Details of the Target

General Information of Target

Target ID LDTP08799
Target Name Lysophosphatidylserine lipase ABHD12 (ABHD12)
Gene Name ABHD12
Gene ID 26090
Synonyms
C20orf22; Lysophosphatidylserine lipase ABHD12; EC 3.1.-.-; 2-arachidonoylglycerol hydrolase ABHD12; Abhydrolase domain-containing protein 12; hABHD12; Monoacylglycerol lipase ABHD12; EC 3.1.1.23; Oxidized phosphatidylserine lipase ABHD12; EC 3.1.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKR
ALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQ
GLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGT
RGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPV
YIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWF
FLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQ
FVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
Target Bioclass
Enzyme
Family
Serine esterase family
Subcellular location
Endoplasmic reticulum membrane
Function
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding.
Uniprot ID
Q8N2K0
Ensemble ID
ENST00000339157.10
HGNC ID
HGNC:15868
ChEMBL ID
CHEMBL5516

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.I310V .
Ishikawa (Heraklio) 02 ER Deletion: p.L80WfsTer21 .
LU65 SNV: p.P145L .
MOLT4 SNV: p.M58I IA-alkyne    Probe Info 
PF382 SNV: p.P334L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		3.83  LDD0197  [1]
DA-P2
 Probe Info  		7.41  LDD0348  [2]
HRP
 Probe Info  		5.56  LDD0347  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K283(10.00); K319(5.12); K343(7.14); K373(0.77)  LDD0277  [4]
DBIA
 Probe Info  		C93(6.46)  LDD3312  [5]
AHL-Pu-1
 Probe Info  		C323(2.85)  LDD0170  [6]
HPAP
 Probe Info  		3.02  LDD0062  [7]
Alkyne-RA190
 Probe Info  		2.76  LDD0299  [8]
IA-alkyne
 Probe Info  		C323(0.00); C52(0.00)  LDD0162  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C52(0.00); C323(0.00); C93(0.00)  LDD0037  [11]
IPM
 Probe Info  		C34(0.00); C15(0.00)  LDD0025  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		C93(0.00); C15(0.00)  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
DA-P3
 Probe Info  		C15(0.00); C52(0.00)  LDD0178  [2]
VSF
 Probe Info  		N.A.  LDD0007  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		C52(0.00); C323(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		9.85  LDD1760  [16]
C091
 Probe Info  		10.13  LDD1782  [16]
C094
 Probe Info  		28.64  LDD1785  [16]
C134
 Probe Info  		37.53  LDD1816  [16]
C143
 Probe Info  		14.52  LDD1825  [16]
C153
 Probe Info  		15.45  LDD1834  [16]
C159
 Probe Info  		8.06  LDD1839  [16]
C233
 Probe Info  		9.58  LDD1906  [16]
C235
 Probe Info  		17.88  LDD1908  [16]
C275
 Probe Info  		6.59  LDD1945  [16]
C314
 Probe Info  		13.45  LDD1981  [16]
C349
 Probe Info  		12.04  LDD2010  [16]
C350
 Probe Info  		31.78  LDD2011  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe15
 Probe Info  		10.83  LDD0478  [17]
FFF probe2
 Probe Info  		13.59  LDD0463  [17]
JN0003
 Probe Info  		20.00  LDD0469  [17]
A-DA
 Probe Info  		2.10  LDD0143  [18]
Alk-rapa
 Probe Info  		2.91  LDD0213  [19]
OEA-DA
 Probe Info  		20.00  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C323(2.85)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C52(2.79); C34(2.86); C15(2.03)  LDD0171  [6]
 LDCM0214  AC1 HEK-293T C52(1.10); C93(0.80); C15(1.84)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C52(1.20); C93(0.93); C15(1.34)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C52(1.07); C93(0.96); C15(1.43)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C52(1.04); C93(1.09); C15(1.80)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C52(1.05); C93(0.92)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C52(1.18); C93(0.97); C15(1.04)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C52(1.10); C93(0.88); C15(1.16)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C52(1.13); C93(0.94); C15(0.98)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C52(1.19); C93(0.92); C15(1.16)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C52(1.09); C93(0.89); C15(0.67)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C52(0.99); C93(1.09); C15(1.31)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C52(1.01); C93(0.95); C15(1.13)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C52(1.01); C93(0.95)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C52(1.00); C93(1.01); C15(0.85)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C52(0.97); C93(0.95); C323(0.89); C15(1.14)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C52(1.10); C93(0.88); C15(1.36)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C52(1.10); C93(0.93); C15(0.98)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C52(1.06); C93(1.00); C15(1.16)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C52(1.00); C93(1.04); C15(1.11)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C52(1.04); C93(1.00); C15(0.83)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C52(1.03); C93(1.01); C15(1.10)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C52(1.02); C93(0.97)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C52(0.98); C93(0.94); C15(0.82)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