Details of the Probe

General Information of Probe

Probe ID
LDPC0342
Probe Name
C091
Synonyms
Z4282860054
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 372.4
Lipid-water partition coefficient (xlogp) 3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H25FN4O2
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[3-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-5-fluorophenyl]propanamide
Canonical SMILES
CC1CN(CC(O1)C)C2=CC(=CC(=C2)NC(=O)CCC3(N=N3)CCC#C)F
InChI
InChI=1S/C20H25FN4O2/c1-4-5-7-20(23-24-20)8-6-19(26)22-17-9-16(21)10-18(11-17)25-12-14(2)27-15(3)13-25/h1,9-11,14-15H,5-8,12-13H2,2-3H3,(H,22,26)/t14-,15+
InChIKey
YQBSXGHMTAAYSY-GASCZTMLSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

172 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) LDTP06657 10.85  LDD1782 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 16.00  LDD1782 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 13.00  LDD1782 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 12.30  LDD1782 
Acid ceramidase (ASAH1) LDTP05905 24.59  LDD1782 
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) LDTP09814 9.99  LDD1782 
Adenosine deaminase (ADA) LDTP01803 99.73  LDD1782 
Adenosine kinase (ADK) LDTP04689 10.63  LDD1782 
ADP-dependent glucokinase (ADPGK) LDTP11127 48.50  LDD1782 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 17.75  LDD1782 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 30.27  LDD1782 
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2) LDTP05622 10.34  LDD1782 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 10.13  LDD1782 
Atlastin-2 (ATL2) LDTP09251 19.29  LDD1782 
ATP synthase membrane subunit K, mitochondrial (ATP5MK) LDTP10432 10.70  LDD1782 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 12.64  LDD1782 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 10.85  LDD1782 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 11.96  LDD1782 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 30.06  LDD1782 
Calcium-transporting ATPase type 2C member 1 (ATP2C1) LDTP05228 11.55  LDD1782 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 32.22  LDD1782 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 13.45  LDD1782 
Catechol O-methyltransferase (COMT) LDTP03145 18.64  LDD1782 
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) LDTP00416 10.93  LDD1782 
Ceramide glucosyltransferase (UGCG) LDTP06617 14.42  LDD1782 
Ceramide synthase 1 (CERS1) LDTP03394 17.03  LDD1782 
Ceramide synthase 2 (CERS2) LDTP10329 33.59  LDD1782 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 21.56  LDD1782 
Choline/ethanolaminephosphotransferase 1 (CEPT1) LDTP14264 19.29  LDD1782 
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (ST3GAL4) LDTP05638 21.11  LDD1782 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 10.13  LDD1782 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 40.50  LDD1782 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 16.22  LDD1782 
Cytochrome b5 type B (CYB5B) LDTP00697 64.89  LDD1782 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 23.59  LDD1782 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 19.43  LDD1782 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 10.93  LDD1782 
DCN1-like protein 4 (DCUN1D4) LDTP09799 13.64  LDD1782 
Dehydrogenase/reductase SDR family member 7 (DHRS7) LDTP13959 12.30  LDD1782 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 12.30  LDD1782 
Delta(24)-sterol reductase (DHCR24) LDTP06375 12.30  LDD1782 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 11.79  LDD1782 
Deoxyhypusine synthase (DHPS) LDTP04248 11.39  LDD1782 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 16.34  LDD1782 
Diacylglycerol lipase-beta (DAGLB) LDTP09095 36.50  LDD1782 
Dihydroxyacetone phosphate acyltransferase (GNPAT) LDTP00577 10.34  LDD1782 
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) LDTP04420 10.41  LDD1782 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 41.36  LDD1782 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 25.46  LDD1782 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) LDTP09388 21.41  LDD1782 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 38.59  LDD1782 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 10.85  LDD1782 
E3 ubiquitin-protein ligase TRIM13 (TRIM13) LDTP01065 72.00  LDD1782 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 24.93  LDD1782 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 12.55  LDD1782 
Epoxide hydrolase 1 (EPHX1) LDTP02175 10.48  LDD1782 
Fumarylacetoacetase (FAH) LDTP02868 13.45  LDD1782 
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) LDTP06721 10.27  LDD1782 
