Details of the Target

General Information of Target

Target ID LDTP12914
Target Name Hsp70-binding protein 1 (HSPBP1)
Gene Name HSPBP1
Gene ID 23640
Synonyms
HSPBP; Hsp70-binding protein 1; HspBP1; Heat shock protein-binding protein 1; Hsp70-binding protein 2; HspBP2; Hsp70-interacting protein 1; Hsp70-interacting protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTFKEAMTFKDVAVVFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQAFHRDTFHFL
REEKIWMMKTAIQREGNSGDKIQTEMETVSEAGTHQEWSFQQIWEKIASDLTRSQDLMIN
SSQFSKEGDFPCQTEAGLSVIHTRQKSSQGNGYKPSFSDVSHFDFHQQLHSGEKSHTCDE
CGKNFCYISALRIHQRVHMGEKCYKCDVCGKEFSQSSHLQTHQRVHTGEKPFKCVECGKG
FSRRSALNVHHKLHTGEKPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKCDICGKSFCGR
SRLNRHSMVHTAEKPFRCDTCDKSFRQRSALNSHRMIHTGEKPYKCEECGKGFICRRDLY
THHMVHTGEKPYNCKECGKSFRWASCLLKHQRVHSGEKPFKCEECGKGFYTNSQCYSHQR
SHSGEKPYKCVECGKGYKRRLDLDFHQRVHTGEKLYNCKECGKSFSRAPCLLKHERLHSG
EKPFQCEECGKRFTQNSHLHSHQRVHTGEKPYKCEKCGKGYNSKFNLDMHQKVHTGERPY
NCKECGKSFGWASCLLKHQRLHSGEKPFKCEECGKRFTQNSQLHSHQRVHTGEKPYKCDE
CGKGFSWSSTRLTHQRRHSRETPLKCEQHGKNIVQNSFSKVQEKVHSVEKPYKCEDCGKG
YNRRLNLDMHQRVHMGEKTWKCRECDMCFSQASSLRLHQNVHVGEKP
Target Bioclass
Other
Function
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Uniprot ID
Q9NZL4
Ensemble ID
ENST00000255631.9
HGNC ID
HGNC:24989

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1993 SNV: p.A177S .
SHP77 SNV: p.G170C DBIA    Probe Info 
SKMM2 SNV: p.M1? DBIA    Probe Info 
SKNSH SNV: p.M271I .
TOV21G SNV: p.R164W; p.L296M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [2]
SAHA-CA-4PAP
 Probe Info  		4.00  LDD0360  [3]
BTD
 Probe Info  		C201(1.14)  LDD2096  [4]
DA-P3
 Probe Info  		4.49  LDD0181  [5]
HHS-465
 Probe Info  		Y334(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C204(1.06)  LDD0078  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		C348(0.00); C172(0.00); C310(0.00)  LDD0032  [9]
IPIAA_L
 Probe Info  		C297(0.00); C348(0.00); C172(0.00); C325(0.00)  LDD0031  [10]
IPM
 Probe Info  		N.A.  LDD0025  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
ENE
 Probe Info  		N.A.  LDD0006  [12]
TFBX
 Probe Info  		C172(0.00); C348(0.00)  LDD0148  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		C201(0.00); C348(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		C351(0.00); C217(0.00)  LDD0236  [15]
AOyne
 Probe Info  		13.00  LDD0443  [16]
NAIA_5
 Probe Info  		C172(0.00); C214(0.00); C310(0.00); C22(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe3
 Probe Info  		6.73  LDD0465  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C201(0.92)  LDD2117  [4]
 LDCM0214  AC1 HCT 116 C204(1.03); C217(0.70); C22(0.98); C272(0.96)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C204(1.33); C217(0.66); C22(1.27); C328(0.77)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C204(1.08); C217(0.36); C22(1.05); C328(0.81)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C204(1.15); C217(0.38); C22(1.16); C328(0.65)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C204(1.00); C217(0.36); C22(1.09); C328(0.67)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C204(1.36); C217(0.34); C22(1.32); C328(0.54)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C204(1.24); C217(0.40); C22(1.23); C328(0.69)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C204(1.23); C217(0.34); C22(1.16); C328(0.68)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C204(1.43); C217(0.29); C22(1.23); C328(0.64)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C204(1.22); C217(0.14); C22(1.34); C328(0.66)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C204(1.24); C217(0.61); C22(1.00); C328(0.52)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C204(1.04); C217(0.46); C22(0.96); C328(0.81)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C204(1.18); C217(0.58); C22(1.40); C328(0.77)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C204(1.06); C217(0.45); C22(1.13); C328(0.69)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C204(1.17); C217(0.43); C22(1.13); C328(0.59)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C204(1.16); C217(0.24); C22(1.28); C328(0.62)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C204(0.98); C217(1.01); C22(1.04); C328(1.12)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C204(1.09); C217(0.78); C22(1.14); C328(0.83)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C204(1.05); C217(0.70); C22(1.40); C328(0.92)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C204(1.12); C217(0.61); C22(1.56); C328(0.90)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C204(1.08); C217(0.76); C22(1.12); C328(1.08)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C204(1.00); C217(0.70); C22(1.07); C328(1.15)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C204(1.21); C217(0.66); C22(1.29); C328(1.12)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C204(1.02); C217(0.63); C22(1.07); C328(0.91)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C204(1.08); C217(0.80); C22(1.44); C328(