Details of the Target

General Information of Target

Target ID LDTP06643
Target Name Uridine phosphorylase 1 (UPP1)
Gene Name UPP1
Gene ID 7378
Synonyms
UP; Uridine phosphorylase 1; UPase 1; UrdPase 1; EC 2.4.2.3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG
SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH
ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT
DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY
AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
YFIKKKLSKA
Target Bioclass
Enzyme
Family
PNP/UDP phosphorylase family
Function
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (Probable).
Uniprot ID
Q16831
Ensemble ID
ENST00000331803.8
HGNC ID
HGNC:12576
ChEMBL ID
CHEMBL4811

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.R297Q DBIA    Probe Info 
SNGM SNV: p.S42N DBIA    Probe Info 
TOV21G SNV: p.G5V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K10(2.36)  LDD0274  [2]
STPyne
 Probe Info  		K174(1.06); K30(5.27)  LDD0277  [2]
BTD
 Probe Info  		C17(1.14)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C17(2.35)  LDD0169  [4]
HHS-482
 Probe Info  		Y227(1.13); Y240(0.37); Y291(1.05); Y35(0.91)  LDD0285  [5]
HHS-475
 Probe Info  		Y301(0.82); Y35(0.87); Y240(1.06)  LDD0264  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
DBIA
 Probe Info  		C17(1.01); C80(0.97); C89(0.96); C71(0.96)  LDD0078  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
WYneN
 Probe Info  		C80(0.00); C162(0.00)  LDD0021  [11]
aHNE
 Probe Info  		N.A.  LDD0001  [11]
IA-alkyne
 Probe Info  		C162(0.00); C209(0.00)  LDD0151  [12]
TFBX
 Probe Info  		C17(0.00); C162(0.00); C89(0.00)  LDD0148  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		11.20  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C17(0.76)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C17(1.00)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C17(1.28)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C17(1.69); C57(1.15)  LDD2152  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C17(2.35)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C17(0.95); C71(0.92); C80(0.96); C89(1.03)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C17(1.20); C71(1.35); C80(1.30)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C162(0.90); C17(1.07); C71(1.07); C80(1.07)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C162(0.99); C17(1.03); C71(1.01); C80(1.01)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C162(0.95); C17(1.01); C71(0.92); C80(0.92)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C162(1.24); C17(1.19); C71(1.12); C80(1.12)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C162(1.27); C17(0.96); C71(0.99); C80(0.99)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C162(1.11); C17(1.21); C71(1.25); C80(1.25)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C162(1.15); C17(1.24); C71(1.17); C80(1.17)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C162(1.20); C17(1.34); C71(0.97); C80(0.97)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C162(1.41); C17(0.95); C71(1.24); C80(1.24)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C162(0.89); C17(0.91); C71(0.96); C80(0.96)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C17(1.11); C71(1.13); C80(1.10)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C162(1.10); C17(1.18); C71(1.09); C80(1.09)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C162(1.32); C17(1.12); C71(0.97); C80(0.97)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C162(0.95); C17(1.20); C71(1.06); C80(1.06)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C17(0.81); C71(1.08); C80(1.12)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C17(0.85); C71(1.44); C80(1.36)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C17(0.61); C71(1.93); C80(1.70)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C17(0.90); C71(1.31); C80(1.36)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C17(1.09); C71(1.24); C80(1.28)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C17(0.76); C71(1.27); C80(1.31)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C17(1.49); C71(1.45); C80(1.47)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C17(1.02); C71(1.10); C80(1.05)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C17(0.89); C71(1.17); C80(1.15)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C17(0.98); C71(1.13); C80(1.17)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C17(0.84); C71(1.36); C80(1.36)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C17(1.13); C71(1.11); C80(1.06)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C17(1.28); C71(1.18); C80(1.23)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C17(1.29); C71(1.16); C80(1.24)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C17(0.72); C71(1.32); C80(1.38)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C17(0.69); C71(1.42); C80(1.41)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C17(0.72)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C17(0.83)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C17(0.88)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C17(0.89)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C17(0.91)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C17(0.95)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C17(1.13)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C17(0.94)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C17(1.01)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C17(1.04)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