Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment42					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP02733	Pyruvate kinase PKM (PKM)				C423	20.0
LDTP09912	DNA repair protein RAD50 (RAD50)				C1296	1.5
LDTP14159	Ubiquitin carboxyl-terminal hydrolase 16 (USP16)				C205	1.5
LDTP02502	Thioredoxin (TXN)				C32	1.4
LDTP05992	Bleomycin hydrolase (BLMH)				C73	1.3
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.3
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.1
LDTP04689	Adenosine kinase (ADK)				C353	1.1
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.1
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.1
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	1.0
LDTP02672	Elongation factor 2 (EEF2)				C41	1.0
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.0
LDTP10177	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)				C64	1.0
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.0
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	1.0
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C453	1.0
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	1.0
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	1.0
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	1.0
LDTP04374	Dynamin-2 (DNM2)				C27	1.0
LDTP09598	Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)				C207	1.0
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.0
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.0
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	0.9
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	0.9
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	0.9
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	0.9
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	0.9
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	0.9
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	0.9
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.9
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	0.9
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	0.9
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	0.9
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	0.9
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	0.9
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	0.9
LDTP01633	Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)				C170	0.9
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	0.9
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	0.9
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	0.9
LDTP03786	Glutaredoxin-1 (GLRX)				C23	0.9
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.9
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	0.9
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.9
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	0.9
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	0.9
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	0.9
LDTP02672	Elongation factor 2 (EEF2)				C136	0.9
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	0.9
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	0.9
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	0.9
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	0.9
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	0.8
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	0.8
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.8
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	0.8
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	0.8
LDTP05289	AMP deaminase 2 (AMPD2)				C107	0.8
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	0.8
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	0.8
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.8
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	0.8
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.8
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	0.8
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	0.8
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	0.8
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	0.8
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	0.8
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	0.8
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	0.8
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	0.8
LDTP12190	NmrA-like family domain-containing protein 1 (NMRAL1)				C154	0.8
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	0.8
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	0.7
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	0.7
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	0.7
LDTP10774	Elongation factor G, mitochondrial (GFM1)				C153	0.5
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C193	0.4

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11855	Pinin (PNN)				C249	1.2
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.0
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.0
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	1.0
LDTP00501	Exportin-1 (XPO1)				C34	0.9
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	0.9
LDTP04707	Protein SEC13 homolog (SEC13)				C187	0.9
LDTP04801	Gasdermin-D (GSDMD)				C268	0.8
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	0.8
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	0.8
LDTP13661	Sorting nexin-6 (SNX6)				C264	0.8
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12792	CDKN2A-interacting protein (CDKN2AIP)				C516	1.3
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	1.0
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	1.0
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.0
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	0.9
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	0.9
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.4
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.3
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.3
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	1.3
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	1.3
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	1.2
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.2
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	1.2
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	1.2
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	1.1
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	1.1
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	1.1
LDTP18494	Tropomodulin-3 (TMOD3)				C132	1.1
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	1.1
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.1
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	1.1
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	1.1
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.1
LDTP01532	ZW10 interactor (ZWINT)				C54	1.1
LDTP10864	Calponin-2 (CNN2)				C164	1.0
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	1.0
LDTP10864	Calponin-2 (CNN2)				C215	1.0
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.0
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.0
LDTP02205	Tubulin beta chain (TUBB)				C354	1.0
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.0
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	1.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	1.0
LDTP12412	Reticulon-4 (RTN4)				C1101	1.0
LDTP02205	Tubulin beta chain (TUBB)				C239	1.0
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.0
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)				C35	1.0
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	1.0
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.0
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	0.9
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	0.9
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	0.9
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	0.9
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	0.9
LDTP13837	Trafficking protein particle complex subunit 4 (TRAPPC4)				C195	0.9
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	0.9
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	0.9
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	0.9
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	0.9
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	0.9
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	0.9
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	0.9
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	0.9
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	0.9
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	0.9
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	0.9
LDTP04092	Crk-like protein (CRKL)				C249	0.8
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	0.8
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	0.8
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	0.8
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	0.8
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.8
LDTP00202	AH receptor-interacting protein (AIP)				C122	0.8
LDTP12669	Mediator of RNA polymerase II transcription subunit 17 (MED17)				C649	0.8
LDTP04902	Actin-related protein 3 (ACTR3)				C235	0.8
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	0.8
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.8
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	0.7
LDTP04487	Cyclin-H (CCNH)				C244	0.7
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	0.7
LDTP14351	RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)				C179	0.7

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.