0.95)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C204(0.89); C217(0.67); C22(1.11); C328(1.11)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C204(1.11); C217(0.58); C22(1.29); C328(1.02)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C204(0.89); C217(0.71); C22(1.12); C328(0.94)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C204(0.88); C217(0.81); C22(1.08); C328(1.20)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C204(1.16); C217(0.72); C22(1.17); C328(1.08)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C204(0.89); C217(0.63); C22(1.40); C328(0.94)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C204(1.04); C217(0.60); C22(1.44); C328(1.03)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C204(1.22); C217(0.89); C22(1.11); C272(0.80)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C204(1.04); C217(1.27); C22(0.80); C272(1.37)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C204(1.44); C217(0.83); C22(1.05); C272(1.16)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C204(0.93); C217(1.51); C22(0.82); C272(0.88)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C204(1.24); C217(0.89); C22(0.89); C272(0.89)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C204(1.21); C217(0.68); C22(1.05); C272(0.96)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C204(1.42); C217(0.78); C22(1.14); C272(0.90)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C204(1.28); C217(0.75); C22(1.02); C272(0.61)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C204(1.35); C217(0.84); C22(1.04); C272(1.17)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C204(1.14); C217(0.79); C22(0.99); C272(0.91)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C204(1.35); C217(0.69); C22(1.16); C272(0.90)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C204(1.27); C217(0.81); C22(1.13); C272(0.92)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C204(1.09); C217(0.51); C22(1.29); C328(0.82)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C204(1.56); C217(0.76); C22(1.23); C272(1.14)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C204(1.50); C217(0.81); C22(1.15); C272(1.16)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C204(1.18); C217(0.82); C22(0.94); C272(0.71)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C204(1.21); C22(1.20); C272(0.90); C328(0.80)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C328(0.56); C344(0.67); C272(0.74); C204(0.92)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C272(0.54); C328(0.69); C344(0.71); C204(0.95)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C272(0.54); C344(0.72); C328(0.80); C204(1.10)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C344(0.71); C328(0.74); C272(0.78); C351(1.00)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C272(0.68); C328(0.68); C344(0.69); C204(1.07)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C272(0.56); C344(0.69); C328(0.73); C204(1.04)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C217(0.51); C328(0.78); C344(0.78); C204(1.14)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C272(0.62); C328(0.76); C344(0.77); C204(1.15)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C328(0.77); C272(0.87); C344(0.87); C22(1.08)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C328(0.68); C272(0.72); C344(0.73); C204(1.08)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C272(0.64); C344(0.70); C328(0.79); C204(1.50)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C204(1.13); C22(1.37); C272(0.64); C328(0.68)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C204(1.24); C22(1.34); C272(0.49); C328(0.73)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C204(1.08); C22(1.11); C272(0.98); C328(0.89)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C204(1.16); C22(0.92); C272(0.78); C328(0.82)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C328(0.79); C344(0.79); C351(0.85); C175(0.93)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C175(0.49); C328(0.54); C344(0.54); C217(0.64)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C175(0.65); C328(0.72); C344(0.72); C351(0.79)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C328(0.70); C344(0.70); C217(0.77); C351(0.94)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C175(0.73); C351(0.81); C328(0.90); C344(0.90)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C175(0.56); C217(0.76); C328(0.78); C344(0.78)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C175(0.69); C217(1.00); C22(1.02); C328(1.10)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C328(0.76); C344(0.76); C351(0.84); C175(0.94)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C175(0.71); C328(0.87); C344(0.87); C351(0.87)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C328(0.69); C344(0.69); C351(0.94); C22(0.97)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C328(0.57); C344(0.57); C217(0.71); C351(0.94)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C328(0.60); C344