Details of the Target

General Information of Target

Target ID LDTP01707
Target Name Thioredoxin domain-containing protein 12 (TXNDC12)
Gene Name TXNDC12
Gene ID 51060
Synonyms
TLP19; Thioredoxin domain-containing protein 12; EC 1.8.4.2; Endoplasmic reticulum resident protein 18; ER protein 18; ERp18; Endoplasmic reticulum resident protein 19; ER protein 19; ERp19; Thioredoxin-like protein p19; hTLP19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI
IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP
SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum lumen
Function Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.
TTD ID
T36419
Uniprot ID
O95881
DrugMap ID
TTL0E3Y
Ensemble ID
ENST00000371626.9
HGNC ID
HGNC:24626

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Alkylaryl probe 3
 Probe Info  		11.65  LDD0381  [2]
DA-P2
 Probe Info  		11.76  LDD0348  [3]
HRP
 Probe Info  		6.65  LDD0347  [3]
SAA-alkyne
 Probe Info  		1.09  LDD0252  [4]
TH211
 Probe Info  		Y137(20.00)  LDD0257  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K123(20.00)  LDD2219  [7]
Probe 1
 Probe Info  		Y111(10.86); Y137(105.37)  LDD3495  [8]
P12
 Probe Info  		18.87  LDD0202  [9]
P26
 Probe Info  		2.04  LDD0409  [10]
BTD
 Probe Info  		C69(0.31)  LDD2109  [11]
Jackson_1
 Probe Info  		2.45  LDD0120  [12]
MCL-14
 Probe Info  		7.00  LDD0050  [13]
MCL-4
 Probe Info  		1.50  LDD0049  [13]
YY4-yne
 Probe Info  		10.48  LDD0400  [14]
HHS-482
 Probe Info  		Y137(1.02)  LDD0285  [15]
HHS-475
 Probe Info  		Y137(0.87)  LDD0264  [16]
BDBM50514113
 Probe Info  		1.73  LDD0041  [17]
HHS-465
 Probe Info  		Y137(8.71)  LDD2237  [18]
DBIA
 Probe Info  		C66(1.06); C69(1.06)  LDD0078  [19]
5E-2FA
 Probe Info  		N.A.  LDD2235  [20]
IA-alkyne
 Probe Info  		C66(0.00); C69(0.00)  LDD0036  [21]
Lodoacetamide azide
 Probe Info  		C66(0.00); C69(0.00)  LDD0037  [21]
ATP probe
 Probe Info  		N.A.  LDD0035  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
IPM
 Probe Info  		N.A.  LDD0005  [24]
SF
 Probe Info  		N.A.  LDD0028  [25]
Phosphinate-6
 Probe Info  		C66(0.00); C69(0.00)  LDD0018  [26]
1c-yne
 Probe Info  		N.A.  LDD0228  [27]
Acrolein
 Probe Info  		C66(0.00); C69(0.00)  LDD0217  [28]
W1
 Probe Info  		K63(0.00); S53(0.00); H62(0.00)  LDD0236  [29]
TPP-AC
 Probe Info  		N.A.  LDD0427  [30]
PAL-AfBPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C010
 Probe Info  		5.54  LDD1719  [31]
C108
 Probe Info  		8.46  LDD1795  [31]
C140
 Probe Info  		8.11  LDD1822  [31]
C179
 Probe Info  		5.86  LDD1858  [31]
C211
 Probe Info  		14.03  LDD1885  [31]
C220
 Probe Info  		11.55  LDD1894  [31]
C265
 Probe Info  		13.45  LDD1936  [31]
C278
 Probe Info  		50.21  LDD1948  [31]
C290
 Probe Info  		6.15  LDD1960  [31]
C349
 Probe Info  		11.24  LDD2010  [31]
C376
 Probe Info  		6.41  LDD2036  [31]
C423
 Probe Info  		6.63  LDD2078  [31]
C428
 Probe Info  		5.10  LDD2083  [31]
C431
 Probe Info  		15.03  LDD2086  [31]
FFF probe13
 Probe Info  		20.00  LDD0475  [32]
FFF probe3
 Probe Info  		5.73  LDD0465  [32]
JN0003
 Probe Info  		20.00  LDD0469  [32]
SAHA-CA-8PAP
 Probe Info  		5.50  LDD0362  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C69(1.28)  LDD2152  [11]
 LDCM0214  AC1 HCT 116 C66(1.70)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C66(4.14); C69(0.85)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C66(1.10); C69(1.27)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C66(1.03); C69(1.24)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C66(1.00); C69(1.00)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C66(1.27); C69(1.39)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C66(1.18); C69(1.29)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C66(1.16); C69(1.28)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C66(1.08); C69(1.55)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C66(1.33); C69(1.29)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C66(1.34); C69(1.35)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C66(1.15); C69(0.94)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C66(0.99); C69(1.07)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C66(1.03); C69(1.28)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C66(1.21); C69(1.30)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C66(1.28); C69(1.29)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C66(1.05); C69(1.29)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C66(1.32); C69(1.39)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C66(1.44); C69(1.38)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C66(1.27); C69(1.85)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C66(1.34); C69(1.45)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C66(1.10); C69(1.25)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C66(1.06); C69(1.39)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C66(0.87); C69(0.93)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C66(1.29); C69(1.34)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C66(0.88); C69(1.24)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C66(0.81); C69(1.28)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C66(1.19); C69(1.28)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C66(0.93); C69(1.39)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C66(0.93); C69(1.17)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C66(0.93); C69(1.18)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C66(1.07); C69(1.39)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C66(1.19)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C66(1.07)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C66(1.24)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C66(1.01)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C66(1.10)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C66(1.14)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C66(1.30)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C66(1.30)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C66(1.18)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C66(1.14)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C66(1.46)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C66(0.97)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C66(1.06); C69(0.85)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C66(1.24)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C66(1.36)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C66(1.12)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