Details of the Target

General Information of Target

Target ID LDTP05973
Target Name CD166 antigen (ALCAM)
Gene Name ALCAM
Gene ID 214
Synonyms
MEMD; CD166 antigen; Activated leukocyte cell adhesion molecule; CD antigen CD166
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEK
PDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDN
VFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPL
EGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVF
DIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTL
TDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASR
NATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKM
TKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEEN
VTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAA
LVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Subcellular location
Secreted; Cell membrane
Function
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts . Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal hematopoietic stem cell engraftment in the bone marrow. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons.; [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
TTD ID
T73404
Uniprot ID
Q13740
DrugMap ID
TT2AFT6
Ensemble ID
ENST00000306107.9
HGNC ID
HGNC:400
ChEMBL ID
CHEMBL4665584

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G166D; p.Y224C .
ICC137 SNV: p.A183S DBIA    Probe Info 
KYSE410 SNV: p.H178Q .
MM1S SNV: p.A6P .
NCIH2172 SNV: p.D213Y .
NCIH358 SNV: p.G155C DBIA    Probe Info 
RKO Deletion: p.K153SfsTer34 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		12.59  LDD0318  [1]
STPyne
 Probe Info  		K419(6.25); K423(10.00); K55(7.60); K559(7.18)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K87(1.41); K60(2.97); K76(6.62); K75(9.89)  LDD3494  [3]
DBIA
 Probe Info  		C270(3.38); C76(1.80)  LDD3311  [4]
BTD
 Probe Info  		C313(1.05)  LDD2091  [5]
Jackson_14
 Probe Info  		2.44  LDD0123  [6]
FBP2
 Probe Info  		2.30  LDD0053  [1]
Acrolein
 Probe Info  		C392(0.00); C43(0.00)  LDD0222  [7]
ATP probe
 Probe Info  		K55(0.00); K57(0.00); K423(0.00); K403(0.00)  LDD0199  [8]
m-APA
 Probe Info  		H383(0.00); H436(0.00); H330(0.00)  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C392(0.00); C270(0.00); C313(0.00)  LDD0037  [10]
NHS
 Probe Info  		K55(0.00); K60(0.00)  LDD0010  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		20.68  LDD1838  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C313(0.97)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C435(0.70)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C435(1.15)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C435(1.07)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C313(0.75)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C313(0.98)  LDD2131  [5]
 LDCM0214  AC1 HEK-293T C354(1.21); C435(1.05)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C435(1.04)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C354(1.21)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C354(1.37); C313(1.07); C113(0.89)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C354(1.05); C313(1.15); C113(1.17)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C354(0.90)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C354(1.27); C435(1.07)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C435(1.10)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C354(1.07)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C435(1.02)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C354(1.01); C313(1.01); C113(0.68)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C113(1.08)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C354(1.01); C313(0.96); C113(0.81)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C354(1.09)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C354(0.97); C435(0.99); C313(0.91)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C354(1.13); C435(1.06)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C435(0.96)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C354(1.06)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C354(1.03); C313(1.01); C113(0.79)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C113(1.08)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C354(0.87)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C354(1.01); C313(0.96); C113(0.86)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C354(0.98)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C354(1.02); C435(1.07); C313(1.05)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C354(1.05); C435(1.15)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C435(1.08)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C354(1.43)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C354(0.84); C313(1.11); C113(0.85)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C113(1.12)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C354(1.05); C313(1.19); C113(0.79)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C354(0.92)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C354(1.07); C313(1.13); C113(0.80)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C354(1.00); C435(1.11); C313(1.06)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C354(1.01); C435(1.14)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C435(1.13)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C354(0.90)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C354(1.04); C313(1.12); C113(1.14)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C113(1.18)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C354(0.95); C313(1.11); C113(0.82)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C354(1.01)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C354(1.09); C435(1.08); C313(1.01)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C354(1.16); C435(1.21)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C113(0.97)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C435(1.07)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C354(0.84)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C354(1.51); C313(1.05); C113(0.98)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C113(1.06)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C354(1.05); C313(1.12); C113(0.83)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C354(1.00)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C354(0.92); C435(1.06); C313(1.00)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C354(1.43); C435(1.22)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C435(1.11)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C354(1.10)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C354(1.02); C313(1.01); C113(0.83)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C354(1.00); C313(1.10); C113(1.05)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C113(0.77)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C354(1.07); C313(1.18); C113(0.92)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C354(0.88)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C354(1.05); C435(1.07); C313(1.12)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C354(0.91)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C354(1.13); C435(1.06); C313(1.03)  LDD1569  [14]
 LDCM0520  AKOS000195272 MDA-MB-231 C435(0.98)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C113(1.10)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C354(1.13); C435(1.17)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C354(1.01); C435(1.03); C313(1.09)  LDD1514  [14]
 LDCM0498  BS-3668 MDA-MB-231 C313(1.05)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C392(0.00); C43(0.00)  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C354(1.06)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C354(0.95); C313(0.95); C113(1.38)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C354(1.14); C435(1.04)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C354(1.10)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C354(1.06)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C354(0.97)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C354(1.16); C435(1.04)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C354(1.09)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C354(1.22)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C354(1.08)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C354(0.92); C435(1.08)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C354(1.06)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C354(0.94)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C354(1.02)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C354(1.06)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C354(1.44); C435(1.06)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C354(1.19)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C354(1.16)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C354(0.85)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C354(1.13); C435(1.03)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C354(1.17)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C354(0.94)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C354(0.89)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C354(1.00); C435(1.08); C313(0.73)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C354(1.31); C435(1.02)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C354(1.07)