Details of the Target

General Information of Target

Target ID LDTP02672
Target Name Elongation factor 2 (EEF2)
Gene Name EEF2
Gene ID 1938
Synonyms
EF2; Elongation factor 2; EF-2; EC 3.6.5.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTR
KDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALR
VTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQR
IVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKG
EGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKV
FDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPS
PVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGL
VSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLV
KTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEE
SGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHN
RLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPN
ILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQ
IIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTP
MFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRK
RKGLKEGIPALDNFLDKL
Target Bioclass
Enzyme
Family
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
Subcellular location
Cytoplasm
Function
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Uniprot ID
P13639
Ensemble ID
ENST00000309311.7
HGNC ID
HGNC:3214
ChEMBL ID
CHEMBL1795108

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 73 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P1
 Probe Info  		1.56  LDD0452  [2]
P2
 Probe Info  		1.62  LDD0449  [2]
P3
 Probe Info  		2.11  LDD0450  [2]
P8
 Probe Info  		1.74  LDD0455  [2]
A-EBA
 Probe Info  		4.00  LDD0215  [3]
11RK72
 Probe Info  		5.93  LDD0327  [4]
11RK73
 Probe Info  		6.04  LDD0328  [4]
8RK64
 Probe Info  		N.A.  LDD0039  [4]
7-N3
 Probe Info  		0.75  LDD0281  [5]
CHEMBL5175495
 Probe Info  		7.04  LDD0196  [6]
CY-1
 Probe Info  		8.69  LDD0243  [7]
CY4
 Probe Info  		5.57  LDD0244  [7]
N1
 Probe Info  		4.92  LDD0242  [7]
TH211
 Probe Info  		Y639(18.23); Y443(13.39); Y411(12.18)  LDD0257  [8]
TH214
 Probe Info  		Y730(15.49); Y639(14.08); Y265(10.75); Y443(10.51)  LDD0258  [8]
TH216
 Probe Info  		Y367(20.00); Y634(17.00); Y579(11.83); Y730(11.38)  LDD0259  [8]
YN-1
 Probe Info  		100.00  LDD0444  [9]
YN-4
 Probe Info  		100.00  LDD0445  [9]
AZ-9
 Probe Info  		E689(0.74); D7(0.89); E248(0.99); E640(10.00)  LDD2208  [10]
ONAyne
 Probe Info  		K598(0.00); K252(0.00); K275(0.00); K572(0.00)  LDD0273  [11]
OPA-S-S-alkyne
 Probe Info  		K598(1.36); K407(1.45); K439(1.76); K42(1.82)  LDD3494  [12]
Probe 1
 Probe Info  		Y232(13.57); Y265(41.28); Y367(20.51); Y373(48.16)  LDD3495  [13]
AF-1
 Probe Info  		2.20  LDD0421  [14]
JZ128-DTB
 Probe Info  		C591(0.00); C751(0.00); C41(0.00); C728(0.00)  LDD0462  [15]
THZ1-DTB
 Probe Info  		C693(1.10); C728(1.14); C651(1.08); C591(1.07)  LDD0460  [15]
DA-P3
 Probe Info  		4.98  LDD0183  [16]
AHL-Pu-1
 Probe Info  		C751(2.45); C728(2.78)  LDD0169  [17]
EA-probe
 Probe Info  		C131(0.92); C131(0.79); C466(0.84)  LDD2210  [18]
HHS-482
 Probe Info  		Y265(2.42); Y373(2.15); Y397(0.94); Y443(1.01)  LDD0285  [19]
HHS-475
 Probe Info  		Y367(0.46); Y603(0.71); Y411(0.88); Y443(0.88)  LDD0264  [20]
HHS-465
 Probe Info  		Y265(0.67); Y397(10.00); Y443(10.00); Y457(6.84)  LDD2237  [21]
DBIA
 Probe Info  		C136(1.33); C812(1.22); C651(1.04); C41(1.02)  LDD0078  [22]
5E-2FA
 Probe Info  		H565(0.00); H769(0.00); H30(0.00); H816(0.00)  LDD2235  [23]
AMP probe
 Probe Info  		K275(0.00); K318(0.00); K239(0.00); K439(0.00)  LDD0200  [24]
ATP probe
 Probe Info  		K275(0.00); K318(0.00); K239(0.00); K439(0.00)  LDD0199  [24]
4-Iodoacetamidophenylacetylene
 Probe Info  		C369(0.00); C728(0.00); C567(0.00); C693(0.00)  LDD0038  [25]
IA-alkyne
 Probe Info  		C728(0.00); C591(0.00); C693(0.00); C41(0.00)  LDD0032  [26]
IPIAA_H
 Probe Info  		C693(0.00); C369(0.00); C290(0.00); C41(0.00)  LDD0030  [27]
IPIAA_L
 Probe Info  		C728(0.00); C369(0.00); C567(0.00); C751(0.00)  LDD0031  [27]
Lodoacetamide azide
 Probe Info  		C369(0.00); C728(0.00); C567(0.00); C693(0.00)  LDD0037  [25]
ATP probe
 Probe Info  		K598(0.00); K235(0.00); K152(0.00); K481(0.00)  LDD0035  [28]
BTD
 Probe Info  		C369(0.00); C567(0.00); C67(0.00)  LDD0004  [29]
JW-RF-010
 Probe Info  		C466(0.00); C131(0.00); C728(0.00); C290(0.00)  LDD0026  [30]
NAIA_4
 Probe Info  		C41(0.00); C290(0.00); C369(0.00); C388(0.00)  LDD2226  [31]
TFBX
 Probe Info  		C41(0.00); C728(0.00)  LDD0027  [30]
WYneC
 Probe Info  		N.A.  LDD0014  [29]
WYneN
 Probe Info  		C41(0.00); C567(0.00); C290(0.00)  LDD0021  [29]
WYneO
 Probe Info  		C567(0.00); C41(0.00)  LDD0022  [29]
aHNE
 Probe Info  		C41(0.00); C728(0.00)  LDD0001  [29]
aONE
 Probe Info  		N.A.  LDD0002  [29]
1d-yne
 Probe Info  		K605(0.00); K318(0.00); K785(0.00)  LDD0356  [32]
Compound 10
 Probe Info  		C369(0.00); C41(0.00); C567(0.00); C591(0.00)  LDD2216  [33]
Compound 11
 Probe Info  		C290(0.00); C41(0.00); C567(0.00); C591(0.00)  LDD2213  [33]
ENE
 Probe Info  		C567(0.00); C591(0.00); C693(0.00); C41(0.00)  LDD0006  [29]
IPM
 Probe Info  		C290(0.00); C651(0.00); C728(0.00); C41(0.00)  LDD0005  [29]
NHS
 Probe Info  		K308(0.00); K318(0.00); K498(0.00); K512(0.00)  LDD0010  [29]
NPM
 Probe Info  		N.A.  LDD0016  [29]
PF-06672131
 Probe Info  		C41(0.00); C290(0.00); C567(0.00)  LDD0017  [34]
PPMS
 Probe Info  		C567(0.00); C591(0.00)  LDD0008  [29]
SF
 Probe Info  		K445(0.00); K598(0.00); K498(0.00); K42(0.00)  LDD0028  [35]
STPyne
 Probe Info  		K308(0.00); K337(0.00); K235(0.00); K333(0.00)  LDD0009  [29]
VSF
 Probe Info  		C651(0.00); C41(0.00); C591(0.00); C812(0.00)  LDD0007  [29]
Phosphinate-6
 Probe Info  		C136(0.00); C812(0.00); C728(0.00); C41(0.00)  LDD0018  [36]
Ox-W18
 Probe Info  		W261(0.00); W641(0.00); W685(0.00); W650(0.00)  LDD2175  [37]
1c-yne
 Probe Info  		K498(0.00); K638(0.00); K235(0.00); K688(0.00)  LDD0228  [32]
Acrolein