C66(1.02)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C66(1.15)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C66(1.41)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C66(1.20)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C66(1.16)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C66(1.83)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C66(1.45)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C69(0.84); C66(0.87)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C66(1.05)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C66(1.07)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C66(1.28)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C66(1.38)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C66(1.05)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C66(0.87)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C66(0.85)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C66(1.03)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C69(1.09); C66(1.25)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C69(1.23); C66(1.41)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C69(1.07); C66(1.23)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C66(1.54)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C69(1.19); C66(1.25)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C66(1.09); C69(1.22)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C69(1.12); C66(1.18)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C69(1.40); C66(1.85)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C69(1.13); C66(1.38)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C66(1.36)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C66(1.06)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C66(0.87)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C66(1.05)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C66(1.12)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C66(1.41)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C66(0.91)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C66(0.98)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C66(1.20)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C66(0.95)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C66(1.02)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C66(0.95); C69(0.99)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C69(0.90); C66(1.10)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C69(0.81); C66(1.01)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C69(0.91); C66(0.95)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C69(1.00); C66(1.01)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C66(1.34)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C69(1.09); C66(1.24)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C69(1.08); C66(1.37)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C69(1.15); C66(1.16)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C69(1.19); C66(1.33)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C66(1.08); C69(1.14)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C69(1.25); C66(1.25)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C66(1.14); C69(1.21)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C69(0.92); C66(0.94)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C66(1.02); C69(1.04)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C66(1.26); C69(1.30)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C66(1.77)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C69(1.40); C66(1.51)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C69(1.15); C66(1.27)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C69(0.98); C66(1.04)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C69(1.16); C66(1.18)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C66(0.98); C69(1.05)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C66(0.93); C69(1.00)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C69(1.00); C66(1.01)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C66(1.24); C69(1.26)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C66(1.10); C69(1.28)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C66(1.30); C69(1.56)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C69(0.98); C66(10.51)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C66(1.38); C69(1.39)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C66(1.31); C69(1.66)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C66(1.29); C69(1.57)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C66(1.31); C69(1.55)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C66(1.31); C69(1.48)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C69(1.50); C66(1.55)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C66(1.49); C69(1.81)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C69(1.09); C66(1.36)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C66(1.00); C69(1.00)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C66(0.87); C69(1.12)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C69(0.97); C66(1.09)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C66(1.03); C69(1.09)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C66(0.81); C69(1.12)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C66(0.97); C69(1.05)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C66(1.02); C69(1.03)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C66(0.91); C69(1.04)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C66(0.93); C69(0.96)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C66(0.84); C69(0.85)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C69(1.08); C66(1.09)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C66(0.94); C69(1.12)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C66(0.86); C69(1.08)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C69(1.04); C66(7.38)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C66(0.83); C69(1.26)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C66(0.95); C69(1.11)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C66(1.12); C69(1.49)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C69(1.13); C66(2.01)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C69(1.06); C66(1.44)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C69(1.05); C66(1.48)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C69(0.99); C66(1.35)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C69(0.84); C66(1.07)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C69(0.96); C66(1.01)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C66(0.86); C69(0.96)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C66(0.63); C69(0.98)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C69(0.88); C66(1.61)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C66(0.76); C69(0.82)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C66(0.83); C69(0.94)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C69(0.86); C66(1.08)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C69(0.83); C66(1.14)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C66(0.99); C69(1.30)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C69(0.91); C66(2.06)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C69(1.60); C66(3.23)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C69(1.14); C66(1.14)  LDD0683  [19]
