Details of the Target

General Information of Target

Target ID LDTP09589
Target Name Charged multivesicular body protein 7 (CHMP7)
Gene Name CHMP7
Gene ID 91782
Synonyms
Charged multivesicular body protein 7; Chromatin-modifying protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWSPEREAEAPAGGDPAGLLPPEWEEDEERMSFLFSAFKRSREVNSTDWDSKMGFWAPLV
LSHSRRQGVVRLRLRDLQEAFQRKGSVPLGLATVLQDLLRRGELQRESDFMASVDSSWIS
WGVGVFLLKPLKWTLSNMLGDNKVPAEEVLVAVELLKEKAEEVYRLYQNSPLSSHPVVAL
SELSTLCANSCPDERTFYLVLLQLQKEKRVTVLEQNGEKIVKFARGPRAKVSPVNDVDVG
VYQLMQSEQLLSRKVESLSQEAERCKEEARRACRAGKKQLALRSLKAKQRTEKRIEALHA
KLDTVQGILDRIYASQTDQMVFNAYQAGVGALKLSMKDVTVEKAESLVDQIQELCDTQDE
VSQTLAGGVTNGLDFDSEELEKELDILLQDTTKEPLDLPDNPRNRHFTNSVPNPRISDAE
LEAELEKLSLSEGGLVPSSKSPKRQLEPTLKPL
Target Bioclass
Other
Family
SNF7 family
Subcellular location
Cytoplasm
Function
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase. Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming NE during anaphase by LEMD2. Plays a role in the endosomal sorting pathway.
Uniprot ID
Q8WUX9
Ensemble ID
ENST00000313219.8
HGNC ID
HGNC:28439

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P176S .
HCT116 SNV: p.A324T .
HCT15 SNV: p.A112T .
HEC1B SNV: p.L387I .
IM95 SNV: p.V177M .
SBC5 SNV: p.A8G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		2.53  LDD0323  [1]
STPyne
 Probe Info  		K219(6.25); K301(1.21)  LDD0277  [2]
DBIA
 Probe Info  		C355(1.02)  LDD1507  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		22.78  LDD1816  [7]
C135
 Probe Info  		12.47  LDD1817  [7]
C139
 Probe Info  		10.56  LDD1821  [7]
C140
 Probe Info  		7.94  LDD1822  [7]
C244
 Probe Info  		14.72  LDD1917  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C355(1.02)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C191(1.07)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C355(1.04)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C355(0.97)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C355(0.87)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C191(0.72)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C355(1.10)  LDD1519  [3]
 LDCM0282  AC22 HEK-293T C355(0.83)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C355(1.20); C191(1.07)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C355(0.93)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C191(1.96)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C355(1.12)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C191(1.40)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C355(1.40)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C355(0.93); C191(0.91)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C355(1.40)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C191(0.91)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C355(1.14)  LDD1536  [3]
 LDCM0299  AC38 HEK-293T C355(1.07)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C355(1.03)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C355(0.93); C191(0.83)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C355(1.01)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C191(1.05)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C355(1.29)  LDD1545  [3]
 LDCM0308  AC46 HEK-293T C355(0.81)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C355(0.98); C191(0.94)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C355(0.86)  LDD1550  [3]
 LDCM0314  AC51 HEK-293T C191(1.23)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C355(1.15)  LDD1554  [3]
 LDCM0317  AC54 HEK-293T C355(1.02)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C355(1.09); C191(0.93)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C355(0.98)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C191(1.15)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C355(1.26)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C355(1.28)  LDD1563  [3]
 LDCM0326  AC62 HEK-293T C355(1.16)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C355(1.06); C191(1.04)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C355(1.14); C191(0.84)  LDD1569  [3]
 LDCM0356  AKOS034007680 HEK-293T C355(1.08)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C355(0.92); C191(0.90)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C355(0.81)  LDD1572  [3]
 LDCM0371  CL102 HEK-293T C355(1.19)  LDD1575  [3]
 LDCM0375  CL106 HEK-293T C355(0.96)  LDD1579  [3]
 LDCM0380  CL110 HEK-293T C355(0.96)  LDD1584  [3]
 LDCM0384  CL114 HEK-293T C355(0.91)  LDD1588  [3]
 LDCM0388  CL118 HEK-293T C355(1.30)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C355(0.94); C191(0.73)  LDD1594  [3]
 LDCM0393  CL122 HEK-293T C355(1.13)  LDD1597  [3]
 LDCM0397  CL126 HEK-293T C355(0.89)  LDD1601  [3]
 LDCM0401  CL14 HEK-293T C355(1.26)  LDD1605  [3]
 LDCM0404  CL17 HEK-293T C355(0.70)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C191(0.90)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C355(1.06)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C355(1.20)  LDD1612  [3]
 LDCM0410  CL22 HEK-293T C355(0.94)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C355(0.96); C191(0.75)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C355(1.38)  LDD1618  [3]
 LDCM0417  CL29 HEK-293T C355(0.84)  LDD1621  [3]
 LDCM0420  CL31 HEK-293T C191(0.90)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C355(1.13)  LDD1625  [3]
 LDCM0423  CL34 HEK-293T C355(0.86)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C355(1.08); C191(0.84)  LDD1629  [3]
 LDCM0431  CL41 HEK-293T C355(0.96)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C191(0.75)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C355(1.06)  LDD1638  [3]
 LDCM0436  CL46 HEK-293T C355(0.96)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C355(1.15); C191(0.65)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C355(1.20)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C355(1.55)  LDD1645  [3]
 LDCM0444  CL53 HEK-293T C355(0.80)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C191(0.99)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C355(1.18)  LDD1650  [3]
 LDCM0449  CL58 HEK-293T C355(1.13)  LDD1652  [3]
 LDCM0452  CL60 HEK-293T C355(1.24); C191(0.73)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C355(1.63)  LDD1657  [3]
 LDCM0457  CL65 HEK-293T C355(1.12)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C191(1.08)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C355(1.08)  LDD1663  [3]
 LDCM0462  CL7 HEK-293T C191(1.11)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C355(0.97)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C355(1.18); C191(0.73)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C355(1.23)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C355(0.73)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C191(1.02)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C355(0.90)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C355(1.31)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C355(0.81)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C355(0.92); C191(0.73)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C355(1.48)  LDD1683  [3]
 LDCM0483  CL89 HEK-293T C355(0.95)  LDD1686  [3]
 LDCM0486  CL91 HEK-293T C191(0.91)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C355(0.84)  LDD1690  [3]
 LDCM0489  CL94 HEK-293T C355(1.08)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C355(0.99); C191(0.83)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C355(0.99)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C355(0.84)  LDD1631  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Charged multivesicular body protein 4b (CHMP4B) SNF7 family Q9H444
Gelsolin (GSN) Villin/gelsolin family P06396
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587