Details of the Target

General Information of Target

Target ID LDTP14535
Target Name 6-phosphogluconolactonase (PGLS)
Gene Name PGLS
Gene ID 25796
Synonyms
6-phosphogluconolactonase; 6PGL; EC 3.1.1.31
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGK
YVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTM
DDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSG
EPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPS
LFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQM
VIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILP
NCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKG
QYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIM
PYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN
Target Bioclass
Enzyme
Family
Glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily
Subcellular location
Cytoplasm
Function Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Uniprot ID
O95336
Ensemble ID
ENST00000252603.7
HGNC ID
HGNC:8903

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
BTD
 Probe Info  		C32(5.23)  LDD1699  [4]
AZ-9
 Probe Info  		E253(1.04)  LDD2208  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
Sulforaphane-probe2
 Probe Info  		3.56  LDD0042  [7]
YY4-yne
 Probe Info  		11.09  LDD0400  [8]
DA-P3
 Probe Info  		9.28  LDD0182  [9]
AHL-Pu-1
 Probe Info  		C237(3.06); C78(3.16); C156(3.54)  LDD0170  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
HHS-475
 Probe Info  		Y92(0.68)  LDD0264  [12]
DBIA
 Probe Info  		C32(1.42); C33(1.14); C237(0.88)  LDD0078  [13]
5E-2FA
 Probe Info  		H232(0.00); H87(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		K180(0.00); K254(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C237(0.00); C156(0.00); C78(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_H
 Probe Info  		C237(0.00); C156(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C237(0.00); C156(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C32(0.00); C33(0.00); C237(0.00); C156(0.00)  LDD0037  [16]
NAIA_4
 Probe Info  		C156(0.00); C237(0.00)  LDD2226  [19]
TFBX
 Probe Info  		C32(0.00); C33(0.00)  LDD0027  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
ENE
 Probe Info  		N.A.  LDD0006  [21]
IPM
 Probe Info  		N.A.  LDD0005  [21]
NHS
 Probe Info  		K208(0.00); K180(0.00)  LDD0010  [21]
STPyne
 Probe Info  		N.A.  LDD0009  [21]
Phosphinate-6
 Probe Info  		C32(0.00); C237(0.00)  LDD0018  [23]
1c-yne
 Probe Info  		N.A.  LDD0228  [24]
Acrolein
 Probe Info  		C237(0.00); C78(0.00); C32(0.00)  LDD0217  [25]
Methacrolein
 Probe Info  		C237(0.00); C32(0.00); C78(0.00); C33(0.00)  LDD0218  [25]
AOyne
 Probe Info  		15.00  LDD0443  [26]
NAIA_5
 Probe Info  		C237(0.00); C156(0.00); C78(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		N.A.  LDD2240  [27]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		5.90  LDD1945  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C33(0.87)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C33(0.95)  LDD2112  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C33(1.08)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C33(0.62)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C33(0.92); C32(0.92)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C33(1.54)  LDD2103  [4]
 LDCM0025  4SU-RNA DM93 C237(3.06); C78(3.16); C156(3.54)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA DM93 C237(2.70); C32(3.76)  LDD0171  [10]
 LDCM0214  AC1 HCT 116 C32(1.00); C33(1.18); C237(0.77); C78(0.67)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C32(1.11); C33(1.68); C237(0.91); C78(0.87)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C32(1.05); C33(1.52); C237(0.79); C78(0.98)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C32(0.91); C33(0.82); C237(0.89); C78(0.88)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C32(0.93); C33(1.12); C237(0.83); C78(0.92)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C32(1.06); C33(0.93); C237(0.88); C78(0.87)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C32(0.94); C33(1.00); C237(0.82); C78(0.84)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C32(0.87); C33(1.10); C237(0.81); C78(0.91)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C32(0.91); C33(1.05); C237(0.82); C78(0.87)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C32(1.06); C33(1.34); C237(0.87); C78(0.80)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C32(0.89); C33(0.85); C237(0.86); C78(0.89)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C32(0.86); C33(1.03); C237(0.90); C78(0.98)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C32(1.29); C33(1.50); C237(0.93); C78(0.80)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C32(0.94); C33(1.00); C237(0.82); C78(0.84)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C32(0.81); C33(0.83); C237(0.90); C78(0.84)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C32(0.94); C33(0.83); C237(0.66); C78(0.88)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C32(1.03); C33(1.12); C237(1.11); C78(0.93)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C32(1.51); C33(1.00); C237(0.98); C78(0.76)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C32(1.16); C33(0.97); C237(0.95); C78(0.63)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C32(1.32); C33(0.99); C237(0.89); C78(0.63)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C32(1.10); C33(0.75); C237(1.00); C78(0.86)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C32(1.07); C33(1.18); C237(1.13); C78(0.98)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C32(1.00); C33(0.94); C237(1.01); C78(0.82)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C32(1.15); C33(1.69); C237(1.03); C78(1.22)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C32(1.11); C33(1.09); C237(1.02); C78(0.74)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C32(1.07); C33(1.30); C237(1.12); C78(1.33)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C32(0.88); C33(0.96); C237(1.04); C78(0.74)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C32(1.11); C33(0.84); C237(0.93); C78(1.01)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C32(0.96); C33(0.88); C237(1.20); C78(1.10)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C32(1.38); C33(1.58); C237(1.14); C78(1.04)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C32(1.07); C33(1.05); C237(1.03); C78(0.82)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C32(1.34); C33(1.01); C237(1.00); C78(0.79)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C32(0.95); C78(1.05)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C32(1.06); C78(1.22)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C32(1.26); C78(0.88)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C32(1.11); C78(1.01)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C32(1.33); C78(1.22)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C32(1.38); C78(0.92)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C32(1.80); C78(0.97)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C32(1.53); C78(0.98)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C32(1.59); C78(0.99)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C32(1.50); C78(1.14)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C32(2.16); C78(0.98)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C32(2.31); C78(0.99)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C32(1.09); C33(1.34); C237(0.88); C78(0.71)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C32(2.73); C78(1.00)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C32(1.82); C78(1.01)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C32(1.53); C78(0.93)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C32(1.00); C33(0.78); C78(0.87); C237(0.96)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C33(0.71); C78(0.77); C237(0.83); C32(0.94)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C33(0.83); C237(0.86); C32(1.11); C78(1.40)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C33(0.54); C237(0.73); C78(0.73); C32(1.11)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C237(0.84); C78(0.97); C33(0.98); C32(1.06)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C33(0.64); C78(0.74); C237(0.76); C32(1.19)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C33(0.59); C78(0.61); C237(0.73); C32(1.07)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C78(0.90); C32(0.91); C237(1.03); C33(1.46)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C33(0.88); C78(0.91); C237(0.96); C32(1.20)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C33(0.78); C78(0.84); C237(0.93); C32(1.03)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C33(0.64); C237(0.79); C78(0.80); C32(1.00)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C33(0.49); C78(0.71); C237(0.72); C32(1.33)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C32(1.04); C33(0.66); C237(0.93); C78(0.87)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C32(0.76); C33(0.66); C237(0.82); C78(0.82)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C32(1.08); C33(0.96); C237(1.00); C78(0.84)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C32(1.80); C33(0.95); C237(0.96); C78(0.80)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C33(0.96); C237(1.01); C78(1.10); C32(1.21)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C78(0.83); C237(0.90); C33(1.27); C32(1.38)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C237(1.00); C78(1.09); C32(1.20); C33(1.28)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C33(0.88); C78(0.90); C237(1.02); C32(1.19)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C33(0.96); C32(0.96); C78(1.06); C237(1.16)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C78(0.96); C237(1.03); C33(1.23); C32(1.29)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C33(0.94); C237(1.16); C78(1.17); C32(1.17)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C78(1.04); C237(1.06); C32(1.38); C33(1.47)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C33(1.02); C78(1.15); C237(1.16); C32(1.50)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C78(0.92); C32(0.92); C237(0.92); C33(1.15)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C78(0.82); C33(0.84); C237(0.86); C32(0.90)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C78(0.78); C32(0.88); C237(0.90); C33(0.96)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C78(0.80); C237(0.85); C33(0.97); C32(1.06)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C33(0.74); C78(0.75); C237(0.79); C32(1.06)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C32(0.89); C78(0.90); C237(0.94); C33(0.95)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C33(0.62); C78(0.79); C237(0.90); C32(1.07)