Details of the Target

General Information of Target

Target ID LDTP11544
Target Name F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)
Gene Name TBL1XR1
Gene ID 79718
Synonyms
IRA1; TBLR1; F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN
AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF
LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG
RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM
QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW
LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF
KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE
ETSEFLEQQLTSDIIMSDSYLRPAASPRLES
Target Type
Literature-reported
Target Bioclass
Other
Family
WD repeat EBI family
Subcellular location
Nucleus
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
TTD ID
T89793
Uniprot ID
Q9BZK7
DrugMap ID
TTYXT16
Ensemble ID
ENST00000352800.10
HGNC ID
HGNC:29529

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.62  LDD0402  [1]
TH211
 Probe Info  		Y480(20.00); Y456(11.30)  LDD0257  [2]
TH216
 Probe Info  		Y480(15.60); Y456(8.65); Y446(5.63)  LDD0259  [2]
Probe 1
 Probe Info  		Y446(8.22)  LDD3495  [3]
SAHA-CA-4PAP
 Probe Info  		13.70  LDD0269  [4]
BTD
 Probe Info  		C434(1.45)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C508(2.75)  LDD0170  [6]
HHS-475
 Probe Info  		Y456(0.69)  LDD0264  [7]
DBIA
 Probe Info  		C367(0.90); C490(1.34)  LDD0531  [8]
5E-2FA
 Probe Info  		H478(0.00); H385(0.00)  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C465(0.00); C175(0.00); C434(0.00); C490(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C465(0.00); C175(0.00); C434(0.00); C508(0.00)  LDD0036  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C465(0.00); C175(0.00); C434(0.00); C490(0.00)  LDD0037  [10]
Acrolein
 Probe Info  		C490(0.00); C434(0.00); C367(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		C383(0.00); C434(0.00)  LDD0218  [12]
AOyne
 Probe Info  		14.70  LDD0443  [13]
NAIA_5
 Probe Info  		C465(0.00); C434(0.00); C508(0.00); C490(0.00)  LDD2223  [14]
HHS-465
 Probe Info  		N.A.  LDD2240  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SAHA-CA-8PAP
 Probe Info  		N.A.  LDD0362  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C434(0.51)  LDD2142  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C434(1.74)  LDD2152  [5]
 LDCM0025  4SU-RNA DM93 C508(2.75)  LDD0170  [6]
 LDCM0214  AC1 HCT 116 C367(0.90); C490(1.34)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C434(1.01); C490(0.96)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C383(0.72); C490(0.65)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C383(0.84); C490(0.57)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C383(0.90); C490(0.55)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C383(0.85); C490(0.59)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C383(0.78); C490(0.55)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C383(0.87); C490(0.59)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C383(0.79); C490(0.57)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C383(0.81); C490(0.72)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C383(0.75); C490(0.73)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C383(0.85); C490(0.84)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C434(0.92); C490(1.04)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C383(0.83); C490(0.71)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C383(0.79); C490(0.68)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C383(0.79); C490(0.78)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C383(1.07)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C383(0.75)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C383(0.96)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C383(0.94)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C383(1.05)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C383(0.83)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C383(0.97)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C434(0.92); C490(0.83)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C383(0.86)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C383(1.24)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C383(0.96)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C383(0.73)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C383(1.06)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C383(0.94)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C383(0.77)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C383(0.82)  LDD0562  [8]
 LDCM0246  AC128 PaTu 8988t C434(1.15); C490(1.28)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C434(1.08); C490(0.99)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C434(1.03); C490(0.95)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C434(1.07); C490(1.08)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C434(1.28); C490(1.08)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C434(1.28); C490(1.33)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C434(1.19); C490(1.10)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C434(1.31); C490(1.11)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C434(1.20); C490(1.15)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C434(1.09); C490(1.06)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C434(1.12); C490(1.05)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C434(1.19); C490(1.06)  LDD1137  [8]
 LDCM0259  AC14 HCT 116 C434(1.06); C490(1.08)  LDD0576  [8]
 LDCM0260  AC140 PaTu 8988t C434(1.02); C490(1.14)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C434(1.01); C490(1.11)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C434(0.87); C490(1.00)  LDD1141  [8]
 LDCM0263  AC143 HCT 116 C490(0.94); C367(0.98); C434(1.01); C383(1.07)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C367(0.77); C490(0.91); C434(0.94); C383(1.02)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C490(0.83); C434(0.87); C367(0.89); C383(1.05)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C367(0.89); C490(1.04); C434(1.09); C383(1.23)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C367(0.81); C490(1.03); C383(1.16); C434(1.26)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C367(0.87); C490(0.93); C434(1.23); C383(1.23)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C367(0.86); C490(1.03); C434(1.14); C383(1.21)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C490(0.94); C434(1.00)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C367(0.89); C490(0.98); C434(1.02); C383(1.04)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C367(0.68); C490(0.80); C383(0.96); C434(0.99)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C367(0.72); C490(0.93); C434(1.06); C383(1.09)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C367(0.84); C490(1.00); C383(1.15); C434(1.36)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C367(0.88); C383(1.08); C434(1.12); C490(0.95)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C367(0.77); C383(1.02); C434(1.05); C490(0.94)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C367(1.15); C383(1.07); C434(1.07); C490(0.93)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C367(0.88); C383(0.95); C434(0.95); C490(0.92)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C383(0.95); C490(0.98)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C490(0.96); C383(1.11)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C490(0.90); C383(0.93)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C367(0.80); C490(1.12)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C490(0.99); C383(0.99)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C490(0.93); C383(0.93)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C490(0.93); C383(0.93)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C383(0.84); C490(0.85)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C383(0.89); C490(0.95)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C434(1.03); C490(1.07); C383(1.14)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C490(0.99); C434(1.07); C383(1.17)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C490(1.00); C434(1.12); C383(1.15)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C490(0.88); C383(0.95); C434(1.10)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C490(0.97); C434(1.04); C383(1.10)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C490(1.09); C367(1.15)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C490(1.03); C434(1.07); C383(1.20)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C383(1.12); C434(1.19); C490(1.19)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C490(0.97); C434(1.23); C383(1.24)