Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0581
Competitor Name
Fragment22
Synonyms
1440-61-5; 4-(2-chloroacetyl)morpholine; 4-(Chloroacetyl)morpholine; Morpholine, 4-(chloroacetyl)-; N-(Chloroacetyl)morpholine; 2-chloro-1-morpholin-4-ylethanone; 2-chloro-1-morpholinoethanone; 2-Chloro-1-(morpholin-4-yl)ethanone; 2-Chloro-1-(Morpholin-4-Yl)Ethan-1-One; Chloroacetic acid morpholide; 2-Chloro-1-morpholin-4-yl-ethanone; n-chloroacetylmorpholine; Ethanone, 2-chloro-1-(4-morpholinyl)-; MFCD00721939; Chloroacetic acid, morpholide; N-chloroacetyl-morpholine; NSC-54542; 2-chloro-1-morpholinoethan-1-one; EINECS 215-880-3; AI3-23546; 2-Chloro-1-(4-morpholinyl)ethanone; chloroacetylmorpholine; 4-chloroacetylmorpholine; chloro acetyl morpholine; Morpholine chloroacetamide; QDM98ZM5WS; N-(chloroacetyl)-morpholine; 4-(chloroacetyl) morpholine; 4-(chloroacetyl)-morpholine; 4-(Chloroacetyl)morpho line; SCHEMBL78389; 4-(2-chloroacetyl) morpholine; 4-(2-chloroacetyl)-morpholine; DTXSID9073258; 2-morpholino-2-oxoethyl chloride; 4-(Chloroacetyl)morpholine, 97%; NSC54542; STR08276; BBL034789; NSC 54542; STL419472; 2-chloro-1-(4-morpholinyl)-ethanone; AKOS000266941; AM86594; CS-W021985; Ethanone,2-chloro-1-(4-morpholinyl)-; SY019836; 1-chloro-2-oxo-2-(morpholin-4-yl)ethane; DB-042719; NS00024677; EN300-01805; O11063; A808168; J-508617; Z56891388; F0176-0215
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 163.6
Lipid-water partition coefficient (xlogp) 0
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C6H10ClNO2
IUPAC Name
2-chloro-1-morpholin-4-ylethanone
Canonical SMILES
C1COCCN1C(=O)CCl
InChI
InChI=1S/C6H10ClNO2/c7-5-6(9)8-1-3-10-4-2-8/h1-5H2
InChIKey
YMQRPXBBBOXHNZ-UHFFFAOYSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
IA-alkyne
 Probe Info  		100 uM Human breast adenocarcinoma cell lysate (MDA-MB-231) [1]

Target(s) List of this Competitor

94 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 1.13; 1.09  LDD1406 
26S proteasome regulatory subunit 6B (PSMC4) LDTP04061 1.01  LDD1406 
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) LDTP10954 1.20  LDD1406 
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) LDTP03998 1.00  LDD1407 
5'-nucleotidase domain-containing protein 1 (NT5DC1) LDTP17247 1.67  LDD1406 
6-phosphogluconolactonase (PGLS) LDTP14535 3.35  LDD1406 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 1.09  LDD1406 
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) LDTP03291 1.00; 1.36; 1.12 ...  LDD1406 
Adenosine kinase (ADK) LDTP04689 0.99  LDD1406 
ADP-ribosylation factor-like protein 3 (ARL3) LDTP03806 1.07  LDD1407 
Aldo-keto reductase family 1 member B1 (AKR1B1) LDTP02765 1.13  LDD1406 
AMP deaminase 2 (AMPD2) LDTP05289 1.01  LDD1407 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 1.11  LDD1407 
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) LDTP05314 1.26; 1.13  LDD1406 
ATPase WRNIP1 (WRNIP1) LDTP10801 0.75  LDD1407 
Bleomycin hydrolase (BLMH) LDTP05992 1.01  LDD1406 
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) LDTP02580 0.87; 1.23  LDD1407 
Cathepsin B (CTSB) LDTP02223 1.37; 1.95  LDD1406 
Cathepsin Z (CTSZ) LDTP13147 1.95  LDD1406 
Cell cycle checkpoint control protein RAD9A (RAD9A) LDTP10929 0.89  LDD1407 
Cyclin-dependent kinase 2 (CDK2) LDTP03299 1.43  LDD1406 
Cyclin-dependent kinase inhibitor 3 (CDKN3) LDTP06603 1.30  LDD1407 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 0.74  LDD1407 
Deoxycytidine kinase (DCK) LDTP03400 1.56; 1.37  LDD1406 
DNA repair protein RAD50 (RAD50) LDTP09912 1.73  LDD1406 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 0.86  LDD1407 
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) LDTP04103 0.96  LDD1406 
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) LDTP04077 1.03  LDD1406 
Dual specificity protein phosphatase 12 (DUSP12) LDTP13663 1.06  LDD1406 
