Details of the Target

General Information of Target

Target ID LDTP08058
Target Name Mitochondrial antiviral-signaling protein (MAVS)
Gene Name MAVS
Gene ID 57506
Synonyms
IPS1; KIAA1271; VISA; Mitochondrial antiviral-signaling protein; MAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFN
TLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPP
TPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLES
SSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRL
PGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPT
TLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVP
SKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSK
PGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLE
GNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH
Target Bioclass
Other
Subcellular location
Mitochondrion outer membrane
Function
Adapter required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.
Uniprot ID
Q7Z434
Ensemble ID
ENST00000416600.6
HGNC ID
HGNC:29233
ChEMBL ID
CHEMBL4523363

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR37 SNV: p.T393I DBIA    Probe Info 
IGR39 SNV: p.T393I DBIA    Probe Info 
KYSE30 SNV: p.T445I DBIA    Probe Info 
MCC13 SNV: p.L190Q DBIA    Probe Info 
MDAMB468 SNV: p.V82I DBIA    Probe Info 
SNU1 SNV: p.V506L DBIA    Probe Info 
SUPT1 SNV: p.P493T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DAyne
 Probe Info  		2.39  LDD0261  [2]
CHEMBL5175495
 Probe Info  		6.66  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
TG42
 Probe Info  		11.05  LDD0043  [5]
FBP2
 Probe Info  		3.13  LDD0323  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
YN-4
 Probe Info  		100.00  LDD0445  [7]
STPyne
 Probe Info  		K10(4.01); K362(10.00); K7(8.82)  LDD0277  [8]
ONAyne
 Probe Info  		K7(7.49)  LDD0275  [8]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [9]
BTD
 Probe Info  		C46(1.00)  LDD1700  [10]
AHL-Pu-1
 Probe Info  		C452(2.96); C283(2.46)  LDD0168  [11]
Acrolein
 Probe Info  		N.A.  LDD0222  [12]
DBIA
 Probe Info  		C283(1.99)  LDD0531  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C79(0.00); C46(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C20(0.00); C46(0.00); C79(0.00)  LDD0162  [15]
Lodoacetamide azide
 Probe Info  		C46(0.00); C79(0.00)  LDD0037  [14]
IPM
 Probe Info  		N.A.  LDD0025  [16]
DA-P3
 Probe Info  		N.A.  LDD0178  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C33(0.00); C46(0.00)  LDD0018  [20]
W1
 Probe Info  		C283(0.00); C133(0.00)  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		C46(0.00); C13(0.00); C79(0.00); C133(0.00)  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C231
 Probe Info  		15.56  LDD1904  [24]
C232
 Probe Info  		35.51  LDD1905  [24]
C233
 Probe Info  		13.09  LDD1906  [24]
C234
 Probe Info  		5.98  LDD1907  [24]
C235
 Probe Info  		25.28  LDD1908  [24]
C275
 Probe Info  		5.39  LDD1945  [24]
C289
 Probe Info  		25.28  LDD1959  [24]
C355
 Probe Info  		24.59  LDD2016  [24]
C383
 Probe Info  		11.88  LDD2042  [24]
FFF probe11
 Probe Info  		15.11  LDD0471  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe14
 Probe Info  		20.00  LDD0477  [25]
FFF probe2
 Probe Info  		20.00  LDD0463  [25]
FFF probe3
 Probe Info  		20.00  LDD0464  [25]
FFF probe9
 Probe Info  		6.03  LDD0470  [25]
JN0003
 Probe Info  		17.16  LDD0469  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C46(1.00)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C46(0.94)  LDD2112  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C46(0.57)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C46(0.95)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C46(1.11)  LDD2103  [10]
 LDCM0025  4SU-RNA HEK-293T C452(2.96); C283(2.46)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C452(5.35); C283(2.09)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C283(1.99)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C283(0.95)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C283(1.17)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C283(1.42)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C283(1.12)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C283(1.26)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C283(1.42)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C283(1.42)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C283(1.32)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C283(1.36)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C283(0.97)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C283(0.89)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