Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C383  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
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Target ID Target Name Binding Ratio
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 99.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 77.7
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 67.6
 LDTP01803  Adenosine deaminase (ADA) 60.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 41.4
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 38.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 37.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 34.5
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 33.6
 LDTP10329  Ceramide synthase 2 (CERS2) 33.4
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 29.0
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 28.4
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 28.2
 LDTP05905  Acid ceramidase (ASAH1) 26.4
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 26.2
 LDTP03394  Ceramide synthase 1 (CERS1) 25.6
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 25.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 22.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 22.5
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 22.3
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 22.2
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 22.0
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 21.4
 LDTP03842  Squalene synthase (FDFT1) 20.8
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 19.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 19.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 18.6
 LDTP05480  Amidophosphoribosyltransferase (PPAT) 18.1
 LDTP02505  Lysosomal protective protein (CTSA) 18.1
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 18.1
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 18.0
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 17.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 17.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 17.6
 LDTP02539  Lysosomal acid phosphatase (ACP2) 17.4
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 17.4
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 17.4
 LDTP03984  Caspase-3 (CASP3) 17.3
 LDTP03813  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) 17.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 17.0
 LDTP00844  Maleylacetoacetate isomerase (GSTZ1) 16.7
 LDTP09225  sn-1-specific diacylglycerol lipase ABHD11 (ABHD11) 16.7
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 16.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 16.4
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 16.3
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 15.8
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 15.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 15.6
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 15.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 15.5
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 15.2
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 14.9
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 14.7
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 14.5
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 14.2
 LDTP11494  Neurolysin, mitochondrial (NLN) 14.2
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 14.2
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 14.0
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 13.8
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 13.6
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 13.5
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 13.5
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 13.3
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 13.2
 LDTP02188  Protein disulfide-isomerase (P4HB) 12.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 12.7
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 12.7
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 12.6
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 12.6
 LDTP06427  Translin (TSN) 12.6
 LDTP02141  Alpha-galactosidase A (GLA) 12.4
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 12.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 12.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 12.1
 LDTP13972  Oligoribonuclease, mitochondrial (REXO2) 12.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 11.9
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 11.9
 LDTP01769  Dihydrofolate reductase (DHFR) 11.8
 LDTP00415  Acyl-coenzyme A thioesterase 8 (ACOT8) 11.7
 LDTP02713  Macrophage migration inhibitory factor (MIF) 11.7
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 11.7
 LDTP17785  Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPR) 11.7
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 11.6
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 11.6
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 11.6
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 11.6
 LDTP00316  Ribonuclease T2 (RNASET2) 11.4
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 11.3
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 11.2
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) 11.2
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17) 11.0
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 10.9
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 10.9
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 10.9
 LDTP03289  Low molecular weight phosphotyrosine protein phosphatase (ACP1) 10.7
Transporter and channel
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 63.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 49.9
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 40.8
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 34.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 34.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 33.8
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 31.6
 LDTP02215  Prosaposin (PSAP) 31.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 27.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 26.4
 LDTP20002  Transmembrane protein 160 (TMEM160) 25.5
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 24.3
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 23.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 22.5
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 21.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 21.0
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 19.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 18.9
 LDTP07236  Protein GPR107 (GPR107) 18.8
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 18.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 18.4
 LDTP00592  Surfeit locus protein 4 (SURF4) 17.5
 LDTP16813  Tetraspanin-3 (TSPAN3) 17.5
 LDTP12636  Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1) 16.9
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 16.8
 LDTP11615  Protein tweety homolog 3 (TTYH3) 16.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.9
 LDTP16190  Protein FAM8A1 (FAM8A1) 15.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 15.5