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C78(0.69); C33(0.74); C237(0.78); C32(1.01)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C78(0.58); C33(0.76); C237(0.77); C32(1.42)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C78(0.63); C237(0.88); C33(1.03); C32(1.22)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C78(0.69); C237(0.85); C33(0.88); C32(0.99)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C32(1.08); C237(1.11); C33(1.27); C78(1.29)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C32(0.97); C33(1.03); C237(1.13); C78(1.31)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C237(1.07); C32(1.12); C78(1.30); C33(1.46)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C78(0.99); C33(1.01); C237(1.07); C32(1.10)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C237(0.96); C33(0.97); C32(1.01); C78(1.14)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C78(0.88); C237(0.93); C32(0.97); C33(1.11)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C78(1.01); C32(1.02); C237(1.10); C33(1.11)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C78(1.03); C237(1.09); C33(1.19); C32(1.27)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C33(1.02); C78(1.02); C237(1.10); C32(1.16)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C78(0.80); C237(0.87); C32(1.37); C33(1.40)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C237(1.05); C32(1.21); C78(1.23); C33(1.65)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C78(1.02); C237(1.04); C32(1.16); C33(1.41)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C78(0.73); C33(0.80); C237(0.91); C32(1.11)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C237(0.90); C78(1.02); C33(1.02); C32(1.02)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C78(0.77); C237(1.00); C33(1.01); C32(1.06)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C33(0.80); C78(0.91); C237(1.00); C32(1.18)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C78(0.87); C32(0.93); C237(0.95); C33(1.04)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C78(0.86); C237(0.90); C33(0.94); C32(1.23)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C33(0.95); C237(1.08); C78(1.33); C32(1.33)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C33(0.92); C237(1.03); C32(1.09); C78(1.13)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C78(0.77); C237(0.98); C32(1.39); C33(1.45)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C32(1.14); C237(1.18); C78(1.22); C33(1.26)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C78(0.75); C237(1.09); C32(1.20); C33(1.32)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C78(0.74); C33(1.05); C237(1.07); C32(1.13)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C78(0.83); C237(0.85); C33(1.15); C32(1.28)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C237(0.77); C78(0.92); C32(1.05); C33(1.18)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C237(0.82); C78(1.02); C33(1.12); C32(1.30)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C78(0.78); C237(0.96); C32(1.10); C33(1.32)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C78(0.71); C237(0.76); C33(0.78); C32(1.08)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C237(0.77); C78(0.78); C33(0.88); C32(1.26)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C33(0.78); C78(0.79); C237(0.91); C32(1.20)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C78(0.72); C237(0.74); C33(1.06); C32(1.09)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C237(0.83); C33(0.84); C78(0.85); C32(1.46)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C78(0.92); C237(0.92); C33(0.95); C32(1.62)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C237(0.86); C78(0.88); C33(1.11); C32(1.87)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C237(0.63); C78(0.65); C33(0.89); C32(1.51)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C237(0.81); C78(0.89); C32(0.91)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C32(0.65); C237(0.76); C78(0.86)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C78(0.77); C237(0.95); C32(1.27); C33(1.70)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C237(0.74); C78(0.93); C32(1.15)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C32(0.80); C237(0.93); C78(1.11)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C237(0.89); C32(1.17); C78(1.18)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C237(0.61); C78(0.96); C32(1.69)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C237(0.57); C78(0.79); C32(0.93)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C237(0.52); C78(0.89); C32(1.21)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C237(0.85); C32(1.02); C78(1.05)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C237(0.81); C78(0.99); C32(1.26)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C32(0.75); C237(0.86); C78(0.92)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C237(0.97); C32(1.03); C78(1.39)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C78(0.80); C237(0.93); C33(1.14); C32(1.15)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C32(0.70); C237(0.89); C78(1.10)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C78(0.76); C237(0.84); C32(1.09)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C237(0.48); C78(0.77); C32(1.23)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C78(0.68