Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C275  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03786  Glutaredoxin-1 (GLRX) 83.9
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 19.6
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 16.1
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) 14.7
 LDTP07763  Kynurenine--oxoglutarate transaminase 3 (KYAT3) 14.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 11.2
 LDTP01374  Glutaredoxin-3 (GLRX3) 10.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 10.1
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 9.7
 LDTP04581  Holocytochrome c-type synthase (HCCS) 8.1
 LDTP05850  Probable methyltransferase TARBP1 (TARBP1) 7.7
 LDTP10137  Cytochrome c oxidase assembly factor 7 (COA7) 7.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 7.2
 LDTP10329  Ceramide synthase 2 (CERS2) 6.8
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 6.6
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 6.5
 LDTP12676  Exonuclease 3'-5' domain-containing protein 2 (EXD2) 6.4
 LDTP08687  tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) 6.2
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 6.1
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 6.1
 LDTP14535  6-phosphogluconolactonase (PGLS) 5.9
 LDTP03481  DNA-3-methyladenine glycosylase (MPG) 5.9
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 5.9
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 5.9
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 5.7
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 5.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 5.7
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 5.6
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 5.5
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 5.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 5.5
 LDTP10399  Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) 5.4
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) 5.4
 LDTP11268  Acireductone dioxygenase (ADI1) 5.4
 LDTP03145  Catechol O-methyltransferase (COMT) 5.3
 LDTP14074  Ribosomal biogenesis protein LAS1L (LAS1L) 5.2
 LDTP11683  Mitochondrial disaggregase (CLPB) 5.1
 LDTP02935  Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) 5.1
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 5.1
 LDTP03813  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) 5.1
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 5.0
 LDTP06547  Mitogen-activated protein kinase 14 (MAPK14) 4.9
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 12.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 7.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 6.9
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 6.7
 LDTP03952  Reduced folate transporter (SLC19A1) 6.5
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) 6.4
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 6.4
 LDTP01060  PRA1 family protein 2 (PRAF2) 6.3
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 5.9
 LDTP07058  Transmembrane protein 201 (TMEM201) 5.4
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 5.1
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 5.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) 9.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 5.5
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06393  Splicing factor 3A subunit 1 (SF3A1) 8.2
 LDTP07345  Cell division cycle-associated protein 2 (CDCA2) 7.2
 LDTP05533  Kinesin light chain 1 (KLC1) 7.0
 LDTP10381  Peroxisomal membrane protein 11C (PEX11G) 6.5
 LDTP01522  Reticulon-3 (RTN3) 6.1
 LDTP12591  Kinesin light chain 4 (KLC4) 6.0
 LDTP19963  TraB domain-containing protein (TRABD) 5.9
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.7
 LDTP08795  GH3 domain-containing protein (GHDC) 5.5
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 5.4
 LDTP15623  Neuferricin (CYB5D2) 5.4
 LDTP02526  Clusterin (CLU) 5.2
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 5.1
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) 5.0
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 5.0
 LDTP06305  WD repeat-containing protein 43 (WDR43) 5.0
 LDTP10810  Structural maintenance of chromosomes protein 6 (SMC6) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587