Details of the Target

General Information of Target

Target ID LDTP01600
Target Name BAG family molecular chaperone regulator 4 (BAG4)
Gene Name BAG4
Gene ID 9530
Synonyms
SODD; BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; Silencer of death domains
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAET
TWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVR
PELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSP
TPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQE
DAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSY
PYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQD
QSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKEL
LELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
Uniprot ID
O95429
Ensemble ID
ENST00000287322.5
HGNC ID
HGNC:940

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.G456DfsTer6
Insertion: p.I383NfsTer12		 .
DU145 Insertion: p.T405DfsTer23 .
EFO27 Insertion: p.G143RfsTer54 .
HUH28 SNV: p.C443Y .
LNCaP clone FGC Deletion: p.G456DfsTer6 .
SUPT1 SNV: p.P265L .
UMUC3 SNV: p.L334I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TG42
 Probe Info  		4.65  LDD0043  [2]
HPAP
 Probe Info  		6.53  LDD0063  [3]
DBIA
 Probe Info  		C193(1.03)  LDD0532  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		14.90  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		17.51  LDD1845  [9]
C206
 Probe Info  		16.00  LDD1881  [9]
C249
 Probe Info  		16.11  LDD1922  [9]
C284
 Probe Info  		25.28  LDD1954  [9]
C363
 Probe Info  		15.45  LDD2024  [9]
C383
 Probe Info  		11.79  LDD2042  [9]
FFF probe11
 Probe Info  		20.00  LDD0472  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [10]
FFF probe2
 Probe Info  		20.00  LDD0463  [10]
FFF probe3
 Probe Info  		20.00  LDD0465  [10]
FFF probe6
 Probe Info  		20.00  LDD0468  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C193(1.01)  LDD1507  [11]
 LDCM0215  AC10 HCT 116 C193(1.03)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C193(0.94)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C193(1.08)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C193(0.86)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C193(1.22)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C193(1.27)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C193(1.22)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C193(1.41)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C193(1.31)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C193(1.17)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C193(0.92)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C193(0.97)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C193(0.99)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C193(1.16)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C193(1.14)  LDD0546  [4]
 LDCM0237  AC12 HCT 116 C193(0.97)  LDD0554  [4]
 LDCM0246  AC128 HCT 116 C193(0.59)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C193(0.73)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C193(0.75)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C193(0.63)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C193(0.81)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C193(0.64)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C193(0.73)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C193(0.60)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C193(0.83)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C193(0.77)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C193(0.83)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C193(0.76)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C193(0.93)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C193(0.73)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C193(0.79)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C193(0.70)  LDD0579  [4]
 LDCM0270  AC15 HCT 116 C193(0.76)  LDD0587  [4]
 LDCM0276  AC17 HEK-293T C193(1.15)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C193(0.85)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C193(1.08)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C193(0.93)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C193(1.25)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C193(1.11)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C193(1.02)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C193(1.29)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C193(1.04)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C193(0.97)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C193(0.84)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C193(0.94)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C193(0.95)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C193(0.99)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C193(1.01)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C193(0.93)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C193(0.97)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C193(1.09)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C193(1.21)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C193(0.90)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C193(1.09)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C193(1.06)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C193(0.96)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C193(1.08)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C193(1.12)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C193(0.99)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C193(1.04)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C193(1.25)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C193(0.88)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C193(1.12)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C193(1.11)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C193(1.04)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C193(1.05)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C193(1.10)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C193(1.19)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C193(1.09)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C193(0.94)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C193(0.88)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C193(1.12)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C193(1.14)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C193(1.11)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C193(1.18)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C193(1.05)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C193(1.09)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C193(1.12)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C193(0.92)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C193(0.86)  LDD1561  [11]
 LDCM0323  AC6 HCT 116 C193(1.08)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C193(1.10)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C193(1.05)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C193(1.14)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C193(1.24)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C193(1.05)  LDD1567  [11]
 LDCM0334  AC7 HCT 116 C193(0.93)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C193(0.86)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C193(0.90)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C193(0.83)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C193(0.73)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C193(0.82)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C193(0.93)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C193(1.01)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C193(0.88)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C193(1.30)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C193(0.94)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C193(0.86)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C193(0.74)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C193(0.57)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C193(1.00)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C193(0.56)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C193(1.09)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C193(1.51)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C193(0.99)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C193(0.91)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C193(0.99)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C193(0.84)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.69  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C193(1.00)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C193(0.78)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C193(0.97)  LDD1573  [11]