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (QRSL1) LDTP11728 13.55  LDD1782 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 85.63  LDD1782 
Glycerol-3-phosphate acyltransferase 4 (GPAT4) LDTP08232 9.99  LDD1782 
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) LDTP04032 11.96  LDD1782 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 30.48  LDD1782 
GPI ethanolamine phosphate transferase 2 (PIGG) LDTP06977 20.82  LDD1782 
GTP-binding protein SAR1a (SAR1A) LDTP12470 14.52  LDD1782 
Heme A synthase COX15 (COX15) LDTP07931 19.56  LDD1782 
Heme oxygenase 1 (HMOX1) LDTP02359 99.73  LDD1782 
Heme oxygenase 2 (HMOX2) LDTP03540 34.54  LDD1782 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 19.16  LDD1782 
Hexokinase-2 (HK2) LDTP04531 18.13  LDD1782 
Holocytochrome c-type synthase (HCCS) LDTP04581 16.56  LDD1782 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 16.91  LDD1782 
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) LDTP08532 14.03  LDD1782 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 18.51  LDD1782 
Lathosterol oxidase (SC5D) LDTP01329 12.47  LDD1782 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 11.39  LDD1782 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 25.11  LDD1782 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 11.88  LDD1782 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 12.13  LDD1782 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 11.96  LDD1782 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 10.13  LDD1782 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 19.16  LDD1782 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 16.91  LDD1782 
Lysosomal acid phosphatase (ACP2) LDTP02539 10.85  LDD1782 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 12.73  LDD1782 
Lysosomal protective protein (CTSA) LDTP02505 10.34  LDD1782 
Metalloreductase STEAP3 (STEAP3) LDTP07292 17.63  LDD1782 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 41.07  LDD1782 
Microsomal glutathione S-transferase 2 (MGST2) LDTP10966 14.93  LDD1782 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 20.53  LDD1782 
Mitochondrial ribosome-associated GTPase 1 (MTG1) LDTP11177 10.70  LDD1782 
Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) LDTP10038 30.70  LDD1782 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 30.91  LDD1782 
Mitofusin-1 (MFN1) LDTP08530 11.88  LDD1782 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 34.06  LDD1782 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 22.32  LDD1782 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 43.41  LDD1782 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 13.00  LDD1782 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 12.21  LDD1782 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 54.19  LDD1782 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 22.47  LDD1782 
NADH dehydrogenase 1 subunit C2 (NDUFC2) LDTP01560 14.32  LDD1782 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 42.52  LDD1782 
NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) LDTP01986 13.64  LDD1782 
NADPH--cytochrome P450 reductase (POR) LDTP02848 12.38  LDD1782 
Neutral cholesterol ester hydrolase 1 (NCEH1) LDTP07591 12.38  LDD1782 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 20.11  LDD1782 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 39.95  LDD1782 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 12.13  LDD1782 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 10.27  LDD1782 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 12.47  LDD1782 
Phosphatidate cytidylyltransferase 2 (CDS2) LDTP01649 14.42  LDD1782 
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) LDTP09578 9.99  LDD1782 
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) LDTP12608 10.13  LDD1782 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 19.97  LDD1782 
Phosphatidylserine synthase 2 (PTDSS2) LDTP11284 18.90  LDD1782 
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) LDTP03024 10.63  LDD1782 
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) LDTP03249 10.56  LDD1782 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 14.52  LDD1782 
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) LDTP08859 13.45  LDD1782 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 40.79  LDD1782 
Prenylcysteine oxidase-like (PCYOX1L) LDTP15480 16.45  LDD1782 
Presenilin-associated rhomboid-like protein, mitochondrial (PARL) LDTP11852 14.22  LDD1782 
Probable glutathione peroxidase 8 (GPX8) LDTP09495 10.06  LDD1782 
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 12.64  LDD1782 
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) LDTP00645 10.27  LDD1782 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 15.78  LDD1782 