); C237(0.82); C33(0.83); C32(1.24)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C78(0.71); C237(0.79); C33(0.82); C32(0.99)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C78(0.73); C237(0.77); C33(0.88); C32(0.97)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C78(0.89); C237(0.97); C33(1.04); C32(1.46)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C33(0.83); C32(0.86); C78(0.87); C237(0.88)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C78(0.93); C237(0.97); C32(1.04); C33(1.05)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C78(0.75); C33(0.84); C237(0.92); C32(0.94)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C32(1.17); C237(1.24); C33(1.40); C78(1.45)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C78(0.80); C33(0.89); C237(0.92); C32(1.20)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C32(0.87); C78(0.87); C237(0.96); C33(1.02)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C33(0.87); C32(0.88); C78(0.90); C237(0.91)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C237(0.83); C32(0.90); C33(0.94); C78(0.95)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C33(0.65); C237(0.70); C78(0.72); C32(0.86)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C78(0.79); C237(0.87); C32(0.90); C33(1.00)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C78(0.73); C33(0.89); C237(0.96); C32(1.18)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C237(0.64); C33(0.76); C78(0.80); C32(1.83)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C237(0.84); C32(0.94); C78(0.94); C33(1.05)  LDD0683  [13]
 LDCM0520  AKOS000195272 MDA-MB-231 C33(0.85); C32(0.88)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C32(1.12); C33(1.64); C237(1.05); C78(1.07)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C78(0.84); C237(0.95); C32(1.59); C33(1.88)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C78(0.73); C237(0.86); C32(1.06); C33(1.13)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 13.01  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C32(1.42); C33(1.14); C237(0.88)  LDD0078  [13]
 LDCM0087  Capsaicin HEK-293T 6.59  LDD0185  [9]
 LDCM0630  CCW28-3 231MFP C237(1.88)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C32(0.00); C78(0.00); C237(0.00); C33(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C32(1.47); C237(1.10); C78(0.75)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C237(0.76); C78(0.89); C32(1.94)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C78(0.53); C237(0.63); C32(1.16)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C78(0.75); C237(0.87); C32(1.14); C33(1.18)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C78(0.62); C237(0.78); C33(1.33); C32(1.96)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C78(0.81); C237(0.96); C32(4.75); C33(5.23)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C78(0.92); C237(0.94); C32(1.45); C33(2.31)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C78(0.73); C237(0.91); C33(1.43); C32(1.83)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C237(0.82); C78(0.83); C33(1.49); C32(1.68)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C237(0.65); C78(0.73); C32(1.45); C33(1.77)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C237(0.92); C78(0.92); C32(1.28); C33(1.46)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C237(0.90); C78(0.92); C33(1.45); C32(1.46)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C78(0.76); C237(0.79); C33(1.36); C32(2.13)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C78(0.56); C237(0.61); C32(1.30)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C78(0.76); C237(0.77); C33(1.95); C32(2.21)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C78(0.80); C237(0.87); C32(1.59); C33(1.66)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C237(0.82); C78(0.86); C33(1.84); C32(2.32)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C78(0.68); C33(0.77); C237(0.84); C32(1.03)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C78(0.60); C237(0.87); C33(1.86); C32(12.67)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C237(0.82); C33(0.89); C78(1.07); C32(1.36)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C78(0.70); C237(0.93); C33(1.02); C32(1.10)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C237(0.88); C78(1.07); C33(1.19); C32(1.40)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C78(0.96); C237(1.03); C33(1.14); C32(1.48)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C78(0.84); C237(0.98); C32(1.37); C33(1.50)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C78(0.66); C237(0.75); C32(1.21)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C237(1.07); C33(1.08); C78(1.15); C32(1.41)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C78(0.67); C237(0.86); C33(1.31); C32(1.52)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C78(0.71); C237(1.01); C33(1.17); C32(1.52)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C78(0.86); C237(0.92); C32(1.44); C33(1.61)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C78(0.84); C237(0.94); C33(1.53); C32(1.55)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C237(1.05); C33(1.10); C78(1.20); C32(1.56)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C78(0.94); C237(1.07); C33(1.31); C32(2.42)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C78(0.86); C237(1.00); C33(1.05); C32(1.40)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C32(0.83); C237(0.92); C78(1.09); C33(1.14)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C78(0.55); C237(0.69); C32(1.07)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C78(0.72); C237(0.78); C32(1.06)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C78(0.56); C237(0.67); C32(1.81)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C78(0.68); C237(0.72); C33(0.94); C32(0.95)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C78(0.73); C237(0.81); C33(0.93); C32(1.13)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C78(0.56); C237(0.64); C32(0.65); C33(0.76)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C78(0.68); C32(0.79); C237(0.81); C33(0.82)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C237(0.79); C78(0.86); C32(1.27)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C78(0.68); C33(0.92); C237(0.98); C32(1.04)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C237(0.50); C78(0.61); C33(1.19); C32(1.33)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C78(0.68); C237(0.70); C33(0.89); C32(1.05)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C33(0.76); C32(0.78); C78(0.78); C237(1.05)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C78(0.69); C33(0.82); C237(0.84); C32(0.87)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C32(1.21); C33(1.12); C237(0.74); C78(0.60)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C32(0.91); C33(0.87); C237(0.92); C78(0.65)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C32(0.85); C33(0.98); C237(0.91); C78(0.71)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C32(1.03); C33(0.81); C237(0.71); C78(0.55)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C32(0.95); C33(0.84); C237(0.86); C78(0.61)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C32(1.08); C237(0.86); C78(0.87)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C32(1.03); C33(0.89); C237(0.89); C78(0.83)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C32(1.09); C33(1.05); C237(0.91); C78(0.80)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C32(0.68); C33(0.69); C237(0.66); C78(0.50)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C32(1.10); C33(0.95); C237(0.56); C78(0.40)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C32(1.08); C33(0.72); C237(0.80); C78(0.56)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C32(0.82); C33(0.78); C237(0.88); C78(0.70)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C32(1.32); C33(0.94); C237(0.91); C78(0.67)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C32(0.88); C33(0.84); C237(0.89); C78(0.63)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C32(0.96); C33(0.98); C237(0.81); C78(0.72)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C32(2.07); C237(1.00); C78(0.70)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C32(0.85); C33(0.84); C237(0.86); C78(0.64)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C32(1.00); C33(0.91); C237(0.98); C78(0.76)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C32(0.96); C33(0.93); C237(0.85); C78(0.59)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C32(0.72); C33(0.71); C237(0.90); C78(0.57)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C32(0.61); C33(0.67); C237(0.76); C78(0.55)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C32(1.10); C33(0.91); C237(0.68); C78(0.54)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C32(1.65); C33(1.61); C237(0.75); C78(1.46)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C32(1.57); C33(1.48); C237(0.85); C78(1.32)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C32(1.90); C33(1.83); C237(0.78); C78(1.26)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C32(1.86); C33(1.76); C237(0.65); C78(1.29)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C32(1.28); C237(1.03); C78(0.78)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C32(2.16); C33(2.17); C237(0.82); C78(1.21)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C32(1.83); C33(1.76); C237(0.67); C78(1.31)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C32(2.26); C33(1.53); C237(0.76); C78(1.29)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C32(1.74); C33(1.44); C237(1.14); C78(1.11)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C32(1.53); C33(1.41); C237(0.71); C78(1.10)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C32(1.35); C33(1.32); C237(0.76); C78(1.33)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C32(1.21); C33(1.17); C237(0.95); C78(1.19)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C32(1.40); C33(1.35); C237(1.09); C78(1.22)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C32(1.66); C33(1.30); C237(0.83); C78(1.25)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C32(1.45); C33(1.40); C237(0.76); C78(1.20)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C32(1.56); C237(0.61); C78(0.47)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C32(1.37); C33(1.35); C237(0.74); C78(1.06)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C32(1.11); C33(1.17); C237(1.03); C78(0.74)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C32(1.15); C33(1.25); C237(0.97); C78(0.78)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C32(1.12); C33(1.11); C237(0.89); C78(0.71)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