Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0008
Competitor Name
Tranylcypromine
Synonyms
SCHEMBL2755938; AB01566946_01
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 133.19
Lipid-water partition coefficient (xlogp) 1.5
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 1
Chemical Identifiers
Formula
C9H11N
IUPAC Name
(1S)-2-phenylcyclopropan-1-amine
Canonical SMILES
C1C(C1N)C2=CC=CC=C2
InChI
InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8?,9-/m0/s1
InChIKey
AELCINSCMGFISI-GKAPJAKFSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 2 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
FBP2
 Probe Info  		100 uM Human neuroblastoma cells (SH-SY5Y) [1]
FBPP2
 Probe Info  		10 uM Human endocervical adenocarcinoma cell lysate (HeLa) [1]

Target(s) List of this Competitor

41 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ADP-ribose glycohydrolase MACROD1 (MACROD1) LDTP11059 8.43  LDD0054 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 2.76  LDD0320 
Aldehyde dehydrogenase, mitochondrial (ALDH2) LDTP02074 2.35  LDD0320 
Alpha-galactosidase A (GLA) LDTP02141 4.00  LDD0054 
Alpha-L-iduronidase (IDUA) LDTP03748 3.52  LDD0054 
Alpha-N-acetylgalactosaminidase (NAGA) LDTP02883 2.40  LDD0054 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 2.07  LDD0054 
Amine oxidase [flavin-containing] A (MAOA) LDTP03109 9.22  LDD0320 
Arylsulfatase B (ARSB) LDTP02807 2.09  LDD0054 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 2.97  LDD0054 
Beta-hexosaminidase subunit beta (HEXB) LDTP02216 2.99  LDD0054 
Beta-mannosidase (MANBA) LDTP00282 2.11  LDD0054 
Carboxypeptidase E (CPE) LDTP02865 2.17  LDD0054 
Cathepsin B (CTSB) LDTP02223 3.35  LDD0054 
Cathepsin D (CTSD) LDTP02198 2.44  LDD0053 
Cathepsin F (CTSF) LDTP13172 3.86  LDD0054 
Deoxyribonuclease-2-alpha (DNASE2) LDTP00185 2.33  LDD0054 
Di-N-acetylchitobiase (CTBS) LDTP14801 7.33  LDD0054 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 2.24  LDD0054 
Dipeptidyl peptidase 2 (DPP7) LDTP13294 3.29  LDD0054 
Gamma-glutamyl hydrolase (GGH) LDTP09886 2.29  LDD0054 
Legumain (LGMN) LDTP10888 3.27  LDD0054 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 2.45  LDD0054 
Lysosomal acid phosphatase (ACP2) LDTP02539 2.01  LDD0054 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 7.62  LDD0054 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 3.57  LDD0054 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 6.72  LDD0054 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 4.10  LDD0054 
Phospholipase A2 group XV (PLA2G15) LDTP09088 2.80  LDD0054 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 8.98  LDD0054 
Pro-cathepsin H (CTSH) LDTP02366 5.70  LDD0054 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 3.74  LDD0054 
Procathepsin L (CTSL) LDTP02217 7.07  LDD0054 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 5.46  LDD0054 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 5.29  LDD0054 
Ribonuclease T2 (RNASET2) LDTP00316 3.61  LDD0054 
Sialate O-acetylesterase (SIAE) LDTP12135 4.18  LDD0054 
Sialidase-1 (NEU1) LDTP10884 13.03  LDD0054 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 2.76  LDD0054 
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) LDTP04255 2.02  LDD0054 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 2.80  LDD0054 
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⏷ Show the Full List of 41 Enzyme
13 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ADP-ribosylation factor-binding protein GGA3 (GGA3) LDTP12874 4.93  LDD0054 
Bax inhibitor 1 (TMBIM6) LDTP04663 2.90  LDD0320 
Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 2.69  LDD0054 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 2.36  LDD0054 
Lysosome membrane protein 2 (SCARB2) LDTP06034 2.27  LDD0321 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 2.21  LDD0054 
Osteopetrosis-associated transmembrane protein 1 (OSTM1) LDTP08327 3.50  LDD0054 
Proton-activated chloride channel (PACC1) LDTP12042 5.36  LDD0054 
Proton-transporting V-type ATPase complex assembly regulator TMEM9 (TMEM9) LDTP12981 4.29  LDD0054 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 2.86  LDD0054 
Sodium-dependent glucose transporter 1 (MFSD4B) LDTP17246 3.75  LDD0054 
Sortilin (SORT1) LDTP10885 2.43  LDD0054 
Synaptophysin (SYP) LDTP02266 2.85  LDD0054 
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⏷ Show the Full List of 13 Transporter and channel
1 Immunoglobulin Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
CD166 antigen (ALCAM) LDTP05973 2.30  LDD0053 
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1 Cytokine and receptor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Ciliary neurotrophic factor receptor subunit alpha (CNTFR) LDTP03377 2.14  LDD0054 
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17 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
A-kinase anchor protein 9 (AKAP9) LDTP11033 19.75  LDD0320 
Armadillo repeat-containing X-linked protein 2 (ARMCX2) LDTP17517 3.17  LDD0320 
Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1) LDTP09196 2.78  LDD0320 
CD99 antigen (CD99) LDTP02715 2.71  LDD0054 
Galanin peptides (GAL) LDTP03175 2.76  LDD0054 
Ganglioside GM2 activator (GM2A) LDTP02927 2.76  LDD0054 
Insulin-like growth factor-binding protein 2 (IGFBP2) LDTP02937 2.96  LDD0054 
Metalloproteinase inhibitor 3 (TIMP3) LDTP03773 3.22  LDD0054 
Microfibrillar-associated protein 2 (MFAP2) LDTP04650 2.26  LDD0054 
ORM1-like protein 1 (ORMDL1) LDTP12978 3.62  LDD0320 
Perilipin-2 (PLIN2) LDTP10889 2.46  LDD0054 
ProSAAS (PCSK1N) LDTP13281 2.88  LDD0054 
Seizure 6-like protein (SEZ6L) LDTP11461 2.47  LDD0054 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 2.14  LDD0054 
Small ribosomal subunit protein mS23 (MRPS23) LDTP13985 3.54  LDD0053 
Tissue factor pathway inhibitor 2 (TFPI2) LDTP04172 4.46  LDD0054 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 2.59  LDD0054 
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⏷ Show the Full List of 17 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method LFQ
Competitor Name Tranylcypromine
Competitor Concentration 1 mM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Adrenal
Disease Model Bone marrow neuroblastoma [ICD11: 2A00]
Model Name Human neuroblastoma cells (SH-SY5Y)
Interaction Atlas ID  LDD0053  Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method LFQ
Competitor Name Tranylcypromine
Competitor Concentration 1 mM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)
Interaction Atlas ID  LDD0320  Download The Altas
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 10 uM
Quantitative Method LFQ
Competitor Name Tranylcypromine
Competitor Concentration 100 uM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Adrenal
Disease Model Bone marrow neuroblastoma [ICD11: 2A00]
Model Name Human neuroblastoma cells (SH-SY5Y)
Interaction Atlas ID  LDD0054  Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 10 uM
Quantitative Method LFQ
Competitor Name Tranylcypromine
Competitor Concentration 20 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)
Interaction Atlas ID  LDD0321  Download The Altas

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580