Prostaglandin reductase 3 (PTGR3) LDTP15422 10.70  LDD1782 
Proteasome subunit beta type-5 (PSMB5) LDTP03419 15.89  LDD1782 
Protein disulfide-isomerase TMX3 (TMX3) LDTP10471 17.03  LDD1782 
Protein O-mannose kinase (POMK) LDTP11957 25.63  LDD1782 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 10.63  LDD1782 
Protein-L-histidine N-pros-methyltransferase (METTL9) LDTP15962 19.84  LDD1782 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 48.50  LDD1782 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 13.45  LDD1782 
Ras-related protein Rab-24 (RAB24) LDTP10020 21.56  LDD1782 
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) LDTP09666 18.77  LDD1782 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 17.15  LDD1782 
Retinol dehydrogenase 13 (RDH13) LDTP09061 15.45  LDD1782 
Retinol dehydrogenase 14 (RDH14) LDTP12180 12.04  LDD1782 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 43.11  LDD1782 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 11.24  LDD1782 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 12.47  LDD1782 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 16.80  LDD1782 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 14.72  LDD1782 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 14.12  LDD1782 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 99.73  LDD1782 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 19.84  LDD1782 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 10.85  LDD1782 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 14.22  LDD1782 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 25.28  LDD1782 
Squalene monooxygenase (SQLE) LDTP06142 28.64  LDD1782 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 15.24  LDD1782 
Sulfhydryl oxidase 2 (QSOX2) LDTP07813 10.93  LDD1782 
Sulfide:quinone oxidoreductase, mitochondrial (SQOR) LDTP14278 15.03  LDD1782 
Thiol S-methyltransferase TMT1B (TMT1B) LDTP15155 10.93  LDD1782 
Thioredoxin-like protein 1 (TXNL1) LDTP00758 18.13  LDD1782 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 11.00  LDD1782 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 18.13  LDD1782 
Torsin-1B (TOR1B) LDTP00400 12.64  LDD1782 
Translin (TSN) LDTP06427 10.85  LDD1782 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 17.03  LDD1782 
Ubiquitin thioesterase OTUB1 (OTUB1) LDTP10318 15.89  LDD1782 
Ubiquitin-associated domain-containing protein 2 (UBAC2) LDTP09060 14.03  LDD1782 
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) LDTP11867 11.16  LDD1782 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 12.04  LDD1782 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 13.64  LDD1782 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 11.71  LDD1782 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 10.27  LDD1782 
Vesicle transport protein GOT1B (GOLT1B) LDTP13986 17.15  LDD1782 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 14.32  LDD1782 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 20.53  LDD1782 
------------------------------------------------------------------------------------
⏷ Show the Full List of 172 Enzyme
123 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 18.13  LDD1782 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 14.03  LDD1782 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 11.39  LDD1782 
Anoctamin-6 (ANO6) LDTP06855 12.04  LDD1782 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 15.89  LDD1782 
ATP synthase subunit a (MT-ATP6) LDTP01804 21.56  LDD1782 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 45.57  LDD1782 
Autophagy-related protein 9A (ATG9A) LDTP08030 11.24  LDD1782 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 10.78  LDD1782 
Bax inhibitor 1 (TMBIM6) LDTP04663 11.55  LDD1782 
Calcium uptake protein 1, mitochondrial (MICU1) LDTP11041 13.64  LDD1782 
Calnexin (CANX) LDTP03405 10.13  LDD1782 
Chloride channel CLIC-like protein 1 (CLCC1) LDTP10804 12.55  LDD1782 
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) LDTP08981 51.63  LDD1782 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 25.81  LDD1782 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 14.72  LDD1782 
Derlin-2 (DERL2) LDTP11634 11.63  LDD1782 
Endophilin-B1 (SH3GLB1) LDTP13953 10.13  LDD1782 
Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) LDTP12331 14.62  LDD1782 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 66.72  LDD1782 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 54.19  LDD1782 
Etoposide-induced protein 2.4 homolog (EI24) LDTP00405 14.93  LDD1782 
Gap junction alpha-1 protein (GJA1) LDTP02894 11.39  LDD1782 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 13.64  LDD1782 
