Details of the Target

General Information of Target

Target ID LDTP07940
Target Name eIF5-mimic protein 2 (BZW1)
Gene Name BZW1
Gene ID 9689
Synonyms
5MP2; BZAP45; KIAA0005; eIF5-mimic protein 2; Basic leucine zipper and W2 domain-containing protein 1; Protein Orf
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNNQKQQKPTLSGQRFKTRKRDEKERFDPTQFQDCIIQGLTETGTDLEAVAKFLDASGAK
LDYRRYAETLFDILVAGGMLAPGGTLADDMMRTDVCVFAAQEDLETMQAFAQVFNKLIRR
YKYLEKGFEDEVKKLLLFLKGFSESERNKLAMLTGVLLANGTLNASILNSLYNENLVKEG
VSAAFAVKLFKSWINEKDINAVAASLRKVSMDNRLMELFPANKQSVEHFTKYFTEAGLKE
LSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIVWSSV
MSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQ
KIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWLKNAEEESESEAEEGD
Target Bioclass
Transcription factor
Family
BZW family
Function
Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function. Enhances histone H4 gene transcription but does not seem to bind DNA directly.
Uniprot ID
Q7L1Q6
Ensemble ID
ENST00000409226.5
HGNC ID
HGNC:18380

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.G84D DBIA    Probe Info 
DOTC24510 SNV: p.E289Q DBIA    Probe Info 
HT Deletion: p.N285TfsTer11 .
JURKAT SNV: p.H385Y .
SW756 SNV: p.S192L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.48  LDD0402  [1]
CHEMBL5175495
 Probe Info  		6.57  LDD0196  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH211
 Probe Info  		Y232(5.45)  LDD0260  [4]
ONAyne
 Probe Info  		K390(0.79); K60(0.87)  LDD0274  [5]
AZ-9
 Probe Info  		E235(0.98)  LDD2208  [6]
Probe 1
 Probe Info  		Y232(31.22); Y244(64.99)  LDD3495  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
THZ1-DTB
 Probe Info  		C35(1.04)  LDD0460  [8]
BTD
 Probe Info  		C349(1.76)  LDD2099  [9]
AHL-Pu-1
 Probe Info  		C35(2.02)  LDD0168  [10]
EA-probe
 Probe Info  		C35(1.08); C96(1.62); C35(1.38)  LDD2210  [11]
DBIA
 Probe Info  		C35(4.05)  LDD0209  [12]
HHS-465
 Probe Info  		Y350(10.00)  LDD2237  [13]
ATP probe
 Probe Info  		K390(0.00); K60(0.00); K223(0.00); K239(0.00)  LDD0199  [14]
CY4
 Probe Info  		D198(0.00); D212(0.00)  LDD0247  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C35(0.00); C349(0.00); C96(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C35(0.00); C349(0.00); C96(0.00)  LDD0036  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C35(0.00); C349(0.00); C96(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K399(0.00); K116(0.00); K140(0.00); K60(0.00)  LDD0035  [17]
IPM
 Probe Info  		C35(0.00); C349(0.00)  LDD0025  [18]
JW-RF-010
 Probe Info  		C349(0.00); C96(0.00); C35(0.00)  LDD0026  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
NHS
 Probe Info  		K60(0.00); K191(0.00); K223(0.00); K390(0.00)  LDD0010  [20]
STPyne
 Probe Info  		K319(0.00); K309(0.00); K398(0.00); K390(0.00)  LDD0009  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [22]
1c-yne
 Probe Info  		K5(0.00); K223(0.00); K197(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		N.A.  LDD0217  [24]
Methacrolein
 Probe Info  		N.A.  LDD0218  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
NAIA_5
 Probe Info  		C35(0.00); C349(0.00)  LDD2223  [19]
HHS-482
 Probe Info  		Y350(1.03)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		13.07  LDD0475  [26]
STS-1
 Probe Info  		N.A.  LDD0137  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C349(0.59)  LDD2132  [9]
 LDCM0025  4SU-RNA HEK-293T C35(2.02)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C96(4.51)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C349(0.95); C96(1.02); C35(0.98)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C349(0.84); C96(1.09); C35(0.92)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C349(1.01); C96(1.10); C35(1.02)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C349(0.91); C96(1.03); C35(1.04)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C349(0.85); C96(1.02); C35(0.88)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C349(1.03); C96(0.97); C35(0.95)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C349(0.85); C96(1.00); C35(0.86)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C349(0.88); C96(1.01); C35(0.97)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C349(0.97); C96(1.44); C35(1.27)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C349(0.92); C96(1.06); C35(0.92)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C349(0.95); C96(0.97); C35(0.98)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C349(0.94); C96(1.00); C35(0.96)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C349(0.93); C96(1.09); C35(1.01)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C349(1.07); C96(0.96); C35(0.96)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C349(0.96); C96(0.95); C35(0.92)