C52(1.01); C93(0.97); C323(0.96); C15(0.98)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C52(1.13); C93(0.84); C15(0.99)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C52(1.22); C93(0.91); C15(1.32)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C52(1.00); C93(0.92); C15(0.96)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C52(0.98); C93(0.99); C15(1.04)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C52(1.07); C93(0.92); C15(0.90)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C52(1.00); C93(0.95)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C52(1.33); C93(1.01); C15(1.00)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C52(0.98); C93(1.04); C15(1.08)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C52(1.01); C93(0.91); C323(0.94); C15(1.08)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C52(1.19); C93(0.79); C15(1.39)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C52(1.57); C93(0.87); C15(1.09)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C52(1.04); C93(0.94); C15(0.88)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C52(1.03); C93(1.03); C15(1.05)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C52(1.08); C93(0.87); C15(1.88)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C52(1.02); C93(0.87)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C52(1.29); C93(0.94); C15(0.98)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C52(0.98); C93(0.90); C323(1.01); C15(0.86)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C52(1.19); C93(0.91); C15(1.01)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C52(1.05); C93(0.92); C15(1.46)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C52(1.17); C93(0.92); C15(1.18)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C52(1.06); C93(0.93); C15(1.05)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C52(1.02); C93(1.08); C15(1.13)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C52(1.05); C93(0.89); C15(1.26)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C52(1.03); C93(0.88)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C52(1.28); C93(0.97); C15(1.03)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C52(0.98); C93(0.99); C323(1.01); C15(0.99)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C52(1.14); C93(1.02); C15(1.14)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C52(1.07); C93(1.02); C15(0.85)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C52(1.01); C93(1.02); C15(0.90)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C52(1.04); C93(0.98)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C52(1.03); C93(1.13); C15(0.95)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C52(1.08); C93(0.92); C15(1.02)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C52(1.00); C93(0.97)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C52(1.15); C93(0.98); C15(0.92)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C52(0.97); C93(0.99); C323(1.04); C15(0.82)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C52(1.26); C93(1.05); C15(1.04)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C52(0.98); C93(0.87); C323(0.98); C15(0.92)  LDD1569  [21]
 LDCM0248  AKOS034007472 HEK-293T C52(1.08); C93(0.90); C15(0.90)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C52(1.11); C93(0.81); C15(1.14)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C52(1.02); C93(0.96); C323(0.92); C15(1.06)  LDD1514  [21]
 LDCM0083  Avasimibe A-549 2.10  LDD0143  [18]
 LDCM0087  Capsaicin HEK-293T 31.39  LDD0185  [2]
 LDCM0632  CL-Sc Hep-G2 C52(0.20)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C52(1.04); C93(0.98); C323(1.17); C15(1.20)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C52(1.08); C93(1.12)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C52(1.11); C93(1.03)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C52(1.06); C93(0.89); C323(1.08); C15(1.16)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C52(1.01); C93(0.98); C15(0.85)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C52(1.02); C93(1.01)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C52(1.13); C93(1.01)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C52(1.01); C93(0.99); C323(1.14); C15(1.31)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C52(1.07); C93(0.99); C15(0.87)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C52(0.93); C93(1.03)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C52(1.08); C93(1.01)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C52(1.03); C93(0.86); C323(1.16); C15(1.11)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C52(1.18); C93(1.12); C15(0.83)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C52(1.03); C93(1.12); C15(0.79)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C52(0.96); C93(1.03)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C52(1.12); C93(0.91)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C52(1.02); C93(0.97); C323(1.11); C15(1.23)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C52(1.04); C93(1.01); C15(1.09)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C52(1.02); C93(1.00)