Golgin subfamily A member 5 (GOLGA5) LDTP09333 13.00  LDD1782 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 13.83  LDD1782 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 10.20  LDD1782 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 14.52  LDD1782 
Integral membrane protein 2B (ITM2B) LDTP13833 12.47  LDD1782 
Integral membrane protein 2C (ITM2C) LDTP12451 11.96  LDD1782 
Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) LDTP01100 13.45  LDD1782 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 16.91  LDD1782 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 11.24  LDD1782 
Lysosome membrane protein 2 (SCARB2) LDTP06034 27.10  LDD1782 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 20.39  LDD1782 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 18.51  LDD1782 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 32.00  LDD1782 
Metal cation symporter ZIP14 (SLC39A14) LDTP06293 10.48  LDD1782 
Metaxin-1 (MTX1) LDTP05900 32.90  LDD1782 
MICOS complex subunit MIC26 (APOO) LDTP11250 33.36  LDD1782 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 11.39  LDD1782 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 18.38  LDD1782 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 13.74  LDD1782 
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) LDTP08279 29.45  LDD1782 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 45.89  LDD1782 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 20.53  LDD1782 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 25.63  LDD1782 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 99.73  LDD1782 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 18.25  LDD1782 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 10.27  LDD1782 
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) LDTP01748 10.34  LDD1782 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 21.11  LDD1782 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 15.35  LDD1782 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 23.26  LDD1782 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 15.67  LDD1782 
Mitoguardin 1 (MIGA1) LDTP09028 10.70  LDD1782 
Mpv17-like protein 2 (MPV17L2) LDTP14952 36.00  LDD1782 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 15.78  LDD1782 
Nucleoporin NDC1 (NDC1) LDTP11213 17.27  LDD1782 
Nucleoporin NUP35 (NUP35) LDTP09204 12.47  LDD1782 
Pannexin-1 (PANX1) LDTP10754 11.55  LDD1782 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 18.00  LDD1782 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 11.71  LDD1782 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 11.71  LDD1782 
Peroxisomal membrane protein PMP34 (SLC25A17) LDTP00872 12.38  LDD1782 
PRA1 family protein 2 (PRAF2) LDTP01060 10.48  LDD1782 
Prosaposin (PSAP) LDTP02215 24.76  LDD1782 
Protein FAM8A1 (FAM8A1) LDTP16190 10.93  LDD1782 
Protein GPR107 (GPR107) LDTP07236 30.27  LDD1782 
Protein GPR108 (GPR108) LDTP12383 19.70  LDD1782 
Protein Mpv17 (MPV17) LDTP03869 15.67  LDD1782 
Protein RER1 (RER1) LDTP00590 12.82  LDD1782 
Protein RFT1 homolog (RFT1) LDTP10073 12.55  LDD1782 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 12.55  LDD1782 
Protein spinster homolog 1 (SPNS1) LDTP11844 22.16  LDD1782 
Protein tweety homolog 3 (TTYH3) LDTP11615 25.28  LDD1782 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 14.52  LDD1782 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 25.99  LDD1782 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 35.26  LDD1782 
Reduced folate transporter (SLC19A1) LDTP03952 13.83  LDD1782 
Reticulon-1 (RTN1) LDTP06633 17.51  LDD1782 
Rhomboid domain-containing protein 2 (RHBDD2) LDTP07467 16.80  LDD1782 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 11.47  LDD1782 
Secretory carrier-associated membrane protein 3 (SCAMP3) LDTP00451 14.12  LDD1782 
Sideroflexin-2 (SFXN2) LDTP10621 10.06  LDD1782 
Sideroflexin-4 (SFXN4) LDTP07531 21.26  LDD1782 
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) LDTP10731 13.55  LDD1782 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 14.52  LDD1782 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 35.75  LDD1782 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 12.91  LDD1782 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 10.78  LDD1782 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 11.39  LDD1782 
Sorting nexin-19 (SNX19) LDTP09788 23.59  LDD1782 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 10.13  LDD1782 
Store-operated calcium entry-associated regulatory factor (SARAF) LDTP10148 12.04  LDD1782 
SUN domain-containing protein 1 (SUN1) LDTP01454 14.03  LDD1782 
