEM160) LDTP20002 24.59  LDD1845 
Transmembrane protein 199 (TMEM199) LDTP08881 15.45  LDD1845 
Transmembrane protein 201 (TMEM201) LDTP07058 13.45  LDD1845 
Transmembrane protein 230 (TMEM230) LDTP10065 15.03  LDD1845 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 31.12  LDD1845 
Vang-like protein 1 (VANGL1) LDTP09288 14.42  LDD1845 
Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B) LDTP13201 55.33  LDD1845 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 32.67  LDD1845 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 30.27  LDD1845 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 13.83  LDD1845 
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⏷ Show the Full List of 59 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
PHD finger-like domain-containing protein 5A (PHF5A) LDTP08006 17.27  LDD1845 
Y-box-binding protein 1 (YBX1) LDTP05065 15.56  LDD1845 
------------------------------------------------------------------------------------
78 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
A-kinase anchor protein 8-like (AKAP8L) LDTP13591 14.72  LDD1845 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 25.99  LDD1845 
Apolipoprotein L2 (APOL2) LDTP11076 30.91  LDD1845 
BAG family molecular chaperone regulator 4 (BAG4) LDTP01600 17.51  LDD1845 
BTB/POZ domain-containing protein KCTD12 (KCTD12) LDTP15705 15.03  LDD1845 
Calumenin (CALU) LDTP00887 18.38  LDD1845 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 15.14  LDD1845 
Cytotoxic granule associated RNA binding protein TIA1 (TIA1) LDTP03598 12.91  LDD1845 
DBIRD complex subunit ZNF326 (ZNF326) LDTP06952 29.86  LDD1845 
Emerin (EMD) LDTP04356 13.00  LDD1845 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 25.28  LDD1845 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 13.45  LDD1845 
Far upstream element-binding protein 1 (FUBP1) LDTP10078 16.68  LDD1845 
Far upstream element-binding protein 2 (KHSRP) LDTP09938 17.15  LDD1845 
Far upstream element-binding protein 3 (FUBP3) LDTP10408 14.12  LDD1845 
GATOR2 complex protein MIOS (MIOS) LDTP12775 16.45  LDD1845 
General transcription factor IIF subunit 1 (GTF2F1) LDTP03729 12.91  LDD1845 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 16.68  LDD1845 
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) LDTP10962 21.56  LDD1845 
Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0) LDTP05768 14.52  LDD1845 
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) LDTP04495 14.93  LDD1845 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 26.91  LDD1845 
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) LDTP06032 15.89  LDD1845 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 14.32  LDD1845 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 17.39  LDD1845 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 14.83  LDD1845 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 15.78  LDD1845 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 20.25  LDD1845 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 18.77  LDD1845 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 17.27  LDD1845 
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) LDTP05525 12.82  LDD1845 
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) LDTP01246 16.22  LDD1845 
Large proline-rich protein BAG6 (BAG6) LDTP04094 12.73  LDD1845 
LYR motif-containing protein 2 (LYRM2) LDTP18467 30.27  LDD1845 
MAGUK p55 subfamily member 2 (MPP2) LDTP06068 21.26  LDD1845 
Mitochondrial calcium uniporter regulator 1 (MCUR1) LDTP10093 13.93  LDD1845 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 34.54  LDD1845 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 28.05  LDD1845 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 18.64  LDD1845 
Negative elongation factor C/D (NELFCD) LDTP08594 38.85  LDD1845 
Nucleobindin-1 (NUCB1) LDTP05375 13.45  LDD1845 
Nucleobindin-2 (NUCB2) LDTP05160 21.41  LDD1845 
Nucleolysin TIAR (TIAL1) LDTP05274 13.64  LDD1845 
Protein CutA (CUTA) LDTP01075 19.84  LDD1845 
Protein FAM162A (FAM162A) LDTP10056 12.55  LDD1845 
Protein LYRIC (MTDH) LDTP08224 14.22  LDD1845 
Protein PALS2 (PALS2) LDTP16156 14.72  LDD1845 
Protein SET (SET) LDTP05277 12.91  LDD1845 
Protein transport protein Sec23A (SEC23A) LDTP06390 12.47  LDD1845 
Protein transport protein Sec23B (SEC23B) LDTP06391 21.26  LDD1845 
Protein unc-119 homolog B (UNC119B) LDTP00105 26.35  LDD1845 
Reticulocalbin-1 (RCN1) LDTP06352 13.27  LDD1845 
Reticulocalbin-2 (RCN2) LDTP06097 22.63  LDD1845 
Reticulon-3 (RTN3) LDTP01522 12.73  LDD1845 
Reticulon-4 (RTN4) LDTP12412 17.39  LDD1845 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 18.51  LDD1845 
RNA-binding protein 14 (RBM14) LDTP10684 13.09  LDD1845 
RNA-binding protein 3 (RBM3) LDTP05226 14.62  LDD1845 
RNA-binding protein 4 (RBM4) LDTP11324 16.34  LDD1845 
RNA-binding protein EWS (EWSR1) LDTP05318 16.91  LDD1845 
RNA-binding protein FUS (FUS) LDTP03775 22.16  LDD1845 
RNA-binding protein with multiple splicing (RBPMS) LDTP09970 13.00  LDD1845 
Serine/arginine-rich splicing factor 9 (SRSF9) LDTP05800 14.22  LDD1845 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 14.22  LDD1845 
Superkiller complex protein 8 (SKIC8) LDTP11643 17.15  LDD1845 
Survival of motor neuron-related-splicing factor 30 (SMNDC1) LDTP01362 16.80  LDD1845 
Synaptogyrin-2 (SYNGR2) LDTP00859 12.55  LDD1845 
Syntaxin-18 (STX18) LDTP13086 21.11  LDD1845 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 26.54  LDD1845 
Testis-expressed protein 264 (TEX264) LDTP14259 17.75  LDD1845 
Tetraspanin-6 (TSPAN6) LDTP14458 13.55  LDD1845 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 24.42  LDD1845 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 26.91  LDD1845 
Transmembrane protein 209 (TMEM209) LDTP18272 14.52  LDD1845 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 16.91  LDD1845 
Vimentin (VIM) LDTP02297 12.21  LDD1845 
WD repeat-containing protein 43 (WDR43) LDTP06305 16.68  LDD1845 
Zinc finger CCHC domain-containing protein 3 (ZCCHC3) LDTP12623 21.41  LDD1845 
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⏷ Show the Full List of 78 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1845 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587