C283(1.05)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C283(0.87)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C283(1.03)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C283(1.39)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C283(0.99)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C283(1.19)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C283(1.08)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C283(1.00)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C283(0.99)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C283(1.03)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C283(1.06)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C283(0.89)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C283(1.08)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C283(0.94)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C283(1.00)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C283(1.02)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C283(0.97)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C283(1.11)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C283(1.00)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C283(0.90)  LDD0562  [13]
 LDCM0246  AC128 HEK-293T C283(0.97)  LDD0844  [13]
 LDCM0247  AC129 HEK-293T C283(1.27)  LDD0845  [13]
 LDCM0249  AC130 HEK-293T C283(1.20)  LDD0847  [13]
 LDCM0250  AC131 HEK-293T C283(1.07)  LDD0848  [13]
 LDCM0251  AC132 HEK-293T C283(1.16)  LDD0849  [13]
 LDCM0252  AC133 HEK-293T C283(1.32)  LDD0850  [13]
 LDCM0253  AC134 HEK-293T C283(1.32)  LDD0851  [13]
 LDCM0254  AC135 HEK-293T C283(1.19)  LDD0852  [13]
 LDCM0255  AC136 HEK-293T C283(1.32)  LDD0853  [13]
 LDCM0256  AC137 HEK-293T C283(1.61)  LDD0854  [13]
 LDCM0257  AC138 HEK-293T C283(1.81)  LDD0855  [13]
 LDCM0258  AC139 HEK-293T C283(1.58)  LDD0856  [13]
 LDCM0259  AC14 HCT 116 C283(0.90)  LDD0576  [13]
 LDCM0260  AC140 HEK-293T C283(1.50)  LDD0858  [13]
 LDCM0261  AC141 HEK-293T C283(1.67)  LDD0859  [13]
 LDCM0262  AC142 HEK-293T C283(1.40)  LDD0860  [13]
 LDCM0263  AC143 HEK-293T C283(1.10)  LDD0861  [13]
 LDCM0264  AC144 HEK-293T C283(1.52)  LDD0862  [13]
 LDCM0265  AC145 HEK-293T C283(1.40)  LDD0863  [13]
 LDCM0266  AC146 HEK-293T C283(1.57)  LDD0864  [13]
 LDCM0267  AC147 HEK-293T C283(1.66)  LDD0865  [13]
 LDCM0268  AC148 HEK-293T C283(1.34)  LDD0866  [13]
 LDCM0269  AC149 HEK-293T C283(1.06)  LDD0867  [13]
 LDCM0270  AC15 HCT 116 C283(0.99)  LDD0587  [13]
 LDCM0271  AC150 HEK-293T C283(1.20)  LDD0869  [13]
 LDCM0272  AC151 HEK-293T C283(1.25)  LDD0870  [13]
 LDCM0273  AC152 HEK-293T C283(1.19)  LDD0871  [13]
 LDCM0274  AC153 HEK-293T C283(1.20)  LDD0872  [13]
 LDCM0621  AC154 HEK-293T C283(1.28)  LDD2162  [13]
 LDCM0622  AC155 HEK-293T C283(1.17)  LDD2163  [13]
 LDCM0623  AC156 HEK-293T C283(1.55)  LDD2164  [13]
 LDCM0624  AC157 HEK-293T C283(1.77)  LDD2165  [13]
 LDCM0276  AC17 HCT 116 C283(1.05)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C283(1.07)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C283(1.07)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C283(1.35)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C283(0.96)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C283(1.05)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C283(0.94)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C283(1.00)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C283(1.12)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C283(1.11)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C283(1.30)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C283(1.34)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C283(1.34)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C283(1.23)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C283(1.11)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C283(1.48)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C283(1.27)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C283(1.66)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C283(1.48)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C283(1.59)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C283(0.88)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C283(0.84)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C283(0.77)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C283(1.06)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C283(0.93)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C283(1.77)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