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C52(1.16); C93(0.94)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C52(1.05); C93(0.88); C323(1.01); C15(1.25)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C52(1.02); C93(0.93); C15(0.87)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C52(1.03); C93(0.99)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C52(0.99); C93(1.05); C323(0.86); C15(1.31)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C52(1.25); C93(0.97)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C52(1.01); C93(0.93); C323(1.04); C15(1.24)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C52(1.05); C93(1.02); C15(0.84)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C52(1.10); C93(1.14)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C52(1.17); C93(1.03)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C52(0.98); C93(0.93); C323(1.14); C15(1.10)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C52(0.94); C93(1.06); C15(0.92)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C52(0.97); C93(1.00)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C52(1.16); C93(1.03)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C52(1.05); C93(0.89); C323(1.16); C15(0.96)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C52(0.99); C93(1.00); C15(0.65)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C52(1.02); C93(1.07)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C52(1.05); C93(1.08)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C52(1.22); C93(0.97); C15(1.20)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C52(1.08); C93(0.96); C15(1.07)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C52(1.10); C93(0.96); C15(1.31)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C52(0.95); C93(0.92); C15(0.88)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C52(0.99); C93(1.15); C15(1.03)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C52(1.10); C93(0.97); C15(1.02)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C52(1.05); C93(0.88)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C52(1.15); C93(0.91); C15(0.95)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C52(0.99); C93(0.87); C323(0.92); C15(0.99)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C52(0.98); C93(1.01); C323(1.16); C15(1.35)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C52(0.95); C93(1.00); C15(0.94)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C52(0.97); C93(1.00)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C52(1.13); C93(0.97)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C52(1.07); C93(0.88); C15(0.85)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C52(0.94); C93(1.05)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C52(1.08); C93(0.98); C15(0.98)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C52(1.13); C93(1.05); C15(1.12)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C52(1.06); C93(1.10); C15(1.05)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C52(1.34); C93(1.09); C15(1.01)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C52(1.05); C93(0.99)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C52(1.21); C93(0.96); C15(0.77)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C52(1.03); C93(0.92); C323(1.02); C15(0.90)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C52(0.98); C93(0.94); C323(1.11); C15(0.99)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C52(0.93); C93(0.92)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C52(0.96); C93(1.08)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C52(1.02); C93(1.00)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C52(1.07); C93(0.89); C15(1.34)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C52(1.05); C93(0.95); C15(1.13)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C52(0.99); C93(1.01); C15(1.20)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C52(1.07); C93(1.00); C15(1.09)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C52(1.14); C93(0.92); C15(1.19)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C52(1.09); C93(0.87)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C52(1.10); C93(0.96); C15(1.00)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C52(1.03); C93(0.99); C323(0.84); C15(1.08)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C52(0.98); C93(0.92); C323(0.98); C15(1.37)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C52(1.05); C93(1.00); C15(0.90)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C52(0.97); C93(1.06); C15(0.64)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C52(1.21); C93(1.03)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C52(1.29); C93(0.96); C15(1.28)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C52(1.60); C93(1.13); C15(1.09)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C52(1.10); C93(0.96); C15(1.23)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C52(1.07); C93(1.08); C15(1.13)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C52(1.15); C93(0.92); C15(0.91)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C52(1.10); C93(0.84)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