C32(1.16); C33(1.17); C237(0.79); C78(0.90)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C32(1.04); C33(1.13); C237(1.05); C78(1.35)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C32(0.97); C33(1.01); C237(1.01); C78(0.79)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C32(1.00); C33(0.92); C237(1.10); C78(0.99)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C32(0.91); C33(0.76); C237(0.70); C78(0.67)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C32(0.86); C33(0.67); C237(0.61); C78(0.56)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C32(1.14); C237(0.71); C78(0.62)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C32(0.79); C33(0.71); C237(0.81); C78(0.84)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C32(2.52); C33(2.30); C237(0.91); C78(0.74)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C32(1.34); C33(1.18); C237(1.12); C78(0.64)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C32(1.20); C33(1.23); C237(0.88); C78(0.67)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C32(1.39); C33(1.43); C237(1.00); C78(0.95)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C32(0.82); C33(0.68); C237(0.94); C78(0.73)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C32(1.35); C33(1.35); C237(0.94); C78(0.82)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C32(1.16); C33(1.12); C237(0.94); C78(0.91)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C32(0.95); C33(0.86); C237(1.05); C78(0.92)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C32(1.67); C237(0.51); C78(0.58)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C32(0.90); C33(0.88); C237(0.83); C78(0.74)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C32(0.96); C33(1.06); C237(0.95); C78(0.96)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C32(0.83); C33(0.91); C237(0.82); C78(0.91)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C32(2.71); C33(2.53); C237(0.82); C78(0.85)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C32(1.24); C33(1.31); C237(0.71); C78(0.73)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C32(0.99); C33(0.84); C237(0.97); C78(0.95)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C32(1.12); C33(1.07); C237(1.05); C78(1.04)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C32(1.14); C33(1.20); C237(1.06); C78(1.12)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C32(0.89); C33(0.96); C237(0.90); C78(0.90)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C32(0.90); C33(1.05); C237(0.69); C78(0.77)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C32(1.37); C237(0.84); C78(0.68)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C32(2.09); C33(2.12); C237(0.65); C78(1.26)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C32(1.23); C33(1.00); C237(0.86); C78(0.94)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C32(1.36); C33(1.28); C237(0.75); C78(0.88)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C32(1.07); C33(1.12); C237(0.99); C78(0.90)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C32(1.30); C33(1.35); C237(0.73); C78(0.74)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C32(3.60); C33(2.41); C237(0.75); C78(0.77)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C32(1.23); C33(0.99); C237(0.84); C78(0.82)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C32(1.31); C33(1.00); C237(0.72); C78(0.68)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C32(1.25); C33(0.85); C237(0.94); C78(0.80)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C32(1.07); C33(1.07); C237(0.83); C78(0.82)  LDD0811  [13]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C32, C33(8.99)  LDD0513  [30]
 LDCM0495  E2913 HEK-293T C78(1.04); C237(0.89); C32(1.32)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C32(4.58)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0202  EV-93 T cell C32, C33(15.25)  LDD0514  [30]
 LDCM0625  F8 Ramos C78(0.63); C237(0.74); 1.40  LDD2187  [32]
 LDCM0572  Fragment10 MDA-MB-231 C32(20.00)  LDD1389  [33]
 LDCM0573  Fragment11 Ramos C32(8.85)  LDD1392  [33]
 LDCM0574  Fragment12 Ramos C32(2.51)  LDD1394  [33]
 LDCM0575  Fragment13 MDA-MB-231 C32(3.67)  LDD1395  [33]
 LDCM0576  Fragment14 MDA-MB-231 C32(3.38)  LDD1397  [33]
 LDCM0577  Fragment15 Ramos C32(1.42)  LDD1400  [33]
 LDCM0579  Fragment20 MDA-MB-231 C32(3.26)  LDD1402  [33]
 LDCM0580  Fragment21 MDA-MB-231 C32(2.92)  LDD1404  [33]
 LDCM0581  Fragment22 MDA-MB-231 C32(3.35)  LDD1406  [33]
 LDCM0582  Fragment23 MDA-MB-231 C32(0.98)  LDD1408  [33]
 LDCM0583  Fragment24 Ramos C32(1.20)  LDD1410  [33]
 LDCM0584  Fragment25 MDA-MB-231 C32(0.95)  LDD1411  [33]
 LDCM0585  Fragment26 Ramos C32(0.87)  LDD1412  [33]
 LDCM0578  Fragment27 MDA-MB-231 C32(0.58)  LDD1401  [33]
 LDCM0586  Fragment28 MDA-MB-231 C32(1.29)  LDD1415  [33]
 LDCM0587  Fragment29 MDA-MB-231 C32(1.61)  LDD1417  [33]
 LDCM0588  Fragment30 MDA-MB-231 C32(1.41)  LDD1419  [33]
 LDCM0589  Fragment31 MDA-MB-231 C32(2.06)  LDD1421  [33]
 LDCM0590  Fragment32 MDA-MB-231 C32(3.46)  LDD1423  [33]
 LDCM0468  Fragment33 HCT 116 C32(1.21); C33(1.05); C237(1.03); C78(0.66)  LDD0785  [13]
 LDCM0592  Fragment34 MDA-MB-231 C32(0.88)  LDD1427  [33]
 LDCM0593  Fragment35 Ramos C32(1.14)  LDD1430  [33]
 LDCM0594  Fragment36 MDA-MB-231 C32(2.82)  LDD1431  [33]
 LDCM0595  Fragment37 Ramos C32(1.02)  LDD1432  [33]