Dynamin-1-like protein (DNM1L) LDTP00273 1.76  LDD1406 
Dynamin-2 (DNM2) LDTP04374 0.98  LDD1406 
E3 ubiquitin-protein ligase UBR5 (UBR5) LDTP01495 1.10  LDD1407 
Elongation factor 2 (EEF2) LDTP02672 1.57; 1.07  LDD1406 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 0.44  LDD1407 
Enoyl-CoA delta isomerase 2 (ECI2) LDTP01245 1.04  LDD1406 
ERO1-like protein alpha (ERO1A) LDTP10386 1.17; 1.11; 1.59  LDD1406 
Eukaryotic translation initiation factor 3 subunit F (EIF3F) LDTP00246 1.04  LDD1406 
Galactokinase (GALK1) LDTP04424 0.94  LDD1407 
Glutaredoxin-1 (GLRX) LDTP03786 2.12  LDD1407 
Glutaredoxin-related protein 5, mitochondrial (GLRX5) LDTP08181 1.00  LDD1406 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 20.00  LDD1406 
Glutathione S-transferase P (GSTP1) LDTP02333 0.93  LDD1406 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 0.99  LDD1406 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 2.25  LDD1406 
GMP reductase 2 (GMPR2) LDTP13080 1.20  LDD1406 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 1.71; 1.36  LDD1406 
Integrin-linked protein kinase (ILK) LDTP05859 1.19  LDD1406 
Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) LDTP17082 1.43  LDD1406 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 0.95  LDD1406 
Ketosamine-3-kinase (FN3KRP) LDTP16025 1.29  LDD1406 
Mannose-1-phosphate guanyltransferase alpha (GMPPA) LDTP10418 0.98  LDD1407 
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) LDTP10177 2.37  LDD1406 
Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) LDTP09598 1.33  LDD1407 
Mitogen-activated protein kinase 9 (MAPK9) LDTP04076 1.48  LDD1407 
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) LDTP12837 1.04  LDD1406 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 1.68  LDD1407 
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) LDTP01005 1.27  LDD1406 
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) LDTP11388 1.10; 0.90  LDD1406 
Omega-amidase NIT2 (NIT2) LDTP12428 9.58  LDD1406 
Parkinson disease protein 7 (PARK7) LDTP10878 2.16  LDD1407 
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) LDTP05912 1.10  LDD1406 
Peroxiredoxin-4 (PRDX4) LDTP05773 2.15  LDD1406 
Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 0.88  LDD1406 
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) LDTP01633 1.24  LDD1406 
Pre-rRNA-processing protein TSR1 homolog (TSR1) LDTP14888 1.12  LDD1406 
Probable ATP-dependent RNA helicase DDX59 (DDX59) LDTP07098 1.31  LDD1407 
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) LDTP05373 1.30  LDD1406 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 1.04  LDD1406 
Protein arginine N-methyltransferase 1 (PRMT1) LDTP10997 1.03  LDD1406 
Protein disulfide-isomerase (P4HB) LDTP02188 1.77  LDD1407 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 1.93  LDD1406 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 2.15; 1.93  LDD1406 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 2.13  LDD1406 
Protein PML (PML) LDTP03496 1.24  LDD1406 
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) LDTP03146 0.76  LDD1406 
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) LDTP03152 1.08  LDD1406 
Pyruvate kinase PKM (PKM) LDTP02733 1.14  LDD1406 
Ras-related GTP-binding protein C (RRAGC) LDTP12166 1.71; 1.72  LDD1406 
Ribonuclease H2 subunit C (RNASEH2C) LDTP09446 0.78  LDD1407 
Serine--tRNA ligase, cytoplasmic (SARS1) LDTP04265 1.10  LDD1406 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) LDTP06199 1.64  LDD1406 
Serine/threonine-protein phosphatase CPPED1 (CPPED1) LDTP11107 1.33  LDD1407 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 1.25  LDD1406 
Thioredoxin (TXN) LDTP02502 3.54  LDD1406 
Thioredoxin domain-containing protein 5 (TXNDC5) LDTP09067 1.87  LDD1407 
Thymidine kinase, cytosolic (TK1) LDTP02022 1.55  LDD1406 