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 15.1
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 15.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 15.0
 LDTP15648  BRI3-binding protein (BRI3BP) 14.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 14.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 14.7
 LDTP11406  Transmembrane protein 59 (TMEM59) 14.7
 LDTP01804  ATP synthase subunit a (MT-ATP6) 14.6
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 14.6
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 14.5
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 14.1
 LDTP05900  Metaxin-1 (MTX1) 13.5
 LDTP12451  Integral membrane protein 2C (ITM2C) 13.4
 LDTP13335  Exportin-7 (XPO7) 12.6
 LDTP04849  CD81 antigen (CD81) 12.6
 LDTP09180  Zinc transporter 7 (SLC30A7) 12.5
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 12.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 12.2
 LDTP06947  Transmembrane protein 128 (TMEM128) 12.2
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 12.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 12.0
 LDTP10073  Protein RFT1 homolog (RFT1) 11.7
 LDTP11116  45 kDa calcium-binding protein (SDF4) 11.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 11.6
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 11.5
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 11.2
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 11.2
 LDTP06331  Pericentriolar material 1 protein (PCM1) 11.1
 LDTP11634  Derlin-2 (DERL2) 11.0
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 10.9
Transcription factor
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Target ID Target Name Binding Ratio
 LDTP02016  Glucocorticoid receptor (NR3C1) 10.9
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 13.8
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03538  HLA class I histocompatibility antigen, alpha chain F (HLA-F) 28.6
Other
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 74.5
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 72.0
 LDTP05160  Nucleobindin-2 (NUCB2) 70.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 63.1
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 41.6
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 34.1
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 31.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 29.4
 LDTP14939  Membralin (TMEM259) 27.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 27.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 26.2
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 23.9
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 23.4
 LDTP09297  Large ribosomal subunit protein mL64 (GADD45GIP1) 22.5
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 22.0
 LDTP11379  TBC1 domain family member 10A (TBC1D10A) 21.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 21.1
 LDTP05375  Nucleobindin-1 (NUCB1) 20.5
 LDTP00887  Calumenin (CALU) 20.1
 LDTP16006  Optic atrophy 3 protein (OPA3) 19.0
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 18.9
 LDTP06097  Reticulocalbin-2 (RCN2) 18.9
 LDTP04558  Arfaptin-1 (ARFIP1) 18.1
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 18.1
 LDTP18883  Protein CEBPZOS (CEBPZOS) 18.0
 LDTP10442  Thioredoxin domain-containing protein 15 (TXNDC15) 17.9
 LDTP01608  Proteasome assembly chaperone 1 (PSMG1) 17.4
 LDTP07574  Superkiller complex protein 3 (SKIC3) 17.4
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 17.3
 LDTP01075  Protein CutA (CUTA) 17.3
 LDTP16577  DENN domain-containing protein 11 (DENND11) 17.0
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 17.0
 LDTP07476  RAD50-interacting protein 1 (RINT1) 16.9
 LDTP15101  Armadillo repeat-containing protein 6 (ARMC6) 16.8
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 16.4
 LDTP04557  Arfaptin-2 (ARFIP2) 15.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 15.8
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 15.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 15.5
 LDTP19963  TraB domain-containing protein (TRABD) 15.3
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 15.1
 LDTP16156  Protein PALS2 (PALS2) 15.1
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 14.5
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 14.5
 LDTP10056  Protein FAM162A (FAM162A) 14.5
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 14.4
 LDTP02297  Vimentin (VIM) 14.3
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 14.2
 LDTP17477  WD repeat-containing protein 87 (WDR87) 14.1
 LDTP13086  Syntaxin-18 (STX18) 14.0
 LDTP01246  KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) 13.9
 LDTP02180  Neurofilament light polypeptide (NEFL) 13.9
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) 13.8
 LDTP08606  Nurim (NRM) 13.8
 LDTP11825  Phosducin-like protein 3 (PDCL3) 13.7
 LDTP03926  Centrin-2 (CETN2) 13.5
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 13.5
 LDTP13019  Vacuolar protein sorting-associated protein 18 homolog (VPS18) 13.5
 LDTP01522  Reticulon-3 (RTN3) 13.4
 LDTP11695  Kinesin light chain 2 (KLC2) 13.3
 LDTP01652  Centrosomal protein 43 (CEP43) 13.2
 LDTP06756  Erythroid differentiation-related factor 1 (EDRF1) 13.0
 LDTP06853  TBC1 domain family member 10B (TBC1D10B) 13.0
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 12.9
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 12.6
 LDTP00986  Syntaxin-10 (STX10) 12.6
 LDTP15623  Neuferricin (CYB5D2) 12.4
 LDTP03775  RNA-binding protein FUS (FUS) 12.4
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 12.4
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 12.3
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 12.0
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 11.9
 LDTP01600  BAG family molecular chaperone regulator 4 (BAG4) 11.8
 LDTP07839  Capping protein-inhibiting regulator of actin dynamics (CRACD) 11.6
 LDTP06527  Alpha-internexin (INA) 11.5
 LDTP13114  C-type mannose receptor 2 (MRC2) 11.5
 LDTP01286  Centriole and centriolar satellite protein OFD1 (OFD1) 11.5
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 11.5
 LDTP01582  Pre-mRNA-splicing factor SLU7 (SLU7) 11.5
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 11.4
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 11.3
 LDTP05828  Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) 11.3
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 11.3
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 11.2
 LDTP02927  Ganglioside GM2 activator (GM2A) 11.2
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 11.2
 LDTP08346  Cerebellar degeneration-related protein 2-like (CDR2L) 11.1
 LDTP07318  HAUS augmin-like complex subunit 3 (HAUS3) 11.0
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 10.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 10.9
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 10.9
 LDTP00417  Programmed cell death protein 5 (PDCD5) 10.9
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 10.8
 LDTP06948  Protein YIF1B (YIF1B) 10.7
 LDTP12412  Reticulon-4 (RTN4) 10.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587