Details of the Target

General Information of Target

Target ID LDTP05830
Target Name Metastasis-associated protein MTA1 (MTA1)
Gene Name MTA1
Gene ID 9112
Synonyms
Metastasis-associated protein MTA1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALAD
KHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPAT
HIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDL
LKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHM
SAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEAL
EKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN
KPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASC
WTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTR
IARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRY
LETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDGNMKKRLL
MPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYM
ATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Cytoplasm; Nucleus
Function
Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation.; [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.
TTD ID
T23619
Uniprot ID
Q13330
DrugMap ID
TTO4HUS
Ensemble ID
ENST00000331320.12
HGNC ID
HGNC:7410

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R531C DBIA    Probe Info 
COLO792 Substitution: p.S232F DBIA    Probe Info 
HCC1937 SNV: p.S219Y .
HCT15 SNV: p.V12I .
IGROV1 Deletion: p.V220GfsTer105 DBIA    Probe Info 
RPMI8226 SNV: p.Y303Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.07  LDD0402  [1]
TH211
 Probe Info  		Y355(20.00); Y540(16.48); Y585(12.28); Y472(5.51)  LDD0257  [2]
SAHA-CA-4PAP
 Probe Info  		N.A.  LDD0360  [3]
BTD
 Probe Info  		C229(1.90)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C68(3.26)  LDD0168  [5]
HHS-475
 Probe Info  		Y22(0.41)  LDD0264  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
DBIA
 Probe Info  		C417(1.06); C420(1.06); C393(0.84); C396(0.84)  LDD0078  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C281(0.00); C229(0.00); C68(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C281(0.00); C229(0.00); C68(0.00); C417(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		C68(0.00); C281(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C281(0.00); C229(0.00); C68(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		C68(0.00); C512(0.00)  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
Compound 10
 Probe Info  		C229(0.00); C68(0.00)  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
IPM
 Probe Info  		C229(0.00); C68(0.00)  LDD0005  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		7.60  LDD0443  [17]
NAIA_5
 Probe Info  		C512(0.00); C229(0.00); C126(0.00)  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C229(0.74)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C229(0.76)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C229(0.92); C281(0.99)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C68(3.26)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C68(3.26); C229(2.27)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C126(0.89); C229(1.40); C281(1.23); C396(1.01)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C126(0.79); C229(1.25); C281(0.96); C393(0.93)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C126(0.86); C229(1.08); C281(0.64); C417(0.78)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C126(0.74); C229(1.11); C281(0.65); C417(0.73)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C126(1.03); C229(0.96); C281(0.65); C417(0.86)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C126(0.82); C229(1.17); C281(0.55); C417(0.74)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C126(0.87); C229(1.06); C281(0.60); C417(0.98)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C126(0.77); C229(0.97); C281(0.60); C417(0.73)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C126(0.74); C229(1.07); C281(0.56); C417(0.76)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C126(0.83); C229(1.25); C281(0.56); C417(0.86)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C126(0.83); C229(1.06); C281(0.69); C417(0.83)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C126(0.85); C229(0.91); C281(0.63); C417(0.81)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C126(0.94); C229(1.29); C281(0.95); C393(1.63)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C126(0.76); C229(0.96); C281(0.65); C417(0.78)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C126(0.71); C229(0.98); C281(0.59); C417(0.88)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C126(0.66); C229(1.18); C281(0.49); C417(0.88)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C126(1.02); C229(0.92); C281(0.98); C417(0.97)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C126(0.92); C229(1.08); C281(0.79); C417(0.84)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C126(0.99); C229(1.40); C281(0.86); C417(0.82)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C126(0.92); C229(1.12); C281(0.76); C417(0.76)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C126(0.86); C229(1.05); C281(0.95); C417(0.90)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C126(0.92); C229(1.12); C281(0.78); C417(0.78)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C126(0.96); C229(1.28); C281(0.84); C417(0.82)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C126(0.94); C229(1.30); C281(1.04); C393(1.02)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C126(0.98); C229(1.27); C281(0.84); C417(0.99)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C126(0.98); C229(1.15); C281(1.07); C417(1.13)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C126(0.91); C229(1.03); C281(0.92); C417(0.82)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C126(0.96); C229(1.11); C281(1.01); C417(1.17)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C126(0.99); C229(0.90); C281(0.95); C417(1.05)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C126(0.95); C229(1.03); C281(0.82); C417(0.93)