C283(0.92)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C283(0.83)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C283(0.99)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C283(1.02)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C283(0.98)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C283(0.70)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C283(0.89)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C283(0.97)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C283(1.11)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C283(1.43)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C283(1.31)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C283(1.40)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C283(0.82)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C283(0.97)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C283(1.44)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C283(1.13)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C283(1.33)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C283(1.74)  LDD0636  [13]
 LDCM0320  AC57 HEK-293T C283(0.83); C46(1.19)  LDD0918  [13]
 LDCM0321  AC58 HEK-293T C283(1.14); C46(1.06)  LDD0919  [13]
 LDCM0322  AC59 HEK-293T C283(1.18); C46(1.31)  LDD0920  [13]
 LDCM0323  AC6 HCT 116 C283(0.99)  LDD0640  [13]
 LDCM0324  AC60 HEK-293T C283(0.77); C46(1.24)  LDD0922  [13]
 LDCM0325  AC61 HEK-293T C283(1.35); C46(1.48)  LDD0923  [13]
 LDCM0326  AC62 HEK-293T C283(0.98); C46(1.19)  LDD0924  [13]
 LDCM0327  AC63 HEK-293T C283(1.11); C46(1.28)  LDD0925  [13]
 LDCM0328  AC64 HEK-293T C283(1.00); C46(1.28)  LDD0926  [13]
 LDCM0329  AC65 HEK-293T C283(1.11); C46(1.34)  LDD0927  [13]
 LDCM0330  AC66 HEK-293T C283(1.02); C46(1.17)  LDD0928  [13]
 LDCM0331  AC67 HEK-293T C283(1.20); C46(1.31)  LDD0929  [13]
 LDCM0332  AC68 HEK-293T C283(1.08)  LDD0930  [13]
 LDCM0333  AC69 HEK-293T C283(1.07)  LDD0931  [13]
 LDCM0334  AC7 HCT 116 C283(0.95)  LDD0651  [13]
 LDCM0335  AC70 HEK-293T C283(1.55)  LDD0933  [13]
 LDCM0336  AC71 HEK-293T C283(1.37)  LDD0934  [13]
 LDCM0337  AC72 HEK-293T C283(1.05)  LDD0935  [13]
 LDCM0338  AC73 HEK-293T C283(1.01)  LDD0936  [13]
 LDCM0339  AC74 HEK-293T C283(1.32)  LDD0937  [13]
 LDCM0340  AC75 HEK-293T C283(1.53)  LDD0938  [13]
 LDCM0341  AC76 HEK-293T C283(1.22)  LDD0939  [13]
 LDCM0342  AC77 HEK-293T C283(1.15)  LDD0940  [13]
 LDCM0343  AC78 HEK-293T C283(1.25)  LDD0941  [13]
 LDCM0344  AC79 HEK-293T C283(1.25)  LDD0942  [13]
 LDCM0345  AC8 HCT 116 C283(0.94)  LDD0662  [13]
 LDCM0346  AC80 HEK-293T C283(1.42)  LDD0944  [13]
 LDCM0347  AC81 HEK-293T C283(1.30)  LDD0945  [13]
 LDCM0348  AC82 HEK-293T C283(1.43)  LDD0946  [13]
 LDCM0349  AC83 HCT 116 C283(1.73)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C283(2.23)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C283(1.10)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C283(1.38)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C283(1.15)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C283(1.50)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C283(1.41)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C283(1.21)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C283(1.59)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C283(1.41)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C283(1.44)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C283(1.08)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C283(1.43)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C283(1.36)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C283(1.81)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C283(1.50)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C283(0.85)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C283(1.05)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C283(0.93)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C283(0.92)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 11.98  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C133(0.91); C46(1.12)  LDD2171  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C46(0.83)  LDD2227  [23]
 LDCM0367  CL1 HEK-293T C283(1.02)  LDD0965  [13]
 LDCM0368  CL10 HEK-293T C283(2.12)  LDD0966  [13]