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C490(0.94); C434(1.08); C383(1.52)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C490(0.99); C383(1.20); C434(1.25)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C490(0.99); C434(1.00); C383(1.02)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C434(0.83); C383(0.94); C490(1.05)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C434(0.88); C383(0.97); C490(1.04)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C434(0.90); C490(0.98); C383(1.09)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C434(0.91); C490(0.98); C383(1.21)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C367(0.98); C490(1.04)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C490(1.01); C434(1.01); C383(1.16)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C383(0.89); C434(0.93); C490(1.00)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C490(0.93); C434(0.94); C383(1.04)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C383(0.95); C434(1.02); C490(1.04)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C434(0.99); C490(1.01); C383(1.13)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C434(0.95); C383(1.01); C490(1.03)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C490(1.05); C383(1.08)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C490(1.07); C383(1.07)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C383(1.29); C490(1.35)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C383(1.02); C490(1.15)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C367(0.82); C490(1.09)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C383(0.90); C490(0.99)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C383(0.91); C490(1.06)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C490(0.88); C383(0.91)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C383(0.99); C490(1.05)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C490(0.96); C383(0.96)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C383(1.04); C490(1.12)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C383(1.02); C490(1.13)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C367(1.24); C383(1.26); C490(1.41)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C367(1.11); C383(1.27); C490(1.32)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C367(0.93); C383(1.19); C490(1.27)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C490(0.90); C434(1.16)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C367(1.39); C383(1.40); C490(1.43)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C383(1.62); C490(1.72); C367(2.09)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C490(1.07); C367(1.08); C383(1.26)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C367(1.05); C383(1.27); C490(1.39)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C367(1.11); C383(1.28); C490(1.35)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C383(1.40); C367(1.46); C490(1.54)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C367(1.25); C383(1.54); C490(1.62)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C367(1.17); C383(1.21); C490(1.35)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C434(1.02); C490(1.22)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C434(1.02); C490(1.17)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C490(0.93); C434(0.94)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C490(0.78); C434(0.81)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C490(0.97); C434(1.06)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C434(0.86); C490(1.03)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C490(0.98); C434(1.03)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C490(1.10); C434(1.22)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C490(0.96); C434(1.01)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C434(0.94); C490(1.13)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C434(1.05); C490(1.09)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C434(1.00); C490(1.20)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C490(0.93); C434(0.99)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C434(0.94); C490(1.07)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C434(0.99); C490(1.00)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C434(1.10); C490(1.20)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C490(0.61); C434(0.68)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C490(0.94)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C490(1.11)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C490(0.92)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C490(0.80)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C490(1.15)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C490(0.78)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C490(0.84)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C490(0.92)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C490(0.78)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C490(0.77)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C490(0.91)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C490(0.90)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C490(1.60)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C490(0.90)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C490(0.75)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C490(0.44); C383(0.77)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C490(0.69); C383(0.80)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C434(1.03); C490(0.90)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C434(0.98); C490(1.00)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C490(1.05); C434(1.09)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 13.14  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C508(0.94); C490(0.98); C434(0.97)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa C367(0.00); C383(0.00); C434(0.00); C490(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C465(0.30)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C490(1.23)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C490(1.15)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C367(0.86); C490(1.05)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C490(0.94); C434(1.07)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C434(0.93); C490(0.98)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C434(0.90); C490(0.92)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C490(0.82); C434(0.91)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C490(0.85); C383(0.90)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C490(1.09); C383(1.26)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C490(0.94); C383(1.06)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C490(0.89); C383(1.05)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C490(0.84); C383(0.86)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C490(1.47)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C490(0.81); C383(0.85)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C383(0.79); C490(0.83)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C490(0.88); C383(1.10); C434(1.18)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C490(0.98); C383(1.05); C434(1.13)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C490(0.95); C434(1.01); C383(1.05)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C490(0.92); C434(1.03); C383(1.07)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C490(0.98); C434(1.14); C383(1.64)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C383(1.03); C490(1.05); C434(1.10)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C434(1.02); C383(1.03); C490(1.07)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C383(0.96); C490(0.97); C434(0.98)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C490(1.79)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C383(0.87); C434(0.94); C490(1.06)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C490(0.98); C383(1.03)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C490(1.00); C383(1.02)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C383(0.83); C490(0.95)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C383(0.97); C490(1.11)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C383(1.18); C367(1.21); C490(1.30)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C367(0.91); C490(1.02); C383(1.03)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C367(0.87); C383(1.06); C490(1.16)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C490(1.08); C383(1.16); C367(1.23)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C490(1.78)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