Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C183  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 75 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00325  Pirin (PIR) 29.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 22.6
 LDTP01769  Dihydrofolate reductase (DHFR) 20.3
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 15.1
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 13.8
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 13.5
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 12.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 12.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 12.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 12.0
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 11.6
 LDTP02505  Lysosomal protective protein (CTSA) 11.4
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 10.9
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 10.8
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 10.3
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 10.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 9.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 9.8
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 9.1
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 9.0
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 8.6
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 8.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 8.3
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 8.3
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 8.1
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 8.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.0
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 8.0
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 7.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 7.9
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.9
 LDTP04456  Ubiquitin carboxyl-terminal hydrolase 11 (USP11) 7.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 7.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.7
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) 7.6
 LDTP01329  Lathosterol oxidase (SC5D) 7.6
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 7.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 7.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.4
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 7.2
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 7.1
 LDTP13751  Exonuclease 1 (EXO1) 7.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 7.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 6.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 6.5
 LDTP06262  N-alpha-acetyltransferase 25, NatB auxiliary subunit (NAA25) 6.3
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 6.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 6.2
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 6.2
 LDTP05971  Mannosyl-oligosaccharide glucosidase (MOGS) 5.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 5.9
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 5.7
 LDTP10329  Ceramide synthase 2 (CERS2) 5.6
 LDTP10951  Methionine synthase (MTR) 5.5
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 5.5
 LDTP03145  Catechol O-methyltransferase (COMT) 5.5
 LDTP00988  Protein O-GlcNAcase (OGA) 5.5
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 5.4
 LDTP05905  Acid ceramidase (ASAH1) 5.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 5.3
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 5.3
 LDTP02837  Beta-galactosidase (GLB1) 5.1
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 5.1
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 5.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.1
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 5.1
 LDTP11237  DNA-directed RNA polymerase III subunit RPC3 (POLR3C) 5.1
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 5.0
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 5.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.0
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 5.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 5.0
 LDTP04569  Geranylgeranyl transferase type-2 subunit beta (RABGGTB) 5.0
Transporter and channel
Click to Show/Hide to Show 38 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 32.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 31.3
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 23.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 22.2
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 18.1
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 16.3
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 15.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 13.5
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 13.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 12.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 11.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 11.6
 LDTP07236  Protein GPR107 (GPR107) 11.3
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 11.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 10.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 10.1
 LDTP00383  AP-3 complex subunit delta-1 (AP3D1) 9.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 9.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 9.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 8.5
 LDTP11615  Protein tweety homolog 3 (TTYH3) 8.2
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 7.6
 LDTP20002  Transmembrane protein 160 (TMEM160) 6.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 6.7
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 6.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 5.9
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 5.8
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 5.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 5.4
 LDTP05900  Metaxin-1 (MTX1) 5.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 5.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.2
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 5.2
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 5.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 5.1
 LDTP02215  Prosaposin (PSAP) 5.0
Other
Click to Show/Hide to Show 33 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 17.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 10.9
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 9.5
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 9.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 9.1
 LDTP05375  Nucleobindin-1 (NUCB1) 7.2
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.6
 LDTP16577  DENN domain-containing protein 11 (DENND11) 6.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.5
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 6.4
 LDTP05277  Protein SET (SET) 6.3
 LDTP18883  Protein CEBPZOS (CEBPZOS) 6.1
 LDTP05960  Trophoblast glycoprotein (TPBG) 6.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 5.9
 LDTP13086  Syntaxin-18 (STX18) 5.9
 LDTP13863  DnaJ homolog subfamily C member 16 (DNAJC16) 5.9
 LDTP14259  Testis-expressed protein 264 (TEX264) 5.7
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 5.6
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 5.5
 LDTP01652  Centrosomal protein 43 (CEP43) 5.5
 LDTP06097  Reticulocalbin-2 (RCN2) 5.4
 LDTP03926  Centrin-2 (CETN2) 5.4
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 5.3
 LDTP01522  Reticulon-3 (RTN3) 5.3
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 5.2
 LDTP08000  Dymeclin (DYM) 5.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 5.0
 LDTP14939  Membralin (TMEM259) 5.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 5.0
 LDTP10056  Protein FAM162A (FAM162A) 5.0
 LDTP09773  Protein FAM3C (FAM3C) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587