 LDCM0369  CL100 HCT 116 C283(1.49)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C283(1.08)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C283(0.91)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C283(1.03)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C283(0.94)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C283(1.17)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C283(1.23)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C283(1.17)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C283(1.33)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C283(1.14)  LDD0695  [13]
 LDCM0379  CL11 HEK-293T C283(1.89)  LDD0977  [13]
 LDCM0380  CL110 HCT 116 C283(1.19)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C283(1.16)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C283(1.16)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C283(1.34)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C283(1.23)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C283(1.52)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C283(1.39)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C283(1.12)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C283(0.84)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C283(0.85)  LDD0706  [13]
 LDCM0390  CL12 HEK-293T C283(1.07)  LDD0988  [13]
 LDCM0391  CL120 HCT 116 C283(1.04)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C283(1.40)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C283(1.08)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C283(1.15)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C283(1.34)  LDD0712  [13]
 LDCM0396  CL125 HEK-293T C283(1.12); C46(1.23)  LDD0994  [13]
 LDCM0397  CL126 HEK-293T C283(1.29); C46(1.14)  LDD0995  [13]
 LDCM0398  CL127 HEK-293T C283(0.99); C46(1.22)  LDD0996  [13]
 LDCM0399  CL128 HEK-293T C283(0.94); C46(0.91)  LDD0997  [13]
 LDCM0400  CL13 HEK-293T C283(1.04)  LDD0998  [13]
 LDCM0401  CL14 HEK-293T C283(1.04)  LDD0999  [13]
 LDCM0402  CL15 HEK-293T C283(1.45)  LDD1000  [13]
 LDCM0403  CL16 HCT 116 C283(0.57)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C283(0.69)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C283(0.79)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C283(0.75)  LDD0723  [13]
 LDCM0407  CL2 HEK-293T C283(1.13)  LDD1005  [13]
 LDCM0408  CL20 HCT 116 C283(0.68)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C283(0.87)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C283(1.02)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C283(1.23)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C283(0.86)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C283(0.75)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C283(0.73)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C283(0.81)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C283(0.69)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C283(0.58)  LDD0734  [13]
 LDCM0418  CL3 HEK-293T C283(1.12)  LDD1016  [13]
 LDCM0419  CL30 HCT 116 C283(0.86)  LDD0736  [13]
 LDCM0420  CL31 HEK-293T C283(1.26); C46(0.90)  LDD1018  [13]
 LDCM0421  CL32 HEK-293T C283(1.02); C46(0.86)  LDD1019  [13]
 LDCM0422  CL33 HEK-293T C283(1.42); C46(0.95)  LDD1020  [13]
 LDCM0423  CL34 HEK-293T C283(1.15); C46(1.25)  LDD1021  [13]
 LDCM0424  CL35 HEK-293T C283(1.23); C46(0.98)  LDD1022  [13]
 LDCM0425  CL36 HEK-293T C283(1.07); C46(0.98)  LDD1023  [13]
 LDCM0426  CL37 HEK-293T C283(1.27); C46(1.19)  LDD1024  [13]
 LDCM0428  CL39 HEK-293T C283(1.77); C46(0.90)  LDD1026  [13]
 LDCM0429  CL4 HEK-293T C283(1.23)  LDD1027  [13]
 LDCM0430  CL40 HEK-293T C283(1.15); C46(1.10)  LDD1028  [13]
 LDCM0431  CL41 HEK-293T C283(1.41); C46(0.76)  LDD1029  [13]
 LDCM0432  CL42 HEK-293T C283(1.60); C46(1.12)  LDD1030  [13]
 LDCM0433  CL43 HEK-293T C283(1.47); C46(1.03)  LDD1031  [13]
 LDCM0434  CL44 HEK-293T C283(1.20); C46(1.16)  LDD1032  [13]
 LDCM0435  CL45 HEK-293T C283(1.43); C46(1.07)  LDD1033  [13]
 LDCM0436  CL46 HEK-293T C283(1.23)  LDD1034  [13]
 LDCM0437  CL47 HEK-293T C283(1.07)  LDD1035  [13]
 LDCM0438  CL48 HEK-293T C283(1.11)  LDD1036  [13]
 LDCM0439  CL49 HEK-293T C283(1.24)  LDD1037  [13]
 LDCM0440  CL5 HEK-293T C283(1.18)  LDD1038  [13]
 LDCM0441  CL50 HEK-293T C283(1.43)  LDD1039  [13]
 LDCM0442  CL51 HEK-293T C283(1.13)  LDD1040  [13]
 LDCM0443  CL52 HEK-293T C283(0.95)  LDD1041  [13]
 LDCM0444  CL53 HEK-293T C283(1.00)  LDD1042  [13]
 LDCM0445  CL54 HEK-293T C283(1.16)  LDD1043  [13]
 LDCM0446  CL55 HEK-293T C283(1.10)  LDD1044  [13]
 LDCM0447  CL56 HEK-293T C283(0.93)  LDD1045  [13]
 LDCM0448  CL57 HEK-293T C283(1.10)  LDD1046  [13]
 LDCM0449  CL58 HEK-293T C283(0.94)  LDD1047  [13]
 LDCM0450  CL59 HEK-293T C283(1.20)  LDD1048  [13]
 LDCM0451  CL6 HEK-293T C283(1.19)  LDD1049  [13]
 LDCM0452  CL60 HEK-293T C283(1.34)  LDD1050  [13]