 LDCM0248  AKOS034007472 HCT 116 C66(0.71); C69(0.91)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C69(1.11); C66(8.16)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C69(0.94); C66(0.97)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 13.42  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C66(1.06); C69(1.06)  LDD0078  [19]
 LDCM0088  C45 HEK-293T 18.87  LDD0202  [9]
 LDCM0108  Chloroacetamide HeLa H39(0.00); H37(0.00); C69(0.00)  LDD0222  [28]
 LDCM0071  Cisar_cp14 MDA-MB-231 7.62  LDD0121  [12]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.45  LDD0120  [12]
 LDCM0367  CL1 HCT 116 C66(17.63)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C66(18.67)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C66(2.28)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C69(1.44); C66(11.00)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C69(4.23); C66(18.01)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C69(5.29); C66(6.85)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C69(1.76); C66(4.08)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C69(2.30); C66(4.31)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C69(1.73); C66(3.53)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C69(1.42); C66(2.21)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C69(3.02); C66(15.29)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C69(2.60); C66(5.50)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C66(12.88)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C69(2.88); C66(12.53)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C69(3.63); C66(19.91)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C66(1.33)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C66(1.09)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C66(3.80)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C66(9.12)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C66(1.69)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C69(3.40); C66(4.23)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C69(4.63); C66(5.33)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C69(1.37); C66(1.52)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C66(5.43)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C69(1.39); C66(1.55)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C69(1.68); C66(1.90)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C69(1.95); C66(13.03)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C69(1.79); C66(16.44)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C69(1.37); C66(6.05)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C69(1.83); C66(3.07)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C69(3.97); C66(10.81)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C69(12.99); C66(13.68)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C69(4.04); C66(5.48)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C66(16.41)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C66(13.52)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C66(16.87)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C66(11.36)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C69(4.74); C66(18.73)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C69(3.54); C66(12.71)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C69(2.45); C66(4.86)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C66(20.00)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C69(1.81); C66(2.43)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C69(3.54); C66(12.36)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C69(5.59); C66(16.16)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C69(0.75); C66(1.18)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C69(1.46); C66(1.98)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C66(17.90); C69(4.28)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C66(11.62); C69(3.68)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C66(14.44); C69(4.70)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C66(4.20); C69(2.07)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C66(1.51); C69(1.46)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C66(12.02)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C66(1.51); C69(1.08)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C66(11.07); C69(4.11)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C66(15.22)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C66(17.31)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C66(15.30)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C66(11.03)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C66(13.75)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C66(5.21)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C66(16.23)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C66(18.72)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C66(13.66)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C66(3.77)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C66(4.44)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C66(11.10)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C66(11.90)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C66(3.86)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C66(8.97)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C66(18.22)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C66(6.93)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C66(3.44)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C66(13.75)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C66(4.86)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C66(3.13)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