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C126(1.06); C229(1.11); C281(0.78); C417(0.96)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C126(0.88); C229(1.06); C281(0.80); C417(0.96)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C126(1.31); C229(1.10); C281(1.63); C396(0.67)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C126(1.20); C229(0.93); C281(1.26); C396(0.51)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C126(1.08); C229(1.18); C281(1.22); C396(0.82)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C126(1.25); C229(0.87); C281(1.19); C396(0.88)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C126(1.01); C229(1.08); C281(1.32); C396(0.51)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C126(1.22); C229(1.07); C281(1.35); C396(0.40)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C126(1.11); C229(1.20); C281(0.95); C396(0.48)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C126(1.21); C229(1.06); C281(1.09); C396(0.91)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C126(0.94); C229(1.13); C281(1.05); C396(0.86)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C126(1.06); C229(1.01); C281(1.12); C396(0.55)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C126(0.87); C229(1.25); C281(1.07); C396(0.54)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C126(1.06); C229(1.21); C281(1.24); C396(0.52)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C126(0.89); C229(1.30); C281(1.07); C393(0.66)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C126(1.15); C229(1.26); C281(0.92); C396(0.46)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C126(0.99); C229(1.28); C281(1.06); C396(0.58)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C126(1.09); C229(1.12); C281(1.80); C396(0.62)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C281(0.77); C417(0.90); C420(0.93); C414(0.94)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C281(0.63); C417(0.88); C420(0.95); C229(1.13)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C414(0.55); C281(0.77); C417(0.89); C420(0.89)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C281(0.63); C417(0.87); C414(0.90); C396(1.01)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C414(0.69); C281(0.81); C417(0.81); C396(0.87)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C414(0.64); C281(0.77); C417(0.81); C396(0.81)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C414(0.61); C396(0.66); C281(0.67); C393(0.71)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C417(0.79); C126(0.89); C420(0.91); C281(0.94)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C414(0.54); C281(0.67); C396(0.69); C420(0.83)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C281(0.69); C417(0.84); C420(0.87); C393(1.11)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C281(0.65); C414(0.77); C396(0.87); C417(0.91)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C281(0.69); C417(0.83); C414(0.91); C420(0.92)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C229(1.13); C281(0.63); C393(0.98); C396(0.78)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C229(1.23); C281(0.57); C393(0.98); C396(1.08)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C229(1.10); C281(0.69); C393(1.27); C396(0.98)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C229(1.03); C281(0.65); C393(0.99); C396(0.84)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C281(0.96); C417(1.04); C229(1.06); C126(1.12)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C229(0.83); C281(0.89); C417(0.96); C126(1.49)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C281(0.83); C229(0.87); C396(1.05); C414(1.05)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C396(0.50); C414(0.50); C420(0.72); C417(0.84)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C281(0.80); C229(1.02); C126(1.07); C417(1.13)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C281(0.81); C229(0.94); C417(0.97); C396(1.13)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C229(0.95); C281(0.95); C396(1.05); C414(1.05)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C281(0.90); C229(0.95); C396(1.00); C414(1.00)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C281(0.90); C229(0.97); C126(1.07); C417(1.19)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C393(0.86); C414(0.86); C281(0.89); C420(0.90)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C281(0.78); C417(0.82); C420(0.84); C393(0.90)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C281(0.74); C420(0.84); C417(0.92); C229(0.99)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C281(0.80); C417(0.81); C420(0.91); C229(0.99)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C420(0.74); C281(0.75); C417(0.84); C229(1.24)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C420(0.66); C396(0.73); C414(0.73); C417(0.77)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C281(0.70); C420(0.72); C417(0.81); C229(1.17)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C281(0.79); C417(0.82); C229(0.90); C420(0.93)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C417(0.74); C281(0.75); C420(0.78); C229(1.14)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C281(0.69); C417(0.86); C420(0.88); C393(0.93)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C281(0.71); C417(0.97); C420(0.97); C229(1.09)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C414(0.83); C229(0.84); C420(0.96); C396(1.03)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C393(0.75); C396(0.76); C414(0.76); C229(0.99)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C414(0.77); C396(0.87); C393(0.88); C417(0.88)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C414(0.87); C417(0.94); C229(0.95); C396(1.01)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C414(0.80); C417(0.82); C396(0.88); C229(0.91)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C420(0.63); C417(0.81); C126(0.92); C396(1.10)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