(0.60); C217(0.84); C204(1.05)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C328(0.58); C344(0.58); C217(0.71); C22(0.96)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C328(0.56); C344(0.56); C217(0.83); C351(0.98)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C217(0.72); C328(0.74); C344(0.74); C22(0.94)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C328(0.56); C344(0.56); C217(1.00); C351(1.08)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C328(0.58); C344(0.58); C217(0.68); C22(0.96)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C328(0.47); C344(0.47); C217(0.65); C351(1.03)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C328(0.62); C344(0.62); C351(0.94); C217(0.94)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C328(0.63); C344(0.63); C217(0.88); C351(1.03)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C272(0.68); C22(0.85); C204(0.91); C351(0.91)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C217(0.77); C351(0.79); C204(0.96); C22(0.98)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C204(0.86); C22(0.88); C217(0.91); C351(0.94)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C22(0.88); C217(0.91); C272(0.92); C204(0.98)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C217(0.65); C272(0.80); C22(1.00); C328(1.11)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C328(0.62); C344(0.62); C217(0.65); C272(1.01)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C217(0.83); C272(0.85); C351(0.94); C328(1.04)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C217(0.79); C272(0.82); C351(0.86); C22(1.00)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C217(0.76); C328(1.00); C344(1.00); C272(1.03)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C351(0.72); C217(0.76); C328(1.00); C344(1.00)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C217(0.70); C328(1.02); C344(1.02); C351(1.03)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C217(0.74); C351(0.94); C328(1.00); C344(1.00)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C328(0.81); C344(0.81); C217(0.90); C272(0.98)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C217(0.74); C328(0.83); C344(0.83); C351(1.01)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C217(0.70); C272(0.75); C351(0.76); C328(0.83)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C328(0.81); C344(0.81); C217(0.87); C272(0.91)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C217(0.53); C328(0.58); C344(0.58); C272(1.03)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C328(0.80); C344(0.80); C217(0.83); C351(0.94)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C217(0.88); C328(0.97); C344(0.97); C272(1.09)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C217(0.79); C328(0.83); C344(0.83); C351(0.98)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C217(0.78); C328(0.85); C344(0.85); C351(0.86)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C272(0.90); C328(0.94); C344(0.94); C351(1.09)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C328(0.84); C344(0.84); C217(0.87); C351(0.97)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C328(0.86); C344(0.86); C272(0.88); C217(0.91)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C328(0.64); C344(0.64); C175(1.01); C204(1.06)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C328(0.69); C344(0.69); C351(0.95); C175(0.98)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C328(0.78); C344(0.78); C217(1.09); C175(1.09)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C217(0.61); C328(0.72); C344(0.72); C22(1.28)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C328(0.64); C344(0.64); C217(0.97); C204(1.06)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C328(0.90); C344(0.90); C217(0.95); C351(0.96)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C328(0.71); C344(0.71); C217(1.06); C351(1.07)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C328(0.67); C344(0.67); C217(0.91); C175(0.95)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C328(0.71); C344(0.71); C204(0.90); C217(1.03)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C328(0.61); C344(0.61); C217(0.98); C204(1.02)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C328(0.63); C344(0.63); C217(0.95); C351(1.07)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C328(0.55); C344(0.55); C217(0.84); C351(0.89)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C217(0.71); C328(0.77); C344(0.77); C204(0.77)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C217(0.76); C328(0.78); C344(0.78); C204(0.88)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C217(0.60); C328(0.82); C344(0.82); C22(1.02)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C217(0.61); C328(0.70); C344(0.70); C204(0.95)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C328(0.77); C344(0.77); C217(0.85); C204(0.86)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C328(0.80); C344(0.80); C204(0.91); C217(0.95)