 Probe Info  		C369(0.00); H769(0.00); C567(0.00); H27(0.00)  LDD0217  [38]
Cinnamaldehyde
 Probe Info  		C41(0.00); C693(0.00); C567(0.00)  LDD0220  [38]
Crotonaldehyde
 Probe Info  		C693(0.00); C41(0.00); H30(0.00)  LDD0219  [38]
Methacrolein
 Probe Info  		C567(0.00); H30(0.00); C693(0.00); C41(0.00)  LDD0218  [38]
W1
 Probe Info  		C41(0.00); C812(0.00); C651(0.00); C567(0.00)  LDD0236  [39]
AOyne
 Probe Info  		15.00  LDD0443  [40]
NAIA_5
 Probe Info  		C41(0.00); C67(0.00); C728(0.00); C567(0.00)  LDD2223  [31]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		6.47  LDD0465  [41]
VE-P
 Probe Info  		N.A.  LDD0396  [42]
Diazir
 Probe Info  		N.A.  LDD0011  [29]
BD-F
 Probe Info  		N.A.  LDD0024  [43]
LD-F
 Probe Info  		L174(0.00); E742(0.00); E170(0.00); E748(0.00)  LDD0015  [43]
STS-1
 Probe Info  		N.A.  LDD0068  [44]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C567(0.49); C41(0.65); C369(0.62); C591(0.41)  LDD2142  [45]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C567(1.14); C41(0.96); C369(0.81); C591(0.62)  LDD2112  [45]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C567(1.14); C41(0.70); C369(0.66); C591(0.52)  LDD2095  [45]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C41(1.02); C369(0.79); C591(0.77); C693(0.97)  LDD2130  [45]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C567(1.20); C41(1.44); C369(1.56); C591(1.63)  LDD2117  [45]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C567(1.79); C41(1.85); C591(1.81); C693(1.78)  LDD2152  [45]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C41(1.23); C591(1.39); C67(1.08)  LDD2103  [45]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C567(0.68); C41(0.63); C369(0.68); C591(0.62)  LDD2132  [45]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C567(0.88); C41(0.79); C591(0.73); C693(0.79)  LDD2131  [45]
 LDCM0025  4SU-RNA DM93 C557(5.98)  LDD0170  [17]
 LDCM0026  4SU-RNA+native RNA HEK-293T C751(2.45); C728(2.78)  LDD0169  [17]
 LDCM0214  AC1 HCT 116 C131(0.62); C136(0.62); C290(0.67); C369(1.02)  LDD0531  [22]
 LDCM0215  AC10 HCT 116 C290(0.79); C369(1.08); C41(1.11); C466(0.74)  LDD0532  [22]
 LDCM0216  AC100 HCT 116 C136(0.94); C290(0.75); C369(1.16); C41(1.07)  LDD0533  [22]
 LDCM0217  AC101 HCT 116 C136(0.81); C290(0.75); C369(0.90); C41(1.05)  LDD0534  [22]
 LDCM0218  AC102 HCT 116 C136(0.65); C290(0.74); C369(0.84); C41(1.02)  LDD0535  [22]
 LDCM0219  AC103 HCT 116 C136(0.95); C290(0.70); C369(0.94); C41(1.59)  LDD0536  [22]
 LDCM0220  AC104 HCT 116 C136(1.12); C290(0.76); C369(0.90); C41(1.31)  LDD0537  [22]
 LDCM0221  AC105 HCT 116 C136(0.94); C290(0.73); C369(0.90); C41(1.30)  LDD0538  [22]
 LDCM0222  AC106 HCT 116 C136(0.55); C290(0.72); C369(1.12); C41(1.38)  LDD0539  [22]
 LDCM0223  AC107 HCT 116 C136(1.57); C290(1.31); C369(0.91); C41(1.27)  LDD0540  [22]
 LDCM0224  AC108 HCT 116 C136(0.85); C290(0.94); C369(0.72); C41(0.87)  LDD0541  [22]
 LDCM0225  AC109 HCT 116 C136(0.56); C290(0.94); C369(0.73); C41(0.91)  LDD0542  [22]
 LDCM0226  AC11 HCT 116 C290(0.84); C369(0.93); C41(1.20); C466(0.85)  LDD0543  [22]
 LDCM0227  AC110 HCT 116 C136(0.92); C290(0.91); C369(0.76); C41(1.35)  LDD0544  [22]
 LDCM0228  AC111 HCT 116 C136(0.87); C290(1.01); C369(0.79); C41(1.05)  LDD0545  [22]
 LDCM0229  AC112 HCT 116 C136(0.70); C290(1.38); C369(0.86); C41(1.39)  LDD0546  [22]
 LDCM0230  AC113 HCT 116 C290(0.85); C369(1.09); C41(1.03); C536(1.08)  LDD0547  [22]
 LDCM0231  AC114 HCT 116 C290(0.91); C369(1.13); C41(1.20); C536(1.26)  LDD0548  [22]
 LDCM0232  AC115 HCT 116 C290(0.90); C369(1.12); C41(1.32); C536(1.18)  LDD0549  [22]
 LDCM0233  AC116 HCT 116 C290(0.91); C369(1.07); C41(1.36); C536(1.36)  LDD0550  [22]
 LDCM0234  AC117 HCT 116 C290(0.82); C369(1.07); C41(1.15); C536(1.07)  LDD0551  [22]
 LDCM0235  AC118 HCT 116 C290(0.92); C369(1.08); C41(1.13); C536(0.92)  LDD0552  [22]
 LDCM0236  AC119 HCT 116 C290(0.97); C369(1.03); C41(1.25); C536(1.18)  LDD0553  [22]
 LDCM0237  AC12 HCT 116 C290(0.98); C369(0.98); C41(1.02); C466(1.02)  LDD0554  [22]
 LDCM0238  AC120 HCT 116 C290(0.86); C369(0.89); C41(1.24); C536(1.24)  LDD0555  [22]
 LDCM0239  AC121 HCT 116 C290(0.86); C369(1.03); C41(1.09); C536(0.93)  LDD0556  [22]
 LDCM0240  AC122 HCT 116 C290(0.52); C369(0.89); C41(1.19); C536(1.00)  LDD0557  [22]
 LDCM0241  AC123 HCT 116 C290(0.75); C369(0.88); C41(1.04); C536(0.94)  LDD0558  [22]
 LDCM0242  AC124 HCT 116 C290(0.93); C369(1.08); C41(1.00); C536(1.06)  LDD0559  [22]
 LDCM0243  AC125 HCT 116 C290(0.85); C369(1.10); C41(1.15); C536(1.09)  LDD0560  [22]
 LDCM0244  AC126 HCT 116 C290(0.78); C369(1.02); C41(1.35); C536(1.07)  LDD0561  [22]
 LDCM0245  AC127 HCT 116 C290(0.77); C369(0.97); C41(1.28); C536(0.94)  LDD0562  [22]
 LDCM0246  AC128 HCT 116 C290(0.88); C369(1.21); C41(1.20); C536(1.14)  LDD0563  [22]
 LDCM0247  AC129 HCT 116 C290(0.99); C369(1.23); C41(0.95); C536(0.65)  LDD0564  [22]
 LDCM0249  AC130 HCT 116 C290(0.76); C369(1.25); C41(1.18); C536(0.84)  LDD0566  [22]
 LDCM0250  AC131 HCT 116 C290(0.84); C369(1.18); C41(0.95); C536(0.84)  LDD0567  [22]
 LDCM0251  AC132 HCT 116 C290(1.20); C369(1.32); C41(1.10); C536(0.78)  LDD0568  [22]
 LDCM0252  AC133 HCT 116 C290(0.86); C369(1.17); C41(1.21); C536(0.97)  LDD0569  [22]
 LDCM0253  AC134 HCT 116 C290(1.01); C369(1.12); C41(1.14); C536(0.90)  LDD0570  [22]
 LDCM0254  AC135 HCT 116 C290(1.12); C369(1.63); C41(1.13); C536(1.13)  LDD0571  [22]
 LDCM0255  AC136 HCT 116 C290(0.95); C369(1.55); C41(1.18); C536(0.89)  LDD0572  [22]
 LDCM0256  AC137 HCT 116 C290(0.88); C369(1.64); C41(1.12); C536(0.81)  LDD0573  [22]
 LDCM0257  AC138 HCT 116 C290(0.95); C369(1.57); C41(1.30); C536(0.94)  LDD0574  [22]
 LDCM0258  AC139 HCT 116 C290(1.10); C369(1.70); C41(1.29); C536(0.88)  LDD0575  [22]
 LDCM0259  AC14 HCT 116 C290(0.77); C369(0.86); C41(1.13); C466(0.68)  LDD0576  [22]