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C354(1.16)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C354(0.86)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C354(1.21); C435(1.06)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C354(1.11)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C354(1.39)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C354(1.23)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C354(0.95); C435(1.04)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C354(1.15)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C354(1.18)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C354(1.06)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C354(1.24); C435(1.07)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C354(1.04); C435(1.11)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C435(1.12)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C354(1.08)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C354(0.94)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C354(1.50); C313(0.87); C113(0.63)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C113(1.14)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C354(1.07); C313(0.87); C113(1.19)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C354(0.92)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C354(1.03); C435(1.07); C313(0.73)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C354(0.95)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C354(1.20)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C354(0.87)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C354(1.02); C435(0.93)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C354(1.08); C435(1.00)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C354(0.96)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C435(0.98)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C354(1.05)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C354(0.87); C313(0.88); C113(0.77)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C113(0.78)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C354(1.02); C313(0.80); C113(0.92)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C354(0.85)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C354(1.15); C435(1.12); C313(0.69)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C354(1.45)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C354(1.07)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C354(1.30); C435(1.02)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C354(1.02); C435(1.01)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C354(1.16); C435(1.07)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C435(1.06)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C354(0.95)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C354(1.32); C313(0.94); C113(0.93)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C113(1.06)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C354(0.99); C313(0.81); C113(1.10)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C354(0.89)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C354(1.04); C435(1.06); C313(0.73)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C354(1.50)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C354(1.14); C435(1.23)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C354(1.03)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C354(1.27); C435(0.97)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C354(1.26); C435(1.01)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C435(1.05)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C354(1.26)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C354(0.99); C313(0.93); C113(0.83)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C113(0.83)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C354(0.96); C313(1.02); C113(0.76)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C354(0.98)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C435(1.14)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C354(1.13); C435(1.06); C313(0.68)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C354(1.21)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C354(0.92)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C354(1.11)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C354(1.17); C435(1.00)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C354(1.07); C435(1.25)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C435(1.06)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C354(1.10)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C354(1.15); C313(0.93); C113(0.89)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C113(0.97)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C354(1.05)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C354(1.15); C313(1.03); C113(0.85)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C354(0.97)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C354(1.13); C435(1.02); C313(0.75)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C354(1.03)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C354(0.91)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C354(1.22); C435(0.95)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C354(1.21); C435(1.14)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C435(1.00)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C354(1.17)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C354(0.98); C313(1.15); C113(0.93)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C354(1.24); C313(0.95); C113(0.99)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C113(1.62)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C354(1.16); C313(0.95); C113(0.95)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C354(0.90)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C354(0.87); C435(1.05); C313(0.83)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C354(0.97)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C354(1.27)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C354(1.07)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C354(1.45); C435(1.01)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C354(1.24); C435(1.14)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C113(1.30)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C435(1.03)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C354(1.02)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C354(0.87); C313(1.18); C113(0.79)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C113(1.00)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C354(1.00); C313(1.02); C113(0.76)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C354(0.96)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C354(1.17); C435(1.12); C313(1.06)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C354(1.03)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C354(1.35)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C354(1.03)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C354(0.89)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C354(1.24)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C354(1.22)  LDD1631  [14]
 LDCM0022  KB02 HEK-293T C354(0.99); C157(0.99)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C354(0.98); C157(1.18)  LDD1497  [14]
 LDCM0024  KB05 G361 C270(3.38); C76(1.80)  LDD3311  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C313(0.75)  LDD2121  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C435(0.98)  LDD2094  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C435(0.57); C354(0.88); C43(0.46)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C435(1.63)  LDD2101  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C354(0.72)  LDD2107  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C435(0.64); C354(0.49)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C435(0.95)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C435(0.35); C313(0.52)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C435(0.80)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C354(0.62)  LDD2125  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C435(0.63)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C435(0.88)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C435(1.01)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C435(0.63)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C435(0.89); C354(0.76)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C435(0.63)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C354(0.75)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C435(0.97)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C435(0.60); C313(1.37)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C435(0.95); C354(0.91)  LDD2148  [5]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.44  LDD0123  [6]
 LDCM0008  Tranylcypromine SH-SY5Y 2.30  LDD0053  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-cell differentiation antigen CD6 (CD6) . P30203
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galectin-3 (LGALS3) . P17931
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD166 antigen (ALCAM) . Q13740
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galectin-1 (LGALS1) . P09382

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cx2009 Probody drug conjugate D1PC9J

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402