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C328(0.80); C344(0.80); C217(0.82); C351(1.01)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C328(0.78); C344(0.78); C217(0.82); C204(0.93)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C217(0.80); C328(0.84); C344(0.84); C204(1.01)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C217(0.76); C328(0.82); C344(0.82); C204(0.94)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C217(0.82); C328(0.82); C344(0.82); C204(0.96)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C328(0.81); C344(0.81); C217(0.86); C204(0.90)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C217(0.80); C328(0.87); C344(0.87); C204(0.89)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C217(0.58); C328(0.82); C344(0.82); C204(1.10)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C217(0.82); C351(0.91); C204(0.92); C328(0.95)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C217(0.59); C328(0.86); C344(0.86); C204(0.91)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C217(0.81); C328(0.88); C344(0.88); C204(0.94)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C351(0.82); C328(0.99); C344(0.99); C204(1.24)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C351(0.90); C328(0.92); C344(0.92); C204(1.15)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C351(0.89); C328(1.03); C344(1.03); C204(1.27)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C351(0.95); C328(1.27); C344(1.27); C204(1.34)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C351(0.97); C22(1.06); C204(1.19); C328(1.24)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C351(0.94); C22(1.11); C204(1.18); C328(1.42)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C351(1.01); C204(1.14); C22(1.18); C328(1.32)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C351(0.87); C22(1.01); C204(1.09); C328(1.21)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C351(0.94); C204(1.05); C328(1.31); C344(1.31)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C351(0.79); C204(0.93); C328(1.13); C344(1.13)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C351(0.84); C204(1.05); C328(1.11); C344(1.11)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C204(0.99); C351(1.02); C22(1.16); C328(1.25)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C351(0.89); C204(1.02); C328(1.28); C344(1.28)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C351(1.05); C204(1.14); C328(1.20); C344(1.20)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C351(0.75); C328(1.21); C344(1.21); C204(1.34)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C217(0.21); C328(0.49); C344(0.49); C351(0.71)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C217(0.48); C328(0.67); C344(0.67); C351(0.88)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C204(1.09); C217(0.71); C22(1.03); C328(0.89)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C217(0.66); C328(0.86); C344(0.86); C204(1.27)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C217(0.59); C328(0.75); C344(0.75); C204(1.78)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.32  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C204(1.06)  LDD0078  [7]
 LDCM0630  CCW28-3 231MFP C201(1.00)  LDD2214  [20]
 LDCM0108  Chloroacetamide HeLa C348(0.00); C201(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C22(2.78); C22(0.75); C201(0.38)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C351(0.82); C22(0.98); C204(1.08); C328(1.14)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C351(0.77); C175(0.84); C217(0.86); C272(0.91)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C328(0.60); C344(0.60); C217(0.66); C272(0.96)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C217(0.57); C328(0.77); C344(0.77); C22(1.23)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C217(0.82); C328(0.85); C344(0.85); C22(1.01)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C217(0.85); C328(0.90); C344(0.90); C204(1.02)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C217(0.85); C328(0.85); C344(0.85); C204(0.98)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C328(0.62); C344(0.62); C175(0.65); C217(0.69)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C175(0.47); C328(0.57); C344(0.57); C217(0.57)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C328(0.60); C344(0.60); C175(0.62); C217(0.64)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C328(0.62); C344(0.62); C175(0.63); C217(0.74)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C328(0.67); C344(0.67); C217(0.78); C351(0.84)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C351(0.68); C175(0.85); C328(0.86); C344(0.86)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C175(0.58); C217(0.70); C328(0.73); C344(0.73)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C328(0.63); C344(0.63); C175(0.64); C351(0.80)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C328(0.74); C344(0.74); C217(0.89); C22(0.99)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