C52(1.38); C93(0.93); C15(1.19)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C52(1.11); C93(1.09); C15(1.12)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C52(1.04); C93(0.85); C323(0.87); C15(1.36)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C52(0.99); C93(0.93); C323(0.99); C15(1.59)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C52(0.98); C93(0.96); C15(1.05)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C52(1.04); C93(0.96)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C52(1.18); C93(0.97)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C52(1.13); C93(0.92); C15(1.00)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C52(1.15); C93(0.90); C15(1.37)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C52(1.07); C93(0.97); C15(0.90)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C52(1.04); C93(1.18); C15(0.91)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C52(1.13); C93(0.91); C15(0.88)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C52(1.04); C93(0.95); C15(1.07)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C52(1.05); C93(0.88)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C52(1.31); C93(0.96); C15(0.87)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C52(1.01); C93(0.92); C323(0.86); C15(1.34)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C52(0.96); C93(0.79); C323(1.11); C15(1.10)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C52(1.03); C93(0.90); C15(0.96)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C52(1.13); C93(0.98)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C52(1.15); C93(0.88); C15(1.01)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C52(1.13); C93(1.06); C15(1.15)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C52(1.03); C93(0.99); C15(0.94)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C52(1.30); C93(2.59); C15(0.98)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C52(1.00); C93(1.07); C15(1.16)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C52(1.14); C93(0.83); C15(1.04)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C52(1.05); C93(0.81)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C52(1.20); C93(0.87); C15(0.83)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C52(1.02); C93(0.93); C323(0.98); C15(0.96)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C52(0.99); C93(0.96); C323(1.05); C15(1.09)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C52(0.93); C93(1.03); C15(0.78)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C52(0.98); C93(1.12)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C52(1.17); C93(1.02)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C52(1.13); C93(0.95); C15(1.10)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C52(1.05); C93(1.06); C15(1.03)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C52(1.67); C93(1.34); C15(0.99)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C52(1.00); C93(1.09); C15(1.15)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C52(1.01); C93(1.28); C15(0.99)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C52(1.13); C93(0.95); C15(0.94)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C52(1.04); C93(0.91)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C52(1.54); C93(1.29); C15(0.84)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C52(1.03); C93(0.96); C323(0.88); C15(0.94)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C52(1.02); C93(1.09); C323(1.23); C15(1.09)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C52(0.98); C93(1.06); C15(0.87)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C52(1.02); C93(1.03)  LDD1697  [21]
 LDCM0185  Compound 17 HEK-293T 5.93  LDD0512  [17]
 LDCM0184  Compound 20 HEK-293T 17.24  LDD0503  [17]
 LDCM0186  Compound 31 HEK-293T 4.95  LDD0506  [17]
 LDCM0028  Dobutamine HEK-293T 50.49  LDD0180  [2]
 LDCM0495  E2913 HEK-293T C52(1.07); C93(0.99)  LDD1698  [21]
 LDCM0031  Epigallocatechin gallate HEK-293T 17.29  LDD0183  [2]
 LDCM0625  F8 Ramos C93(0.63)  LDD2187  [22]
 LDCM0573  Fragment11 Ramos C93(13.79)  LDD2190  [22]
 LDCM0578  Fragment27 Ramos C93(1.03)  LDD2197  [22]
 LDCM0468  Fragment33 HEK-293T C52(1.00); C93(1.00)  LDD1671  [21]
 LDCM0427  Fragment51 HEK-293T C52(0.97); C93(0.95); C15(0.96)  LDD1631  [21]
 LDCM0614  Fragment56 Ramos C93(2.17)  LDD2205  [22]
 LDCM0022  KB02 HEK-293T C52(0.89); C93(0.87); C323(0.95)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C52(0.96); C93(0.88); C323(1.00)  LDD1497  [21]
 LDCM0024  KB05 HMCB C93(6.46)  LDD3312  [5]
 LDCM0030  Luteolin HEK-293T 153.01  LDD0182  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C52(1.00)  LDD2206  [23]
 LDCM0014  Panhematin HEK-293T 3.02  LDD0062  [7]
 LDCM0029  Quercetin HEK-293T 27.42  LDD0181  [2]
 LDCM0131  RA190 MM1.R 2.76  LDD0299  [8]
 LDCM0090  Rapamycin JHH-7 2.91  LDD0213  [19]

References

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Mass spectrometry data entry: PXD043348
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Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD044625
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.