Details of the Target

General Information of Target

Target ID LDTP12757
Target Name E3 ubiquitin-protein ligase MARCHF5 (MARCHF5)
Gene Name MARCHF5
Gene ID 54708
Synonyms
MARCH5; RNF153; E3 ubiquitin-protein ligase MARCHF5; EC 2.3.2.27; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153; RING-type E3 ubiquitin transferase MARCHF5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEP
DPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGV
VTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQL
THASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEER
PYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNS
LQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVF
QKS
Target Bioclass
Enzyme
Subcellular location
Mitochondrion outer membrane
Function
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Uniprot ID
Q9NX47
Ensemble ID
ENST00000358935.3
HGNC ID
HGNC:26025

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.08  LDD0402  [1]
P11
 Probe Info  		12.21  LDD0201  [2]
SAHA-CA-4PAP
 Probe Info  		5.70  LDD0269  [3]
BTD
 Probe Info  		C46(1.11)  LDD2119  [4]
Jackson_14
 Probe Info  		2.78  LDD0123  [5]
AHL-Pu-1
 Probe Info  		C188(2.17)  LDD0171  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
DBIA
 Probe Info  		C65(0.96); C68(0.96)  LDD0078  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C46(0.00); C211(0.00); C188(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C211(0.00); C188(0.00); C46(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C46(0.00); C188(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
W1
 Probe Info  		C188(0.00); C46(0.00); C33(0.00)  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C97(0.00); C46(0.00); C211(0.00); C65(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.25  LDD1740  [16]
C056
 Probe Info  		18.90  LDD1753  [16]
C201
 Probe Info  		52.35  LDD1877  [16]
C206
 Probe Info  		20.25  LDD1881  [16]
C285
 Probe Info  		22.94  LDD1955  [16]
C287
 Probe Info  		8.82  LDD1957  [16]
C289
 Probe Info  		42.81  LDD1959  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		13.98  LDD0477  [17]
FFF probe2
 Probe Info  		20.00  LDD0463  [17]
JN0003
 Probe Info  		20.00  LDD0469  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C188(2.65)  LDD0172  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C188(2.17)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C46(1.07); C65(0.77); C68(0.77)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C46(1.03); C65(0.72); C68(0.72)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C14(0.69); C17(0.69); C65(0.37); C68(0.37)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C14(0.64); C17(0.64); C65(0.39); C68(0.39)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C14(0.83); C17(0.83); C65(0.44); C68(0.44)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C14(0.70); C17(0.70); C65(0.30); C68(0.30)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C14(0.61); C17(0.61); C65(0.32); C68(0.32)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C14(0.58); C17(0.58); C65(0.33); C68(0.33)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C14(0.58); C17(0.58); C65(0.32); C68(0.32)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C14(1.02); C17(1.02); C65(0.32); C68(0.36)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C14(4.00); C17(4.00); C65(0.48); C68(0.47)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C14(0.83); C17(0.83); C65(0.44); C68(0.45)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C46(0.77); C65(0.81); C68(0.81)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C14(0.95); C17(0.95); C65(0.38); C68(0.42)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C14(0.82); C17(0.82); C65(0.43); C68(0.42)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C14(0.77); C17(0.77); C65(0.34); C68(0.37)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C14(1.10); C17(0.99); C46(1.10)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C14(0.83); C17(1.02); C46(1.00)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C14(0.91); C17(1.06); C46(1.00)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C14(0.99); C17(1.10); C46(1.04)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C14(1.25); C17(1.02); C46(1.14)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C14(0.94); C17(1.11); C46(1.11)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C14(1.07); C17(0.95); C46(1.16)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C46(1.05); C65(0.97); C68(0.97)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C14(0.80); C17(1.06); C46(0.99)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C14(1.50); C17(1.04); C46(1.26)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C14(0.95); C17(1.03); C46(1.11)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C14(1.92); C17(1.34); C46(1.16)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C14(1.09); C17(1.00); C46(1.19)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C14(0.78); C17(1.06); C46(1.05)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C14(0.89); C17(1.10); C46(1.09)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C14(0.97); C17(1.00); C46(1.21)  LDD0562  [9]
 LDCM0246  AC128 HEK-293T C14(1.57); C46(0.98)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C14(2.06); C46(0.81)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C14(2.25); C46(0.87)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C14(1.09); C46(0.90)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C14(1.01); C46(0.89)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C14(1.57); C46(0.98)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C14(1.67); C46(0.87)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C14(1.44); C46(0.92)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C14(1.71); C46(0.89)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C14(1.90); C46(0.92)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C14(1.99); C46(1.01)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C14(1.87); C46(1.05)  LDD0856  [9]