C328(0.50); C344(0.50); C217(0.84); C351(1.06)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C328(0.65); C344(0.65); C217(0.85); C351(1.08)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C328(0.61); C344(0.61); C217(0.75); C351(1.14)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C328(0.68); C344(0.68); C217(0.72); C351(0.90)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C217(0.81); C351(0.91); C272(0.98); C328(1.13)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C217(0.76); C351(0.80); C272(0.90); C22(0.98)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C351(0.80); C217(0.86); C272(1.03); C328(1.10)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C351(0.70); C328(0.91); C344(0.91); C175(0.93)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C351(0.67); C217(0.71); C272(1.04); C22(1.04)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C272(0.65); C351(1.04); C217(1.14); C22(1.21)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C217(0.81); C328(0.82); C344(0.82); C272(0.92)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C217(0.79); C328(0.83); C344(0.83); C351(0.93)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C328(0.83); C344(0.83); C217(0.85); C272(0.90)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C328(0.87); C344(0.87); C175(1.05); C217(1.08)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C328(1.09); C344(1.09); C22(1.11); C204(1.12)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C328(0.71); C344(0.71); C351(0.97); C204(1.05)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C328(0.74); C344(0.74); C204(0.94); C351(0.99)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C175(0.68); C328(0.85); C344(0.85); C351(0.94)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C351(0.76); C175(0.81); C328(0.95); C344(0.95)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C175(0.74); C217(0.86); C328(0.86); C344(0.86)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C351(1.00); C328(1.03); C344(1.03); C22(1.08)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C351(0.86); C204(0.92); C328(1.02); C344(1.02)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C328(0.82); C344(0.82); C175(0.83); C204(0.90)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C217(0.85); C175(0.89); C204(0.90); C328(0.95)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C175(0.87); C351(0.97); C328(0.99); C344(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C175(0.78); C351(0.85); C204(0.87); C217(0.93)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C175(0.76); C217(0.84); C351(0.92); C204(0.93)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C175(0.84); C217(0.87); C328(0.93); C344(0.93)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C328(0.91); C344(0.91); C351(0.92); C175(1.09)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C175(0.84); C217(0.91); C351(0.93); C328(0.98)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C175(0.80); C204(0.96); C217(0.89); C22(1.47)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C175(0.96); C204(1.04); C217(0.99); C22(1.23)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C175(0.84); C204(1.00); C217(0.77); C22(1.19)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C175(0.82); C204(0.95); C217(0.94); C22(1.55)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C175(0.91); C204(1.04); C217(0.88); C22(1.50)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C175(0.99); C204(1.03); C217(1.18); C22(0.90)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C175(0.87); C204(0.84); C217(1.07); C22(1.16)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C204(1.19); C217(0.80); C22(0.95); C272(0.84)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C204(1.14); C217(0.75); C22(1.07); C272(0.77)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C204(1.44); C217(0.89); C22(1.13); C272(0.83)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C204(1.26); C217(0.74); C22(1.04); C272(0.78)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C204(1.46); C217(0.89); C22(1.03); C272(0.83)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C204(1.38); C217(0.83); C22(1.05); C272(0.83)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C204(1.52); C217(0.81); C22(1.08); C272(0.76)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C204(1.60); C217(0.80); C22(1.08); C272(0.76)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C175(1.04); C204(1.11); C217(1.09); C22(1.01)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C204(1.33); C217(0.86); C22(1.07); C272(0.90)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C204(1.47); C217(0.77); C22(1.01); C272(0.90)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C204(2.13); C217(0.75); C22(1.04); C272(0.83)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C204(1.55); C217(0.91); C22(1.07); C272(0.82)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C204(1.44); C217(0.81); C22(0.95); C272(0.85)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