Probe Name	Jackson_14					Probe Info
Probe concentration	10 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	SILAC
Competitor Name	Ranjitkar_cp1					Competitor Info
Competitor Concentration	10 uM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Breast
	Disease Model		Breast adenocarcinoma [ICD-11:2C60]
	Model Name		Human breast adenocarcinoma cells (MDA-MB-231)

Target ID	Target Name					Binding Ratio
LDTP07762	Hydroxysteroid dehydrogenase-like protein 2 (HSDL2)					33.3
LDTP09749	Titin (TTN)					20.0
LDTP03163	Sterol carrier protein 2 (SCP2)					12.5
LDTP02264	Asparagine synthetase [glutamine-hydrolyzing] (ASNS)					11.1
LDTP01165	NADH dehydrogenase iron-sulfur protein 7, mitochondrial (NDUFS7)					5.9
LDTP10887	Synaptic vesicle membrane protein VAT-1 homolog (VAT1)					5.0
LDTP05066	Signal peptidase complex catalytic subunit SEC11A (SEC11A)					4.0
LDTP05434	Lactoylglutathione lyase (GLO1)					3.8
LDTP06608	Cytochrome P450 1B1 (CYP1B1)					3.6
LDTP04353	Protoporphyrinogen oxidase (PPOX)					3.4
LDTP08061	Cytochrome P450 2U1 (CYP2U1)					3.3
LDTP19892	DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68)					3.3
LDTP03319	3-mercaptopyruvate sulfurtransferase (MPST)					3.0
LDTP01687	Apoptosis-inducing factor 1, mitochondrial (AIFM1)					3.0
LDTP05476	3-ketodihydrosphingosine reductase (KDSR)					2.9
LDTP08209	Acyl-coenzyme A thioesterase 1 (ACOT1)					2.9
LDTP04291	Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)					2.9
LDTP00589	Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3)					2.9
LDTP12538	Ras-related protein Rab-6B (RAB6B)					2.9
LDTP12757	E3 ubiquitin-protein ligase MARCHF5 (MARCHF5)					2.8
LDTP06631	NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9)					2.6
LDTP03051	Ras-related protein Rab-6A (RAB6A)					2.6
LDTP14427	Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L)					2.6
LDTP03560	Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)					2.5
LDTP02557	Ras-related protein Ral-A (RALA)					2.4
LDTP05905	Acid ceramidase (ASAH1)					2.4
LDTP05077	Casein kinase II subunit alpha (CSNK2A1)					2.4
LDTP01772	Cytochrome c oxidase subunit 1 (MT-CO1)					2.4
LDTP00407	Prostaglandin E synthase (PTGES)					2.4
LDTP06617	Ceramide glucosyltransferase (UGCG)					2.3
LDTP10329	Ceramide synthase 2 (CERS2)					2.3
LDTP12954	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3)					2.3
LDTP03445	Mitogen-activated protein kinase 1 (MAPK1)					2.3
LDTP05348	Sterol 26-hydroxylase, mitochondrial (CYP27A1)					2.3
LDTP04671	Trifunctional enzyme subunit beta, mitochondrial (HADHB)					2.3
LDTP03230	Tyrosine-protein kinase JAK1 (JAK1)					2.3
LDTP13189	Cytochrome b-c1 complex subunit 9 (UQCR10)					2.2
LDTP06006	Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)					2.2
LDTP07679	Lysocardiolipin acyltransferase 1 (LCLAT1)					2.2
LDTP07591	Neutral cholesterol ester hydrolase 1 (NCEH1)					2.2
LDTP04203	Phosphatidylserine synthase 1 (PTDSS1)					2.2
LDTP03469	Tripeptidyl-peptidase 2 (TPP2)					2.2
LDTP10514	Cytosolic non-specific dipeptidase (CNDP2)					2.1
LDTP04561	ATP-citrate synthase (ACLY)					2.1
LDTP03511	Flavin reductase (NADPH) (BLVRB)					2.1
LDTP01168	NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2)					2.1
LDTP06192	Neutral alpha-glucosidase AB (GANAB)					2.1
LDTP05623	Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2)					2.1
LDTP02096	Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB)					2.1
LDTP06501	Ras-related protein Rab-11B (RAB11B)					2.1
LDTP07813	Sulfhydryl oxidase 2 (QSOX2)					2.1
LDTP00769	Peptidyl-prolyl cis-trans isomerase H (PPIH)					2.0
LDTP04893	Ras-related protein Rab-5B (RAB5B)					2.0
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)					2.0
LDTP05449	Tyrosine-protein phosphatase non-receptor type 12 (PTPN12)					2.0
LDTP00186	Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS)					2.0
LDTP01773	Cytochrome c oxidase subunit 2 (MT-CO2)					2.0
LDTP12803	Dipeptidyl peptidase 3 (DPP3)					2.0
LDTP08728	Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1)					2.0