 LDCM0259  AC14 HCT 116 C46(0.94); C65(0.85); C68(0.85)  LDD0576  [9]
 LDCM0260  AC140 HEK-293T C14(1.65); C46(0.97)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C14(1.58); C46(1.02)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C14(2.20); C46(0.90)  LDD0860  [9]
 LDCM0263  AC143 HEK-293T C46(1.55)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C46(1.53)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C46(1.80)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C46(1.61)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C46(1.80)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C46(1.32)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C46(1.43)  LDD0867  [9]
 LDCM0270  AC15 HCT 116 C65(0.70); C68(0.70); C46(1.12)  LDD0587  [9]
 LDCM0271  AC150 HEK-293T C46(1.66)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C46(1.26)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C46(1.39)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C46(1.33)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C46(1.64)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C46(1.69)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C46(1.69)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C46(1.48)  LDD2165  [9]
 LDCM0276  AC17 HCT 116 C65(0.82); C68(0.82)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C65(0.68); C68(0.68)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C65(0.85); C68(0.85)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C65(0.89); C68(0.89); C46(1.22)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C65(0.82); C68(0.82)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C65(0.73); C68(0.73)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C65(0.90); C68(0.90)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C65(0.65); C68(0.65)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C65(0.99); C68(0.99)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C46(0.97); C65(1.00); C68(1.00)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C65(0.80); C68(0.80); C46(0.97)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C65(0.77); C68(0.77); C46(0.93)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C65(0.82); C68(0.82); C46(0.96)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C65(0.82); C68(0.82); C46(0.88)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C65(0.97); C68(0.97); C46(1.14)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C65(0.84); C68(0.84); C46(0.84)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C65(0.73); C68(0.73); C46(1.09)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C65(0.74); C68(0.74); C46(1.00)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C65(0.80); C68(0.80); C46(0.91)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C65(0.71); C68(0.71); C46(1.00)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C65(1.10); C68(1.10)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C65(0.87); C68(0.87)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C65(1.05); C68(1.05)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C65(0.99); C68(0.99)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C65(0.85); C68(0.85)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C65(0.72); C68(0.72); C46(1.40)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C65(0.84); C68(0.84)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C65(0.83); C68(0.83)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C65(0.83); C68(0.83)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C65(0.73); C68(0.73)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C65(0.97); C68(0.97)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C65(0.97); C68(0.97)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C14(1.09); C17(1.09)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C14(0.89); C17(0.89)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C14(0.79); C17(0.79)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C14(0.83); C17(0.83)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C65(0.84); C68(0.84); C46(1.36)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C14(0.70); C17(0.70)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C14(0.91); C17(0.91)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C14(1.37); C17(1.37)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C14(0.99); C17(0.99)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C14(0.91); C17(0.91)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C14(1.04); C17(1.04)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C14(0.94); C17(0.94)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C68(0.75); C14(0.79); C17(0.79); C65(0.80)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C68(0.68); C65(0.69); C14(0.91); C17(0.91)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C68(0.70); C65(0.74); C14(0.77); C17(0.77)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C65(0.69); C68(0.69); C46(0.94)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C68(0.64); C14(0.65); C17(0.65); C65(0.70)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C14(0.58); C17(0.58); C68(0.65); C65(0.68)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C14(0.54); C17(0.54); C68(0.66); C65(0.68)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C68(0.72); C65(0.75); C14(0.75); C17(0.75)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C14(0.58); C17(0.58); C68(0.74); C65(0.78)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C14(0.58); C17(0.58); C68(0.75); C65(0.76)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C14(0.56); C17(0.56); C68(0.77); C65(0.80)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C14(0.37); C17(0.37); C68(0.70); C65(0.75)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C65(0.86); C68(0.86)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C65(0.82); C68(0.82)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C46(0.89); C65(0.94); C68(0.94)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C65(0.77); C68(0.77)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C65(0.86); C68(0.86)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C65(0.80); C68(0.80)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C65(0.77); C68(0.77)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C65(0.91); C68(0.91)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C65(0.88); C68(0.88)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C65(0.84); C68(0.84)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C65(0.82); C68(0.82)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C65(0.76); C68(0.76)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C65(0.86); C68(0.86)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C65(0.88); C68(0.88); C46(0.93)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C65(0.91); C68(0.91)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C65(0.90); C68(0.90)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C65(0.93); C68(0.93)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C14(0.55); C17(0.55); C65(0.67); C68(0.67)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C14(0.42); C17(0.42); C65(0.64); C68(0.64)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C14(0.51); C17(0.51); C65(0.62); C68(0.62)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C65(0.84); C68(0.84); C14(0.95); C17(0.95)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C14(0.75); C17(0.75); C65(0.91); C68(0.91)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C14(0.75); C17(0.75); C65(0.89); C68(0.89)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C14(0.59); C17(0.59); C65(0.72); C68(0.72)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C65(1.35); C68(1.35); C14(1.38); C17(1.38)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C14(0.47); C17(0.47); C65(0.68); C68(0.68)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C14(0.58); C17(0.58); C65(0.68); C68(0.68)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C14(0.65); C17(0.65); C65(0.81); C68(0.81)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C14(0.49); C17(0.49); C65(0.74); C68(0.74)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C14(0.63); C17(0.63); C65(0.70); C68(0.70)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C14(0.49); C17(0.49); C65(0.64); C68(0.64)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C14(0.56); C17(0.56); C65(0.71); C68(0.71)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C65(0.26); C68(0.26); C14(0.35); C17(0.35)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C65(0.49); C68(0.49); C14(0.71); C17(0.71)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C46(0.90); C65(0.90); C68(0.90)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C46(0.73); C65(0.83); C68(0.83)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C65(0.67); C68(0.67); C46(1.12)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.79  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C65(0.96); C68(0.96)  LDD0078  [9]
 LDCM0088  C45 HEK-293T 12.21  LDD0201  [2]
 LDCM0630  CCW28-3 231MFP C188(1.64)  LDD2214  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C188(0.61)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C65(1.51); C68(1.51)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C65(0.80); C68(0.80)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C65(0.82); C68(0.82); C46(1.00)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C65(0.70); C68(0.70); C46(0.99)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C65(0.95); C68(0.95); C46(1.03)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C65(0.89); C68(0.89); C46(0.92)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C65(0.76); C68(0.76); C46(0.97)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C65(0.68); C68(0.68)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C65(0.55); C68(0.55)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C65(0.64); C68(0.64)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C65(0.63); C68(0.63)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C65(0.75); C68(0.75)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C65(0.95); C68(0.95)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C65(0.67); C68(0.67)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C65(0.73); C68(0.73)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C46(0.98); C65(0.99); C68(0.99)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C65(0.69); C68(0.69); C46(1.02)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C65(0.72); C68(0.72); C46(1.01)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C65(0.83); C68(0.83); C46(1.00)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C65(0.88); C68(0.88); C46(1.02)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C65(0.81); C68(0.81)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C65(0.81); C68(0.81)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C65(0.87); C68(0.87)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C65(0.88); C68(0.88)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C65(0.88); C68(0.88)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