Surfeit locus protein 4 (SURF4) LDTP00592 11.16  LDD1782 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 28.05  LDD1782 
Tetraspanin-10 (TSPAN10) LDTP15967 18.64  LDD1782 
Tetraspanin-3 (TSPAN3) LDTP16813 54.95  LDD1782 
Thioredoxin-related transmembrane protein 2 (TMX2) LDTP13943 12.13  LDD1782 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 34.54  LDD1782 
Translocation protein SEC62 (SEC62) LDTP15838 11.47  LDD1782 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 82.14  LDD1782 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 19.03  LDD1782 
Transmembrane 9 superfamily member 4 (TM9SF4) LDTP09789 11.55  LDD1782 
Transmembrane emp24 domain-containing protein 10 (TMED10) LDTP04293 13.93  LDD1782 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 10.41  LDD1782 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 12.82  LDD1782 
Transmembrane protein 104 (TMEM104) LDTP17797 10.13  LDD1782 
Transmembrane protein 126A (TMEM126A) LDTP15948 29.86  LDD1782 
Transmembrane protein 14C (TMEM14C) LDTP12979 11.79  LDD1782 
Transmembrane protein 199 (TMEM199) LDTP08881 55.33  LDD1782 
Transmembrane protein 201 (TMEM201) LDTP07058 12.64  LDD1782 
Transmembrane protein 205 (TMEM205) LDTP07667 14.62  LDD1782 
Transmembrane protein 230 (TMEM230) LDTP10065 31.12  LDD1782 
Transmembrane protein 33 (TMEM33) LDTP04787 12.13  LDD1782 
Transmembrane protein 59 (TMEM59) LDTP11406 18.38  LDD1782 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 21.71  LDD1782 
Vang-like protein 1 (VANGL1) LDTP09288 12.13  LDD1782 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 56.89  LDD1782 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 73.01  LDD1782 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 30.91  LDD1782 
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⏷ Show the Full List of 123 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 23.26  LDD1782 
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2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 13.45  LDD1782 
Leukocyte surface antigen CD47 (CD47) LDTP05572 14.22  LDD1782 
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110 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
60S ribosome subunit biogenesis protein NIP7 homolog (NIP7) LDTP13779 10.70  LDD1782 
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 11.88  LDD1782 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 18.51  LDD1782 
Armadillo repeat-containing protein 10 (ARMC10) LDTP08793 18.25  LDD1782 
ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) LDTP14716 13.83  LDD1782 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 15.03  LDD1782 
C-type mannose receptor 2 (MRC2) LDTP13114 14.32  LDD1782 
Centromere protein K (CENPK) LDTP11143 64.45  LDD1782 
Clustered mitochondria protein homolog (CLUH) LDTP14486 16.68  LDD1782 
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) LDTP13954 11.31  LDD1782 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 95.01  LDD1782 
DnaJ homolog subfamily C member 16 (DNAJC16) LDTP13863 10.63  LDD1782 
Dymeclin (DYM) LDTP08000 17.27  LDD1782 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 20.39  LDD1782 
ELMO domain-containing protein 2 (ELMOD2) LDTP17659 13.00  LDD1782 
Elongin-C (ELOC) LDTP06368 10.70  LDD1782 
Emerin (EMD) LDTP04356 14.83  LDD1782 
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) LDTP10046 10.70  LDD1782 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 35.75  LDD1782 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 23.59  LDD1782 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 82.14  LDD1782 
FAS-associated factor 2 (FAF2) LDTP10185 10.06  LDD1782 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 14.83  LDD1782 
Ganglioside GM2 activator (GM2A) LDTP02927 11.31  LDD1782 
Ganglioside-induced differentiation-associated protein 1 (GDAP1) LDTP09324 9.99  LDD1782 
Gem-associated protein 8 (GEMIN8) LDTP12746 11.39  LDD1782 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 17.27  LDD1782 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 39.12  LDD1782 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 16.45  LDD1782 
Golgi SNAP receptor complex member 2 (GOSR2) LDTP00397 23.10  LDD1782 
Golgin subfamily B member 1 (GOLGB1) LDTP06210 10.48  LDD1782 
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GNG5) LDTP05054 13.36  LDD1782 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 12.73  LDD1782 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 17.27  LDD1782 
HEAT repeat-containing protein 3 (HEATR3) LDTP15253 11.16  LDD1782 
Heat shock 70 kDa protein 13 (HSPA13) LDTP04207 11.47  LDD1782 
HIG1 domain family member 1A, mitochondrial (HIGD1A) LDTP13797 19.16  LDD1782 