Target ID	Target Name					Binding Ratio
LDTP13824	Voltage-dependent anion-selective channel protein 3 (VDAC3)					8.3
LDTP09789	Transmembrane 9 superfamily member 4 (TM9SF4)					5.0
LDTP03869	Protein Mpv17 (MPV17)					4.5
LDTP00592	Surfeit locus protein 4 (SURF4)					4.5
LDTP02215	Prosaposin (PSAP)					4.3
LDTP03132	Voltage-dependent anion-selective channel protein 1 (VDAC1)					3.6
LDTP12526	Oligosaccharyltransferase complex subunit OSTC (OSTC)					3.4
LDTP01574	Importin-7 (IPO7)					3.3
LDTP01631	Mitochondrial pyruvate carrier 2 (MPC2)					3.2
LDTP03064	Cytochrome c oxidase subunit 5A, mitochondrial (COX5A)					2.8
LDTP13599	Calcium load-activated calcium channel (TMCO1)					2.6
LDTP04849	CD81 antigen (CD81)					2.6
LDTP12331	Endoplasmic reticulum membrane protein complex subunit 7 (EMC7)					2.6
LDTP04071	Voltage-dependent anion-selective channel protein 2 (VDAC2)					2.6
LDTP03284	ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB)					2.5
LDTP10985	Equilibrative nucleoside transporter 1 (SLC29A1)					2.5
LDTP12958	ER membrane protein complex subunit 3 (EMC3)					2.5
LDTP10731	Sodium-coupled neutral amino acid symporter 2 (SLC38A2)					2.5
LDTP16136	Claudin domain-containing protein 1 (CLDND1)					2.3
LDTP11869	Growth hormone-inducible transmembrane protein (GHITM)					2.2
LDTP05443	Proteolipid protein 2 (PLP2)					2.2
LDTP09547	Scavenger receptor class B member 1 (SCARB1)					2.2
LDTP12090	Sideroflexin-1 (SFXN1)					2.2
LDTP01525	Mitochondrial proton/calcium exchanger protein (LETM1)					2.1
LDTP04553	Tricarboxylate transport protein, mitochondrial (SLC25A1)					2.1
LDTP06275	Lysosomal-associated transmembrane protein 4A (LAPTM4A)					2.1
LDTP07472	Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24)					2.1
LDTP04932	Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1)					2.1
LDTP01601	Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)					2.0
LDTP00310	Syntenin-1 (SDCBP)					2.0
LDTP05529	Bcl-2-like protein 1 (BCL2L1)					2.0
LDTP05394	Caveolin-1 (CAV1)					2.0
LDTP02018	Major prion protein (PRNP)					2.0
LDTP14235	Mitochondrial carrier homolog 2 (MTCH2)					2.0
LDTP01352	PRA1 family protein 3 (ARL6IP5)					2.0
LDTP11760	Protein unc-93 homolog B1 (UNC93B1)					2.0

Target ID	Target Name					Binding Ratio
LDTP09694	Paraspeckle component 1 (PSPC1)					2.1

Target ID	Target Name					Binding Ratio
LDTP05973	CD166 antigen (ALCAM)					2.4
LDTP02491	HLA class I histocompatibility antigen, C alpha chain (HLA-C)					2.0

Target ID	Target Name					Binding Ratio
LDTP02674	Keratin, type I cytoskeletal 10 (KRT10)					16.7
LDTP02031	Keratin, type II cytoskeletal 1 (KRT1)					16.7
LDTP03755	Keratin, type I cytoskeletal 9 (KRT9)					14.3
LDTP05424	Keratin, type I cytoskeletal 17 (KRT17)					8.3
LDTP01930	Keratin, type I cytoskeletal 14 (KRT14)					7.7
LDTP02308	Keratin, type I cytoskeletal 16 (KRT16)					7.7
LDTP02974	Keratin, type I cytoskeletal 15 (KRT15)					5.9
LDTP12755	OCIA domain-containing protein 1 (OCIAD1)					4.5
LDTP11167	Protein YIPF4 (YIPF4)					3.7
LDTP13797	HIG1 domain family member 1A, mitochondrial (HIGD1A)					3.2
LDTP05974	Laminin subunit beta-3 (LAMB3)					3.0
LDTP13839	Nck-associated protein 1 (NCKAP1)					2.9
LDTP06291	ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1)					2.6
LDTP12677	DnaJ homolog subfamily C member 11 (DNAJC11)					2.6
LDTP11894	DnaJ homolog subfamily C member 5 (DNAJC5)					2.6
LDTP02756	Junction plakoglobin (JUP)					2.6
LDTP13532	Malignant T-cell-amplified sequence 1 (MCTS1)					2.6
LDTP10056	Protein FAM162A (FAM162A)					2.6
LDTP05697	Heat shock protein 75 kDa, mitochondrial (TRAP1)					2.5
LDTP02085	Plasminogen activator inhibitor 1 (SERPINE1)					2.5
LDTP00323	CCN family member 1 (CCN1)					2.3
LDTP04557	Arfaptin-2 (ARFIP2)					2.3
LDTP03968	Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO)					2.3
LDTP06948	Protein YIF1B (YIF1B)					2.3
LDTP03399	CD82 antigen (CD82)					2.2
LDTP13260	LIM domain and actin-binding protein 1 (LIMA1)					2.2
LDTP02306	Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)					2.2
LDTP00698	U4/U6 small nuclear ribonucleoprotein Prp4 (PRPF4)					2.2
LDTP15976	Large ribosomal subunit protein mL46 (MRPL46)					2.1
LDTP10924	Prohibitin-2 (PHB2)					2.1
LDTP11210	Transmembrane protein 43 (TMEM43)					2.1
LDTP06121	Caprin-1 (CAPRIN1)					2.1
LDTP09082	LEM domain-containing protein 2 (LEMD2)					2.1
LDTP10015	GPI transamidase component PIG-T (PIGT)					2.0
LDTP07718	MICOS complex subunit MIC27 (APOOL)					2.0
LDTP03503	Myristoylated alanine-rich C-kinase substrate (MARCKS)					2.0
LDTP03712	Catenin beta-1 (CTNNB1)					2.0
LDTP05719	Cleavage stimulation factor subunit 3 (CSTF3)					2.0
LDTP09773	Protein FAM3C (FAM3C)					2.0
LDTP10285	Small ribosomal subunit protein mS39 (PTCD3)					2.0
LDTP02683	Translationally-controlled tumor protein (TPT1)					2.0

1	Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.