C204(1.43); C217(0.72); C22(0.92); C272(0.73)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C175(1.14); C204(0.86); C217(1.64); C22(0.77)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C175(0.96); C204(0.91); C217(1.58); C22(0.80)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C175(1.02); C204(0.91); C217(1.60); C22(0.73)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C175(0.86); C204(1.11); C217(1.94); C22(0.77)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C175(0.95); C204(1.23); C217(1.09); C22(1.13)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C175(1.08); C204(0.98); C217(1.38); C22(0.78)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C175(1.07); C204(0.96); C217(1.16); C22(0.76)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C175(0.85); C204(0.85); C217(1.15); C22(0.78)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C175(0.98); C204(0.94); C217(1.63); C22(0.77)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C175(1.16); C204(0.87); C217(1.67); C22(0.74)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C175(0.91); C204(0.86); C217(1.55); C22(0.73)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C175(1.02); C204(1.08); C217(1.16); C22(0.91)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C175(0.83); C204(1.28); C217(1.22); C22(0.79)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C175(0.98); C204(0.78); C217(1.49); C22(0.74)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C175(0.95); C204(0.88); C217(1.23); C22(0.85)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C175(1.03); C204(1.30); C217(1.04); C22(1.14)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C175(0.96); C204(0.80); C217(1.64); C22(0.89)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C175(0.98); C204(1.06); C217(0.77); C22(1.18)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C175(0.98); C204(1.35); C217(0.84); C22(1.19)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C175(0.82); C204(1.61); C217(0.59); C22(1.28)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C175(0.94); C204(1.29); C217(0.72); C22(1.33)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C175(0.90); C204(1.39); C217(0.67); C22(1.12)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C175(0.82); C204(1.73); C217(0.62); C22(1.63)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C175(0.86); C204(1.45); C217(0.70); C22(1.42)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C175(1.00); C204(1.63); C217(0.52); C22(1.36)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C175(0.85); C204(1.51); C217(0.76); C22(1.25)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C175(0.98); C204(1.22); C217(0.99); C22(1.22)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C175(0.86); C204(1.15); C217(0.60); C22(1.31)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C175(0.88); C204(1.65); C217(0.57); C22(1.44)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C175(0.89); C204(1.31); C217(0.67); C22(1.24)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C175(0.98); C204(1.78); C217(0.85); C22(1.35)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C175(0.95); C204(1.68); C217(0.76); C22(1.35)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C175(0.91); C204(1.37); C217(0.68); C22(1.18)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C175(0.93); C204(1.33); C217(1.53); C22(1.06)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C175(0.81); C204(1.30); C217(0.74); C22(1.35)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C175(0.85); C204(1.56); C217(0.80); C22(1.45)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C175(1.41); C204(2.05); C217(0.96); C22(1.50)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C175(0.90); C204(1.28); C217(1.54); C22(1.09)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C175(0.82); C204(1.48); C217(0.78); C22(1.19)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C175(0.95); C204(1.55); C217(0.76); C22(1.65)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C175(0.85); C204(2.07); C217(0.67); C22(1.77)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C175(0.99); C204(2.29); C217(0.74); C22(2.19)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C175(0.91); C204(1.45); C217(0.76); C22(1.32)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C175(0.93); C204(1.49); C217(0.90); C22(1.16)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C175(1.00); C204(1.72); C217(0.70); C22(1.43)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C175(0.98); C204(1.70); C217(0.67); C22(1.54)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C175(0.93); C204(1.99); C217(0.72); C22(2.55)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C175(0.82); C204(1.39); C217(0.99); C22(1.30)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C175(0.87); C204(1.25); C217(1.59); C22(1.11)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C204(1.10); C217(0.65); C22(1.28); C272(0.97)