C17(1.13)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C17(1.09)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C17(1.19); C71(1.37); C80(1.26)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C17(1.24)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C17(1.20)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C17(1.19)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C89(0.92); C71(1.00); C80(1.00); C17(1.22)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C89(0.96); C17(1.11); C71(1.29); C80(1.29)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C89(0.74); C17(1.02); C71(1.13); C80(1.16)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C17(0.82); C89(0.88); C71(1.29); C80(1.33)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C89(0.77); C17(1.23); C80(1.44); C71(1.46)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C89(0.65); C17(0.80); C80(1.80); C71(1.84)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C17(0.64); C89(0.79); C80(1.51); C71(1.55)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C17(1.23); C80(1.33); C71(1.46)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C89(0.94); C17(0.98); C71(1.14); C80(1.18)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C89(0.70); C17(0.96); C80(1.32); C71(1.33)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C17(0.78); C89(0.79); C71(1.18); C80(1.19)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C89(0.58); C17(0.75); C80(1.86); C71(1.86)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C17(1.02); C71(1.31); C80(1.26); C89(0.73)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C17(1.07); C71(1.16); C80(1.18); C89(0.68)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C17(0.88); C71(0.99); C80(0.99); C89(0.77)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C17(0.82); C71(1.02); C80(1.04); C89(0.75)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C80(0.91); C71(0.93); C17(0.98)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C80(0.95); C71(1.14); C17(1.18)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C17(1.05); C80(1.20); C71(1.24)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C17(0.94); C80(1.01); C71(1.03); C89(1.24)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C80(0.96); C17(1.01); C71(1.06)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C71(0.94); C80(0.97); C17(1.00)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C80(0.80); C71(0.90); C17(0.97)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C17(0.89); C80(0.93); C71(1.00)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C17(0.92); C80(0.92); C71(1.00)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C17(0.94); C71(1.14); C80(1.18)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C17(1.10); C71(1.48); C80(1.71)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C17(1.13); C71(1.49); C80(1.57)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C17(1.06); C71(1.35); C80(1.41)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C17(1.27); C71(1.39); C80(1.55)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C17(0.85); C71(1.01); C80(1.06); C89(1.33)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C17(1.41); C71(1.53); C80(1.69)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C17(1.15); C71(1.40); C80(1.41)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C17(1.35); C71(1.71); C80(1.80)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C17(1.13); C71(1.43); C80(1.62)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C17(1.16); C71(1.43); C80(1.49)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C17(0.83); C80(1.02); C71(1.02); C162(1.08)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C162(0.83); C17(0.87); C80(1.01); C71(1.03)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C162(0.79); C17(0.86); C71(0.94); C80(0.97)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C71(0.89); C80(0.91); C17(0.94); C162(1.24)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C71(1.04); C80(1.06); C17(1.07); C162(1.40)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C17(0.82); C71(1.07); C80(1.08); C89(1.13)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C71(1.00); C80(1.00); C17(1.11); C162(1.58)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C17(0.93); C80(1.13); C71(1.14); C162(1.37)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C80(0.98); C71(1.00); C17(1.02); C162(1.32)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C162(0.93); C17(1.06); C80(1.20); C71(1.20)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C17(1.05); C71(1.30); C80(1.31); C162(1.32)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C17(1.11); C71(1.14); C80(1.15); C162(1.47)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C17(1.03); C80(1.04); C71(1.08)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C17(0.99); C80(1.16); C71(1.17)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C17(1.05); C80(1.22); C71(1.25)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C17(1.31); C80(1.32); C71(1.35)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C17(0.88); C71(1.08); C80(1.21); C89(1.21)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C17(1.18); C80(1.40); C71(1.43)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C17(0.96); C80(1.04); C71(1.06)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C17(1.05); C80(1.19); C71(1.22)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C17(1.07); C80(1.26); C71(1.27)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C17(1.18); C80(1.21); C71(1.24)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C17(1.26); C80(1.32); C71(1.33)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C17(1.38); C80(1.75); C71(1.78)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C162(0.83); C17(1.19); C80(1.50); C71(1.52)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C162(0.90); C17(1.00); C71(1.45); C80(1.45)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C17(1.17); C162(1.19); C80(1.59); C71(1.60)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C80(1.21); C17(1.25); C71(1.27)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C17(1.02); C162(1.14); C80(1.51); C71(1.53)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C17(1.00); C162(1.19); C80(1.49); C71(1.53)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C17(1.04); C162(1.36); C80(1.95); C71(1.98)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C17(0.95); C162(1.06); C80(1.55); C71(1.60)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C17(0.94); C162(1.72); C80(1.80); C71(1.80)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C17(1.03); C162(1.34); C80(1.83); C71(1.89)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C17(0.90); C162(1.44); C80(1.60); C71(1.70)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C17(0.99); C162(1.21); C80(1.69); C71(1.70)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C17(0.80); C71(1.00); C80(1.01)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C17(0.85); C71(0.91); C80(0.95)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C17(1.06); C80(1.14); C71(1.23)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C17(0.90); C80(0.99); C71(1.01)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C17(0.85); C71(0.94); C80(0.96)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C17(0.89); C71(1.02); C80(1.06)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C17(0.96); C71(1.28); C80(1.32)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C17(0.89); C71(1.02); C80(1.05)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C17(0.87); C80(1.58); C71(1.61)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C17(0.94); C71(1.11); C80(1.16)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C17(0.86); C71(1.04); C80(1.05)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C17(0.83); C80(1.01); C71(1.04)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C17(0.84); C80(0.96); C71(0.98)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C71(1.13); C80(1.16); C17(1.19)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C17(0.85); C80(1.04); C71(1.07)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C80(0.87); C17(0.88); C71(0.89)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C17(0.80); C71(1.05); C80(1.06)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C17(0.96); C89(1.12); C71(1.42); C80(1.43)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C89(0.94); C17(1.09); C80(1.28); C71(1.31)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C89(0.98); C71(1.03); C80(1.07); C17(1.08)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C17(0.88); C89(1.02); C71(1.30); C80(1.30)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C71(1.05); C80(1.05); C17(1.13); C89(1.16)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C17(0.95); C89(0.97); C71(1.20); C80(1.21)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C17(0.88); C71(1.32); C80(1.34); C89(1.39)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C71(1.14); C80(1.15); C89(1.22); C17(1.23)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C17(0.76); C89(1.21); C71(1.44); C80(1.46)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C17(0.92); C71(1.43); C80(1.46); C89(1.77)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C71(1.03); C17(1.04); C80(1.05); C89(1.18)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C17(1.01); C71(1.03); C80(1.07); C89(1.36)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C17(0.94); C71(1.03); C80(1.03); C89(1.18)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C17(0.95); C71(1.31); C80(1.33); C89(1.70)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C17(0.98); C89(1.24); C71(1.25); C80(1.26)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C162(0.67); C71(1.06); C80(1.06); C17(1.11)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C71(0.90); C80(0.90); C17(1.22); C162(1.34)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C17(0.32)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C57(1.47)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C17(1.07); C71(1.26); C80(1.17)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C17(1.13); C80(1.36); C71(1.47)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C17(1.50); C80(1.60); C71(1.75)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.01  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C17(1.01); C80(0.97); C89(0.96); C71(0.96)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C17(0.41)  LDD2091  [3]
