Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment22  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 83 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 9.6
 LDTP02502  Thioredoxin (TXN) C32 3.5
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 3.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 2.4
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 2.4
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 2.3
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 2.2
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 2.2
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 2.1
 LDTP02223  Cathepsin B (CTSB) C211 2.0
 LDTP13147  Cathepsin Z (CTSZ) C173 2.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.9
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.8
 LDTP09912  DNA repair protein RAD50 (RAD50) C1296 1.7
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C358 1.7
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.7
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 1.7
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.7
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.6
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.6
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 1.6
 LDTP02672  Elongation factor 2 (EEF2) C41 1.6
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.6
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.6
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.4
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.4
 LDTP02223  Cathepsin B (CTSB) C319 1.4
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.4
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) C680 1.3
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.3
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) C691 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.3
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 1.3
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.3
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.2
 LDTP03496  Protein PML (PML) C389 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.2
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.2
 LDTP13080  GMP reductase 2 (GMPR2) C186 1.2
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.2
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.2
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.1
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.1
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.1
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.1
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.1
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.1
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.1
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.1
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.1
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.1
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.1
 LDTP02672  Elongation factor 2 (EEF2) C136 1.1
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.0
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.0
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 1.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 1.0
 LDTP05992  Bleomycin hydrolase (BLMH) C73 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.0
 LDTP04689  Adenosine kinase (ADK) C353 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.0
 LDTP04374  Dynamin-2 (DNM2) C27 1.0
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.0
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.9
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 0.9
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.8
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP04707  Protein SEC13 homolog (SEC13) C187 2.3
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.6
 LDTP04662  Exportin-2 (CSE1L) C842 1.3
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.3
 LDTP04801  Gasdermin-D (GSDMD) C268 1.2
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.2
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.1
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.1
 LDTP00501  Exportin-1 (XPO1) C34 1.1
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.0
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 1.4
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 1.3
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.1
Other
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 4.0
 LDTP04092  Crk-like protein (CRKL) C249 2.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.4
 LDTP18494  Tropomodulin-3 (TMOD3) C132 2.2
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 2.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.9
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 1.8
 LDTP10864  Calponin-2 (CNN2) C215 1.7
 LDTP10864  Calponin-2 (CNN2) C164 1.7
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.5
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.5
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 1.5
 LDTP08885  Actin filament-associated protein 1 (AFAP1) C713 1.5
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.4
 LDTP13580  Coronin-1C (CORO1C) C420 1.4
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 1.4
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.4
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.4
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.3
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.3
 LDTP02205  Tubulin beta chain (TUBB) C354 1.3
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.3
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.3
 LDTP04363  Serpin H1 (SERPINH1) C156 1.3
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.3
 LDTP05233  55 kDa erythrocyte membrane protein (MPP1) C179 1.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.3
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.3
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.2
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 1.2
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.2
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.2
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.2
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.2
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 1.2
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.2
 LDTP13580  Coronin-1C (CORO1C) C456 1.2
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.2
 LDTP02692  Plastin-3 (PLS3) C33 1.2
 LDTP02205  Tubulin beta chain (TUBB) C239 1.1
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.1
 LDTP03620  Protein S100-A11 (S100A11) C91 1.1
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.1
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.1
 LDTP12412  Reticulon-4 (RTN4) C1101 1.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.1
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.1
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.1
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.1
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.0
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.0
 LDTP03244  Cofilin-1 (CFL1) C80 1.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 0.9

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.