C414(0.79); C417(0.88); C229(0.95); C420(0.97)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C414(0.70); C396(0.71); C393(0.74); C417(0.85)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C417(0.82); C281(0.88); C396(0.95); C414(0.98)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C417(0.86); C414(0.91); C281(0.95); C396(0.96)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C417(0.77); C414(0.78); C281(0.90); C396(0.92)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C414(0.78); C417(0.79); C396(0.79); C393(0.90)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C126(0.81); C420(0.86); C417(0.91); C229(0.98)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C420(0.86); C417(0.88); C126(0.90); C393(0.94)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C396(0.71); C126(0.74); C420(0.76); C417(0.79)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C126(0.80); C420(0.96); C417(0.96); C414(1.03)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C420(0.68); C396(0.75); C414(0.75); C417(0.86)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C126(0.75); C414(0.89); C396(0.93); C281(0.99)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C126(0.78); C396(0.89); C414(0.91); C420(0.98)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C396(0.79); C126(0.83); C281(0.92); C414(0.96)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C126(0.92); C281(0.93); C396(0.94); C414(0.97)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C126(0.80); C414(0.87); C396(0.91); C281(0.91)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C414(0.84); C396(0.89); C393(0.91); C417(0.96)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C126(0.84); C420(1.07); C414(1.07); C417(1.09)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C417(0.62); C420(0.66); C281(0.77); C229(1.45)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C417(0.61); C281(0.73); C420(0.75); C229(1.30)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C420(0.59); C417(0.59); C281(0.73); C229(1.27)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C126(0.77); C281(0.80); C417(0.86); C393(0.93)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C281(0.72); C417(0.75); C420(0.75); C229(1.52)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C417(0.55); C420(0.59); C281(0.90); C229(1.43)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C420(0.67); C417(0.68); C281(0.71); C229(1.63)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C417(0.61); C420(0.63); C281(0.73); C229(1.41)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C281(0.75); C417(0.75); C420(0.76); C229(1.58)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C417(0.57); C420(0.59); C281(0.91); C229(1.51)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C417(0.58); C420(0.69); C281(0.89); C229(1.60)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C417(0.64); C420(0.67); C281(0.80); C229(1.68)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C417(0.84); C420(0.92); C126(0.93); C281(0.95)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C417(0.89); C420(0.91); C414(1.01); C229(1.05)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C417(0.84); C393(0.88); C396(0.88); C420(0.91)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C420(0.59); C417(0.61); C414(0.90); C126(0.91)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C420(0.81); C417(0.84); C229(1.10); C414(1.11)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C420(0.85); C417(0.88); C414(1.08); C126(1.10)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C420(0.76); C417(0.79); C414(0.83); C126(0.88)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C420(0.75); C417(0.82); C126(0.97); C414(0.99)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C417(0.83); C420(0.87); C414(0.92); C396(0.94)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C420(0.77); C417(0.80); C414(0.81); C396(1.00)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C417(0.83); C420(0.87); C126(0.90); C281(0.92)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C417(0.73); C420(0.75); C414(0.95); C126(0.97)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C420(0.75); C417(0.75); C414(0.86); C396(0.98)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C281(0.80); C417(0.81); C126(0.82); C420(0.87)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C420(0.79); C417(0.85); C414(1.05); C126(1.05)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C414(0.83); C417(0.83); C420(0.85); C393(0.86)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C420(0.74); C417(0.75); C414(0.87); C396(0.96)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C396(0.64); C414(0.67); C281(0.70); C420(0.72)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C420(0.75); C417(0.76); C281(0.77); C414(0.88)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C420(0.71); C396(0.71); C414(0.72); C417(0.74)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C396(0.66); C414(0.66); C281(0.71); C417(0.78)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C396(0.68); C414(0.70); C417(0.74); C420(0.76)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C396(0.58); C414(0.63); C281(0.68); C393(0.82)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C396(0.70); C281(0.72); C414(0.80); C417(0.83)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C396(0.71); C414(0.73); C281(0.90); C126(0.96)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C396(0.64); C414(0.66); C281(0.72); C417(0.79)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C281(0.67); C396(0.68); C414(0.69); C417(0.77)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C414(0.74); C281(0.76); C393(0.79); C396(0.81)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C281(0.66); C396(0.73); C414(0.81); C420(0.87)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C396(0.69); C414(0.78); C420(0.78); C417(0.80)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C281(0.66); C420(0.71); C417(0.73); C396(0.74)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C396(0.68); C281(0.70); C414(0.71); C417(0.77)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C281(0.61); C126(0.64); C417(0.71); C420(0.73)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C420(0.72); C281(0.73); C417(0.73); C126(0.84)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C126(1.44); C229(1.14); C281(1.12); C393(0.80)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C393(0.66); C396(0.66); C417(0.79); C126(0.85)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C126(0.72); C417(0.74); C393(0.79); C396(0.79)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C417(1.06); C420(1.06); C393(0.84); C396(0.84)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa C44(0.00); C281(0.00)  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C229(3.25); C68(1.65); C229(1.53)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C393(0.37); C396(0.72); C414(0.72); C281(0.82)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C393(0.45); C417(0.73); C281(0.80); C420(0.88)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C126(0.82); C420(0.91); C396(0.93); C414(0.93)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C281(0.85); C417(0.91); C393(0.96); C396(0.96)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C393(0.73); C396(0.73); C126(0.86); C417(0.91)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C417(0.94); C281(0.95); C126(1.02); C393(1.05)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C126(0.93); C417(0.93); C281(1.01); C229(1.11)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C417(0.78); C396(0.83); C414(0.83); C281(0.88)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C417(0.74); C229(0.89); C281(0.97); C396(0.98)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C417(0.73); C229(0.80); C281(0.98); C396(1.02)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C417(0.76); C281(0.93); C229(0.99); C126(1.20)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C281(0.83); C229(0.92); C417(0.92); C396(1.13)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C393(0.34); C417(0.75); C420(0.85); C396(0.94)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C417(0.74); C281(0.82); C229(0.87); C396(1.07)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C281(0.83); C417(1.04); C229(1.17); C396(1.22)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C393(0.74); C414(0.74); C417(0.85); C229(0.86)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C281(0.71); C417(0.86); C420(0.88); C393(0.93)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C281(0.75); C417(0.81); C420(0.86); C393(1.01)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C281(0.69); C417(0.78); C420(0.89); C393(1.00)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C281(0.78); C420(0.84); C417(0.85); C393(1.04)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C414(0.77); C417(0.83); C396(0.94); C420(0.97)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C414(0.76); C417(0.81); C229(0.84); C396(0.89)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C414(0.83); C417(0.96); C396(1.00); C229(1.01)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C393(0.45); C417(0.80); C396(0.83); C414(0.83)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C414(0.70); C396(0.76); C417(0.86); C393(0.86)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C396(0.73); C281(0.78); C126(0.83); C393(0.99)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C126(0.78); C414(0.89); C420(0.90); C417(0.94)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C126(0.77); C420(0.81); C417(0.81); C281(0.91)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C126(0.75); C414(0.87); C281(0.94); C420(0.98)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C420(0.61); C417(0.65); C281(0.79); C229(1.33)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C281(0.76); C420(1.09); C229(1.32); C417(1.51)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C417(0.71); C281(0.72); C420(0.79); C229(1.15)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C417(0.66); C281(0.74); C420(0.74); C229(1.27)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C393(0.49); C417(0.79); C126(0.84); C420(0.93)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C393(0.45); C417(0.80); C396(0.84); C414(0.84)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C393(0.26); C126(0.88); C396(0.90); C414(0.90)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C396(0.65); C393(0.68); C281(0.92); C229(1.14)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C126(0.75); C393(0.77); C396(0.77); C414(0.86)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C393(0.69); C396(0.91); C126(0.94); C281(0.99)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C393(0.58); C396(0.66); C281(0.89); C420(0.95)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C393(0.40); C281(0.85); C417(0.96); C396(1.01)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C393(0.62); C396(0.66); C281(0.80); C420(0.95)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C396(0.66); C393(0.67); C281(0.88); C126(0.89)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C393(0.59); C396(0.69); C229(1.00); C420(1.03)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C393(0.81); C281(0.85); C396(1.01); C126(1.13)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C393(0.63); C396(0.76); C281(0.92); C420(0.98)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C126(1.11); C229(1.11); C281(0.84); C393(0.40)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C126(0.68); C229(1.38); C281(0.79); C393(0.89)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C126(0.83); C229(1.07); C281(0.84); C393(0.57)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C126(0.88); C229(1.12); C281(0.80); C393(0.65)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C126(1.57); C229(1.05); C281(0.84); C393(0.71)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C126(0.91); C229(0.97); C281(0.95); C393(0.33)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C126(1.12); C229(0.99); C281(0.88); C393(0.68)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C126(0.74); C229(1.00); C281(0.86); C396(0.96)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C126(0.64); C229(0.88); C281(1.17); C396(0.79)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C126(0.75); C229(0.84); C281(0.90); C396(0.91)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C126(0.82); C229(1.13); C281(0.87); C396(1.02)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C126(0.72); C229(0.93); C281(0.76); C396(0.85)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C126(0.77); C229(0.92); C281(0.82); C396(0.97)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C126(0.82); C229(1.05); C281(0.85); C396(0.98)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C126(0.86); C229(0.95); C281(0.89); C396(0.93)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C126(0.97); C229(0.98); C281(0.93); C393(0.50)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C126(0.93); C229(1.05); C281(0.77); C396(0.85)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C126(0.77); C229(0.82); C281(0.84); C396(0.98)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C126(0.86); C229(0.91); C281(0.95); C396(0.87)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C126(0.78); C229(1.09); C281(0.88); C396(1.01)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C126(0.79); C229(1.15); C281(0.90); C396(1.00)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C126(0.77); C229(1.04); C281(0.85); C396(1.34)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C126(1.22); C229(1.13); C281(1.05); C393(1.31)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C126(0.85); C229(1.13); C281(0.93); C393(1.00)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C126(1.10); C229(1.18); C281(1.19); C393(2.08)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C126(1.05); C229(1.16); C281(1.30); C393(1.63)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C126(1.04); C229(1.02); C281(1.02); C393(0.43)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C126(0.96); C229(1.07); C281(0.77); C393(1.29)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C126(1.04); C229(1.10); C281(0.86); C393(1.18)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C126(0.98); C229(1.18); C281(0.77); C393(1.23)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C126(0.90); C229(1.04); C281(0.87); C393(1.35)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C126(1.05); C229(1.06); C281(1.02); C393(1.76)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C126(0.92); C229(1.02); C281(0.97); C393(1.90)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C126(0.96); C229(1.28); C281(1.13); C393(0.99)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C126(1.05); C229(1.07); C281(0.97); C393(1.08)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C126(1.04); C229(1.15); C281(1.04); C393(1.12)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C126(0.94); C229(1.03); C281(1.13); C393(1.19)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C126(0.94); C229(1.03); C281(0.90); C393(0.54)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C126(0.95); C229(1.07); C281(0.85); C393(1.29)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C126(1.00); C229(1.01); C281(0.95); C396(0.95)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C126(1.01); C229(1.00); C281(0.85); C396(1.06)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C126(0.91); C229(1.02); C281(0.76); C396(0.75)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C126(0.92); C229(1.05); C281(0.87); C396(0.91)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C126(0.95); C229(1.01); C281(0.81); C396(0.76)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C126(1.00); C229(0.98); C281(0.96); C396(0.66)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C126(0.88); C229(0.97); C281(0.88); C396(0.95)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C126(0.94); C229(0.98); C281(0.82); C396(0.86)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C126(0.92); C229(1.02); C281(1.03); C396(0.86)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C126(1.05); C229(1.12); C281(0.87); C393(0.57)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C126(0.93); C229(1.07); C281(0.81); C396(1.18)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C126(0.81); C229(1.08); C281(0.72); C396(0.95)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C126(0.92); C229(1.07); C281(0.92); C396(1.01)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C126(0.89); C229(0.93); C281(0.81); C396(3.00)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C126(0.89); C229(0.94); C281(0.76); C396(1.35)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C229(0.99); C281(0.97); C417(0.89); C420(0.93)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C229(1.11); C281(0.86); C417(1.08); C420(1.36)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C229(1.01); C281(0.82); C417(0.94); C420(0.85)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C229(0.99); C281(0.91); C417(0.96); C420(0.86)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C126(1.01); C229(0.91); C281(0.80); C393(0.71)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C229(1.00); C281(1.16); C417(1.01); C420(1.06)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C229(0.94); C281(0.84); C417(0.95); C420(0.85)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C229(0.98); C281(1.01); C417(1.04); C420(0.94)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C229(0.96); C281(1.01); C417(0.97); C420(0.88)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C229(1.11); C281(1.08); C417(1.13); C420(1.00)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C229(1.08); C281(0.87); C417(0.98); C420(0.92)