Details of the Target

General Information of Target

Target ID LDTP02006
Target Name Tissue alpha-L-fucosidase (FUCA1)
Gene Name FUCA1
Gene ID 2517
Synonyms
Tissue alpha-L-fucosidase; EC 3.2.1.51; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; Alpha-L-fucosidase 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGV
FIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEW
ADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYG
LYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYW
NSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSID
KFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGK
WLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTK
ITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 29 family
Subcellular location
Lysosome
Function Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Uniprot ID
P04066
Ensemble ID
ENST00000374479.4
HGNC ID
HGNC:4006
ChEMBL ID
CHEMBL4176

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y97(4.99); Y103(7.12)  LDD3495  [1]
DBIA
 Probe Info  		C296(1.59)  LDD3310  [2]
FBPP2
 Probe Info  		2.76  LDD0054  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
PAL-AfBPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		6.54  LDD1733  [5]
C045
 Probe Info  		11.00  LDD1744  [5]
C063
 Probe Info  		11.00  LDD1760  [5]
C070
 Probe Info  		12.55  LDD1766  [5]
C073
 Probe Info  		5.86  LDD1769  [5]
C087
 Probe Info  		7.16  LDD1779  [5]
C115
 Probe Info  		11.47  LDD1802  [5]
C140
 Probe Info  		8.11  LDD1822  [5]
C147
 Probe Info  		6.54  LDD1829  [5]
C149
 Probe Info  		8.51  LDD1830  [5]
C170
 Probe Info  		19.97  LDD1850  [5]
C183
 Probe Info  		5.13  LDD1861  [5]
C184
 Probe Info  		5.78  LDD1862  [5]
C186
 Probe Info  		30.48  LDD1864  [5]
C197
 Probe Info  		7.84  LDD1873  [5]
C208
 Probe Info  		11.88  LDD1883  [5]
C211
 Probe Info  		9.38  LDD1885  [5]
C221
 Probe Info  		10.34  LDD1895  [5]
C223
 Probe Info  		9.92  LDD1897  [5]
C232
 Probe Info  		40.22  LDD1905  [5]
C237
 Probe Info  		7.16  LDD1910  [5]
C239
 Probe Info  		7.06  LDD1912  [5]
C249
 Probe Info  		24.76  LDD1922  [5]
C281
 Probe Info  		8.82  LDD1951  [5]
C288
 Probe Info  		6.32  LDD1958  [5]
C310
 Probe Info  		27.47  LDD1977  [5]
C314
 Probe Info  		12.91  LDD1981  [5]
C343
 Probe Info  		19.16  LDD2005  [5]
C346
 Probe Info  		18.38  LDD2007  [5]
C390
 Probe Info  		29.45  LDD2049  [5]
C425
 Probe Info  		10.70  LDD2080  [5]
FFF probe12
 Probe Info  		20.00  LDD0473  [6]
FFF probe14
 Probe Info  		20.00  LDD0477  [6]
FFF probe9
 Probe Info  		20.00  LDD0470  [6]
JN0003
 Probe Info  		20.00  LDD0469  [6]
VE-P
 Probe Info  		N.A.  LDD0396  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C296(0.85)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C296(0.80)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C296(0.99)  LDD1509  [8]
 LDCM0259  AC14 HEK-293T C296(0.84)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C296(1.16)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C296(0.82)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C296(0.55)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C296(1.16)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C296(0.94)  LDD1518  [8]
 LDCM0282  AC22 HEK-293T C296(0.86)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C296(1.18)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C296(0.82)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C296(0.84)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C296(1.03)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C296(0.89)  LDD1526  [8]
 LDCM0290  AC3 HEK-293T C296(1.05)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C296(0.89)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C296(1.21)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C296(0.90)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C296(0.96)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C296(0.94)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C296(0.93)  LDD1535  [8]
 LDCM0299  AC38 HEK-293T C296(1.00)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C296(1.02)  LDD1539  [8]
 LDCM0302  AC40 HEK-293T C296(0.90)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C296(0.83)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C296(0.86)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C296(0.88)  LDD1544  [8]
 LDCM0308  AC46 HEK-293T C296(0.85)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C296(1.04)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C296(0.92)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C296(0.82)  LDD1550  [8]
 LDCM0313  AC50 HEK-293T C296(0.81)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C296(0.95)  LDD1553  [8]
 LDCM0317  AC54 HEK-293T C296(0.82)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C296(1.35)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C296(1.08)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C296(1.05)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C296(0.85)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C296(1.08)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C296(1.00)  LDD1562  [8]
 LDCM0326  AC62 HEK-293T C296(1.11)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C296(1.07)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C296(0.87)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C296(1.12)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C296(1.00)  LDD1569  [8]
 LDCM0356  AKOS034007680 HEK-293T C296(1.03)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C296(0.87)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C296(1.07)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C296(2.73)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C296(0.75)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C296(1.04)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C296(1.15)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C296(1.12)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C296(0.77)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C296(1.03)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C296(1.02)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C296(0.96)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C296(0.97)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C296(1.12)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C296(2.34)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C296(0.95)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C296(1.25)