Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment12  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 82 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 20.0
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 20.0
 LDTP02672  Elongation factor 2 (EEF2) C41 20.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 20.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 20.0
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 20.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 20.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 8.6
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 8.5
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 7.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 7.2
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 5.9
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 5.3
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 5.1
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 5.0
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 4.7
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 4.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 3.7
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 3.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 3.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 3.4
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 3.0
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 3.0
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 2.9
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 2.8
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 2.7
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 2.4
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 2.2
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 2.2
 LDTP02502  Thioredoxin (TXN) C32 2.2
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.1
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) C680 2.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 2.0
 LDTP02672  Elongation factor 2 (EEF2) C136 2.0
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 2.0
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 1.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.9
 LDTP10002  Ribonuclease P/MRP protein subunit POP5 (POP5) C146 1.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.8
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 1.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.8
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.7
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.7
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C308 1.7
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.6
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.6
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.5
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.5
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.4
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.4
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.4
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) C522 1.4
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.3
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 1.3
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 1.2
 LDTP13147  Cathepsin Z (CTSZ) C92 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.2
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 1.2
 LDTP04689  Adenosine kinase (ADK) C353 1.1
 LDTP03681  DNA replication licensing factor MCM5 (MCM5) C482 1.1
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.1
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.1
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.0
 LDTP02223  Cathepsin B (CTSB) C211 0.9
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.9
 LDTP02223  Cathepsin B (CTSB) C319 0.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.7
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 20.0
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 20.0
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 2.6
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.7
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 1.5
 LDTP00501  Exportin-1 (XPO1) C34 1.2
 LDTP01574  Importin-7 (IPO7) C757 1.2
 LDTP00501  Exportin-1 (XPO1) C528 1.1
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.1
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.0
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
Transcription factor
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 20.0
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 2.8
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 2.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.6
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.6
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.1
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.0
Other
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 20.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 20.0
 LDTP04363  Serpin H1 (SERPINH1) C156 20.0
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 20.0
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 20.0
 LDTP01532  ZW10 interactor (ZWINT) C54 20.0
 LDTP05867  Treacle protein (TCOF1) C1298 12.5
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 9.2
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 7.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 7.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 4.4
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 4.4
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 3.7
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 3.2
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 3.1
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 3.0
 LDTP05867  Treacle protein (TCOF1) C38 2.9
 LDTP11235  Protein PAXX (PAXX) C180 2.6
 LDTP12443  Anillin (ANLN) C712 2.5
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 2.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 2.4
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 2.4
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.2
 LDTP06330  Plectin (PLEC) C3110 2.1
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 2.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 2.0
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 2.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 2.0
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 2.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 2.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.9
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.9
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 1.9
 LDTP02205  Tubulin beta chain (TUBB) C239 1.8
 LDTP06330  Plectin (PLEC) C992 1.8
 LDTP10864  Calponin-2 (CNN2) C164 1.7
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 1.6
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.6
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.6
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.6
 LDTP03620  Protein S100-A11 (S100A11) C91 1.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 1.5
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 1.4
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.4
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.4
 LDTP13580  Coronin-1C (CORO1C) C420 1.3
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.3
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.2
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.2
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.1
 LDTP04487  Cyclin-H (CCNH) C244 1.1
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 1.1
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.1
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.1
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.1
 LDTP13580  Coronin-1C (CORO1C) C456 1.0
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.