Details of the Target

General Information of Target

Target ID LDTP11095
Target Name Mitochondrial 2-oxodicarboxylate carrier (SLC25A21)
Gene Name SLC25A21
Gene ID 89874
Synonyms
ODC; Mitochondrial 2-oxodicarboxylate carrier; ODC; Mitochondrial 2-oxoadipate carrier; Solute carrier family 25 member 21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEK
ATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADT
LQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFAR
RTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELD
QLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQK
QWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDK
KNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEV
NRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHT
SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI
QDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQL
DDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSL
ASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQ
QLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEV
HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRA
HVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR
ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKES
LQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKN
AGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKE
GAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEER
LIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGR
IFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGP
QATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTST
SLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPIT
VAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRT
PGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable).
Uniprot ID
Q9BQT8
Ensemble ID
ENST00000331299.6
HGNC ID
HGNC:14411
ChEMBL ID
CHEMBL4680040

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RAMOS SNV: p.E67Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
HPAP
 Probe Info  		3.53  LDD0063  [2]
DBIA
 Probe Info  		C46(1.92)  LDD0080  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 59 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.21  LDD1714  [5]
C006
 Probe Info  		26.35  LDD1715  [5]
C022
 Probe Info  		10.13  LDD1728  [5]
C027
 Probe Info  		5.54  LDD1733  [5]
C055
 Probe Info  		13.74  LDD1752  [5]
C056
 Probe Info  		36.50  LDD1753  [5]
C063
 Probe Info  		13.09  LDD1760  [5]
C091
 Probe Info  		11.39  LDD1782  [5]
C092
 Probe Info  		18.90  LDD1783  [5]
C094
 Probe Info  		32.00  LDD1785  [5]
C106
 Probe Info  		19.03  LDD1793  [5]
C107
 Probe Info  		5.70  LDD1794  [5]
C108
 Probe Info  		8.22  LDD1795  [5]
C158
 Probe Info  		23.10  LDD1838  [5]
C159
 Probe Info  		7.46  LDD1839  [5]
C160
 Probe Info  		7.52  LDD1840  [5]
C161
 Probe Info  		27.86  LDD1841  [5]
C169
 Probe Info  		24.76  LDD1849  [5]
C177
 Probe Info  		7.41  LDD1856  [5]
C183
 Probe Info  		13.09  LDD1861  [5]
C186
 Probe Info  		13.83  LDD1864  [5]
C201
 Probe Info  		35.26  LDD1877  [5]
C206
 Probe Info  		21.11  LDD1881  [5]
C207
 Probe Info  		22.16  LDD1882  [5]
C210
 Probe Info  		78.25  LDD1884  [5]
C218
 Probe Info  		27.10  LDD1892  [5]
C220
 Probe Info  		20.97  LDD1894  [5]
C226
 Probe Info  		7.84  LDD1899  [5]
C228
 Probe Info  		14.62  LDD1901  [5]
C231
 Probe Info  		12.73  LDD1904  [5]
C233
 Probe Info  		9.32  LDD1906  [5]
C234
 Probe Info  		5.62  LDD1907  [5]
C235
 Probe Info  		23.92  LDD1908  [5]
C238
 Probe Info  		16.91  LDD1911  [5]
C242
 Probe Info  		6.11  LDD1915  [5]
C244
 Probe Info  		42.52  LDD1917  [5]
C252
 Probe Info  		9.38  LDD1925  [5]
C264
 Probe Info  		17.51  LDD1935  [5]
C265
 Probe Info  		16.00  LDD1936  [5]
C272
 Probe Info  		5.50  LDD1942  [5]
C287
 Probe Info  		11.63  LDD1957  [5]
C288
 Probe Info  		7.94  LDD1958  [5]
C289
 Probe Info  		33.82  LDD1959  [5]
C290
 Probe Info  		4.92  LDD1960  [5]
C314
 Probe Info  		11.47  LDD1981  [5]
C322
 Probe Info  		16.00  LDD1988  [5]
C326
 Probe Info  		7.57  LDD1990  [5]
C348
 Probe Info  		28.64  LDD2009  [5]
C349
 Probe Info  		11.55  LDD2010  [5]
C350
 Probe Info  		37.53  LDD2011  [5]
C353
 Probe Info  		17.88  LDD2014  [5]
C355
 Probe Info  		23.92  LDD2016  [5]
C361
 Probe Info  		38.32  LDD2022  [5]
C383
 Probe Info  		40.79  LDD2042  [5]
C388
 Probe Info  		70.03  LDD2047  [5]
C390
 Probe Info  		25.28  LDD2049  [5]
C426
 Probe Info  		20.68  LDD2081  [5]
C429
 Probe Info  		27.28  LDD2084  [5]
C431
 Probe Info  		28.05  LDD2086  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C46(1.46)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C46(1.11)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C46(0.85)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C46(0.96)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C46(1.08)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C46(1.17)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C46(1.05)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C46(0.84)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C46(0.90)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C46(0.95)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C46(1.08)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C46(1.22)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C46(1.17)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C46(1.15)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C46(1.04)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C46(1.03)  LDD1108  [3]
 LDCM0237  AC12 HCT 116 C46(1.01)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C46(1.37)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C46(1.32)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C46(1.27)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C46(1.71)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C46(1.29)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C46(1.26)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C46(1.22)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C46(1.23)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C46(1.00)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C46(1.38)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C46(1.12)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C46(0.97)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C46(1.02)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C46(0.90); C29(0.95)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C46(0.95); C29(0.94)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C46(1.03); C29(1.12)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C46(1.14)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C46(0.99); C29(0.87)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C46(1.03); C29(1.03)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C46(0.91); C29(1.08)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C46(0.98)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C46(0.98)  LDD1534  [6]
 LDCM0296  AC35 HCT 116 C46(1.30)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C46(1.75)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C46(0.96)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C46(0.83)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C46(1.41)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C46(1.11)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C46(1.07)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C46(1.12)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C46(0.95)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C46(0.89)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C46(1.00)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C46(0.89)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C46(1.09)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C46(1.14)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C46(1.21)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C46(1.57)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C46(1.10)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C46(1.74)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C46(0.89)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C46(1.24)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C46(2.08)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C46(1.23)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C46(1.75)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C46(2.11)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C46(1.25)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C46(1.98)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C46(2.02)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C46(1.49)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C46(1.42)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C46(1.32)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C46(2.63)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C46(1.65)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C46(1.93)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C46(1.93)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C46(2.46)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C46(2.22)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C46(1.03)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C46(0.51)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C46(1.13)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C46(0.80)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C46(0.54)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C46(0.79)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C46(0.98)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C46(0.81)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C46(0.88)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C46(0.81)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C46(0.65)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C46(0.80)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C46(0.68)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C46(1.28)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C46(0.50)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C46(0.67)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C46(0.61)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C46(2.40)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C46(1.89)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C46(1.94)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C46(2.07)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C46(1.56)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C46(1.58)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C46(1.97)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C46(0.99)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C46(1.68)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C46(1.92)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C46(1.48)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C46(1.23)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C46(1.47)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C46(1.95)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C46(1.78)  LDD0681  [3]