 LDCM0370  CL101 HCT 116 C193(0.98)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C193(0.82)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C193(0.91)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C193(0.90)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C193(1.01)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C193(1.07)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C193(1.10)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C193(0.93)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C193(1.04)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C193(1.21)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C193(1.05)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C193(1.03)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C193(0.94)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C193(1.08)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C193(1.04)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C193(1.17)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C193(1.26)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C193(1.11)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C193(1.20)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C193(0.85)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C193(1.04)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C193(1.03)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C193(1.02)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C193(1.17)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C193(0.97)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C193(1.07)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C193(0.79)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C193(1.16)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C193(0.98)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C193(1.07)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C193(1.05)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C193(0.99)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C193(1.09)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C193(0.93)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C193(0.98)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C193(0.89)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C193(1.17)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C193(1.01)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C193(1.16)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C193(1.11)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C193(1.02)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C193(1.13)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C193(1.07)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C193(0.89)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C193(1.28)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C193(1.04)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C193(0.99)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C193(1.15)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C193(0.82)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C193(0.81)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C193(0.99)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C193(1.10)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C193(0.93)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C193(0.99)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C193(1.19)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C193(1.20)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C193(1.14)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C193(1.28)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C193(0.85)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C193(1.12)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C193(1.10)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C193(0.88)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C193(1.02)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C193(0.97)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C193(1.11)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C193(0.98)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C193(0.80)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C193(0.86)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C193(0.65)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C193(1.12)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C193(0.88)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C193(0.70)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C193(1.26)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C193(1.03)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C193(0.94)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C193(0.92)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C193(0.98)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C193(0.70)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C193(0.99)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C193(1.00)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C193(0.77)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C193(0.92)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C193(1.00)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C193(1.10)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C193(1.09)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C193(1.13)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C193(1.21)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C193(0.97)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C193(1.05)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C193(1.24)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C193(1.28)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C193(1.04)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C193(1.24)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C193(1.11)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C193(1.60)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C193(0.84)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C193(1.01)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C193(0.98)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C193(0.94)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C193(0.85)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C193(0.92)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C193(0.72)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C193(0.95)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C193(1.23)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C193(1.00)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C193(1.18)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C193(0.98)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C193(0.86)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C193(1.01)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C193(1.01)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C193(1.04)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C193(1.12)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C193(0.91)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C193(0.69)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C193(0.96)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C193(1.04)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C193(1.12)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C193(1.21)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C193(1.19)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C193(0.97)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C193(0.96)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C193(0.95)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C193(0.95)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C193(1.18)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C193(0.90)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C193(1.31)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C193(1.06)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C193(1.02)  LDD1497  [11]
 LDCM0024  KB05 HEK-293T C193(0.98)  LDD1502  [11]
 LDCM0014  Panhematin K562 6.53  LDD0063  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIL6) Cyclophilin-type PPIase family Q8IXY8
mRNA-decapping enzyme 1A (DCP1A) DCP1 family Q9NPI6
mRNA-decapping enzyme 1B (DCP1B) DCP1 family Q8IZD4
Ferritin heavy chain (FTH1) Ferritin family P02794
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Tubulointerstitial nephritis antigen-like (TINAGL1) Peptidase C1 family Q9GZM7
Caspase-2 (CASP2) Peptidase C14A family P42575
Mitochondrial inner membrane protease ATP23 homolog (ATP23) Peptidase M76 family Q9Y6H3
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Pyrroline-5-carboxylate reductase 3 (PYCR3) Pyrroline-5-carboxylate reductase family Q53H96
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) SH3RF family Q8TEC5
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
Programmed cell death protein 6 (PDCD6) . O75340
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Zinc finger and BTB domain-containing protein 45 (ZBTB45) Krueppel C2H2-type zinc-finger protein family Q96K62
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
PHD finger protein 19 (PHF19) Polycomblike family Q5T6S3
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Golgin-45 (BLZF1) . Q9H2G9
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Zinc finger and BTB domain-containing protein 5 (ZBTB5) . O15062
Other
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Protein FAM222B (FAM222B) FAM222 family Q8WU58
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) Fibulin family Q12805
Heat shock 70 kDa protein 1-like (HSPA1L) Heat shock protein 70 family P34931
Heat shock 70 kDa protein 6 (HSPA6) Heat shock protein 70 family P17066
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 4-4 (KRTAP4-4) KRTAP type 4 family Q9BYR3
Keratin-associated protein 4-5 (KRTAP4-5) KRTAP type 4 family Q9BYR2
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Protein CIMAP1C (CIMAP1C) ODF3 family Q8IXM7
Keratin-associated protein 13-4 (KRTAP13-4) PMG family Q3LI77
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
T-cell leukemia/lymphoma protein 1B (TCL1B) TCL1 family O95988
Tektin-5 (TEKT5) Tektin family Q96M29
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
DnaJ homolog subfamily C member 7 (DNAJC7) . Q99615
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
G protein pathway suppressor 2 (GPS2) . Q13227
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Outer dense fiber protein 1 (ODF1) . Q14990
Peflin (PEF1) . Q9UBV8
TBC1 domain family member 3G (TBC1D3G) . Q6DHY5
TBC1 domain family member 7 (TBC1D7) . Q9P0N9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402