Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | SAHA-CA-4PAP | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | 1 uM | |||||
| Criteria | Quantification: Probe vs (Probe+Competitor) | |||||
| Quantitative Method |
LFQ
|
|||||
| Competitor Name | SAHA | Competitor Info | ||||
| Competitor Concentration | 20 uM | |||||
| In Vivo Experiment Model | Model Type |
|
Cell lysate | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Chronic myeloid leukemia [ICD-11:2A20] | |||||
| Model Name | Human chronic myeloid leukemia cell lysate (K562) | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP05918 | Histone deacetylase 1 (HDAC1) | 20.0 | ||||
| LDTP09865 | Histone deacetylase 2 (HDAC2) | 20.0 | ||||
| LDTP00622 | Histone deacetylase 3 (HDAC3) | 20.0 | ||||
| LDTP13136 | Histone deacetylase 6 (HDAC6) | 20.0 | ||||
| LDTP06089 | Eukaryotic initiation factor 4A-II (EIF4A2) | 15.3 | ||||
| LDTP08858 | Probable hydrolase PNKD (PNKD) | 13.0 | ||||
| LDTP10828 | 2-aminoethanethiol dioxygenase (ADO) | 11.5 | ||||
| LDTP00957 | Lysine-specific histone demethylase 1A (KDM1A) | 10.7 | ||||
| LDTP11433 | Histone deacetylase 8 (HDAC8) | 7.0 | ||||
| LDTP12757 | E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) | 5.7 | ||||
| LDTP02260 | Beta-glucuronidase (GUSB) | 5.5 | ||||
| LDTP10935 | Kinesin-like protein KIF2C (KIF2C) | 5.3 | ||||
| LDTP00486 | Cytochrome b-c1 complex subunit 8 (UQCRQ) | 5.0 | ||||
| LDTP18123 | Isochorismatase domain-containing protein 2 (ISOC2) | 4.8 | ||||
| LDTP02848 | NADPH--cytochrome P450 reductase (POR) | 4.5 | ||||
| LDTP01634 | Fatty acid CoA ligase Acsl3 (ACSL3) | 4.3 | ||||
| LDTP04730 | Methionine--tRNA ligase, cytoplasmic (MARS1) | 4.3 | ||||
| LDTP09976 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) | 4.2 | ||||
| LDTP09396 | Minor histocompatibility antigen H13 (HM13) | 4.0 | ||||
| LDTP12586 | Phenylalanine--tRNA ligase beta subunit (FARSB) | 4.0 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP04553 | Tricarboxylate transport protein, mitochondrial (SLC25A1) | 5.5 | ||||
Transcription factor
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP01414 | Metastasis-associated protein MTA2 (MTA2) | 14.0 | ||||
| LDTP08741 | Mesoderm induction early response protein 1 (MIER1) | 11.3 | ||||
| LDTP03903 | Signal transducer and activator of transcription 3 (STAT3) | 4.5 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP19372 | Tetratricopeptide repeat protein 38 (TTC38) | 20.0 | ||||
| LDTP10823 | Paired amphipathic helix protein Sin3a (SIN3A) | 17.0 | ||||
| LDTP11544 | F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) | 13.7 | ||||
| LDTP01156 | Paired amphipathic helix protein Sin3b (SIN3B) | 12.3 | ||||
| LDTP01522 | Reticulon-3 (RTN3) | 9.3 | ||||
| LDTP17159 | Putative heat shock protein HSP 90-beta 4 (HSP90AB4P) | 7.3 | ||||
| LDTP06584 | Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) | 5.5 | ||||
| LDTP03617 | 14-3-3 protein beta/alpha (YWHAB) | 5.3 | ||||
| LDTP05962 | Four and a half LIM domains protein 3 (FHL3) | 4.5 | ||||
| LDTP14012 | Large ribosomal subunit protein eL36 (RPL36) | 4.0 | ||||