 LDCM0453  CL61 HCT 116 C283(0.98)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C283(1.03)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C283(1.12)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C283(1.22)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C283(1.01)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C283(1.66)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C283(1.40)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C283(1.12)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C283(0.88)  LDD0778  [13]
 LDCM0462  CL7 HEK-293T C283(1.25)  LDD1060  [13]
 LDCM0463  CL70 HCT 116 C283(0.99)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C283(1.35)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C283(1.22)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C283(1.13)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C283(1.12)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C283(1.08)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C283(1.02)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C283(0.83)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C283(1.15)  LDD0789  [13]
 LDCM0473  CL8 HEK-293T C283(1.47)  LDD1071  [13]
 LDCM0474  CL80 HCT 116 C283(1.04)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C283(1.04)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C283(0.96)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C283(0.99)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C283(0.93)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C283(1.05)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C283(1.02)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C283(1.01)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C283(0.99)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C283(0.82)  LDD0800  [13]
 LDCM0484  CL9 HEK-293T C283(1.25)  LDD1082  [13]
 LDCM0485  CL90 HCT 116 C283(1.15)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C283(1.17)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C283(1.02)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C283(1.11)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C283(1.11)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C283(1.04)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C283(0.99)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C283(1.29)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C283(1.12)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C283(1.36)  LDD0811  [13]
 LDCM0189  Compound 16 HEK-293T 3.84  LDD0492  [25]
 LDCM0185  Compound 17 HEK-293T 5.36  LDD0512  [25]
 LDCM0191  Compound 21 HEK-293T 7.04  LDD0508  [25]
 LDCM0190  Compound 34 HEK-293T 11.59  LDD0497  [25]
 LDCM0192  Compound 35 HEK-293T 4.71  LDD0491  [25]
 LDCM0193  Compound 36 HEK-293T 7.72  LDD0511  [25]
 LDCM0028  Dobutamine HEK-293T 4.80  LDD0180  [17]
 LDCM0027  Dopamine HEK-293T 6.43  LDD0179  [17]
 LDCM0495  E2913 HEK-293T C46(1.01); C133(1.05); C283(0.95); C33(0.80)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C46(4.74); C133(1.14); C508(0.80)  LDD1702  [10]
 LDCM0625  F8 Ramos C46(1.28); C133(1.36)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C46(7.78); C133(1.73)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C46(0.50); C133(0.27)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C46(9.62); C133(0.58)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C46(1.22); C133(0.86)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C46(2.87); C133(0.98)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C133(1.46)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C46(1.48); C133(0.80)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C46(1.29); C133(0.39)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C46(1.26); C133(0.87)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C46(1.14); C133(1.20)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C46(1.66); C133(0.68)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C46(1.89); C133(0.87)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C46(8.28); C133(1.10)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C283(1.24)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C46(2.01); C133(1.01)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C46(1.74); C133(0.71)  LDD2184  [28]
 LDCM0427  Fragment51 HEK-293T C283(1.25); C46(0.98)  LDD1025  [13]
 LDCM0610  Fragment52 Ramos C46(2.18); C133(1.17)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C46(1.78); C133(0.73)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C46(2.36); C133(1.08)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C133(0.82)  LDD2188  [28]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [9]