C14(2.43); C17(2.43)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C14(0.97); C17(0.97)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C14(1.00); C17(1.00)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C14(0.89); C17(0.89)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C14(0.92); C17(0.92); C68(0.93); C65(0.97)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C68(0.84); C65(0.85); C46(1.00); C14(1.06)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C14(0.79); C17(0.79); C68(0.83); C65(0.84)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C68(0.75); C65(0.79); C14(0.82); C17(0.82)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C65(0.87); C68(0.87)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C65(1.08); C68(1.08)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C65(0.86); C68(0.86)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C14(0.81); C17(0.81); C46(0.85); C65(1.02)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C65(0.83); C68(0.83); C14(0.99); C17(0.99)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C65(0.65); C68(0.65); C46(0.75); C14(1.02)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C65(0.66); C68(0.66); C46(0.87); C14(1.04)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C65(1.46); C68(1.46)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C65(0.71); C68(0.71); C46(0.89); C14(1.01)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C65(0.68); C68(0.68); C14(0.99); C17(0.99)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C65(0.84); C68(0.84); C14(0.99); C17(0.99)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C46(0.73); C65(0.75); C68(0.75); C14(0.98)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C46(0.72); C65(0.74); C68(0.74); C14(1.27)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C14(0.80); C17(0.80); C46(0.67); C65(0.73)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C14(0.73); C17(0.73); C46(0.73); C65(0.88)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C14(1.36); C17(1.36); C46(0.84); C65(0.79)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C14(1.06); C17(1.06); C46(0.77); C65(0.78)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C14(1.24); C17(1.24); C46(0.83); C65(0.68)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C65(1.46); C68(1.46)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C14(1.20); C17(1.20); C46(0.91); C65(0.92)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C65(0.82); C68(0.82)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C14(0.82); C17(0.82); C46(1.01); C65(0.60)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C14(0.80); C17(0.80); C46(0.98); C65(0.48)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C14(0.95); C17(0.95); C46(0.90); C65(0.62)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C14(1.06); C17(1.06); C46(1.25); C65(0.66)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C14(0.94); C17(0.94); C46(0.88); C65(0.67)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C14(0.96); C17(0.96); C46(1.29); C65(0.65)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C14(0.99); C17(0.99); C46(1.12); C65(0.64)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C65(1.14); C68(1.14)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C14(0.85); C17(0.85); C46(0.98); C65(0.61)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C14(0.94); C17(0.94); C46(0.98); C65(0.61)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C14(0.73); C17(0.73); C46(0.88); C65(0.56)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C14(1.01); C17(1.01); C46(1.04); C65(0.61)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C14(1.05); C17(1.05); C46(1.11); C65(0.52)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C14(1.01); C17(1.01); C46(1.21); C65(0.55)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C46(0.96); C65(1.72); C68(1.72)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C46(1.00); C65(1.36); C68(1.36)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C46(0.95); C65(1.48); C68(1.48)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C46(1.10); C65(1.15); C68(1.15)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C65(1.04); C68(1.04)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C46(0.97); C65(1.25); C68(1.25)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C46(1.02); C65(1.19); C68(1.19)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C46(1.05); C65(1.21); C68(1.21)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C46(0.88); C65(1.20); C68(1.20)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C46(0.92); C65(1.40); C68(1.40)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C46(0.93); C65(1.38); C68(1.38)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C46(1.02); C65(1.20); C68(1.20)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C46(1.12); C65(1.32); C68(1.32)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C46(0.91); C65(1.28); C68(1.28)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C46(1.23); C65(1.14); C68(1.14)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C65(0.87); C68(0.87)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C46(1.02); C65(1.11); C68(1.11)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C46(0.90); C65(0.86); C68(0.86)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C46(0.86); C65(0.86); C68(0.86)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C46(0.75); C65(0.81); C68(0.81)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C46(1.03); C65(0.71); C68(0.71)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C46(0.88); C65(0.82); C68(0.82)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C46(0.96); C65(0.74); C68(0.74)