 LDCM0365  AC98 PaTu 8988t C46(0.88)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C46(1.05)  LDD1245  [3]
 LDCM0248  AKOS034007472 HCT 116 C46(0.98)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C46(1.17)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C46(2.02)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C46(0.85)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C46(1.54)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C46(1.07)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C46(1.51)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C46(0.89)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C46(1.24)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C46(1.28)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C46(1.82)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C46(1.94)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C46(1.77)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C46(2.14)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C46(1.51)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C46(1.39)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C46(2.00)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C46(1.52)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C46(1.16); C29(1.06)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C46(0.90); C29(0.86)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C46(1.31); C29(0.94)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C46(1.04); C29(0.92)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C46(0.91); C29(1.02)  LDD1590  [6]
 LDCM0387  CL117 HCT 116 C46(1.36)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C46(1.42)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C46(1.22)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C46(1.69)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C46(1.05)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C46(1.15)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C46(1.36)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C46(1.98)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C46(1.71)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C46(0.80)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C46(1.20)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C46(1.10)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C46(1.39)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C46(1.32)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C46(1.16)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C46(1.13)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C46(1.11); C29(1.09)  LDD1607  [6]
 LDCM0404  CL17 HCT 116 C46(1.28)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C46(1.28)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C46(0.95)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C46(0.99)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C46(1.27)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C46(1.40)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C46(0.82)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C46(0.89)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C46(1.15)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C46(0.75)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C46(0.72)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C46(1.49)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C46(1.33)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C46(1.14)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C46(1.06)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C46(0.88)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C46(1.20)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C46(1.19)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C46(1.62)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C46(1.63)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C46(1.42)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C46(1.63)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C46(2.11)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C46(2.11)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C46(1.21)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C46(1.39)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C46(1.30)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C46(2.73)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C46(1.86)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C46(1.63)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C46(2.32)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C46(1.17)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C46(0.94)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C46(0.98)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C46(0.93)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C46(1.00)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C46(1.01)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C46(1.20)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C46(1.02)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C46(0.93)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C46(0.96)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C46(0.92)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C46(0.87)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C46(1.03)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C46(0.79)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C46(1.04)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C46(1.38)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C46(1.09)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C46(1.24)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C46(1.22)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C46(1.36)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C46(1.89)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C46(1.26)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C46(2.05)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C46(1.38)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C46(1.53)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C46(1.25)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C46(1.27)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C46(1.45)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C46(1.45)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C46(1.09)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C46(1.48)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C46(1.50)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C46(0.94); C29(1.07)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C46(1.13)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C46(0.99)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C46(0.86); C29(1.03)  LDD1675  [6]
 LDCM0473  CL8 HCT 116 C46(1.80)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C46(0.99); C29(0.91)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C46(1.05); C29(0.95)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C46(1.25); C29(0.86)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C46(1.10); C29(1.05)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C46(1.22); C29(1.09)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C46(0.95); C29(1.04)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C46(1.08); C29(1.17)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C46(0.97); C29(1.03)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C46(0.96); C29(1.06)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C46(1.06)  LDD1686  [6]
 LDCM0484  CL9 HCT 116 C46(1.16)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C46(1.62)  LDD1688  [6]
 LDCM0486  CL91 HCT 116 C46(1.61)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C46(1.31)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C46(0.92)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C46(1.23)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C46(1.34)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C46(1.74)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C46(1.78)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C46(1.50)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C46(0.99)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C46(1.03); C29(0.88)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C46(1.25)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C46(2.26)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C46(1.92)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C46(1.75)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C46(3.70)  LDD0082  [3]
 LDCM0014  Panhematin K562 3.53  LDD0063  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402