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C349(0.87); C96(1.05); C35(0.86)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C349(0.86); C96(1.08); C35(0.98)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C349(1.01); C96(1.08); C35(1.02)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C349(0.95); C96(1.05); C35(1.09)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C349(0.94); C96(1.00); C35(0.95)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C349(1.04); C96(1.04); C35(1.01)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C349(0.95); C96(0.97); C35(0.93)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C349(1.09); C96(0.94); C35(0.95)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C349(0.97); C96(1.04); C35(0.96)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C349(0.89); C96(1.08); C35(0.93)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C349(0.88); C96(1.01); C35(0.97)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C349(0.94); C96(1.03); C35(1.01)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C349(0.88); C96(1.05); C35(0.97)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C349(0.97); C96(0.95); C35(1.02)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C349(0.92); C96(0.95); C35(0.92)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C349(1.05); C96(0.98); C35(0.92)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C349(0.92); C96(1.05); C35(1.03)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C349(0.99); C96(1.00); C35(0.93)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C349(0.88); C96(1.00); C35(0.95)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C349(0.87); C96(1.19); C35(1.00)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C349(0.98); C96(1.11); C35(1.11)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C349(0.90); C96(1.02); C35(1.02)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C349(0.86); C96(1.03); C35(1.01)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C349(0.88); C96(1.00); C35(1.04)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C349(0.97); C96(1.10); C35(0.91)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C349(0.99); C96(1.06); C35(0.92)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C349(0.82); C96(1.15); C35(0.93)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C349(0.85); C96(1.05); C35(0.99)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C349(0.95); C96(1.02); C35(0.96)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C349(1.02); C96(1.10); C35(0.95)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C349(0.97); C96(1.02); C35(1.03)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C349(0.92); C96(1.00); C35(0.95)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C349(0.87); C96(0.98); C35(0.99)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C349(1.01); C96(1.04); C35(0.95)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C349(0.95); C96(1.01); C35(0.94)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C349(0.91); C96(1.03); C35(1.00)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C349(0.99); C96(0.99); C35(1.04)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C349(1.02); C96(1.03); C35(1.04)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C349(0.85); C96(1.00); C35(0.94)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C349(0.91); C96(1.01); C35(0.99)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C349(0.97); C96(1.07); C35(0.99)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C349(0.86); C96(0.98); C35(0.98)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C349(1.01); C96(0.98); C35(0.98)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C349(0.96); C96(1.02); C35(0.90)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C349(1.16); C96(0.97); C35(0.93)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C349(1.01); C96(1.05); C35(0.96)  LDD1569  [28]
 LDCM0248  AKOS034007472 HEK-293T C349(0.88); C96(1.05); C35(0.99)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C349(0.86); C96(1.02); C35(0.96)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C349(0.99); C96(1.07); C35(0.93)  LDD1514  [28]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C35(1.59); C96(1.12)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C349(0.00); H228(0.00)  LDD0222  [24]
 LDCM0367  CL1 HEK-293T C349(1.03); C96(1.16); C35(1.11)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C349(1.23); C96(1.70); C35(1.81)  LDD1572  [28]
 LDCM0369  CL100 HEK-293T C349(0.81); C96(1.09); C35(0.95)  LDD1573  [28]
 LDCM0370  CL101 HEK-293T C349(1.05); C96(1.06); C35(1.06)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C349(1.02); C96(1.20); C35(1.03)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C349(0.94); C96(1.05); C35(1.02)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C349(0.92); C96(1.10); C35(0.99)  LDD1577  [28]