 LDCM0260  AC140 HCT 116 C290(0.89); C369(1.69); C41(1.40); C536(0.97)  LDD0577  [22]
 LDCM0261  AC141 HCT 116 C290(0.90); C369(1.56); C41(1.34); C536(1.01)  LDD0578  [22]
 LDCM0262  AC142 HCT 116 C290(1.00); C369(1.45); C41(1.07); C536(0.80)  LDD0579  [22]
 LDCM0263  AC143 HCT 116 C290(0.88); C369(1.02); C41(1.13); C466(0.87)  LDD0580  [22]
 LDCM0264  AC144 HCT 116 C290(0.74); C693(0.91); C536(0.97); C557(0.97)  LDD0581  [22]
 LDCM0265  AC145 HCT 116 C536(0.82); C557(0.82); C693(0.84); C290(0.92)  LDD0582  [22]
 LDCM0266  AC146 HCT 116 C290(0.72); C693(0.84); C466(0.93); C369(0.97)  LDD0583  [22]
 LDCM0267  AC147 HCT 116 C290(0.80); C466(0.93); C567(0.94); C369(1.02)  LDD0584  [22]
 LDCM0268  AC148 HCT 116 C290(0.58); C466(0.58); C369(0.83); C591(0.96)  LDD0585  [22]
 LDCM0269  AC149 HCT 116 C290(0.69); C466(0.84); C369(0.90); C591(0.93)  LDD0586  [22]
 LDCM0270  AC15 HCT 116 C290(0.81); C466(0.81); C651(1.02); C591(1.03)  LDD0587  [22]
 LDCM0271  AC150 HCT 116 C693(0.79); C536(0.86); C557(0.86); C290(0.91)  LDD0588  [22]
 LDCM0272  AC151 HCT 116 C290(0.84); C591(0.87); C693(0.93); C369(0.93)  LDD0589  [22]
 LDCM0273  AC152 HCT 116 C290(0.74); C369(0.84); C466(0.87); C693(0.93)  LDD0590  [22]
 LDCM0274  AC153 HCT 116 C290(0.37); C466(0.42); C369(0.66); C591(0.85)  LDD0591  [22]
 LDCM0621  AC154 HCT 116 C290(0.74); C369(1.02); C41(1.46); C466(0.96)  LDD2158  [22]
 LDCM0622  AC155 HCT 116 C290(0.79); C369(0.97); C41(1.33); C466(1.01)  LDD2159  [22]
 LDCM0623  AC156 HCT 116 C290(0.74); C369(0.89); C41(1.07); C466(1.02)  LDD2160  [22]
 LDCM0624  AC157 HCT 116 C290(0.69); C369(0.95); C41(1.15); C466(0.94)  LDD2161  [22]
 LDCM0276  AC17 HCT 116 C567(0.81); C536(0.87); C557(0.87); C812(0.87)  LDD0593  [22]
 LDCM0277  AC18 HCT 116 C536(0.88); C557(0.88); C131(0.98); C136(0.98)  LDD0594  [22]
 LDCM0278  AC19 HCT 116 C536(0.92); C557(0.92); C812(0.98); C369(1.00)  LDD0595  [22]
 LDCM0279  AC2 HCT 116 C536(0.80); C557(0.80); C131(0.83); C136(0.83)  LDD0596  [22]
 LDCM0280  AC20 HCT 116 C369(0.89); C693(0.92); C536(1.02); C557(1.02)  LDD0597  [22]
 LDCM0281  AC21 HCT 116 C369(0.88); C812(0.88); C536(0.89); C557(0.89)  LDD0598  [22]
 LDCM0282  AC22 HCT 116 C812(0.72); C591(0.79); C651(0.80); C536(0.85)  LDD0599  [22]
 LDCM0283  AC23 HCT 116 C812(0.68); C536(0.81); C557(0.81); C693(0.86)  LDD0600  [22]
 LDCM0284  AC24 HCT 116 C812(0.87); C567(0.92); C536(0.99); C557(0.99)  LDD0601  [22]
 LDCM0285  AC25 HCT 116 C131(0.67); C290(0.90); C567(0.94); C369(0.95)  LDD0602  [22]
 LDCM0286  AC26 HCT 116 C131(0.73); C290(0.89); C728(0.96); C369(0.97)  LDD0603  [22]
 LDCM0287  AC27 HCT 116 C131(0.70); C136(0.80); C290(1.05); C567(1.05)  LDD0604  [22]
 LDCM0288  AC28 HCT 116 C131(0.69); C591(0.84); C728(0.87); C290(0.90)  LDD0605  [22]
 LDCM0289  AC29 HCT 116 C131(0.73); C591(0.87); C290(0.91); C536(1.00)  LDD0606  [22]
 LDCM0290  AC3 HCT 116 C728(0.77); C290(0.80); C131(0.81); C136(0.81)  LDD0607  [22]
 LDCM0291  AC30 HCT 116 C131(0.75); C290(0.77); C369(0.98); C591(1.00)  LDD0608  [22]
 LDCM0292  AC31 HCT 116 C131(0.64); C290(0.84); C591(0.88); C728(0.89)  LDD0609  [22]
 LDCM0293  AC32 HCT 116 C131(0.67); C728(0.84); C591(0.84); C290(0.86)  LDD0610  [22]
 LDCM0294  AC33 HCT 116 C131(0.62); C290(0.78); C136(0.93); C369(0.99)  LDD0611  [22]
 LDCM0295  AC34 HCT 116 C131(0.60); C290(0.83); C369(0.91); C136(1.01)  LDD0612  [22]
 LDCM0296  AC35 HCT 116 C466(0.52); C41(0.88); C812(0.91); C567(0.94)  LDD0613  [22]
 LDCM0297  AC36 HCT 116 C466(0.54); C812(0.88); C41(0.88); C591(0.94)  LDD0614  [22]
 LDCM0298  AC37 HCT 116 C466(0.48); C536(0.75); C557(0.75); C41(0.86)  LDD0615  [22]
 LDCM0299  AC38 HCT 116 C466(0.58); C567(0.94); C693(0.95); C536(0.96)  LDD0616  [22]
 LDCM0300  AC39 HCT 116 C466(0.60); C728(0.87); C812(0.87); C693(0.95)  LDD0617  [22]
 LDCM0301  AC4 HCT 116 C131(0.73); C136(0.73); C728(0.75); C536(0.77)  LDD0618  [22]
 LDCM0302  AC40 HCT 116 C466(0.72); C536(0.72); C557(0.72); C591(0.90)  LDD0619  [22]
 LDCM0303  AC41 HCT 116 C466(0.64); C591(0.89); C812(0.94); C536(0.97)  LDD0620  [22]
 LDCM0304  AC42 HCT 116 C466(0.63); C591(0.89); C693(0.95); C812(0.98)  LDD0621  [22]
 LDCM0305  AC43 HCT 116 C466(0.67); C536(0.87); C557(0.87); C591(0.93)  LDD0622  [22]
 LDCM0306  AC44 HCT 116 C466(0.48); C591(0.78); C536(0.79); C557(0.79)  LDD0623  [22]
 LDCM0307  AC45 HCT 116 C466(0.54); C591(0.81); C536(0.96); C557(0.96)  LDD0624  [22]
 LDCM0308  AC46 HCT 116 C812(0.70); C651(0.86); C567(0.96); C536(0.97)  LDD0625  [22]
 LDCM0309  AC47 HCT 116 C812(0.86); C728(0.88); C651(0.89); C591(0.97)  LDD0626  [22]
 LDCM0310  AC48 HCT 116 C812(0.62); C290(0.73); C651(0.83); C536(0.92)  LDD0627  [22]
 LDCM0311  AC49 HCT 116 C812(0.77); C290(0.84); C369(0.92); C693(0.92)  LDD0628  [22]
 LDCM0312  AC5 HCT 116 C728(0.68); C131(0.68); C136(0.68); C290(0.72)  LDD0629  [22]
 LDCM0313  AC50 HCT 116 C812(0.64); C728(0.91); C369(0.94); C290(0.95)  LDD0630  [22]
 LDCM0314  AC51 HCT 116 C812(0.60); C651(0.75); C536(0.89); C557(0.89)  LDD0631  [22]
 LDCM0315  AC52 HCT 116 C812(0.65); C651(0.93); C591(0.94); C567(0.97)  LDD0632  [22]
 LDCM0316  AC53 HCT 116 C812(0.83); C651(0.90); C536(0.98); C557(0.98)  LDD0633  [22]
 LDCM0317  AC54 HCT 116 C812(0.80); C728(0.90); C591(0.94); C290(0.95)  LDD0634  [22]
 LDCM0318  AC55 HCT 116 C290(0.66); C369(0.81); C728(0.85); C812(0.86)  LDD0635  [22]
 LDCM0319  AC56 HCT 116 C290(0.22); C369(0.60); C728(0.69); C591(0.72)  LDD0636  [22]
 LDCM0320  AC57 HCT 116 C536(0.69); C557(0.69); C131(0.77); C136(0.92)  LDD0637  [22]
 LDCM0321  AC58 HCT 116 C131(0.56); C536(0.70); C557(0.70); C136(0.78)  LDD0638  [22]
 LDCM0322  AC59 HCT 116 C369(0.72); C728(0.82); C536(0.87); C557(0.87)  LDD0639  [22]
 LDCM0323  AC6 HCT 116 C591(0.88); C290(0.90); C466(0.94); C728(1.05)  LDD0640  [22]
 LDCM0324  AC60 HCT 116 C131(0.62); C369(0.73); C728(0.81); C536(0.85)  LDD0641  [22]
 LDCM0325  AC61 HCT 116 C131(0.50); C290(0.67); C136(0.76); C728(0.79)  LDD0642  [22]