C490(1.25)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C490(1.00)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C490(0.92)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C490(1.17)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C490(2.08)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C490(1.20)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C490(1.74)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C490(1.04)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C490(1.03)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C490(1.33)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C490(0.97)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C490(1.13)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C490(1.10)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C490(0.98)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C490(1.12)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C490(1.03)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C490(1.08)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C490(1.16)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C490(0.99)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C367(0.90); C383(0.87); C490(0.74)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C367(1.23); C383(1.00); C490(1.42)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C367(1.17); C383(0.87); C490(0.84)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C367(0.83); C383(0.92); C490(1.00)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C367(1.08); C383(0.89); C490(0.93)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C367(1.04); C383(0.84); C490(0.90)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C367(0.99); C383(0.85); C490(0.88)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C367(0.97); C383(0.85); C490(0.82)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C490(1.29)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C367(0.87); C383(0.74); C490(0.80)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C367(0.94); C383(0.85); C490(0.96)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C367(0.87); C383(0.77); C490(0.80)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C367(1.08); C383(0.79); C490(1.03)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C367(1.17); C383(0.82); C490(1.07)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C367(1.15); C383(0.92); C490(1.11)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C490(0.91)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C490(0.87)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C490(0.86)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C490(0.83)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C490(0.99)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C490(0.88)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C490(0.92)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C490(0.91)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C490(0.86)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C490(0.85)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C490(0.90)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C490(0.79)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C490(0.77)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C490(0.96)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C490(0.81)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C490(1.66)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C490(0.76)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C367(0.96); C434(0.96)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C367(0.86); C434(0.95)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C367(0.92); C434(1.03)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C367(0.92); C434(1.06)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C367(1.00); C434(1.08)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C367(1.00); C434(1.20)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C367(0.94); C434(1.06)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C367(1.16); C434(1.11)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C367(1.26); C434(1.29)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C490(1.59)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C367(1.01); C434(1.04)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C367(0.85); C434(1.04)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C367(1.12); C434(1.13)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C367(0.91); C434(0.99)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C367(0.88); C434(1.02)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C367(1.38); C490(1.38)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C367(0.67); C490(0.93)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C367(1.11); C490(0.93)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C367(0.98); C490(0.99)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C490(1.26)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C367(1.23); C490(1.61)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C367(1.09); C490(0.93)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C367(1.01); C490(1.10)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C367(1.00); C490(1.05)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C367(1.01); C490(1.12)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C367(0.87); C490(1.00)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C367(1.00); C490(1.04)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C367(0.99); C490(1.05)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C367(0.95); C490(1.18)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C367(0.99); C490(1.33)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C490(1.02)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C367(0.79); C490(0.90)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C367(0.77); C490(0.99)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C367(0.71); C490(0.91)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C367(1.03); C490(0.92)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C367(0.88); C490(0.93)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C367(0.66); C490(0.92)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C367(0.93); C490(0.97)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C367(0.87); C490(1.13)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C367(0.78); C490(1.06)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C367(0.93); C490(0.98)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C434(1.04); C490(1.00); C383(0.93)  LDD1698  [16]
 LDCM0468  Fragment33 HCT 116 C367(0.95); C434(0.92)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C367(0.99); C383(0.88); C490(0.97)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y456(0.69)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y456(0.91)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y456(0.83)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y456(0.88)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y456(0.82)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C383(1.05); C490(0.96); C367(1.00); C434(1.01)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C383(1.02); C490(0.91); C367(0.97); C434(0.97)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C490(1.55); C383(1.25); C571(1.81)  LDD3310  [17]
 LDCM0109  NEM HeLa H441(0.00); H478(0.00)  LDD0223  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C434(1.45)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C434(1.48)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C434(0.39)  LDD2100  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C434(1.26)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C434(0.53)  LDD2114  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C434(1.03)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C434(1.10)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C434(1.51)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C434(1.71)  LDD2135  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C434(1.05)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C434(0.70)  LDD2141  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C434(0.75)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C434(1.13)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C434(0.59)  LDD2150  [5]
 LDCM0131  RA190 MM1.R C367(1.41)  LDD0304  [18]
 LDCM0096  SAHA K562 13.70  LDD0269  [4]
 LDCM0021  THZ1 HCT 116 C508(0.94); C490(0.98); C434(0.97)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
ADP-ribosylation factor-like protein 2 (ARL2) Arf family P36404
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.