 LDCM0374  CL105 HEK-293T C349(0.93); C96(1.13); C35(0.98)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C349(1.00); C96(1.06); C35(0.94)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C349(0.84); C96(1.00); C35(1.00)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C349(0.89); C96(1.04); C35(0.97)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C349(0.93); C96(1.14); C35(1.02)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C349(1.47); C96(1.16); C35(1.00)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C349(0.82); C96(1.27); C35(1.02)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C349(0.91); C96(1.14); C35(1.03)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C349(0.89); C96(1.06); C35(1.01)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C349(0.99); C96(1.05); C35(1.08)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C349(1.05); C96(1.45); C35(0.87)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C349(0.90); C96(0.96); C35(0.95)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C349(0.92); C96(1.05); C35(0.97)  LDD1590  [28]
 LDCM0387  CL117 HEK-293T C349(0.98); C96(1.11); C35(0.95)  LDD1591  [28]
 LDCM0388  CL118 HEK-293T C349(0.94); C96(1.17); C35(1.08)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C349(0.92); C96(1.01); C35(1.01)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C349(1.49); C96(1.11); C35(1.11)  LDD1594  [28]
 LDCM0391  CL120 HEK-293T C349(0.92); C96(1.07); C35(1.18)  LDD1595  [28]
 LDCM0392  CL121 HEK-293T C349(0.99); C96(1.07); C35(0.96)  LDD1596  [28]
 LDCM0393  CL122 HEK-293T C349(0.92); C96(1.16); C35(0.88)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C349(0.80); C96(1.44); C35(1.17)  LDD1598  [28]
 LDCM0395  CL124 HEK-293T C349(0.86); C96(1.18); C35(1.04)  LDD1599  [28]
 LDCM0396  CL125 HEK-293T C349(1.03); C96(1.13); C35(0.93)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C349(0.99); C96(1.13); C35(0.95)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C349(0.96); C96(1.04); C35(0.96)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C349(0.98); C96(1.03); C35(1.07)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C349(0.96); C96(1.26); C35(1.02)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C349(1.04); C96(1.09); C35(1.00)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C349(0.85); C96(1.51); C35(1.29)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C349(1.00); C96(0.99); C35(1.05)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C349(0.87); C96(1.61); C35(1.18)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C349(1.00); C96(1.01); C35(1.02)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C349(1.12); C96(1.06); C35(1.06)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C349(1.07); C96(1.00); C35(0.97)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C349(1.11); C96(0.96); C35(1.02)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C349(1.09); C96(1.29); C35(1.23)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C349(1.37); C96(0.98); C35(1.12)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C349(1.74); C96(1.03); C35(1.15)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C349(1.49); C96(1.15); C35(1.17)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C349(1.03); C96(1.31); C35(0.94)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C349(1.09); C96(1.03); C35(0.94)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C349(0.97); C96(1.03); C35(0.93)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C349(1.01); C96(1.05); C35(0.94)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C349(0.93); C96(0.93); C35(0.90)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C349(0.96); C96(1.06); C35(0.99)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C349(0.97); C96(0.91); C35(0.88)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C349(1.08); C96(1.10); C35(1.24)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C349(1.14); C96(0.96); C35(0.99)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C349(1.21); C96(1.49); C35(1.75)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C349(1.50); C96(1.15); C35(1.15)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C349(1.57); C96(1.01); C35(1.09)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C349(1.45); C96(1.14); C35(1.14)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C349(1.06); C96(0.88); C35(0.90)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C349(0.89); C96(1.00); C35(0.92)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C349(1.02); C96(1.13); C35(1.09)  LDD1633  [28]
