Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FBP2  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02217  Procathepsin L (CTSL) 13.7
 LDTP03945  Patatin-like phospholipase domain-containing protein 4 (PNPLA4) 12.9
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 8.6
 LDTP11261  Monoacylglycerol lipase ABHD6 (ABHD6) 8.4
 LDTP03109  Amine oxidase [flavin-containing] A (MAOA) 6.6
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 6.3
 LDTP11055  Telomerase RNA component interacting RNase (TRIR) 5.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.7
 LDTP00185  Deoxyribonuclease-2-alpha (DNASE2) 5.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 5.5
 LDTP01776  Superoxide dismutase [Cu-Zn] (SOD1) 5.4
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 4.8
 LDTP00268  Eukaryotic elongation factor 2 kinase (EEF2K) 4.2
 LDTP12348  Ubiquitin-conjugating enzyme E2 T (UBE2T) 3.8
 LDTP11124  Ferroptosis suppressor protein 1 (AIFM2) 2.8
 LDTP03805  ADP-ribosylation factor-like protein 2 (ARL2) 2.8
 LDTP04144  Cytochrome b-c1 complex subunit Rieske, mitochondrial (UQCRFS1) 2.7
 LDTP06482  Ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) 2.7
 LDTP02718  Glucosidase 2 subunit beta (PRKCSH) 2.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 2.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 2.4
 LDTP08942  Deubiquitinase OTUD6B (OTUD6B) 2.3
 LDTP05853  Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) 2.3
 LDTP00253  Pyruvate dehydrogenase protein X component, mitochondrial (PDHX) 2.3
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 2.3
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 2.2
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 2.2
 LDTP00496  Long-chain fatty acid transport protein 2 (SLC27A2) 2.2
 LDTP02223  Cathepsin B (CTSB) 2.1
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 2.1
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) 2.1
 LDTP05255  Peptidyl-prolyl cis-trans isomerase FKBP3 (FKBP3) 2.1
 LDTP10133  Ubiquitin thioesterase otulin (OTULIN) 2.1
 LDTP05957  Ras-related protein Rab-31 (RAB31) 2.1
 LDTP03242  Adenosylhomocysteinase (AHCY) 2.0
 LDTP03669  Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) 2.0
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 2.0
Transporter and channel
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05631  Bone marrow stromal antigen 2 (BST2) 37.9
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 4.2
 LDTP02307  Annexin A5 (ANXA5) 3.8
 LDTP04597  Methylosome subunit pICln (CLNS1A) 3.7
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) 3.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 3.1
 LDTP05938  Sorting nexin-1 (SNX1) 3.1
 LDTP05231  Cytochrome c (CYCS) 3.0
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 2.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 2.5
 LDTP10313  Protein S100-A16 (S100A16) 2.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 2.4
 LDTP07002  Transport and Golgi organization protein 1 homolog (MIA3) 2.4
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 2.4
 LDTP02352  Clathrin light chain A (CLTA) 2.4
 LDTP03405  Calnexin (CANX) 2.1
 LDTP02122  Integrin beta-1 (ITGB1) 2.0
 LDTP04150  ATP synthase subunit O, mitochondrial (ATP5PO) 2.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 2.0
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12394  Leucine zipper transcription factor-like protein 1 (LZTFL1) 3.3
 LDTP03363  High mobility group protein B2 (HMGB2) 2.4
 LDTP09996  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) 2.1
 LDTP13718  Zinc finger CCCH domain-containing protein 4 (ZC3H4) 2.1
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 5.1
 LDTP04020  Cell surface glycoprotein MUC18 (MCAM) 2.1
Other
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01057  Polyglutamine-binding protein 1 (PQBP1) 8.8
 LDTP07984  Charged multivesicular body protein 1b (CHMP1B) 6.4
 LDTP05922  Dynactin subunit 2 (DCTN2) 4.8
 LDTP11804  SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) 4.3
 LDTP11418  EKC/KEOPS complex subunit GON7 (GON7) 3.6
 LDTP05277  Protein SET (SET) 3.5
 LDTP06191  LRP chaperone MESD (MESD) 3.5
 LDTP03247  Eukaryotic translation initiation factor 4B (EIF4B) 3.5
 LDTP11350  Protein LSM14 homolog B (LSM14B) 3.5
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 3.4
 LDTP11434  Replication termination factor 2 (RTF2) 3.3
 LDTP02116  Lupus La protein (SSB) 3.3
 LDTP08874  Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4) 3.3
 LDTP12951  Spliceosome-associated protein CWC15 homolog (CWC15) 3.2
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 3.1
 LDTP03871  Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) 3.1
 LDTP02570  Ubiquitin-like protein 4A (UBL4A) 3.1
 LDTP03227  Glycine cleavage system H protein, mitochondrial (GCSH) 3.0
 LDTP01323  26S proteasome non-ATPase regulatory subunit 10 (PSMD10) 3.0
 LDTP11139  DNA replication complex GINS protein PSF3 (GINS3) 2.9
 LDTP14228  Transforming acidic coiled-coil-containing protein 3 (TACC3) 2.9
 LDTP15958  Protein FAM234A (FAM234A) 2.8
 LDTP02982  Myosin regulatory light chain 12A (MYL12A) 2.8
 LDTP02526  Clusterin (CLU) 2.7
 LDTP03503  Myristoylated alanine-rich C-kinase substrate (MARCKS) 2.7
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 2.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 2.6
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 2.6
 LDTP09589  Charged multivesicular body protein 7 (CHMP7) 2.5
 LDTP01522  Reticulon-3 (RTN3) 2.5
 LDTP12073  Golgi reassembly-stacking protein 2 (GORASP2) 2.4
 LDTP12412  Reticulon-4 (RTN4) 2.4
 LDTP00880  A-kinase anchor protein 8 (AKAP8) 2.4
 LDTP11408  Nucleolar and spindle-associated protein 1 (NUSAP1) 2.3
 LDTP00759  Tumor protein D54 (TPD52L2) 2.3
 LDTP02092  Ubiquitin-like protein ISG15 (ISG15) 2.2
 LDTP04356  Emerin (EMD) 2.2
 LDTP01143  Zinc finger CCCH domain-containing protein 11A (ZC3H11A) 2.2
 LDTP02734  Endoplasmin (HSP90B1) 2.2
 LDTP06444  Microtubule-associated protein RP/EB family member 1 (MAPRE1) 2.1
 LDTP06588  Drebrin (DBN1) 2.1
 LDTP12826  Bcl-2-associated transcription factor 1 (BCLAF1) 2.1
 LDTP04049  Ran-specific GTPase-activating protein (RANBP1) 2.1
 LDTP02297  Vimentin (VIM) 2.1
 LDTP09843  Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) 2.1
 LDTP05590  Histone-binding protein RBBP4 (RBBP4) 2.1
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 2.1
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 2.1
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 2.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) 2.0

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580