 LDCM0630  CCW28-3 231MFP C162(1.73)  LDD2214  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C17(0.83); C71(0.99); C80(0.99)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C17(0.74); C80(1.57); C71(1.58)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C17(0.81); C71(1.00); C89(1.04); C80(1.05)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C17(1.27); C80(1.47); C71(1.63)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C17(1.10); C80(1.17); C71(1.22)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C17(1.00); C80(1.28); C71(1.44)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C80(1.11); C17(1.16); C71(1.18)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C80(1.11); C17(1.13); C71(1.26)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C80(1.17); C17(1.25); C71(1.27)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C17(1.20); C80(1.25); C71(1.27)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C80(1.13); C71(1.20); C17(1.34)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C80(1.01); C71(1.08); C17(1.08)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C17(0.63); C71(1.34); C80(1.35)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C17(1.19); C80(1.26); C71(1.34)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C80(1.08); C17(1.10); C71(1.19)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C17(1.03); C71(1.10); C80(1.16)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C17(1.20); C71(1.36); C80(1.52)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C17(1.10); C71(1.29); C80(1.41)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C17(1.14); C71(1.24); C80(1.30)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C17(1.15); C80(1.34); C71(1.35)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C162(1.18); C17(1.47); C71(1.56); C80(1.59)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C17(1.00); C71(1.10); C80(1.13); C162(1.34)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C17(1.07); C71(1.10); C80(1.12); C162(1.51)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C17(0.93); C80(1.54); C71(1.55)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C17(0.95); C162(1.13); C71(1.25); C80(1.27)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C17(1.01); C80(2.57); C71(2.59)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C17(1.13); C80(1.18); C71(1.21)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C80(1.29); C71(1.35); C17(1.39)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C17(1.27); C80(1.32); C71(1.35)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C162(0.66); C17(1.10); C80(1.20); C71(1.26)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C162(1.04); C17(1.08); C80(1.20); C71(1.23)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C17(1.07); C162(1.14); C80(1.20); C71(1.20)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C17(1.11); C162(1.19); C80(1.53); C71(1.57)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C17(0.83); C71(1.25); C80(1.25)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C17(0.66); C71(1.24); C80(1.27)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C17(0.82); C71(1.44); C80(1.47)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C71(1.12); C80(1.12)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C71(1.36); C80(1.36)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C71(1.29); C80(1.29)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C71(1.19); C80(1.19)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C17(0.69); C80(1.03); C71(1.04)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C71(1.36); C80(1.36)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C71(2.07); C80(2.07)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C71(2.40); C80(2.40)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C71(1.35); C80(1.35)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C71(1.50); C80(1.50)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C71(1.76); C80(1.76)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C71(1.18); C80(1.18)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C71(1.41); C80(1.41)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C71(1.57); C80(1.57)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C71(1.71); C80(1.71)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C17(0.69); C71(1.08); C80(1.09)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C71(1.18); C80(1.18)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C17(0.95); C71(1.05); C80(1.07); C89(0.62)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C17(0.86); C71(1.10); C80(1.12); C89(1.22)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C17(1.04); C71(1.37); C80(1.38); C89(1.35)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C17(0.94); C71(1.37); C80(1.41); C89(1.15)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C17(0.93); C71(1.26); C80(1.27); C89(1.39)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C17(1.01); C71(1.26); C80(1.28); C89(0.96)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C17(1.01); C71(1.56); C80(1.61); C89(0.97)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C17(1.21); C71(1.44); C80(1.46); C89(0.98)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C17(0.79); C71(1.28); C80(1.24)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C17(0.91); C71(1.33); C80(1.36); C89(0.89)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C17(1.03); C71(1.27); C80(1.28); C89(1.03)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C17(1.41); C71(1.61); C80(1.64); C89(1.01)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C17(1.11); C71(1.44); C80(1.46); C89(0.84)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C17(1.03); C71(1.25); C80(1.27); C89(0.87)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C17(1.19); C71(1.49); C80(1.46); C89(1.35)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C17(1.15); C71(0.97); C80(0.93); C89(1.13)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C17(1.18); C71(0.97); C80(0.97); C89(1.13)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C17(1.33); C71(0.97); C80(1.03); C89(0.92)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C17(0.92); C71(1.09); C80(1.05); C89(1.08)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C17(0.65); C71(1.06); C80(1.08)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C17(0.97); C71(0.97); C80(0.99); C89(1.09)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C17(1.00); C71(1.10); C80(1.14); C89(1.02)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C17(1.30); C71(1.23); C80(1.27); C89(1.19)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C17(1.04); C71(1.06); C80(1.05); C89(1.05)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C17(1.00); C71(0.93); C80(0.95); C89(0.92)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C17(0.92); C71(0.97); C80(0.97); C89(1.20)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C17(1.14); C71(1.23); C80(1.24); C89(1.05)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C17(0.98); C71(0.98); C80(0.99); C89(1.02)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C17(0.97); C71(0.96); C80(0.94); C89(1.08)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C17(0.99); C71(1.08); C80(1.05); C89(0.99)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C17(0.75); C71(1.36); C80(1.37)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C17(1.04); C71(0.98); C80(1.03); C89(1.08)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C162(0.75); C17(1.38); C71(0.92); C80(1.18)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C162(0.89); C17(0.91); C71(0.93); C80(1.16)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C162(1.07); C17(1.26); C71(0.84); C80(0.90)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C162(1.00); C17(1.38); C71(0.87); C80(1.05)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C162(1.03); C17(1.18); C71(0.74); C80(0.84)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C162(1.55); C17(1.04); C71(0.95); C80(1.11)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C162(1.20); C17(1.31); C71(0.74); C80(0.82)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C162(0.74); C17(0.71); C71(0.90); C80(0.90)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C162(1.11); C17(1.10); C71(0.88); C80(1.05)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C17(1.00); C71(1.42); C80(1.41)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C162(0.87); C17(1.00); C71(0.86); C80(0.83)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C162(0.79); C17(1.00); C71(0.81); C80(0.87)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C162(0.75); C17(1.10); C71(0.96); C80(1.00)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C162(2.02); C17(0.97); C71(0.83); C80(0.90)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C162(1.21); C17(1.21); C71(0.72); C80(0.77)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C17(1.04); C71(1.05); C80(1.10)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C17(0.90); C71(1.02); C80(1.06)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C17(0.84); C71(1.08); C80(1.12)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C17(1.17); C71(1.13); C80(1.18)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C17(0.71); C71(1.44); C80(1.45)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C17(1.02); C71(0.85); C80(0.91)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C17(0.91); C71(1.01); C80(1.05)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C17(1.27); C71(1.43); C80(1.44)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C17(1.22); C71(1.29); C80(1.32)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C17(1.16); C71(1.50); C80(1.52)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C17(1.37); C71(1.19); C80(1.21)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C17(1.39); C71(1.02); C80(1.07)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C17(1.06); C71(1.33); C80(1.36)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C17(1.24); C71(1.31); C80(1.34)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C17(0.69); C71(1.53); C80(1.55)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C17(0.94); C71(1.26); C80(1.23)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C17(0.77); C71(1.02); C80(1.05)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C17(1.06); C71(1.34); C80(1.38); C89(1.15)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C17(1.03); C71(1.15); C80(1.17); C89(1.09)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C17(0.83); C71(1.02); C80(1.03); C89(1.09)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C17(0.78); C71(1.22); C80(1.21); C89(0.94)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C17(0.98); C71(1.32); C80(1.27); C89(1.01)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C17(1.05); C71(1.32); C80(1.26); C89(1.28)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C17(1.14); C71(1.37); C80(1.36); C89(1.28)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C17(0.98); C71(1.16); C80(1.17); C89(1.30)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C17(1.02); C71(1.14); C80(1.12); C89(1.23)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C80(1.03)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C17(2.15); C57(1.21); C131(1.09); C162(1.02)  LDD1702  [3]
 LDCM0572  Fragment10 MDA-MB-231 C162(3.66)  LDD1389  [16]
 LDCM0573  Fragment11 MDA-MB-231 C162(1.46)  LDD1391  [16]
 LDCM0574  Fragment12 MDA-MB-231 C162(0.91)  LDD1468  [16]
 LDCM0575  Fragment13 MDA-MB-231 C162(1.27)  LDD1395  [16]
 LDCM0576  Fragment14 MDA-MB-231 C162(1.03)  LDD1397  [16]
 LDCM0580  Fragment21 MDA-MB-231 C162(0.95)  LDD1404  [16]