 LDCM0430  CL40 HEK-293T C349(1.01); C96(0.96); C35(0.98)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C349(0.88); C96(1.08); C35(1.04)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C349(0.98); C96(0.96); C35(0.92)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C349(1.18); C96(0.98); C35(1.07)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C349(1.14); C96(0.98); C35(1.01)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C349(1.06); C96(1.14); C35(0.75)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C349(1.37); C96(0.96); C35(1.09)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C349(1.45); C96(0.97); C35(1.11)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C349(1.50); C96(1.07); C35(1.08)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C349(1.01); C96(1.05); C35(0.83)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C349(1.08); C96(1.05); C35(0.86)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C349(1.02); C96(1.11); C35(0.97)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C349(0.91); C96(0.96); C35(1.05)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C349(0.91); C96(1.35); C35(0.94)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C349(0.86); C96(1.59); C35(1.46)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C349(1.08); C96(1.04); C35(0.97)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C349(1.12); C96(0.95); C35(1.02)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C349(1.01); C96(1.25); C35(1.36)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C349(1.35); C96(1.07); C35(1.12)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C349(1.42); C96(1.00); C35(1.03)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C349(1.06); C96(1.21); C35(0.99)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C349(1.37); C96(1.07); C35(1.08)  LDD1655  [28]
 LDCM0453  CL61 HEK-293T C349(1.04); C96(1.01); C35(0.91)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C349(1.04); C96(1.03); C35(0.86)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C349(0.93); C96(0.99); C35(0.97)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C349(0.90); C96(1.23); C35(1.02)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C349(0.99); C96(1.03); C35(0.93)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C349(0.99); C96(1.03); C35(0.99)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C349(1.07); C96(1.02); C35(1.04)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C349(1.10); C96(0.99); C35(1.03)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C349(1.13); C96(1.14); C35(1.17)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C349(1.17); C96(1.13); C35(1.06)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C349(1.28); C96(0.96); C35(1.07)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C349(1.38); C96(1.04); C35(1.05)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C349(1.25); C96(1.06); C35(1.07)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C349(0.98); C96(1.13); C35(1.03)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C349(0.94); C96(1.07); C35(0.88)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C349(1.00); C96(0.98); C35(0.97)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C349(0.83); C96(1.30); C35(1.09)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C349(1.06); C96(0.93); C35(0.92)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C349(1.04); C96(0.97); C35(1.06)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C349(0.98); C96(1.95); C35(0.67)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C349(1.12); C96(0.93); C35(1.01)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C349(1.09); C96(0.98); C35(1.13)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C349(1.09); C96(0.97); C35(1.06)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C349(1.45); C96(1.06); C35(0.97)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C349(1.25); C96(1.23); C35(1.02)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C349(1.09); C96(1.01); C35(0.88)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C349(1.05); C96(1.05); C35(0.94)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C349(1.00); C96(1.07); C35(0.95)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C349(0.87); C96(1.02); C35(0.95)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C349(1.03); C96(1.04); C35(0.83)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C349(1.22); C96(1.06); C35(1.11)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C349(0.98); C96(1.83); C35(0.71)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C349(1.15); C96(1.02); C35(1.04)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C349(1.02); C96(1.21); C35(1.08)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C349(0.99); C96(1.22); C35(1.16)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C349(1.12); C96(1.01); C35(0.96)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C349(1.03); C96(1.88); C35(1.15)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C349(1.15); C96(1.24); C35(0.94)  LDD1694  [28]