 LDCM0022  KB02 HEK-293T C133(0.91); C283(1.01); C435(0.98); C452(0.98)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C133(0.96); C283(1.04); C435(1.11); C452(1.11)  LDD1497  [27]
 LDCM0024  KB05 HMCB C46(3.02); C283(1.48); C133(2.31)  LDD3312  [29]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C46(1.39)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C46(0.46)  LDD2121  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C46(0.51)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C46(1.55); C133(1.31)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C46(1.24); C133(0.81)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C46(1.08)  LDD2093  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C46(1.62); C133(0.94)  LDD2094  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C46(0.62)  LDD2097  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C133(1.10)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C46(0.68)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C46(0.80)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C46(0.94)  LDD2101  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C46(0.80)  LDD2107  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C46(0.66)  LDD2109  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C46(0.80)  LDD2111  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C46(0.60)  LDD2115  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C46(0.64)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C46(0.63)  LDD2125  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C46(0.71)  LDD2129  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C46(0.68)  LDD2133  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C46(0.91)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C46(0.91)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C46(0.82)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C46(1.00)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C46(0.49)  LDD2140  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C46(4.43)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C46(0.59)  LDD2146  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C46(0.70)  LDD2148  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C46(1.06)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C46(0.88); C46(0.27)  LDD2207  [30]
 LDCM0029  Quercetin HEK-293T 7.90  LDD0181  [17]
 LDCM0131  RA190 MM1.R C283(1.07)  LDD0304  [31]
 LDCM0021  THZ1 HCT 116 C133(0.91); C46(1.12)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2'-5'-oligoadenylate synthase 3 (OAS3) 2-5A synthase family Q9Y6K5
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
ATP-dependent RNA helicase DDX3X (DDX3X) DEAD box helicase family O00571
Antiviral innate immune response receptor RIG-I (RIGI) Helicase family O95786
Interferon-induced helicase C domain-containing protein 1 (IFIH1) Helicase family Q9BYX4
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) NLRP family Q96P20
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) Ser/Thr protein kinase family Q14164
Serine/threonine-protein kinase TBK1 (TBK1) Ser/Thr protein kinase family Q9UHD2
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) TKL Ser/Thr protein kinase family O43353
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Mitofusin-1 (MFN1) Dynamin/Fzo/YdjA family Q8IWA4
Ubiquitin conjugation factor E4 A (UBE4A) Ubiquitin conjugation factor E4 family Q14139
E3 ubiquitin-protein ligase RNF125 (RNF125) . Q96EQ8
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) MAM33 family Q07021
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) Mitochondrial carrier (TC 2.A.29) family O75746
Calsenilin (KCNIP3) Recoverin family Q9Y2W7
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 5 (IRF5) IRF family Q13568
Signal transducer and activator of transcription 1-alpha/beta (STAT1) Transcription factor STAT family P42224
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy protein 5 (ATG5) ATG5 family Q9H1Y0
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Large proline-rich protein BAG6 (BAG6) . P46379

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
6 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD033004
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Mass spectrometry data entry: PXD041264
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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