 LDCM0326  AC62 HCT 116 C131(0.68); C369(0.78); C290(0.83); C591(0.86)  LDD0643  [22]
 LDCM0327  AC63 HCT 116 C131(0.58); C136(0.77); C290(0.77); C536(0.79)  LDD0644  [22]
 LDCM0328  AC64 HCT 116 C131(0.67); C728(0.70); C290(0.76); C369(0.88)  LDD0645  [22]
 LDCM0329  AC65 HCT 116 C728(0.57); C131(0.73); C591(0.83); C290(0.91)  LDD0646  [22]
 LDCM0330  AC66 HCT 116 C728(0.65); C131(0.72); C536(0.86); C557(0.86)  LDD0647  [22]
 LDCM0331  AC67 HCT 116 C131(0.28); C290(0.41); C728(0.50); C136(0.54)  LDD0648  [22]
 LDCM0332  AC68 HCT 116 C136(0.57); C131(0.60); C728(0.68); C466(0.78)  LDD0649  [22]
 LDCM0333  AC69 HCT 116 C131(0.48); C136(0.60); C466(0.64); C290(0.77)  LDD0650  [22]
 LDCM0334  AC7 HCT 116 C591(0.81); C290(0.90); C466(0.96); C728(0.99)  LDD0651  [22]
 LDCM0335  AC70 HCT 116 C466(0.54); C131(0.56); C136(0.63); C290(0.67)  LDD0652  [22]
 LDCM0336  AC71 HCT 116 C131(0.58); C136(0.62); C728(0.83); C466(0.84)  LDD0653  [22]
 LDCM0337  AC72 HCT 116 C728(0.80); C693(0.81); C466(0.82); C536(0.87)  LDD0654  [22]
 LDCM0338  AC73 HCT 116 C131(0.34); C466(0.38); C290(0.48); C136(0.56)  LDD0655  [22]
 LDCM0339  AC74 HCT 116 C131(0.27); C290(0.37); C466(0.38); C136(0.47)  LDD0656  [22]
 LDCM0340  AC75 HCT 116 C290(0.17); C466(0.18); C131(0.21); C136(0.41)  LDD0657  [22]
 LDCM0341  AC76 HCT 116 C131(0.67); C136(0.70); C466(0.83); C591(0.87)  LDD0658  [22]
 LDCM0342  AC77 HCT 116 C131(0.50); C136(0.59); C466(0.73); C591(0.86)  LDD0659  [22]
 LDCM0343  AC78 HCT 116 C131(0.35); C136(0.60); C466(0.61); C290(0.68)  LDD0660  [22]
 LDCM0344  AC79 HCT 116 C136(0.64); C131(0.66); C728(0.76); C466(0.76)  LDD0661  [22]
 LDCM0345  AC8 HCT 116 C591(0.79); C290(0.90); C369(0.95); C466(0.98)  LDD0662  [22]
 LDCM0346  AC80 HCT 116 C131(0.54); C136(0.72); C466(0.82); C693(0.85)  LDD0663  [22]
 LDCM0347  AC81 HCT 116 C466(0.31); C131(0.51); C136(0.55); C290(0.63)  LDD0664  [22]
 LDCM0348  AC82 HCT 116 C290(0.04); C591(0.05); C466(0.06); C131(0.07)  LDD0665  [22]
 LDCM0349  AC83 HCT 116 C290(0.78); C369(0.82); C728(0.96); C591(1.04)  LDD0666  [22]
 LDCM0350  AC84 HCT 116 C290(0.83); C369(0.95); C728(1.02); C591(1.12)  LDD0667  [22]
 LDCM0351  AC85 HCT 116 C728(0.93); C369(1.03); C290(1.04); C591(1.13)  LDD0668  [22]
 LDCM0352  AC86 HCT 116 C812(0.83); C369(1.09); C728(1.10); C567(1.12)  LDD0669  [22]
 LDCM0353  AC87 HCT 116 C812(0.77); C567(0.95); C728(0.96); C369(0.99)  LDD0670  [22]
 LDCM0354  AC88 HCT 116 C591(1.00); C693(1.05); C290(1.09); C369(1.11)  LDD0671  [22]
 LDCM0355  AC89 HCT 116 C812(0.94); C290(0.95); C369(1.00); C567(1.13)  LDD0672  [22]
 LDCM0357  AC90 HCT 116 C812(0.86); C567(0.93); C41(1.06); C369(1.19)  LDD0674  [22]
 LDCM0358  AC91 HCT 116 C290(0.85); C536(0.95); C557(0.95); C369(0.98)  LDD0675  [22]
 LDCM0359  AC92 HCT 116 C728(0.99); C536(1.08); C557(1.08); C369(1.10)  LDD0676  [22]
 LDCM0360  AC93 HCT 116 C812(0.98); C369(1.00); C728(1.03); C290(1.07)  LDD0677  [22]
 LDCM0361  AC94 HCT 116 C369(0.97); C290(0.98); C812(0.98); C728(1.00)  LDD0678  [22]
 LDCM0362  AC95 HCT 116 C290(0.71); C369(0.81); C567(0.96); C812(0.99)  LDD0679  [22]
 LDCM0363  AC96 HCT 116 C290(0.86); C369(0.98); C536(1.03); C557(1.03)  LDD0680  [22]
 LDCM0364  AC97 HCT 116 C369(0.92); C290(0.97); C728(1.00); C536(1.01)  LDD0681  [22]
 LDCM0365  AC98 HCT 116 C290(0.04); C466(0.09); C651(0.30); C369(0.39)  LDD0682  [22]
 LDCM0366  AC99 HCT 116 C651(0.71); C136(0.72); C466(0.75); C693(0.76)  LDD0683  [22]
 LDCM0545  Acetamide MDA-MB-231 C41(0.54); C591(0.96); C693(0.57); C728(0.90)  LDD2138  [45]
 LDCM0166  Afatinib A431 2.20  LDD0421  [14]
 LDCM0520  AKOS000195272 MDA-MB-231 C567(0.77); C41(0.61); C369(0.68); C591(0.89)  LDD2113  [45]
 LDCM0248  AKOS034007472 HCT 116 C290(1.02); C369(1.06); C41(1.03); C466(0.90)  LDD0565  [22]
 LDCM0356  AKOS034007680 HCT 116 C290(0.91); C591(0.93); C466(0.98); C728(1.04)  LDD0673  [22]
 LDCM0275  AKOS034007705 HCT 116 C290(0.65); C466(0.78); C591(0.88); C369(1.02)  LDD0592  [22]
 LDCM0156  Aniline NCI-H1299 C369(0.00); C136(0.00); C41(0.00); C812(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C136(1.33); C812(1.22); C651(1.04); C41(1.02)  LDD0078  [22]
 LDCM0498  BS-3668 MDA-MB-231 C567(0.93); C41(0.74); C369(0.83); C591(0.97)  LDD2091  [45]
 LDCM0630  CCW28-3 231MFP C136(1.84); C812(1.29); C466(1.26); C651(0.89)  LDD2214  [46]
 LDCM0108  Chloroacetamide HeLa C369(0.00); H769(0.00); C651(0.00); H490(0.00)  LDD0222  [38]
 LDCM0632  CL-Sc Hep-G2 C591(1.48); C41(1.00); C567(0.93); C567(0.75)  LDD2227  [31]
 LDCM0367  CL1 HCT 116 C591(0.71); C136(0.73); C567(0.83); C369(0.84)  LDD0684  [22]
 LDCM0368  CL10 HCT 116 C591(0.78); C567(0.89); C369(0.89); C466(0.89)  LDD0685  [22]
 LDCM0369  CL100 HCT 116 C131(0.75); C136(0.75); C290(0.81); C591(0.87)  LDD0686  [22]
 LDCM0370  CL101 HCT 116 C591(0.79); C290(0.86); C651(0.98); C369(1.05)  LDD0687  [22]
 LDCM0371  CL102 HCT 116 C591(0.69); C290(0.86); C466(0.92); C567(0.93)  LDD0688  [22]
 LDCM0372  CL103 HCT 116 C591(0.73); C567(0.81); C466(0.84); C290(0.86)  LDD0689  [22]
 LDCM0373  CL104 HCT 116 C591(0.83); C651(0.83); C369(0.91); C567(0.93)  LDD0690  [22]
 LDCM0374  CL105 HCT 116 C693(0.83); C591(0.86); C536(0.90); C557(0.90)  LDD0691  [22]
 LDCM0375  CL106 HCT 116 C131(0.56); C136(0.56); C290(0.66); C369(0.82)  LDD0692  [22]
 LDCM0376  CL107 HCT 116 C131(0.86); C136(0.86); C536(0.89); C557(0.89)  LDD0693  [22]
 LDCM0377  CL108 HCT 116 C591(0.82); C369(0.92); C536(0.96); C557(0.96)  LDD0694  [22]
 LDCM0378  CL109 HCT 116 C693(0.78); C812(0.88); C369(0.94); C567(1.01)  LDD0695  [22]
 LDCM0379  CL11 HCT 116 C591(0.62); C290(0.77); C369(0.86); C466(0.87)  LDD0696  [22]
 LDCM0380  CL110 HCT 116 C591(0.69); C693(0.77); C728(0.85); C812(0.95)  LDD0697  [22]
 LDCM0381  CL111 HCT 116 C693(0.82); C591(0.83); C651(0.90); C728(0.95)  LDD0698  [22]