 LDCM0581  Fragment22 MDA-MB-231 C162(1.64)  LDD1406  [16]
 LDCM0582  Fragment23 MDA-MB-231 C162(1.40)  LDD1408  [16]
 LDCM0578  Fragment27 MDA-MB-231 C162(0.86)  LDD1401  [16]
 LDCM0586  Fragment28 MDA-MB-231 C162(0.93)  LDD1415  [16]
 LDCM0587  Fragment29 MDA-MB-231 C162(1.21)  LDD1417  [16]
 LDCM0588  Fragment30 MDA-MB-231 C162(0.76)  LDD1419  [16]
 LDCM0590  Fragment32 MDA-MB-231 C162(1.25)  LDD1423  [16]
 LDCM0468  Fragment33 HCT 116 C162(1.04); C17(1.40); C71(0.87); C80(1.19)  LDD0785  [8]
 LDCM0592  Fragment34 MDA-MB-231 C162(0.84)  LDD1427  [16]
 LDCM0596  Fragment38 MDA-MB-231 C162(1.09)  LDD1433  [16]
 LDCM0566  Fragment4 MDA-MB-231 C162(1.08)  LDD1378  [16]
 LDCM0599  Fragment41 MDA-MB-231 C162(2.19)  LDD1438  [16]
 LDCM0602  Fragment44 MDA-MB-231 C162(0.80)  LDD1443  [16]
 LDCM0603  Fragment45 MDA-MB-231 C162(1.68)  LDD1444  [16]
 LDCM0604  Fragment46 MDA-MB-231 C162(0.97)  LDD1445  [16]
 LDCM0605  Fragment47 MDA-MB-231 C162(1.24)  LDD1446  [16]
 LDCM0607  Fragment49 MDA-MB-231 C162(1.25)  LDD1448  [16]
 LDCM0608  Fragment50 MDA-MB-231 C162(0.99)  LDD1449  [16]
 LDCM0427  Fragment51 HCT 116 C17(1.19); C71(1.88); C80(1.94); C89(0.57)  LDD0744  [8]
 LDCM0611  Fragment53 MDA-MB-231 C162(0.85)  LDD1454  [16]
 LDCM0612  Fragment54 MDA-MB-231 C162(1.04)  LDD1456  [16]
 LDCM0613  Fragment55 MDA-MB-231 C162(0.93)  LDD1457  [16]
 LDCM0614  Fragment56 MDA-MB-231 C162(1.17)  LDD1458  [16]
 LDCM0568  Fragment6 MDA-MB-231 C162(1.42)  LDD1382  [16]
 LDCM0570  Fragment8 MDA-MB-231 C162(18.70)  LDD1385  [16]
 LDCM0571  Fragment9 MDA-MB-231 C162(5.22)  LDD1387  [16]
 LDCM0116  HHS-0101 DM93 Y301(0.82); Y35(0.87); Y240(1.06)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y240(0.70); Y35(0.87); Y301(1.13)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y240(0.79); Y301(0.84); Y35(0.90)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y35(1.06); Y301(1.35); Y240(1.60)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y35(0.93); Y301(1.22); Y240(1.42)  LDD0268  [6]
 LDCM0123  JWB131 DM93 Y227(1.13); Y240(0.37); Y291(1.05); Y35(0.91)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y227(0.71); Y240(1.24); Y291(0.78); Y35(0.69)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y227(1.30); Y240(1.00); Y291(0.80); Y35(1.43)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y227(3.54); Y240(7.36); Y291(3.88); Y35(1.75)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y227(1.48); Y240(5.32); Y291(1.79); Y35(1.34)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y227(0.86); Y240(3.60); Y291(0.94); Y35(0.77)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y227(0.93); Y240(1.29); Y291(0.55); Y35(0.52)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y227(0.63); Y240(0.67); Y291(0.64); Y35(0.95)  LDD0292  [5]
 LDCM0022  KB02 HCT 116 C71(2.19); C80(2.19); C162(1.69)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C71(1.58); C80(1.58); C162(1.36)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C71(1.47); C80(1.47); C162(1.15)  LDD0082  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C17(0.56)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C17(0.57)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C17(1.00)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C17(0.93)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C17(0.82)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C17(1.08)  LDD2094  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C17(1.07)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C17(0.80)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C17(0.70); C57(0.93)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C57(0.97)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C17(0.98)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C17(1.29)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C17(1.14)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C17(0.93)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C17(0.90)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C17(1.00)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C17(1.43)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C17(0.97)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C17(0.91); C57(1.10)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C17(1.40)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C17(1.10)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C17(0.84)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C57(0.54)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C17(0.91)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C17(1.18)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C17(1.41)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C17(1.14)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C17(0.97); C57(1.17)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C17(1.04); C57(0.94)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C17(2.49)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C17(0.91); C57(1.06)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C57(0.99)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C17(0.39)  LDD2150  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C17(1.70)  LDD2153  [3]
 LDCM0131  RA190 MM1.R C162(1.22)  LDD0304  [17]
 LDCM0021  THZ1 HCT 116 C71(1.14); C80(1.14)  LDD2173  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fluorouracil Small molecular drug DB00544
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5-benzylacyclouridine . DB07437

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.