Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | SAHA-CA-4PAP | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | 3 uM | |||||
| Criteria | Quantification: Probe vs (Probe+Competitor) | |||||
| Quantitative Method |
LFQ
|
|||||
| Competitor Name | SAHA | Competitor Info | ||||
| Competitor Concentration | 20 uM | |||||
| In Vivo Experiment Model | Model Type |
|
Cell lysate | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Chronic myeloid leukemia [ICD-11:2A20] | |||||
| Model Name | Human chronic myeloid leukemia cell lysate (K562) | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP05918 | Histone deacetylase 1 (HDAC1) | 9.1 | ||||
| LDTP09865 | Histone deacetylase 2 (HDAC2) | 7.7 | ||||
| LDTP13136 | Histone deacetylase 6 (HDAC6) | 7.1 | ||||
| LDTP12873 | CDGSH iron-sulfur domain-containing protein 1 (CISD1) | 6.0 | ||||
| LDTP10828 | 2-aminoethanethiol dioxygenase (ADO) | 6.0 | ||||
| LDTP03847 | Transaldolase (TALDO1) | 5.0 | ||||
| LDTP02640 | X-ray repair cross-complementing protein 6 (XRCC6) | 4.5 | ||||
| LDTP02706 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) | 4.0 | ||||
| LDTP10137 | Cytochrome c oxidase assembly factor 7 (COA7) | 4.0 | ||||
| LDTP11433 | Histone deacetylase 8 (HDAC8) | 4.0 | ||||
| LDTP08858 | Probable hydrolase PNKD (PNKD) | 4.0 | ||||
| LDTP04959 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) | 4.0 | ||||
| LDTP00622 | Histone deacetylase 3 (HDAC3) | . | ||||
| LDTP00957 | Lysine-specific histone demethylase 1A (KDM1A) | . | ||||
Transcription factor
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP08741 | Mesoderm induction early response protein 1 (MIER1) | . | ||||
| LDTP05830 | Metastasis-associated protein MTA1 (MTA1) | . | ||||
| LDTP01414 | Metastasis-associated protein MTA2 (MTA2) | . | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP11911 | Golgi phosphoprotein 3 (GOLPH3) | 4.5 | ||||
| LDTP12914 | Hsp70-binding protein 1 (HSPBP1) | 4.0 | ||||
| LDTP11544 | F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) | . | ||||
| LDTP10823 | Paired amphipathic helix protein Sin3a (SIN3A) | . | ||||
| LDTP01156 | Paired amphipathic helix protein Sin3b (SIN3B) | . | ||||
| LDTP19372 | Tetratricopeptide repeat protein 38 (TTC38) | . | ||||
| LDTP11233 | Tubulin beta-6 chain (TUBB6) | . | ||||