 LDCM0382  CL112 HCT 116 C591(0.69); C131(0.71); C693(0.84); C290(0.85)  LDD0699  [22]
 LDCM0383  CL113 HCT 116 C131(0.69); C290(0.86); C591(0.91); C728(0.98)  LDD0700  [22]
 LDCM0384  CL114 HCT 116 C591(0.66); C131(0.71); C290(0.81); C369(0.89)  LDD0701  [22]
 LDCM0385  CL115 HCT 116 C131(0.59); C591(0.77); C290(0.86); C369(0.98)  LDD0702  [22]
 LDCM0386  CL116 HCT 116 C131(0.69); C290(0.85); C591(0.98); C369(1.04)  LDD0703  [22]
 LDCM0387  CL117 HCT 116 C591(0.58); C369(0.75); C466(0.78); C693(0.80)  LDD0704  [22]
 LDCM0388  CL118 HCT 116 C466(0.53); C728(0.95); C812(0.96); C591(1.02)  LDD0705  [22]
 LDCM0389  CL119 HCT 116 C812(0.94); C591(0.96); C466(0.98); C728(1.05)  LDD0706  [22]
 LDCM0390  CL12 HCT 116 C591(0.70); C369(0.93); C290(0.97); C466(0.98)  LDD0707  [22]
 LDCM0391  CL120 HCT 116 C466(0.45); C536(0.82); C557(0.82); C728(0.89)  LDD0708  [22]
 LDCM0392  CL121 HCT 116 C728(0.85); C290(0.92); C591(0.95); C693(0.96)  LDD0709  [22]
 LDCM0393  CL122 HCT 116 C812(0.57); C290(0.75); C567(0.85); C591(0.87)  LDD0710  [22]
 LDCM0394  CL123 HCT 116 C812(0.57); C290(0.66); C693(0.70); C369(0.71)  LDD0711  [22]
 LDCM0395  CL124 HCT 116 C693(0.70); C290(0.76); C591(0.81); C369(0.86)  LDD0712  [22]
 LDCM0396  CL125 HCT 116 C728(0.78); C369(0.80); C536(0.84); C557(0.84)  LDD0713  [22]
 LDCM0397  CL126 HCT 116 C369(0.65); C536(0.88); C557(0.88); C131(0.88)  LDD0714  [22]
 LDCM0398  CL127 HCT 116 C369(0.76); C536(0.79); C557(0.79); C591(0.90)  LDD0715  [22]
 LDCM0399  CL128 HCT 116 C536(0.77); C557(0.77); C369(0.78); C728(0.86)  LDD0716  [22]
 LDCM0400  CL13 HCT 116 C591(0.84); C536(0.89); C557(0.89); C369(0.95)  LDD0717  [22]
 LDCM0401  CL14 HCT 116 C591(0.75); C136(0.77); C536(0.79); C557(0.79)  LDD0718  [22]
 LDCM0402  CL15 HCT 116 C290(0.57); C651(0.60); C693(0.61); C591(0.74)  LDD0719  [22]
 LDCM0403  CL16 HCT 116 C369(0.82); C290(0.90); C41(1.01); C131(1.02)  LDD0720  [22]
 LDCM0404  CL17 HCT 116 C728(0.69); C290(0.71); C369(0.71); C131(0.80)  LDD0721  [22]
 LDCM0405  CL18 HCT 116 C131(0.34); C290(0.46); C369(0.71); C567(0.86)  LDD0722  [22]
 LDCM0406  CL19 HCT 116 C131(0.53); C290(0.70); C567(0.82); C728(0.86)  LDD0723  [22]
 LDCM0407  CL2 HCT 116 C591(0.75); C567(0.83); C651(0.85); C136(0.85)  LDD0724  [22]
 LDCM0408  CL20 HCT 116 C567(0.81); C290(0.87); C369(0.95); C728(1.01)  LDD0725  [22]
 LDCM0409  CL21 HCT 116 C131(0.39); C290(0.53); C567(0.73); C369(0.75)  LDD0726  [22]
 LDCM0410  CL22 HCT 116 C290(0.30); C131(0.41); C369(0.64); C693(0.93)  LDD0727  [22]
 LDCM0411  CL23 HCT 116 C290(0.75); C369(0.79); C567(0.84); C693(1.06)  LDD0728  [22]
 LDCM0412  CL24 HCT 116 C131(0.63); C290(0.64); C567(0.74); C369(0.86)  LDD0729  [22]
 LDCM0413  CL25 HCT 116 C131(0.58); C136(1.27); C290(0.63); C369(0.71)  LDD0730  [22]
 LDCM0414  CL26 HCT 116 C131(0.63); C136(1.47); C290(0.80); C369(0.67)  LDD0731  [22]
 LDCM0415  CL27 HCT 116 C131(0.88); C136(1.42); C290(0.75); C369(0.91)  LDD0732  [22]
 LDCM0416  CL28 HCT 116 C131(0.64); C136(1.37); C290(0.59); C369(0.78)  LDD0733  [22]
 LDCM0417  CL29 HCT 116 C131(0.79); C136(1.23); C290(0.63); C369(0.89)  LDD0734  [22]
 LDCM0418  CL3 HCT 116 C136(1.08); C290(1.22); C369(1.09); C41(1.02)  LDD0735  [22]
 LDCM0419  CL30 HCT 116 C131(0.75); C136(1.28); C290(0.71); C369(0.86)  LDD0736  [22]
 LDCM0420  CL31 HCT 116 C131(0.83); C136(0.83); C290(0.85); C369(0.94)  LDD0737  [22]
 LDCM0421  CL32 HCT 116 C131(0.40); C136(0.40); C290(0.55); C369(0.76)  LDD0738  [22]
 LDCM0422  CL33 HCT 116 C131(0.49); C136(0.49); C290(0.56); C369(0.70)  LDD0739  [22]
 LDCM0423  CL34 HCT 116 C131(0.47); C136(0.47); C290(0.51); C369(0.73)  LDD0740  [22]
 LDCM0424  CL35 HCT 116 C131(0.74); C136(0.74); C290(0.73); C369(0.84)  LDD0741  [22]
 LDCM0425  CL36 HCT 116 C131(0.67); C136(0.67); C290(0.88); C369(0.90)  LDD0742  [22]
 LDCM0426  CL37 HCT 116 C131(0.58); C136(0.58); C290(0.65); C369(0.83)  LDD0743  [22]
 LDCM0428  CL39 HCT 116 C131(0.76); C136(0.76); C290(0.71); C369(0.85)  LDD0745  [22]
 LDCM0429  CL4 HCT 116 C136(1.15); C290(0.92); C369(0.88); C41(1.01)  LDD0746  [22]
 LDCM0430  CL40 HCT 116 C131(0.65); C136(0.65); C290(0.91); C369(0.82)  LDD0747  [22]
 LDCM0431  CL41 HCT 116 C131(0.62); C136(0.62); C290(0.86); C369(0.89)  LDD0748  [22]
 LDCM0432  CL42 HCT 116 C131(0.27); C136(0.27); C290(0.29); C369(0.62)  LDD0749  [22]
 LDCM0433  CL43 HCT 116 C131(0.50); C136(0.50); C290(0.55); C369(0.77)  LDD0750  [22]
 LDCM0434  CL44 HCT 116 C131(0.38); C136(0.38); C290(0.44); C369(0.73)  LDD0751  [22]
 LDCM0435  CL45 HCT 116 C131(0.34); C136(0.34); C290(0.34); C369(0.67)  LDD0752  [22]
 LDCM0436  CL46 HCT 116 C290(1.18); C369(1.17); C41(0.92); C536(0.65)  LDD0753  [22]
 LDCM0437  CL47 HCT 116 C290(1.44); C369(1.10); C41(0.90); C536(0.63)  LDD0754  [22]
 LDCM0438  CL48 HCT 116 C290(1.21); C369(1.15); C41(0.88); C536(0.75)  LDD0755  [22]
 LDCM0439  CL49 HCT 116 C290(1.40); C369(1.19); C41(0.92); C536(0.79)  LDD0756  [22]
 LDCM0440  CL5 HCT 116 C136(0.97); C290(1.05); C369(1.05); C41(1.04)  LDD0757  [22]
 LDCM0441  CL50 HCT 116 C290(1.45); C369(1.22); C41(0.87); C536(0.91)  LDD0758  [22]
 LDCM0442  CL51 HCT 116 C290(1.28); C369(1.29); C41(0.89); C536(0.80)  LDD0759  [22]
 LDCM0443  CL52 HCT 116 C290(1.20); C369(1.34); C41(0.88); C536(0.88)  LDD0760  [22]
 LDCM0444  CL53 HCT 116 C290(1.03); C369(1.14); C41(0.83); C536(0.82)  LDD0761  [22]
 LDCM0445  CL54 HCT 116 C290(1.22); C369(1.08); C41(0.86); C536(0.76)  LDD0762  [22]
 LDCM0446  CL55 HCT 116 C290(1.47); C369(1.24); C41(0.83); C536(0.74)  LDD0763  [22]
 LDCM0447  CL56 HCT 116 C290(1.04); C369(1.11); C41(0.95); C536(0.77)  LDD0764  [22]
 LDCM0448  CL57 HCT 116 C290(1.05); C369(1.15); C41(0.91); C536(1.07)  LDD0765  [22]
 LDCM0449  CL58 HCT 116 C290(1.24); C369(1.19); C41(0.85); C536(0.81)  LDD0766  [22]
 LDCM0450  CL59 HCT 116 C290(1.04); C369(1.21); C41(0.92); C536(0.85)  LDD0767  [22]