C66(4.00)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C66(2.22)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C66(10.51)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C66(4.14)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C66(9.23)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C66(11.44)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C66(1.00)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C66(2.31)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C66(13.54)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C66(11.05)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C66(2.15); C69(3.07)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C66(3.15); C69(0.78)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C66(1.04); C69(1.98)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C66(4.06); C69(1.38)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C66(2.83); C69(3.21)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C66(9.71); C69(1.43)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C66(5.38); C69(2.74)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C66(9.71); C69(1.78)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C66(8.27); C69(2.97)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C66(7.58)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C66(8.44); C69(3.44)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C66(3.44); C69(2.60)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C66(4.76); C69(1.44)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C66(3.93); C69(2.80)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C66(1.64); C69(2.06)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C66(4.69); C69(1.51)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C66(11.73); C69(5.11)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C66(17.09); C69(4.67)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C66(14.28); C69(6.25)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C66(11.46)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C66(13.29); C69(4.55)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C66(10.98); C69(4.26)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C66(14.04); C69(5.36)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C66(13.95); C69(5.21)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C66(15.38); C69(5.80)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C66(7.00); C69(3.89)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C66(13.46); C69(4.78)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C66(17.75); C69(6.50)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C66(10.20); C69(4.75)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C66(17.72); C69(7.00)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C66(14.29)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C66(13.36); C69(4.48)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C66(8.75)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C66(10.39)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C66(8.47)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C66(6.73)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C66(7.57)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C66(4.71)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C66(5.41)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C66(9.40)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C66(7.60)  LDD0811  [19]
 LDCM0495  E2913 HEK-293T C66(30.79)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C66(1.58)  LDD1702  [11]
 LDCM0201  EV-3 T cell C66(5.97)  LDD0515  [35]
 LDCM0574  Fragment12 MDA-MB-231 C66(20.00)  LDD1468  [36]
 LDCM0575  Fragment13 MDA-MB-231 C66(20.00)  LDD1469  [36]
 LDCM0576  Fragment14 MDA-MB-231 C66(1.34)  LDD1471  [36]
 LDCM0468  Fragment33 HCT 116 C66(7.46); C69(0.96)  LDD0785  [19]
 LDCM0596  Fragment38 MDA-MB-231 C66(1.03)  LDD1480  [36]
 LDCM0599  Fragment41 MDA-MB-231 C66(1.04)  LDD1481  [36]
 LDCM0427  Fragment51 HCT 116 C66(13.22)  LDD0744  [19]
 LDCM0571  Fragment9 Ramos C66(20.00)  LDD1464  [36]
 LDCM0116  HHS-0101 DM93 Y137(0.87)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y137(0.74)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y137(0.79)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y137(0.84)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y137(0.71)  LDD0268  [16]
 LDCM0107  IAA HeLa H39(0.00); H37(0.00); C69(0.00); H125(0.00)  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y137(1.02)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y137(0.91)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y137(0.88)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y137(3.99)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y137(1.67)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y137(1.64)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y137(0.59)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y137(0.89)  LDD0292  [15]
 LDCM0022  KB02 HCT 116 C66(20.00); C69(15.71)  LDD0080  [19]
 LDCM0023  KB03 HCT 116 C66(20.00); C69(8.03)  LDD0081  [19]
 LDCM0024  KB05 HCT 116 C66(11.18); C69(7.79)  LDD0082  [19]
 LDCM0006  Micheliolide M9-ENL1 1.50  LDD0049  [13]
 LDCM0109  NEM HeLa H39(0.00); H62(0.00); H37(0.00)  LDD0223  [28]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C69(0.31)  LDD2109  [11]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C66(1.22)  LDD2118  [11]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C69(1.62)  LDD2119  [11]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C69(2.12)  LDD2144  [11]
 LDCM0159  P28 BxPC-3 2.04  LDD0409  [10]
 LDCM0131  RA190 MM1.R C66(1.07)  LDD0304  [37]
 LDCM0096  SAHA K562 5.50  LDD0362  [33]
 LDCM0021  THZ1 HCT 116 C66(1.13); C69(1.13)  LDD2173  [19]
 LDCM0112  W16 Hep-G2 C66(1.95)  LDD0239  [29]
 LDCM0113  W17 Hep-G2 C66(3.29)  LDD0240  [29]
 LDCM0002  Ward_cp1 U2OS 1.73  LDD0041  [17]
 LDCM0154  YY4 T cell 10.48  LDD0400  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) . P49069
Kelch-like protein 2 (KLHL2) . O95198
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein ubi-d4 (DPF2) Requiem/DPF family Q92785
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
10 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
13 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
14 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
30 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
31 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
36 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.