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) LDTP05530 12.21  LDD1782 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 12.64  LDD1782 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 14.93  LDD1782 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 16.11  LDD1782 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 12.47  LDD1782 
Lipase maturation factor 2 (LMF2) LDTP15887 10.93  LDD1782 
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) LDTP15240 29.04  LDD1782 
m-AAA protease-interacting protein 1, mitochondrial (MAIP1) LDTP09644 12.38  LDD1782 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 29.86  LDD1782 
Matrix-remodeling-associated protein 7 (MXRA7) LDTP17003 19.43  LDD1782 
Membralin (TMEM259) LDTP14939 36.00  LDD1782 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 36.25  LDD1782 
MICOS complex subunit MIC27 (APOOL) LDTP07718 10.06  LDD1782 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 99.73  LDD1782 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 13.93  LDD1782 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 42.22  LDD1782 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 53.08  LDD1782 
Mitoregulin (MTLN) LDTP09108 16.56  LDD1782 
Neuferricin (CYB5D2) LDTP15623 13.45  LDD1782 
Nucleobindin-1 (NUCB1) LDTP05375 24.93  LDD1782 
Nucleobindin-2 (NUCB2) LDTP05160 25.11  LDD1782 
Nurim (NRM) LDTP08606 10.27  LDD1782 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 14.42  LDD1782 
Optic atrophy 3 protein (OPA3) LDTP16006 30.91  LDD1782 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 17.15  LDD1782 
Pre-mRNA-processing factor 39 (PRPF39) LDTP15284 11.47  LDD1782 
PRELI domain containing protein 3B (PRELID3B) LDTP18569 16.11  LDD1782 
Proteasome adapter and scaffold protein ECM29 (ECPAS) LDTP07255 13.74  LDD1782 
Protein CEBPZOS (CEBPZOS) LDTP18883 47.18  LDD1782 
Protein FAM114A2 (FAM114A2) LDTP16080 44.02  LDD1782 
Protein FAM136A (FAM136A) LDTP18132 14.93  LDD1782 
Protein FAM162A (FAM162A) LDTP10056 64.89  LDD1782 
Protein FAM177A1 (FAM177A1) LDTP15398 15.24  LDD1782 
Protein FAM3C (FAM3C) LDTP09773 29.86  LDD1782 
Protein jagunal homolog 1 (JAGN1) LDTP08904 19.97  LDD1782 
Protein LYRIC (MTDH) LDTP08224 25.11  LDD1782 
Protein misato homolog 1 (MSTO1) LDTP11239 13.55  LDD1782 
Protein NCBP2AS2 (NCBP2AS2) LDTP19472 13.83  LDD1782 
Protein SYS1 homolog (SYS1) LDTP08796 19.16  LDD1782 
Protein unc-119 homolog A (UNC119) LDTP05868 32.45  LDD1782 
Protein YIF1A (YIF1A) LDTP01494 17.03  LDD1782 
Raftlin (RFTN1) LDTP06193 13.27  LDD1782 
Receptor expression-enhancing protein 2 (REEP2) LDTP11113 16.00  LDD1782 
Receptor expression-enhancing protein 3 (REEP3) LDTP15095 16.91  LDD1782 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 15.35  LDD1782 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 12.30  LDD1782 
Reticulocalbin-2 (RCN2) LDTP06097 15.14  LDD1782 
Reticulon-2 (RTN2) LDTP01167 41.07  LDD1782 
Reticulon-3 (RTN3) LDTP01522 73.01  LDD1782 
Reticulon-4 (RTN4) LDTP12412 99.73  LDD1782 
RUS family member 1 (RUSF1) LDTP10357 11.00  LDD1782 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 42.22  LDD1782 
SLC35A4 upstream open reading frame protein (SLC35A4) LDTP19005 13.36  LDD1782 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 9.99  LDD1782 
Syntaxin-10 (STX10) LDTP00986 15.78  LDD1782 
Syntaxin-18 (STX18) LDTP13086 38.05  LDD1782 
Tetraspanin-6 (TSPAN6) LDTP14458 91.77  LDD1782 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 15.14  LDD1782 
Tetratricopeptide repeat protein 21B (TTC21B) LDTP08073 12.13  LDD1782 
Thioredoxin domain-containing protein 15 (TXNDC15) LDTP10442 22.16  LDD1782 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 36.76  LDD1782 
TraB domain-containing protein (TRABD) LDTP19963 21.41  LDD1782 
Transducin beta-like protein 2 (TBL2) LDTP16285 11.47  LDD1782 
Translocon-associated protein subunit delta (SSR4) LDTP04425 10.20  LDD1782 
Transmembrane emp24 domain-containing protein 5 (TMED5) LDTP13967 11.00  LDD1782 
Transmembrane protein 209 (TMEM209) LDTP18272 15.67  LDD1782 
U6 snRNA-associated Sm-like protein LSm3 (LSM3) LDTP04979 10.20  LDD1782 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 44.94  LDD1782 
Uncharacterized protein KIAA2013 (KIAA2013) LDTP17652 10.56  LDD1782 
UPF0488 protein C8orf33 (C8orf33) LDTP12025 12.73  LDD1782 
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) LDTP06808 10.27  LDD1782 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 12.55  LDD1782 
Vimentin (VIM) LDTP02297 10.85  LDD1782 
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⏷ Show the Full List of 110 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1782 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587