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C204(1.08); C217(0.80); C22(1.12); C272(1.19)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C204(1.12); C217(0.87); C22(1.01); C272(1.10)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C204(1.11); C217(0.61); C22(1.35); C272(0.97)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C204(1.41); C217(0.64); C22(1.39); C272(1.04)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C204(1.04); C217(0.63); C22(1.14); C272(1.04)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C204(1.17); C217(0.75); C22(1.16); C272(1.00)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C204(1.22); C217(0.71); C22(1.29); C272(1.03)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C204(1.29); C217(0.73); C22(1.11); C272(0.92)  LDD0811  [7]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C204(14.86)  LDD0513  [21]
 LDCM0495  E2913 HEK-293T C201(1.06); C214(0.91); C269(9.51); C172(1.01)  LDD1698  [22]
 LDCM0031  Epigallocatechin gallate HEK-293T 12.11  LDD0183  [5]
 LDCM0625  F8 Ramos C201(1.59); C214(0.44); C348(0.76); 2.04  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C204(2.10)  LDD1390  [24]
 LDCM0573  Fragment11 Ramos C204(7.51)  LDD1392  [24]
 LDCM0574  Fragment12 Ramos C204(1.11)  LDD1394  [24]
 LDCM0575  Fragment13 MDA-MB-231 C204(2.03)  LDD1395  [24]
 LDCM0576  Fragment14 MDA-MB-231 C204(2.57)  LDD1397  [24]
 LDCM0577  Fragment15 Ramos C204(1.14)  LDD1400  [24]
 LDCM0579  Fragment20 MDA-MB-231 C204(1.14)  LDD1402  [24]
 LDCM0580  Fragment21 MDA-MB-231 C204(1.47)  LDD1404  [24]
 LDCM0581  Fragment22 MDA-MB-231 C204(3.96)  LDD1406  [24]
 LDCM0582  Fragment23 Ramos C201(1.40); C214(1.19); C348(1.12); 0.90  LDD2196  [23]
 LDCM0578  Fragment27 MDA-MB-231 C204(1.21)  LDD1401  [24]
 LDCM0586  Fragment28 MDA-MB-231 C204(0.95)  LDD1415  [24]
 LDCM0587  Fragment29 MDA-MB-231 C204(1.66)  LDD1417  [24]
 LDCM0588  Fragment30 Ramos C204(2.25)  LDD1420  [24]
 LDCM0589  Fragment31 Ramos C201(0.96); C214(1.40); C348(1.22); 0.96  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C201(3.27); C214(0.49); C348(0.44); 1.82  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C175(0.74); C204(1.23); C217(0.61); C22(1.20)  LDD0785  [7]
 LDCM0595  Fragment37 Ramos C204(0.94)  LDD1432  [24]
 LDCM0596  Fragment38 MDA-MB-231 C204(1.41)  LDD1433  [24]
 LDCM0566  Fragment4 MDA-MB-231 C204(1.63)  LDD1378  [24]
 LDCM0599  Fragment41 Ramos C204(1.98)  LDD1439  [24]
 LDCM0602  Fragment44 MDA-MB-231 C204(0.82)  LDD1443  [24]
 LDCM0427  Fragment51 HCT 116 C204(1.66); C217(0.83); C22(1.17); C272(0.77)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C201(1.04); C214(0.44); C348(1.44); 1.37  LDD2204  [23]
 LDCM0611  Fragment53 Ramos C204(1.12)  LDD1455  [24]
 LDCM0612  Fragment54 MDA-MB-231 C204(1.23)  LDD1456  [24]
 LDCM0613  Fragment55 MDA-MB-231 C204(1.11)  LDD1457  [24]
 LDCM0614  Fragment56 Ramos C204(1.28)  LDD1459  [24]
 LDCM0569  Fragment7 Ramos C201(1.83); C214(0.65); C348(0.46); 1.22  LDD2186  [23]
 LDCM0570  Fragment8 Ramos C204(1.58)  LDD1386  [24]
 LDCM0571  Fragment9 MDA-MB-231 C204(2.02)  LDD1387  [24]
 LDCM0015  HNE MDA-MB-231 C201(0.93)  LDD0346  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [2]
 LDCM0022  KB02 HCT 116 C204(3.75); C22(1.97)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C204(1.26); C22(1.07)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C204(2.03); C22(1.93)  LDD0082  [7]
 LDCM0030  Luteolin HEK-293T 6.52  LDD0182  [5]
 LDCM0109  NEM HeLa N.A.  LDD0226  [14]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C201(1.14)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C201(0.88)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C201(0.78)  LDD2107  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C201(1.03)  LDD2114  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C201(1.01)  LDD2118  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C201(0.73)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C201(0.76)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C201(0.85)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C201(0.93); C96(0.14)  LDD2126  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C201(0.60)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C201(0.52)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C201(1.18)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C201(0.96)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C201(0.85)  LDD2140  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C201(0.76)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C201(0.63)  LDD2207  [25]
 LDCM0029  Quercetin HEK-293T 4.49  LDD0181  [5]
 LDCM0131  RA190 MM1.R C204(1.32)  LDD0304  [26]
 LDCM0096  SAHA K562 4.00  LDD0360  [3]
 LDCM0021  THZ1 HCT 116 C22(0.94); C204(0.96)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9

References

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2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
21 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.