 LDCM0492  CL97 HEK-293T C349(0.91); C96(1.28); C35(1.00)  LDD1695  [28]
 LDCM0493  CL98 HEK-293T C349(0.99); C96(1.15); C35(1.04)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C349(0.87); C96(1.05); C35(0.92)  LDD1697  [28]
 LDCM0634  CY-0357 Hep-G2 C35(2.48)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C349(0.98); C96(1.03); C35(0.89)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C349(3.80)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa C35(1.08); C96(1.62); C35(1.38)  LDD2210  [11]
 LDCM0625  F8 Ramos C349(0.92); C35(0.35)  LDD2187  [30]
 LDCM0572  Fragment10 MDA-MB-231 C35(1.15)  LDD1389  [31]
 LDCM0573  Fragment11 MDA-MB-231 C35(0.90)  LDD1391  [31]
 LDCM0574  Fragment12 MDA-MB-231 C35(1.14)  LDD1393  [31]
 LDCM0575  Fragment13 MDA-MB-231 C35(0.96)  LDD1395  [31]
 LDCM0576  Fragment14 MDA-MB-231 C35(0.99)  LDD1397  [31]
 LDCM0577  Fragment15 MDA-MB-231 C35(0.83)  LDD1399  [31]
 LDCM0579  Fragment20 MDA-MB-231 C35(1.28)  LDD1402  [31]
 LDCM0580  Fragment21 MDA-MB-231 C35(0.90)  LDD1404  [31]
 LDCM0581  Fragment22 MDA-MB-231 C35(1.09)  LDD1406  [31]
 LDCM0582  Fragment23 MDA-MB-231 C35(7.00)  LDD1408  [31]
 LDCM0583  Fragment24 Ramos C35(1.20)  LDD1410  [31]
 LDCM0584  Fragment25 MDA-MB-231 C35(0.64)  LDD1411  [31]
 LDCM0585  Fragment26 Ramos C35(0.95)  LDD1412  [31]
 LDCM0578  Fragment27 MDA-MB-231 C35(0.94)  LDD1401  [31]
 LDCM0586  Fragment28 MDA-MB-231 C35(0.90)  LDD1415  [31]
 LDCM0587  Fragment29 MDA-MB-231 C35(1.23)  LDD1417  [31]
 LDCM0588  Fragment30 MDA-MB-231 C35(0.68)  LDD1419  [31]
 LDCM0589  Fragment31 MDA-MB-231 C35(1.18)  LDD1421  [31]
 LDCM0590  Fragment32 MDA-MB-231 C35(1.16)  LDD1423  [31]
 LDCM0468  Fragment33 MDA-MB-231 C35(0.87)  LDD1425  [31]
 LDCM0592  Fragment34 MDA-MB-231 C35(0.85)  LDD1427  [31]
 LDCM0593  Fragment35 MDA-MB-231 C35(0.72)  LDD1429  [31]
 LDCM0594  Fragment36 MDA-MB-231 C35(1.33)  LDD1431  [31]
 LDCM0595  Fragment37 Ramos C35(0.85)  LDD1432  [31]
 LDCM0596  Fragment38 MDA-MB-231 C35(0.84)  LDD1433  [31]
 LDCM0597  Fragment39 MDA-MB-231 C35(1.07)  LDD1435  [31]
 LDCM0566  Fragment4 MDA-MB-231 C35(1.16)  LDD1378  [31]
 LDCM0598  Fragment40 MDA-MB-231 C35(0.69)  LDD1436  [31]
 LDCM0599  Fragment41 MDA-MB-231 C35(1.83)  LDD1438  [31]
 LDCM0600  Fragment42 Ramos C35(0.82)  LDD1440  [31]
 LDCM0601  Fragment43 MDA-MB-231 C35(1.10)  LDD1441  [31]
 LDCM0602  Fragment44 MDA-MB-231 C35(0.84)  LDD1443  [31]
 LDCM0603  Fragment45 MDA-MB-231 C35(1.31)  LDD1444  [31]
 LDCM0604  Fragment46 MDA-MB-231 C35(0.77)  LDD1445  [31]
 LDCM0605  Fragment47 MDA-MB-231 C35(1.07)  LDD1446  [31]
 LDCM0606  Fragment48 MDA-MB-231 C35(1.30)  LDD1447  [31]
 LDCM0607  Fragment49 MDA-MB-231 C35(1.31)  LDD1448  [31]
 LDCM0608  Fragment50 MDA-MB-231 C35(0.96)  LDD1449  [31]
 LDCM0427  Fragment51 MDA-MB-231 C35(0.94)  LDD1450  [31]
 LDCM0610  Fragment52 MDA-MB-231 C35(0.79)  LDD1452  [31]
 LDCM0611  Fragment53 MDA-MB-231 C35(0.81)  LDD1454  [31]
 LDCM0612  Fragment54 MDA-MB-231 C35(1.18)  LDD1456  [31]
 LDCM0613  Fragment55 MDA-MB-231 C35(0.92)  LDD1457  [31]
 LDCM0614  Fragment56 MDA-MB-231 C35(1.01)  LDD1458  [31]
 LDCM0568  Fragment6 MDA-MB-231 C35(1.60)  LDD1382  [31]
 LDCM0569  Fragment7 MDA-MB-231 C35(1.08)  LDD1383  [31]
 LDCM0570  Fragment8 MDA-MB-231 C35(1.02)  LDD1385  [31]
 LDCM0571  Fragment9 MDA-MB-231 C35(0.92)  LDD1387  [31]
 LDCM0015  HNE MDA-MB-231 C35(0.96)  LDD0346  [30]
 LDCM0107  IAA HeLa H228(0.00); C349(0.00)  LDD0221  [24]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 MDA-MB-231 C35(1.23)  LDD1374  [31]
 LDCM0023  KB03 Jurkat C35(4.05)  LDD0209  [12]
 LDCM0024  KB05 COLO792 C381(1.42)  LDD3310  [32]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C349(1.76)  LDD2099  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C349(0.98)  LDD2109  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C349(1.26)  LDD2119  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C349(1.13)  LDD2123  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C349(3.35)  LDD2127  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C349(1.69)  LDD2144  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C96(1.01); C35(0.86)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C35(0.88); C96(0.73)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C349(1.28); C35(1.27)  LDD0304  [34]
 LDCM0021  THZ1 HeLa S3 C35(1.04)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
32 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
34 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.