 LDCM0451  CL6 HCT 116 C136(0.83); C290(0.79); C369(0.81); C41(1.14)  LDD0768  [22]
 LDCM0452  CL60 HCT 116 C290(1.35); C369(1.07); C41(0.93); C536(0.75)  LDD0769  [22]
 LDCM0453  CL61 HCT 116 C131(0.63); C136(0.63); C290(1.03); C369(1.02)  LDD0770  [22]
 LDCM0454  CL62 HCT 116 C131(0.58); C136(0.58); C290(0.73); C369(0.90)  LDD0771  [22]
 LDCM0455  CL63 HCT 116 C131(0.67); C136(0.67); C290(0.86); C369(1.09)  LDD0772  [22]
 LDCM0456  CL64 HCT 116 C131(0.86); C136(0.86); C290(0.95); C369(0.92)  LDD0773  [22]
 LDCM0457  CL65 HCT 116 C131(0.69); C136(0.69); C290(0.86); C369(1.01)  LDD0774  [22]
 LDCM0458  CL66 HCT 116 C131(0.52); C136(0.52); C290(0.80); C369(1.01)  LDD0775  [22]
 LDCM0459  CL67 HCT 116 C131(0.64); C136(0.64); C290(0.98); C369(0.99)  LDD0776  [22]
 LDCM0460  CL68 HCT 116 C131(0.53); C136(0.53); C290(0.68); C369(0.89)  LDD0777  [22]
 LDCM0461  CL69 HCT 116 C131(0.35); C136(0.35); C290(0.50); C369(0.70)  LDD0778  [22]
 LDCM0462  CL7 HCT 116 C136(0.90); C290(0.93); C369(0.91); C41(1.26)  LDD0779  [22]
 LDCM0463  CL70 HCT 116 C131(0.36); C136(0.36); C290(0.67); C369(0.94)  LDD0780  [22]
 LDCM0464  CL71 HCT 116 C131(0.70); C136(0.70); C290(0.84); C369(1.00)  LDD0781  [22]
 LDCM0465  CL72 HCT 116 C131(1.15); C136(1.15); C290(0.83); C369(1.11)  LDD0782  [22]
 LDCM0466  CL73 HCT 116 C131(0.68); C136(0.68); C290(0.77); C369(0.94)  LDD0783  [22]
 LDCM0467  CL74 HCT 116 C131(0.50); C136(0.50); C290(0.78); C369(1.05)  LDD0784  [22]
 LDCM0469  CL76 HCT 116 C131(0.81); C136(0.80); C290(0.73); C369(0.77)  LDD0786  [22]
 LDCM0470  CL77 HCT 116 C131(0.87); C136(0.80); C290(0.75); C369(0.66)  LDD0787  [22]
 LDCM0471  CL78 HCT 116 C131(1.00); C136(1.14); C290(1.00); C369(0.86)  LDD0788  [22]
 LDCM0472  CL79 HCT 116 C131(0.95); C136(1.05); C290(0.84); C369(0.81)  LDD0789  [22]
 LDCM0473  CL8 HCT 116 C136(1.13); C290(0.77); C369(0.72); C41(1.64)  LDD0790  [22]
 LDCM0474  CL80 HCT 116 C131(0.60); C136(0.75); C290(0.63); C369(0.70)  LDD0791  [22]
 LDCM0475  CL81 HCT 116 C131(0.97); C136(1.30); C290(0.89); C369(1.06)  LDD0792  [22]
 LDCM0476  CL82 HCT 116 C131(0.65); C136(1.05); C290(0.61); C369(1.01)  LDD0793  [22]
 LDCM0477  CL83 HCT 116 C131(0.67); C136(0.85); C290(0.72); C369(0.93)  LDD0794  [22]
 LDCM0478  CL84 HCT 116 C131(0.46); C136(0.68); C290(0.45); C369(0.65)  LDD0795  [22]
 LDCM0479  CL85 HCT 116 C131(0.96); C136(0.95); C290(0.84); C369(1.17)  LDD0796  [22]
 LDCM0480  CL86 HCT 116 C131(0.95); C136(1.36); C290(0.98); C369(0.87)  LDD0797  [22]
 LDCM0481  CL87 HCT 116 C131(1.13); C136(1.15); C290(0.83); C369(0.95)  LDD0798  [22]
 LDCM0482  CL88 HCT 116 C131(0.75); C136(0.87); C290(0.64); C369(0.99)  LDD0799  [22]
 LDCM0483  CL89 HCT 116 C131(0.27); C136(0.46); C290(0.23); C369(0.60)  LDD0800  [22]
 LDCM0484  CL9 HCT 116 C136(0.74); C290(0.86); C369(0.92); C41(1.17)  LDD0801  [22]
 LDCM0485  CL90 HCT 116 C131(1.08); C136(1.18); C290(0.94); C369(0.87)  LDD0802  [22]
 LDCM0486  CL91 HCT 116 C131(0.95); C136(0.95); C290(0.96); C369(0.96)  LDD0803  [22]
 LDCM0487  CL92 HCT 116 C131(0.80); C136(0.80); C290(0.83); C369(0.92)  LDD0804  [22]
 LDCM0488  CL93 HCT 116 C131(0.87); C136(0.87); C290(0.95); C369(1.06)  LDD0805  [22]
 LDCM0489  CL94 HCT 116 C131(0.76); C136(0.76); C290(0.85); C369(1.20)  LDD0806  [22]
 LDCM0490  CL95 HCT 116 C131(0.77); C136(0.77); C290(0.85); C369(0.98)  LDD0807  [22]
 LDCM0491  CL96 HCT 116 C131(0.73); C136(0.73); C290(0.91); C369(0.90)  LDD0808  [22]
 LDCM0492  CL97 HCT 116 C131(0.98); C136(0.98); C290(0.84); C369(0.85)  LDD0809  [22]
 LDCM0493  CL98 HCT 116 C131(0.93); C136(0.93); C290(0.82); C369(1.00)  LDD0810  [22]
 LDCM0494  CL99 HCT 116 C131(0.67); C136(0.67); C290(0.86); C369(1.13)  LDD0811  [22]
 LDCM0634  CY-0357 Hep-G2 C369(1.10); C693(1.06); C567(0.99); C41(0.95)  LDD2228  [31]
 LDCM0495  E2913 HEK-293T C567(0.84); C41(0.87); C591(0.84); C728(0.84)  LDD1698  [47]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C41(3.40); C728(1.69); C567(0.79)  LDD1702  [45]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.98  LDD0183  [16]
 LDCM0175  Ethacrynic acid HeLa C131(0.92); C131(0.79); C466(0.84)  LDD2210  [18]
 LDCM0625  F8 Ramos C693(0.68); C41(1.11); C728(0.49); C290(1.06)  LDD2187  [48]
 LDCM0572  Fragment10 MDA-MB-231 C41(1.86); C136(1.29)  LDD1389  [49]
 LDCM0573  Fragment11 MDA-MB-231 C41(1.82); C136(1.98)  LDD1391  [49]
 LDCM0574  Fragment12 MDA-MB-231 C41(20.00); C136(1.97)  LDD1393  [49]
 LDCM0575  Fragment13 MDA-MB-231 C41(1.46); C136(0.98)  LDD1395  [49]
 LDCM0576  Fragment14 MDA-MB-231 C41(2.16); C136(0.97)  LDD1397  [49]
 LDCM0577  Fragment15 MDA-MB-231 C41(1.12); C136(0.94)  LDD1399  [49]
 LDCM0579  Fragment20 MDA-MB-231 C41(1.06); C136(0.98)  LDD1402  [49]
 LDCM0580  Fragment21 MDA-MB-231 C41(1.38); C136(0.86)  LDD1404  [49]
 LDCM0581  Fragment22 MDA-MB-231 C41(1.57); C136(1.07)  LDD1406  [49]
 LDCM0582  Fragment23 MDA-MB-231 C41(1.20); C136(0.98)  LDD1408  [49]
 LDCM0583  Fragment24 Ramos C41(1.11); C136(1.25)  LDD1410  [49]
 LDCM0584  Fragment25 MDA-MB-231 C41(0.92); C136(0.91)  LDD1411  [49]
 LDCM0585  Fragment26 Ramos C41(1.04); C136(0.93)  LDD1412  [49]
 LDCM0578  Fragment27 MDA-MB-231 C41(0.86); C136(0.96)  LDD1401  [49]
 LDCM0586  Fragment28 MDA-MB-231 C136(0.92)  LDD1415  [49]
 LDCM0587  Fragment29 MDA-MB-231 C41(1.25); C136(1.19)  LDD1417  [49]
 LDCM0588  Fragment30 MDA-MB-231 C41(0.82); C136(0.76)  LDD1419  [49]
 LDCM0589  Fragment31 MDA-MB-231 C41(2.13); C136(1.06)  LDD1421  [49]
 LDCM0590  Fragment32 MDA-MB-231 C41(1.84); C136(12.65)  LDD1423  [49]
 LDCM0468  Fragment33 HCT 116 C131(0.53); C136(0.53); C290(0.79); C369(0.88)  LDD0785  [22]
 LDCM0592  Fragment34 MDA-MB-231 C41(0.80); C136(0.87)  LDD1427  [49]
 LDCM0593  Fragment35 MDA-MB-231 C41(0.85); C136(0.89)  LDD1429  [49]
 LDCM0594  Fragment36 MDA-MB-231 C41(1.83)  LDD1431  [49]
 LDCM0595  Fragment37 Ramos C41(0.91); C136(0.78)  LDD1432  [49]
 LDCM0596  Fragment38 MDA-MB-231 C41(1.01); C136(1.11)  LDD1433  [49]