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C229(0.97); C281(0.90); C417(0.98); C420(0.86)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C229(1.00); C281(0.90); C417(0.96); C420(0.94)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C229(1.06); C281(0.95); C417(1.02); C420(0.99)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C229(0.95); C281(1.13); C417(0.98); C420(0.86)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C126(0.88); C229(1.09); C281(0.87); C393(0.51)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C229(0.94); C281(1.08); C417(1.01); C420(1.01)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C126(0.94); C229(1.23); C281(0.97); C396(0.69)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C126(0.97); C229(1.14); C281(0.96); C396(0.72)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C126(0.95); C229(1.24); C281(1.07); C396(0.80)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C126(1.00); C229(1.26); C281(0.98); C396(0.76)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C126(0.90); C229(1.23); C281(0.88); C396(0.70)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C126(0.92); C229(1.16); C281(0.96); C396(0.67)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C126(0.82); C229(1.40); C281(0.89); C396(0.76)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C126(0.91); C229(1.35); C281(1.01); C396(0.86)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C126(0.82); C229(1.33); C281(1.03); C396(0.70)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C229(0.91); C68(0.91); C281(1.20); C420(1.02)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C229(1.90)  LDD1702  [4]
 LDCM0625  F8 Ramos C229(0.89)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C229(0.88)  LDD2189  [20]
 LDCM0574  Fragment12 Ramos C229(0.50)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C229(0.77)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C229(0.72)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C229(0.59)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C229(1.25)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C229(0.45)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C229(1.09)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C229(0.62)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C229(1.08)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C229(0.85)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C229(0.58)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C126(0.85); C229(1.02); C281(0.75); C396(0.83)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C229(0.89)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C229(0.52)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C126(0.90); C229(0.93); C281(0.85); C396(1.28)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C229(1.01)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C229(0.64)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C229(0.48)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C229(0.68)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y22(0.41)  LDD0264  [6]
 LDCM0118  HHS-0301 DM93 Y22(7.72)  LDD0266  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HCT 116 C393(3.01); C414(3.01); C229(1.36); C417(1.68)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C393(2.00); C414(2.00); C229(0.97); C417(1.64)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C393(2.41); C414(2.41); C229(1.58); C417(1.50)  LDD0082  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C229(0.75)  LDD2121  [4]
 LDCM0109  NEM HeLa H498(0.00); H202(0.00)  LDD0227  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C229(0.97); C512(0.76)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C229(0.51); C44(0.43)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C512(1.31)  LDD2101  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C229(1.73)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C229(0.67)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C512(0.88)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C229(0.82)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C229(0.69); C44(0.73); C512(0.41); C281(0.70)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C229(0.98)  LDD2111  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C229(0.81); C44(0.86); C512(0.53)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C229(0.89); C44(0.87); C512(0.53); C281(0.85)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C229(0.92); C44(0.81); C512(0.72)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C229(0.95); C44(0.94)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C44(1.49)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C44(1.06); C512(0.88)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C229(0.96); C44(0.96); C512(0.79)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C229(1.90)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C512(0.58)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C229(2.93); C44(1.26)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C229(0.83); C44(1.49)  LDD2146  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C229(2.82); C229(0.98)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C229(0.95); C229(0.93)  LDD2207  [21]
 LDCM0096  SAHA K562 N.A.  LDD0360  [3]
 LDCM0021  THZ1 HCT 116 C417(1.19); C420(1.19)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Histone deacetylase 2 (HDAC2) Histone deacetylase family Q92769
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Jun (JUN) BZIP family P05412
Zinc finger E-box-binding homeobox 2 (ZEB2) Delta-EF1/ZFH-1 C2H2-type zinc-finger family O60315
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Endophilin-A2 (SH3GL1) Endophilin family Q99961
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028
PRKCA-binding protein (PICK1) . Q9NRD5
Puratrophin-1 (PLEKHG4) . Q58EX7
Tumor suppressor ARF (CDKN2A) . Q8N726

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.