Transmembrane protease serine 12 (TMPRSS12) LDTP15306 0.87  LDD1406 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 1.27; 1.38  LDD1406 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 1.42; 1.24; 1.13  LDD1406 
Tudor-interacting repair regulator protein (NUDT16L1) LDTP11111 1.19  LDD1407 
Ubiquitin carboxyl-terminal hydrolase 16 (USP16) LDTP14159 1.61  LDD1407 
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) LDTP05070 0.84  LDD1407 
Ubiquitin-conjugating enzyme E2 S (UBE2S) LDTP06621 0.91  LDD1407 
Uridine phosphorylase 1 (UPP1) LDTP06643 1.64  LDD1406 
------------------------------------------------------------------------------------
⏷ Show the Full List of 94 Enzyme
13 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 1.13  LDD1406 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 1.16  LDD1406 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 1.02  LDD1406 
Exportin-1 (XPO1) LDTP00501 1.06  LDD1406 
Exportin-2 (CSE1L) LDTP04662 1.27  LDD1406 
Gasdermin-D (GSDMD) LDTP04801 1.21  LDD1406 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 3.36  LDD1407 
Protein SEC13 homolog (SEC13) LDTP04707 2.33  LDD1406 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 1.26  LDD1406 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 1.57  LDD1406 
Sorting nexin-6 (SNX6) LDTP13661 1.07  LDD1406 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 20.00  LDD1406 
THO complex subunit 6 homolog (THOC6) LDTP08315 2.01  LDD1407 
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 Transporter and channel
8 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Chromatin accessibility complex protein 1 (CHRAC1) LDTP12507 1.05  LDD1407 
eIF5-mimic protein 2 (BZW1) LDTP07940 1.09  LDD1406 
Glucocorticoid receptor (NR3C1) LDTP02016 0.87  LDD1407 
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 1.52  LDD1407 
Nucleus accumbens-associated protein 1 (NACC1) LDTP10756 1.39  LDD1406 
Recombining binding protein suppressor of hairless (RBPJ) LDTP05485 1.34  LDD1406 
Signal transducer and activator of transcription 1-alpha/beta (STAT1) LDTP03969 2.01  LDD1407 
SWI/SNF complex subunit SMARCC2 (SMARCC2) LDTP09311 1.23  LDD1407 
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 Transcription factor
73 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
55 kDa erythrocyte membrane protein (MPP1) LDTP05233 1.25  LDD1406 
Actin filament-associated protein 1 (AFAP1) LDTP08885 1.47  LDD1406 
AH receptor-interacting protein (AIP) LDTP00202 1.31  LDD1406 
Alpha-actinin-1 (ACTN1) LDTP02631 1.01  LDD1406 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 1.04; 0.89  LDD1407 
Ataxin-7-like protein 3B (ATXN7L3B) LDTP15730 0.76  LDD1407 
Calponin-2 (CNN2) LDTP10864 1.71; 1.74  LDD1406 
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) LDTP02511 1.19  LDD1406 
Cleavage stimulation factor subunit 2 (CSTF2) LDTP03665 1.19  LDD1406 
Cofilin-1 (CFL1) LDTP03244 0.96  LDD1406 
Coronin-1C (CORO1C) LDTP13580 1.43; 1.15  LDD1406 
Crk-like protein (CRKL) LDTP04092 2.70  LDD1406 
Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) LDTP04560 20.00  LDD1407 
Cytosolic iron-sulfur assembly component 2B (CIAO2B) LDTP13979 1.20  LDD1407 
Disks large-associated protein 5 (DLGAP5) LDTP06378 1.00  LDD1407 
DNA mismatch repair protein Msh2 (MSH2) LDTP04028 1.18  LDD1406 
Eukaryotic translation initiation factor 3 subunit M (EIF3M) LDTP07947 0.90  LDD1407 
FH1/FH2 domain-containing protein 1 (FHOD1) LDTP14195 1.29  LDD1407 
GrpE protein homolog 1, mitochondrial (GRPEL1) LDTP12144 1.06  LDD1406 
H/ACA ribonucleoprotein complex subunit 2 (NHP2) LDTP12754 1.09  LDD1406 
Heat shock 70 kDa protein 4 (HSPA4) LDTP03695 1.38  LDD1406 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 1.25  LDD1406 
Hippocalcin-like protein 1 (HPCAL1) LDTP03841 1.07  LDD1406 
Hsp70-binding protein 1 (HSPBP1) LDTP12914 3.96  LDD1406 
