Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | SAHA-CA-8PAP | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | 1 uM | |||||
| Criteria | Quantification: Probe vs (Probe+Competitor) | |||||
| Quantitative Method |
LFQ
|
|||||
| Competitor Name | SAHA | Competitor Info | ||||
| Competitor Concentration | 20 uM | |||||
| In Vivo Experiment Model | Model Type |
|
Cell lysate | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Chronic myeloid leukemia [ICD-11:2A20] | |||||
| Model Name | Human chronic myeloid leukemia cell lysate (K562) | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP13136 | Histone deacetylase 6 (HDAC6) | 37.2 | ||||
| LDTP10828 | 2-aminoethanethiol dioxygenase (ADO) | 31.6 | ||||
| LDTP05918 | Histone deacetylase 1 (HDAC1) | 25.4 | ||||
| LDTP09865 | Histone deacetylase 2 (HDAC2) | 18.7 | ||||
| LDTP11433 | Histone deacetylase 8 (HDAC8) | 17.5 | ||||
| LDTP00957 | Lysine-specific histone demethylase 1A (KDM1A) | 17.3 | ||||
| LDTP08858 | Probable hydrolase PNKD (PNKD) | 11.0 | ||||
| LDTP04374 | Dynamin-2 (DNM2) | 6.5 | ||||
| LDTP18123 | Isochorismatase domain-containing protein 2 (ISOC2) | 5.9 | ||||
| LDTP01707 | Thioredoxin domain-containing protein 12 (TXNDC12) | 5.5 | ||||
| LDTP10951 | Methionine synthase (MTR) | 4.3 | ||||
| LDTP06104 | Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) | 4.1 | ||||
| LDTP00622 | Histone deacetylase 3 (HDAC3) | . | ||||
| LDTP04901 | Ras-related protein Rab-14 (RAB14) | . | ||||
| LDTP04888 | Ras-related protein Rab-8A (RAB8A) | . | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP10663 | Importin-9 (IPO9) | 5.5 | ||||
| LDTP05305 | Large neutral amino acids transporter small subunit 1 (SLC7A5) | 5.5 | ||||
| LDTP01478 | Protein transport protein Sec31A (SEC31A) | 4.7 | ||||
| LDTP00328 | Importin subunit alpha-3 (KPNA4) | 4.5 | ||||
| LDTP05642 | Nuclear pore complex protein Nup160 (NUP160) | 4.0 | ||||
| LDTP05292 | Fatty acid-binding protein 5 (FABP5) | . | ||||
Transcription factor
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP08741 | Mesoderm induction early response protein 1 (MIER1) | . | ||||
| LDTP01414 | Metastasis-associated protein MTA2 (MTA2) | . | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP05567 | Desmocollin-1 (DSC1) | 7.0 | ||||
| LDTP02756 | Junction plakoglobin (JUP) | 5.7 | ||||
| LDTP11709 | Nuclear speckle splicing regulatory protein 1 (NSRP1) | 5.5 | ||||
| LDTP00552 | Actin-related protein 2/3 complex subunit 3 (ARPC3) | 5.0 | ||||
| LDTP06958 | Filaggrin-2 (FLG2) | 5.0 | ||||
| LDTP11890 | Protein unc-45 homolog A (UNC45A) | 4.5 | ||||
| LDTP04518 | DNA mismatch repair protein Msh6 (MSH6) | 4.3 | ||||
| LDTP12680 | Fanconi anemia group I protein (FANCI) | 4.2 | ||||
| LDTP05353 | Desmoglein-1 (DSG1) | 4.1 | ||||
| LDTP11544 | F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) | . | ||||
| LDTP02207 | Involucrin (IVL) | . | ||||
| LDTP10823 | Paired amphipathic helix protein Sin3a (SIN3A) | . | ||||
| LDTP02152 | Protein S100-A9 (S100A9) | . | ||||
| LDTP03493 | Serpin B3 (SERPINB3) | . | ||||
| LDTP19372 | Tetratricopeptide repeat protein 38 (TTC38) | . | ||||
| LDTP05998 | Tubulin beta-2A chain (TUBB2A) | . | ||||