Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C140  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 96 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 52.7
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 51.6
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 41.1
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 38.9
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 37.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 35.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 29.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 28.1
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 27.1
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 21.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 21.4
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 21.4
 LDTP02359  Heme oxygenase 1 (HMOX1) 20.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 19.7
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 19.7
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 19.2
 LDTP05905  Acid ceramidase (ASAH1) 18.4
 LDTP02837  Beta-galactosidase (GLB1) 18.0
 LDTP02743  Insulin-degrading enzyme (IDE) 17.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 17.4
 LDTP05408  Antigen peptide transporter 1 (TAP1) 16.6
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 16.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 15.9
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 15.2
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) 14.8
 LDTP12490  Sphingosine kinase 2 (SPHK2) 14.6
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 14.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 13.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 13.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 13.6
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 13.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 13.5
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 13.0
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 12.5
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 12.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 12.1
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 12.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 12.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 11.8
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 11.8
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 11.7
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 11.6
 LDTP02505  Lysosomal protective protein (CTSA) 11.3
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 11.3
 LDTP07417  Serine/threonine-protein phosphatase 4 regulatory subunit 3A (PPP4R3A) 11.2
 LDTP03842  Squalene synthase (FDFT1) 11.2
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 11.0
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 10.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 10.6
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 10.4
 LDTP10780  Trimethylguanosine synthase (TGS1) 10.3
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 10.1
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 10.0
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 10.0
 LDTP10329  Ceramide synthase 2 (CERS2) 9.9
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 9.9
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 9.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 9.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.7
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 9.6
 LDTP03145  Catechol O-methyltransferase (COMT) 9.4
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 9.4
 LDTP03394  Ceramide synthase 1 (CERS1) 9.3
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 9.3
 LDTP11887  Tyrosine-protein phosphatase non-receptor type 23 (PTPN23) 9.3
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 9.0
 LDTP02260  Beta-glucuronidase (GUSB) 8.9
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 8.8
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 8.7
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 8.5
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 8.5
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 8.4
 LDTP01769  Dihydrofolate reductase (DHFR) 8.4
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.4
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 8.4
 LDTP01300  Cartilage-associated protein (CRTAP) 8.3
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 8.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 8.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 8.3
 LDTP04183  Lanosterol synthase (LSS) 8.3
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 8.2
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 8.2
 LDTP02539  Lysosomal acid phosphatase (ACP2) 8.2
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 8.2
 LDTP02141  Alpha-galactosidase A (GLA) 8.1
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 8.1
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 8.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 8.1
 LDTP03787  Choline kinase alpha (CHKA) 8.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 8.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 7.9
 LDTP12610  Obg-like ATPase 1 (OLA1) 7.9
 LDTP00325  Pirin (PIR) 7.8
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 7.7
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.7
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 7.7
Transporter and channel
Click to Show/Hide to Show 52 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 83.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 44.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 34.3
 LDTP12383  Protein GPR108 (GPR108) 32.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 26.0
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 24.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 24.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 20.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 20.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 19.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 19.0
 LDTP07236  Protein GPR107 (GPR107) 15.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 15.7
 LDTP11615  Protein tweety homolog 3 (TTYH3) 15.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 15.5
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 15.0
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 14.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 14.7
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 14.3
 LDTP02215  Prosaposin (PSAP) 14.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 14.2
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 12.8
 LDTP10663  Importin-9 (IPO9) 12.6
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 12.6
 LDTP05900  Metaxin-1 (MTX1) 12.4
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 12.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 11.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 11.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 11.0
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 10.0
 LDTP15648  BRI3-binding protein (BRI3BP) 9.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 9.7
 LDTP10036  BOS complex subunit NCLN (NCLN) 9.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 9.4
 LDTP11213  Nucleoporin NDC1 (NDC1) 9.3
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 9.3
 LDTP16813  Tetraspanin-3 (TSPAN3) 9.2
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 8.9
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 8.6
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 8.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 8.3
 LDTP00310  Syntenin-1 (SDCBP) 8.3
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 8.2
 LDTP03380  Stomatin (STOM) 8.2
 LDTP12725  Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB) 8.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 8.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 7.9
 LDTP12451  Integral membrane protein 2C (ITM2C) 7.8
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 7.8
 LDTP09949  Transportin-1 (TNPO1) 7.8
 LDTP11844  Protein spinster homolog 1 (SPNS1) 7.7
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 7.7
Other
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 56.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 34.3
 LDTP05160  Nucleobindin-2 (NUCB2) 26.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 21.3
 LDTP11076  Apolipoprotein L2 (APOL2) 20.7
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 17.4
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 17.3
 LDTP05375  Nucleobindin-1 (NUCB1) 15.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 15.7
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 15.1
 LDTP01075  Protein CutA (CUTA) 14.8
 LDTP13807  PRELI domain-containing protein 1, mitochondrial (PRELID1) 14.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 13.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 12.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 11.5
 LDTP10056  Protein FAM162A (FAM162A) 11.2
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 11.1
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 11.0
 LDTP14458  Tetraspanin-6 (TSPAN6) 10.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 10.6
 LDTP18883  Protein CEBPZOS (CEBPZOS) 10.2
 LDTP14080  U6 snRNA-associated Sm-like protein LSm5 (LSM5) 9.8
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 9.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 9.5
 LDTP18569  PRELI domain containing protein 3B (PRELID3B) 9.4
 LDTP04382  Kinetochore-associated protein 1 (KNTC1) 9.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.9
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 8.9
 LDTP09773  Protein FAM3C (FAM3C) 8.9
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 8.8
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 8.6
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 8.6
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 8.6
 LDTP06097  Reticulocalbin-2 (RCN2) 8.6
 LDTP08594  Negative elongation factor C/D (NELFCD) 8.2
 LDTP04626  UV excision repair protein RAD23 homolog A (RAD23A) 8.2
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 8.0
 LDTP09589  Charged multivesicular body protein 7 (CHMP7) 7.9
 LDTP01450  FERM, ARHGEF and pleckstrin domain-containing protein 2 (FARP2) 7.8
 LDTP15623  Neuferricin (CYB5D2) 7.8
 LDTP15714  Mdm2-binding protein (MTBP) 7.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587