Integrator complex subunit 13 (INTS13) LDTP12685 0.83  LDD1407 
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) LDTP00463 2.10  LDD1406 
Kinetochore protein NDC80 homolog (NDC80) LDTP00431 1.11  LDD1406 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 0.89  LDD1407 
LanC-like protein 2 (LANCL2) LDTP12571 1.52  LDD1406 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 1.85; 1.94  LDD1406 
Large ribosomal subunit protein eL30 (RPL30) LDTP05021 1.41  LDD1406 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 1.23  LDD1406 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 1.44  LDD1406 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 0.38  LDD1407 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 0.83  LDD1407 
Mini-chromosome maintenance complex-binding protein (MCMBP) LDTP11197 0.61  LDD1407 
MMS19 nucleotide excision repair protein homolog (MMS19) LDTP10843 0.94  LDD1406 
MOB-like protein phocein (MOB4) LDTP13964 1.26  LDD1406 
Nuclear migration protein nudC (NUDC) LDTP13817 1.15  LDD1406 
NudC domain-containing protein 1 (NUDCD1) LDTP10781 1.26  LDD1406 
Plastin-3 (PLS3) LDTP02692 1.15  LDD1406 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 1.00; 2.41  LDD1406 
Programmed cell death 6-interacting protein (PDCD6IP) LDTP09580 0.97  LDD1407 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 1.08  LDD1406 
Proteasome activator complex subunit 4 (PSME4) LDTP06250 1.28  LDD1406 
Protein lin-7 homolog C (LIN7C) LDTP12638 1.21  LDD1406 
Protein S100-A11 (S100A11) LDTP03620 1.10  LDD1406 
RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) LDTP14351 0.76  LDD1407 
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) LDTP04117 1.48  LDD1406 
Reticulon-4 (RTN4) LDTP12412 1.08  LDD1406 
Ribosomal protein eL42-like (RPL36AL) LDTP15677 0.94  LDD1407 
Serpin H1 (SERPINH1) LDTP04363 1.28  LDD1406 
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) LDTP06684 0.83  LDD1407 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 1.54  LDD1406 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 1.21  LDD1406 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 1.17  LDD1406 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 1.31  LDD1406 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 1.08  LDD1406 
SNW domain-containing protein 1 (SNW1) LDTP05930 0.99  LDD1407 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 0.97  LDD1406 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 1.25  LDD1406 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 0.81  LDD1407 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 0.37  LDD1407 
T-complex protein 1 subunit eta (CCT7) LDTP10990 1.08  LDD1406 
T-complex protein 1 subunit theta (CCT8) LDTP04390 0.98  LDD1406 
TBC1 domain family member 23 (TBC1D23) LDTP12651 1.19  LDD1406 
THUMP domain-containing protein 1 (THUMPD1) LDTP12780 1.29  LDD1406 
Treacle protein (TCOF1) LDTP05867 0.91  LDD1407 
Tropomodulin-3 (TMOD3) LDTP18494 2.16  LDD1406 
Tubulin beta chain (TUBB) LDTP02205 1.13; 1.30  LDD1406 
Tubulin-specific chaperone D (TBCD) LDTP11212 1.75  LDD1406 
WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) LDTP07037 1.42  LDD1406 
WW domain-containing adapter protein with coiled-coil (WAC) LDTP11191 1.24  LDD1407 
------------------------------------------------------------------------------------
⏷ Show the Full List of 73 Other

Full Information of The Labelling Profiles of This Competitor

IA-alkyne
 Probe Info 
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Competitor Name Fragment22
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)
Interaction Atlas ID  LDD1406  Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Competitor Name Fragment22
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)
Interaction Atlas ID  LDD1407  Download The Altas

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.