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C296(1.01)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C296(0.96)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C296(0.90)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C296(1.31)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C296(0.85)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C296(0.90)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C296(1.07)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C296(1.24)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C296(1.76)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C296(0.80)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C296(0.98)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C296(1.21)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C296(1.01)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C296(0.69)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C296(1.05)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C296(0.90)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C296(1.07)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C296(0.71)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C296(0.92)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C296(1.09)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C296(1.20)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C296(0.86)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C296(1.25)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C296(1.21)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C296(1.64)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C296(1.16)  LDD1611  [8]
 LDCM0410  CL22 HEK-293T C296(2.01)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C296(2.69)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C296(1.90)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C296(0.76)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C296(0.86)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C296(1.08)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C296(0.79)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C296(1.01)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C296(1.23)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C296(0.83)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C296(1.23)  LDD1624  [8]
 LDCM0423  CL34 HEK-293T C296(1.34)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C296(1.76)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C296(1.96)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C296(0.92)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C296(1.12)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C296(0.90)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C296(0.79)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C296(0.95)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C296(0.93)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C296(1.24)  LDD1637  [8]
 LDCM0436  CL46 HEK-293T C296(1.40)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C296(2.49)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C296(1.71)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C296(0.62)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C296(0.89)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C296(1.06)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C296(0.76)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C296(1.07)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C296(0.74)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C296(1.12)  LDD1649  [8]
 LDCM0449  CL58 HEK-293T C296(0.97)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C296(1.06)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C296(1.18)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C296(2.11)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C296(0.91)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C296(1.08)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C296(0.90)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C296(0.88)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C296(1.00)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C296(0.97)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C296(1.33)  LDD1662  [8]
 LDCM0462  CL7 HEK-293T C296(1.22)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C296(1.74)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C296(1.99)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C296(1.51)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C296(1.02)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C296(0.81)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C296(0.69)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C296(1.03)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C296(1.02)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C296(0.99)  LDD1675  [8]
 LDCM0476  CL82 HEK-293T C296(1.69)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C296(1.60)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C296(1.30)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C296(1.11)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C296(1.10)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C296(1.17)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C296(0.63)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C296(0.94)  LDD1686  [8]
 LDCM0485  CL90 HEK-293T C296(1.21)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C296(1.27)  LDD1689  [8]
 LDCM0489  CL94 HEK-293T C296(1.22)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C296(1.83)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C296(1.32)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C296(1.25)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C296(1.12)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C296(1.15)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C296(0.94)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C296(1.34)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C296(0.91)  LDD1631  [8]
 LDCM0022  KB02 A-549 C296(1.70)  LDD2260  [2]
 LDCM0023  KB03 A-549 C296(2.03)  LDD2677  [2]
 LDCM0024  KB05 COLO792 C296(1.59)  LDD3310  [2]
 LDCM0008  Tranylcypromine SH-SY5Y 2.76  LDD0054  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium and integrin-binding protein 1 (CIB1) . Q99828
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 10 (MED10) Mediator complex subunit 10 family Q9BTT4
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402