 LDCM0597  Fragment39 MDA-MB-231 C41(1.88); C136(1.56)  LDD1435  [49]
 LDCM0566  Fragment4 MDA-MB-231 C41(1.77); C136(1.42)  LDD1378  [49]
 LDCM0598  Fragment40 MDA-MB-231 C41(0.92); C136(0.82)  LDD1436  [49]
 LDCM0599  Fragment41 MDA-MB-231 C41(1.50); C136(0.90)  LDD1438  [49]
 LDCM0600  Fragment42 Ramos C41(1.01); C136(0.86)  LDD1440  [49]
 LDCM0601  Fragment43 MDA-MB-231 C41(1.71); C136(20.00)  LDD1441  [49]
 LDCM0602  Fragment44 MDA-MB-231 C41(0.91); C136(0.74)  LDD1443  [49]
 LDCM0603  Fragment45 MDA-MB-231 C41(4.62)  LDD1444  [49]
 LDCM0604  Fragment46 MDA-MB-231 C41(0.98); C136(0.94)  LDD1445  [49]
 LDCM0605  Fragment47 MDA-MB-231 C41(1.24)  LDD1446  [49]
 LDCM0606  Fragment48 MDA-MB-231 C41(1.25); C136(1.21)  LDD1447  [49]
 LDCM0607  Fragment49 MDA-MB-231 C41(9.55); C136(2.19)  LDD1448  [49]
 LDCM0608  Fragment50 MDA-MB-231 C41(2.54); C136(1.25)  LDD1449  [49]
 LDCM0427  Fragment51 HCT 116 C131(0.59); C136(0.59); C290(0.49); C369(0.61)  LDD0744  [22]
 LDCM0610  Fragment52 MDA-MB-231 C41(1.17)  LDD1452  [49]
 LDCM0611  Fragment53 MDA-MB-231 C41(0.99); C136(0.99)  LDD1454  [49]
 LDCM0612  Fragment54 MDA-MB-231 C41(1.36); C136(1.08)  LDD1456  [49]
 LDCM0613  Fragment55 MDA-MB-231 C136(0.92)  LDD1457  [49]
 LDCM0614  Fragment56 MDA-MB-231 C41(1.08); C136(1.04)  LDD1458  [49]
 LDCM0568  Fragment6 MDA-MB-231 C41(1.23); C136(0.63)  LDD1382  [49]
 LDCM0569  Fragment7 MDA-MB-231 C41(1.28); C136(0.88)  LDD1383  [49]
 LDCM0570  Fragment8 MDA-MB-231 C41(2.12); C136(1.38)  LDD1385  [49]
 LDCM0571  Fragment9 MDA-MB-231 C41(1.84); C136(0.89)  LDD1387  [49]
 LDCM0116  HHS-0101 DM93 Y367(0.46); Y603(0.71); Y411(0.88); Y443(0.88)  LDD0264  [20]
 LDCM0117  HHS-0201 DM93 Y603(0.71); Y787(0.79); Y411(0.80); Y443(0.83)  LDD0265  [20]
 LDCM0118  HHS-0301 DM93 Y367(0.08); Y443(0.74); Y787(0.77); Y457(0.79)  LDD0266  [20]
 LDCM0119  HHS-0401 DM93 Y787(0.79); Y411(0.85); Y443(0.89); Y457(0.90)  LDD0267  [20]
 LDCM0120  HHS-0701 DM93 Y411(0.68); Y603(0.74); Y443(0.81); Y787(0.86)  LDD0268  [20]
 LDCM0015  HNE MDA-MB-231 C41(1.55)  LDD0346  [48]
 LDCM0107  IAA HeLa H769(0.00); H30(0.00); C567(0.00); C369(0.00)  LDD0221  [38]
 LDCM0123  JWB131 DM93 Y265(2.42); Y373(2.15); Y397(0.94); Y443(1.01)  LDD0285  [19]
 LDCM0124  JWB142 DM93 Y265(1.11); Y397(1.00); Y443(0.83); Y457(0.88)  LDD0286  [19]
 LDCM0125  JWB146 DM93 Y265(2.17); Y373(0.82); Y397(1.74); Y443(1.02)  LDD0287  [19]
 LDCM0126  JWB150 DM93 Y265(5.48); Y373(1.22); Y397(20.00); Y443(3.49)  LDD0288  [19]
 LDCM0127  JWB152 DM93 Y265(3.15); Y373(0.95); Y397(2.48); Y443(2.47)  LDD0289  [19]
 LDCM0128  JWB198 DM93 Y265(1.12); Y373(0.65); Y397(6.50); Y443(1.35)  LDD0290  [19]
 LDCM0129  JWB202 DM93 Y265(1.45); Y373(0.39); Y397(2.51); Y443(0.80)  LDD0291  [19]
 LDCM0130  JWB211 DM93 Y265(1.13); Y373(0.52); Y397(1.78); Y443(0.99)  LDD0292  [19]
 LDCM0179  JZ128 PC-3 C591(0.00); C751(0.00); C41(0.00); C728(0.00)  LDD0462  [15]
 LDCM0022  KB02 HCT 116 C41(1.80); C693(2.24); C728(2.54); C812(1.10)  LDD0080  [22]
 LDCM0023  KB03 HCT 116 C41(2.22); C693(2.17); C728(3.34); C812(1.02)  LDD0081  [22]
 LDCM0024  KB05 HCT 116 C41(4.13); C693(2.98); C728(2.50); C812(1.96)  LDD0082  [22]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C41(1.02); C591(0.87); C693(1.04); C728(1.23)  LDD2102  [45]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C567(1.09); C41(0.75); C591(0.99); C693(1.03)  LDD2121  [45]
 LDCM0109  NEM HeLa H490(0.00); H769(0.00); H492(0.00); H27(0.00)  LDD0223  [38]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C567(0.75); C41(0.85); C369(1.14); C591(1.01)  LDD2089  [45]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C41(1.46); C591(1.09); C693(0.86); C728(0.87)  LDD2090  [45]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C41(0.97); C591(1.38); C693(1.24); C728(1.05)  LDD2092  [45]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C567(1.21); C41(1.59); C369(1.45); C591(1.16)  LDD2093  [45]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C567(1.09); C41(1.20); C591(1.93); C728(2.09)  LDD2094  [45]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C567(1.19); C41(0.70); C369(0.52); C591(0.31)  LDD2096  [45]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C567(1.07); C41(1.01); C591(0.93); C693(0.75)  LDD2097  [45]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C567(0.76); C41(1.66); C369(0.54); C591(0.86)  LDD2098  [45]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C567(1.50); C41(1.57); C591(1.30); C693(1.60)  LDD2099  [45]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C41(0.93); C369(0.75); C693(0.39); C728(0.32)  LDD2100  [45]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C567(1.01); C693(0.62); C67(0.48)  LDD2101  [45]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C41(0.81); C369(0.63); C591(0.45); C693(0.44)  LDD2104  [45]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C41(1.48); C369(1.08); C591(1.38); C693(1.09)  LDD2105  [45]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C41(0.87); C591(0.33); C693(0.41); C728(0.28)  LDD2106  [45]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C567(1.23); C41(1.22); C369(1.49); C693(1.29)  LDD2107  [45]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C567(0.87); C41(0.85); C591(0.39); C693(0.53)  LDD2108  [45]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C567(1.19); C41(1.11); C369(1.02); C591(0.68)  LDD2109  [45]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C41(1.69); C591(0.38); C693(0.55); C67(1.42)  LDD2110  [45]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C41(1.38); C369(1.60); C591(1.25); C693(1.39)  LDD2111  [45]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C567(0.54); C41(1.06); C369(0.61); C591(0.52)  LDD2114  [45]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C567(0.57); C41(0.52); C591(0.38); C693(0.51)  LDD2115  [45]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C41(1.07); C591(0.67); C693(0.50); C728(0.69)  LDD2116  [45]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C567(0.98); C41(1.14); C369(0.98); C591(0.81)  LDD2118  [45]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C567(1.94); C41(2.33); C369(1.72); C591(2.25)  LDD2119  [45]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C567(0.54); C369(0.77); C591(0.74); C693(0.76)  LDD2120  [45]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C567(0.87); C41(1.27); C369(0.72); C591(0.33)  LDD2122  [45]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C567(1.25); C369(1.22); C591(1.06); C693(1.16)  LDD2123  [45]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C41(0.96); C369(0.92); C591(0.55); C728(0.29)  LDD2124  [45]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C567(0.99); C41(1.00); C369(1.16); C591(1.04)  LDD2125  [45]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C567(0.93); C41(1.23); C369(0.99); C591(0.45)  LDD2126  [45]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C567(1.35); C41(1.77); C369(1.63); C591(1.50)  LDD2127  [45]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C567(0.41); C41(0.72); C369(1.00); C591(0.94)  LDD2128  [45]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C567(1.39); C41(1.13); C369(1.59); C591(1.59)  LDD2129  [45]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C567(0.51); C41(0.91); C369(0.79); C591(0.59)  LDD2133  [45]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C567(0.43); C41(0.55); C591(0.92); C693(0.40)  LDD2134  [45]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C567(1.70); C41(1.37); C369(1.71); C591(1.68)  LDD2135  [45]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C567(1.59); C41(1.21); C369(1.69); C591(2.01)  LDD2136  [45]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C567(1.36); C41(1.11); C369(1.02); C693(1.26)  LDD2137  [45]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C693(3.81); C41(2.87); C591(2.57); C567(2.38)  LDD1700  [45]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C567(1.02); C41(1.91); C693(1.08)  LDD2140  [45]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C567(1.00); C41(0.70); C369(1.03); C591(0.43)  LDD2141  [45]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C567(0.69); C41(0.58); C369(0.87); C591(0.92)  LDD2143  [45]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C567(1.87); C41(2.91); C369(1.14); C591(1.56)  LDD2144  [45]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C369(1.30); C693(0.13); C728(0.15); C67(4.75)  LDD2145  [45]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C567(1.16); C369(1.61); C693(1.24); C728(0.89)  LDD2146  [45]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C41(1.03); C591(2.09); C693(2.40); C67(3.58)  LDD2147  [45]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C567(0.73); C41(0.50); C369(0.41); C591(0.39)  LDD2148  [45]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C41(1.07); C369(0.80); C591(0.50); C693(0.44)  LDD2149  [45]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C567(0.87); C41(0.68); C369(0.75); C591(0.69)  LDD2150  [45]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C41(4.56); C369(0.75); C591(0.41); C693(0.32)  LDD2151  [45]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C41(2.13); C591(2.26); C693(1.98); C728(1.84)  LDD2153  [45]
 LDCM0627  NUDT7-COV-1 HEK-293T C67(2.63); C812(1.53); C136(0.85); C41(0.76)  LDD2206  [50]
 LDCM0628  OTUB2-COV-1 HEK-293T C812(3.63); C466(1.78); C290(1.57); C591(1.57)  LDD2207  [50]
 LDCM0131  RA190 MM1.R C290(1.56); C728(1.42); C751(1.38); C812(1.34)  LDD0304  [51]
 LDCM0021  THZ1 HeLa S3 C693(1.10); C728(1.14); C651(1.08); C591(1.07)  LDD0460  [15]
 LDCM0111  W14 Hep-G2 K498(0.57); C41(10.97)  LDD0238  [39]
 LDCM0113  W17 Hep-G2 C41(4.85)  LDD0240  [39]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) Short-chain dehydrogenases/reductases (SDR) family Q99714
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Moxetumomab Pasudotox Monoclonal antibody DB12688
Esketamine . DB11823
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine-5-diphosphoribose Small molecular drug DB02059
Diphthamide Small molecular drug DB03223
Guanosine-5'-diphosphate Small molecular drug DB04315
N~2~n~2~-dimethyl-n~1~-(6-oxo-56-dihydrophenanthridin-2-yl)Glycinamide Small molecular drug DB08348

References

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3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
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Mass spectrometry data entry: PXD021557 , PXD015828
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD042888
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16 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
17 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
18 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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22 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
23 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
24 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
26 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
27 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
28 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
29 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
30 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
31 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
32 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD022279
34 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
35 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
37 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
38 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD025652
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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