 LDCM0596  Fragment38 MDA-MB-231 C32(1.29)  LDD1433  [33]
 LDCM0597  Fragment39 MDA-MB-231 C32(20.00)  LDD1435  [33]
 LDCM0566  Fragment4 MDA-MB-231 C32(4.26)  LDD1378  [33]
 LDCM0598  Fragment40 MDA-MB-231 C32(0.96)  LDD1436  [33]
 LDCM0599  Fragment41 MDA-MB-231 C32(1.12)  LDD1438  [33]
 LDCM0600  Fragment42 Ramos C32(0.90)  LDD1440  [33]
 LDCM0601  Fragment43 Ramos C32(2.88)  LDD1442  [33]
 LDCM0602  Fragment44 MDA-MB-231 C32(0.80)  LDD1443  [33]
 LDCM0604  Fragment46 MDA-MB-231 C32(0.87)  LDD1445  [33]
 LDCM0605  Fragment47 MDA-MB-231 C32(1.22)  LDD1446  [33]
 LDCM0606  Fragment48 MDA-MB-231 C32(1.25)  LDD1447  [33]
 LDCM0608  Fragment50 MDA-MB-231 C32(1.82)  LDD1449  [33]
 LDCM0427  Fragment51 HCT 116 C32(1.10); C33(0.89); C237(0.77); C78(0.64)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C32(1.50)  LDD1453  [33]
 LDCM0611  Fragment53 MDA-MB-231 C32(0.92)  LDD1454  [33]
 LDCM0612  Fragment54 MDA-MB-231 C32(1.24)  LDD1456  [33]
 LDCM0613  Fragment55 MDA-MB-231 C32(1.42)  LDD1457  [33]
 LDCM0614  Fragment56 MDA-MB-231 C32(0.96)  LDD1458  [33]
 LDCM0569  Fragment7 Ramos C32(4.48)  LDD1384  [33]
 LDCM0570  Fragment8 MDA-MB-231 C32(1.64)  LDD1385  [33]
 LDCM0571  Fragment9 MDA-MB-231 C32(5.90)  LDD1387  [33]
 LDCM0116  HHS-0101 DM93 Y92(0.68)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y92(0.31)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y92(0.36)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y92(0.48)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y92(2.16)  LDD0268  [12]
 LDCM0107  IAA HeLa C78(0.00); C33(0.00)  LDD0221  [25]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HCT 116 C32(7.33); C237(1.34)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C32(2.75); C237(1.91)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C32(4.43); C237(1.22)  LDD0082  [13]
 LDCM0030  Luteolin HEK-293T 9.28  LDD0182  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C33(1.16)  LDD2102  [4]
 LDCM0109  NEM HeLa N.A.  LDD0225  [25]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C33(0.95); C32(0.73)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C33(1.00); C32(1.20)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C32(1.09)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C33(0.64); C32(0.65)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C33(1.70)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C33(0.72); C32(0.70)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C33(1.16)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C33(0.98); C32(0.98)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C33(0.86)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C33(1.91); C32(1.46)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C32(0.64)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C33(1.01); C32(0.14)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C33(0.65); C32(0.63)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C33(0.81); C32(0.79)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C33(0.86)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C33(0.75); C32(0.73)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C33(0.19)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C33(1.95); C32(2.08)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C33(0.96); C32(0.92)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C33(0.36)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C33(0.50); C32(0.67)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C33(0.64); C32(1.03)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C32(0.14)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C33(0.82); C32(0.61)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C32(0.96)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C33(0.91)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C33(0.78)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C33(0.55); C32(0.56)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C33(0.74)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C33(1.18); C32(1.18)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C32(0.76)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C33(0.95)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C32(0.81)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C33(0.71)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C33(1.02); C32(1.01)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C33(3.06); C32(3.07)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C32(0.63)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C33(0.69)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C32(3.04)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C33(0.64); C32(0.65)  LDD2148  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C32(0.07)  LDD2206  [34]
 LDCM0032  Oleacein HEK-293T 6.77  LDD0184  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C32(0.66)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C32(1.17)  LDD0304  [35]
 LDCM0170  Structure8 Ramos 13.81  LDD0433  [36]
 LDCM0003  Sulforaphane MCF-7 3.56  LDD0042  [7]
 LDCM0021  THZ1 HCT 116 C32(1.06); C237(1.26)  LDD2173  [13]
 LDCM0154  YY4 T cell 11.09  LDD0400  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bleomycin hydrolase (BLMH) Peptidase C1 family Q13867
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
36 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.