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C46(0.87); C65(0.71); C68(0.71)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C46(0.64); C65(0.70); C68(0.70)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C46(0.85); C65(0.75); C68(0.75)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C65(0.88); C68(0.88)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C46(0.83); C65(0.72); C68(0.72)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C46(0.84); C65(0.77); C68(0.77)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C46(0.71); C65(0.87); C68(0.87)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C46(0.75); C65(0.80); C68(0.80)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C46(0.78); C65(0.71); C68(0.71)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C46(1.10); C65(0.67); C68(0.67)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C46(0.95); C65(0.89); C68(0.89)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C46(0.92); C65(0.81); C68(0.81)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C46(1.02); C65(0.58); C68(0.58)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C65(0.89); C68(0.89)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C46(0.87); C65(0.67); C68(0.67)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C46(0.87); C65(0.64); C68(0.64)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C46(0.96); C65(0.61); C68(0.61)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C46(1.07); C65(0.55); C68(0.55)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C46(0.94); C65(0.68); C68(0.68)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C46(0.75); C65(0.75); C68(0.75)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C46(0.85); C65(0.94); C68(0.94)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C46(1.13); C65(0.77); C68(0.77)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C46(0.94); C65(0.66); C68(0.66)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C46(0.79); C65(0.71); C68(0.71)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C65(0.92); C68(0.92)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C46(0.91); C65(1.08); C68(1.08)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C46(1.12); C65(0.89); C68(0.89)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C46(1.14); C65(0.98); C68(0.98)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C46(1.55); C65(0.92); C68(0.92)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C46(0.94); C65(0.67); C68(0.67)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C46(1.57); C65(0.71); C68(0.71)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C46(1.26); C65(0.85); C68(0.85)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C46(1.15); C65(0.87); C68(0.87)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C46(1.08); C65(0.78); C68(0.78)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C46(0.96); C65(0.85); C68(0.85)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C211(1.04); C188(0.93); C33(0.93); C65(1.11)  LDD1698  [19]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0625  F8 Ramos C188(0.76)  LDD2187  [20]
 LDCM0573  Fragment11 Ramos C188(0.37)  LDD2190  [20]
 LDCM0575  Fragment13 Ramos C188(0.48)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C188(0.36)  LDD2193  [20]
 LDCM0580  Fragment21 Ramos C188(0.27)  LDD2195  [20]
 LDCM0578  Fragment27 Ramos C188(0.99)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C188(0.27)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C188(0.33)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C188(0.35)  LDD2200  [20]
 LDCM0468  Fragment33 HCT 116 C46(0.96); C65(0.83); C68(0.83)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C188(1.16)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C188(0.43)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C14(0.98); C17(0.98); C46(1.02); C65(0.61)  LDD0744  [9]
 LDCM0614  Fragment56 Ramos C188(0.68)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C188(0.59)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C188(0.74)  LDD2188  [20]
 LDCM0022  KB02 HCT 116 C65(1.22); C68(1.22)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C65(2.73); C68(2.73)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C65(1.59); C68(1.59)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0227  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C46(1.11)  LDD2119  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C46(1.28)  LDD2129  [4]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.78  LDD0123  [5]
 LDCM0096  SAHA K562 5.70  LDD0269  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) Protein-tyrosine phosphatase family P54829
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Mitofusin-2 (MFN2) Dynamin/Fzo/YdjA family O95140
Ubiquitin-conjugating enzyme E2 W (UBE2W) Ubiquitin-conjugating enzyme family Q96B02
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) Zinc-containing alcohol dehydrogenase family Q8WWV3
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 139 (TMEM139) . Q8IV31
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Density-regulated protein (DENR) DENR family O43583
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Vesicle transport protein SEC20 (BNIP1) SEC20 family Q12981
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Protein MANBAL (MANBAL) UPF0239 family Q9NQG1
Protein YIF1A (YIF1A) YIF1 family O95070
Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) . Q68DC2
Bcl-2-interacting killer (BIK) . Q13323
Cell growth regulator with RING finger domain protein 1 (CGRRF1) . Q99675
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Outer dense fiber protein 4 (ODF4) . Q2M2E3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578